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KNFRAAAIGLSLFVVFAIGVTTLVYGTLRRDTTGSTKNYTAIFTDVTGVRVGDDVRIAGVRVGRVDSIEL DGSLAKLKFRVKSNQNLYGNTIVAVTYQNIIGQRYISLSRGIEGSPERLPEGSVIPVERTEPSFDVGALL NGFEPLFTLLDPKQVDNLSNGLIDAFAGDRGALAHVVAQTTEITKSFAGRDQSLGGLIDNLNTVLDNVAK QNDNLDQLVIQGQSVVGELDNRRQNLVSSIGSATHVVSRIQTIGDNVYPQMQELVYREPGTAAHILANKD QFAFLGSNLPLLLKGLARTTQDGAYGNSYACQLNINGFFPGLNDLVPEIVRRATHGNVAKYTPKCRGIE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4598c | - | - | 100% (350) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_4567c | - | e-116 | 57.51% (346) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_1009c | - | e-110 | 55.91% (347) | putative MCE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0176 | mce1B | 4e-42 | 31.89% (323) | MCE-family protein MCE1B |
| M. gilvum PYR-GCK | Mflv_0009 | - | 1e-113 | 56.07% (346) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0170 | mce1B | 2e-42 | 31.89% (323) | MCE-family protein MCE1B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 3e-44 | 30.75% (322) | putative secreted protein |
| M. marinum M | MMAR_3865 | mce5B | 1e-114 | 56.65% (346) | Mce family protein, Mce5B |
| M. avium 104 | MAV_2387 | - | 1e-113 | 56.69% (344) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_1144 | - | 1e-113 | 56.52% (345) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3156 | - | 1e-113 | 56.23% (345) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3797 | mce5B | 1e-114 | 56.36% (346) | Mce family protein, Mce5B |
| M. vanbaalenii PYR-1 | Mvan_0960 | - | 1e-113 | 57.23% (346) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1144|M.smegmatis_MC2_155 MK-IRGALIGLSLFMVVALTLTWMVYVTLRRDVAGRTVPYTAVFTDVFGL
TH_3156|M.thermoresistible__bu MR-SRGALIGLSLFMAVAVVLTWLVYVTLRRDVAGSTVPYSAVFTDVFGL
Mflv_0009|M.gilvum_PYR-GCK MK-YRGPLIGLSLFMIVAITLTWLVYVTLRRDVAGEKVPYSAMFTDVFGL
Mvan_0960|M.vanbaalenii_PYR-1 MK-YRGALVGLSLFMVVAVTLTWLVYVTLRRDVAGSTAPYAAVFTDVFGL
MMAR_3865|M.marinum_M MK-FRGPLIGLSLFMVVAVALTWMVYVSLRREVAGKTVAYAAVFTDVYGL
MUL_3797|M.ulcerans_Agy99 MK-FRGPLIGLSLFMVVAVALTWMVYVSLRREVAGKTVAYAAVFTDVYGL
MAV_2387|M.avium_104 MR-FRGPLIALTLFMIVSLTLTWLVYVSLRRDVAGDTARYSAVFSDVYGL
MAB_4598c|M.abscessus_ATCC_199 MKNFRAAAIGLSLFVVFAIGVTTLVYGTLRRDTTGSTKNYTAIFTDVTGV
Mb0176|M.bovis_AF2122/97 MK-ITGTVVKLGIVSVVLLFFTVMIIVIFGQMRFDRTNGYTAEFSNVSGL
Rv0170|M.tuberculosis_H37Rv MK-ITGTVVKLGIVSVVLLFFTVMIIVIFGQMRFDRTNGYTAEFSNVSGL
MLBr_02590|M.leprae_Br4923 MK-LTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRTNGYTAEFTNISGL
*: .. : * :. . : .* :: : : . . *:* *::: *:
MSMEG_1144|M.smegmatis_MC2_155 REGDDVRMAGVRVGRVEKIELD--GKHAKVSFVVQADQQVFGNTVASVTY
TH_3156|M.thermoresistible__bu REGDDVRMAGVRVGRVERIELD--GKYAKVSFVVQSDQQVLGNTVASVTY
Mflv_0009|M.gilvum_PYR-GCK REGDDVRMAGVRVGRVEKIELD--GKLAKVSFVVQGDQQVLGTTVASVTY
Mvan_0960|M.vanbaalenii_PYR-1 REGDDVRMAGVRVGRVEKIELQ--GDLAKVSFVVQNDQQVLGTTVASVTY
MMAR_3865|M.marinum_M REGDDVRMAGVRVGRVEKIDLE--GKLAKVRFVVQNEQRLFGNTVASVTY
MUL_3797|M.ulcerans_Agy99 REGDGVRMAGVRVGRVEKIDLE--GKLAKVRFVVQNEQRLFGNTVASVTY
MAV_2387|M.avium_104 REGDDVRMAGVRVGRVEKIELD--GKLAKVSFVVQSEQRLYGNTLASVTY
MAB_4598c|M.abscessus_ATCC_199 RVGDDVRIAGVRVGRVDSIELD--GSLAKLKFRVKSNQNLYGNTIVAVTY
Mb0176|M.bovis_AF2122/97 RQGQFVRASGVEIGKVKALHLVDGGRRVRVEFNIDRSVPLYQSTTAQIRY
Rv0170|M.tuberculosis_H37Rv RQGQFVRASGVEIGKVKALHLVDGGRRVRVEFNIDRSVPLYQSTTAQIRY
MLBr_02590|M.leprae_Br4923 RTGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTTAQIRY
* *: ** :**.:*:*. : * * .:: * :. . : .* . : *
MSMEG_1144|M.smegmatis_MC2_155 QNIVGQRYLGLSLGK-EGDPTLLAAGSVIPLERTDPSFDVGTLLNGYEPL
TH_3156|M.thermoresistible__bu QNIVGQRYLGLSLGN-LGDPHPLPPGATIPVEQTDPSFDVGALLNGYEPL
Mflv_0009|M.gilvum_PYR-GCK QNIVGQRYLGLTLGS-QGEPVPLPAGSVLPLERSDPSFDVTTLLNGYEPL
Mvan_0960|M.vanbaalenii_PYR-1 QNIVGQRYLGLSLGN-TGDPRPLPAGSVIPLERSEASFDVTTLLNGYEPL
MMAR_3865|M.marinum_M QNIVGQRYLGLSLGK-KGSPDQLAPGSVIPVQRTEPSFDVTALLNGYEPL
MUL_3797|M.ulcerans_Agy99 QNIVGQRYLGLSLGK-KGSPDQLAPGSVIPVQRTEPSFDVTALLNGYEPL
MAV_2387|M.avium_104 QNIVGQRYLGLSLGK-EGNPAQLPPGSTIPLERTEPSFDVTTLLNGYEPL
MAB_4598c|M.abscessus_ATCC_199 QNIIGQRYISLSRGI-EGSPERLPEGSVIPVERTEPSFDVGALLNGFEPL
Mb0176|M.bovis_AF2122/97 SDLIGNRYVELKRGEGKGANDLLPPGGLIPLSRTSPALDLDALIGGFKPV
Rv0170|M.tuberculosis_H37Rv SDLIGNRYVELKRGEGKGANDLLPPGGLIPLSRTSPALDLDALIGGFKPV
MLBr_02590|M.leprae_Br4923 LDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIGGFKPL
:::*:**: *. * * :. *. :*:.::..::*: :*:.*::*:
MSMEG_1144|M.smegmatis_MC2_155 FSVLDPKYANNLTEGVIQSLQGDQGSITALIDQTAQLTEAFAGREEELGS
TH_3156|M.thermoresistible__bu FSVLDPKHADNLTKGVIESLQGDEASITALVDQTAQLTEAFAGRDEELGA
Mflv_0009|M.gilvum_PYR-GCK FSLLDPQAADDLTQGVIQSLQGDEASLVALVDQTSQLTESFAGHDEELGA
Mvan_0960|M.vanbaalenii_PYR-1 FSLLNPRDADNLTQGVIQSLQGDEASIVGLVDQTSQLTESLAGRDEELGT
MMAR_3865|M.marinum_M FSLLNPRDADNLTKGIIESLQGDTASLATLVSQTSTLTETFAGRDQALGD
MUL_3797|M.ulcerans_Agy99 FSLLNPRDADNLTKGIIESLQGDTASLATLVSQTSTLTETFAGRDQALGD
MAV_2387|M.avium_104 FSLLNPHDADNLTKGIIASLQGDTSSLATLVGQTSTLTQTFAGRDQALGN
MAB_4598c|M.abscessus_ATCC_199 FTLLDPKQVDNLSNGLIDAFAGDRGALAHVVAQTTEITKSFAGRDQSLGG
Mb0176|M.bovis_AF2122/97 FRALDPAKVNNIANALITVFQGQGGTINDTLDQTAQLTSQIAERDQAIGE
Rv0170|M.tuberculosis_H37Rv FRALDPAKVNNIANALITVFQGQGGTINDILDQTAQLTSQIAERDQAIGE
MLBr_02590|M.leprae_Br4923 FRALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERDQAIGE
* *:* : ::..:: : *: .:: : **: :* :. ::: :*
MSMEG_1144|M.smegmatis_MC2_155 VITDLNAVAANLARHNDDLDHIVSEAQSVVATFEARRPELVESMGSIAKV
TH_3156|M.thermoresistible__bu VITDLNTVVANLARHNDDLDHVIGEARSVVSTFDDRRDQLIDSMGSAAKV
Mflv_0009|M.gilvum_PYR-GCK VITDLNTVMSNLAKHNDSMDQVLTETQAAVSIFDAQRQELVDSTGSISRV
Mvan_0960|M.vanbaalenii_PYR-1 VITDLNAVMGNLARHNDSLDQVLTQVQSAVTTFDGQRQELVDSTGSMARV
MMAR_3865|M.marinum_M VITNLNKVIYNLAQQNDNLDGVITDTREVVSTLDQRRPELVSSIGSLARV
MUL_3797|M.ulcerans_Agy99 VITNLNKVIYNLAQQNDNLDGVITDTREVVSTLDQRRPELVSSIGSLARV
MAV_2387|M.avium_104 VITNLNKVVGNLAAQNDNLDGVITQTRSVVGELDRRRPDLVASVGSLARL
MAB_4598c|M.abscessus_ATCC_199 LIDNLNTVLDNVAKQNDNLDQLVIQGQSVVGELDNRRQNLVSSIGSATHV
Mb0176|M.bovis_AF2122/97 VVKNLNIVLDTTVKHRKEFDETVNNLENLITGLRNHSDQLAGGLAHISNG
Rv0170|M.tuberculosis_H37Rv VVKNLNIVLDTTVKHRKEFDETVNNLENLITGLRNHSDQLAGGLAHISNG
MLBr_02590|M.leprae_Br4923 VVKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFAHISNA
:: :** * . . :...:* : : . : : : :* . . :.
MSMEG_1144|M.smegmatis_MC2_155 VRQLSTISDEVYPSLSEMVQRQPGFAAHMLGIEPQLAFVGANLPLMLKGF
TH_3156|M.thermoresistible__bu IRQLSAISDEVYQPLNEMVQREPGFAKHMLGIEPQLAFVGANLPLMLKGF
Mflv_0009|M.gilvum_PYR-GCK VSRLSTVSDDVYPSLNELIEREPGFAQHLVSIEPQLAFTGANLPLLLKGF
Mvan_0960|M.vanbaalenii_PYR-1 VRQLSTISDEVYPSLNELITREPGFTQHMVSIEPQLAFTGANLPLLLKGF
MMAR_3865|M.marinum_M LERLSASANDVYPQLREFIDRQPGATRHILSVEPQVAFFGDNIPLLLKGL
MUL_3797|M.ulcerans_Agy99 LERLSASANDVYPQLREFIDRQPGATRHILSVEPQVAFFGDNIPLLLKGL
MAV_2387|M.avium_104 SDRLSASAADVYPALREFIDRQPGVTKHIMDVEPQVAFFGDNIPLLLKGL
MAB_4598c|M.abscessus_ATCC_199 VSRIQTIGDNVYPQMQELVYREPGTAAHILANKDQFAFLGSNLPLLLKGL
Mb0176|M.bovis_AF2122/97 AGTVADLLAENRTLVRKAVSYLDAIQQPVIDQRVELDDLLHKTPTALTAL
Rv0170|M.tuberculosis_H37Rv AGTVADLLAENRTLVRKAVSYLDAIQQPVIDQRVELDDLLHKTPTALTAL
MLBr_02590|M.leprae_Br4923 AGTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPTVLNQI
: : : : : . :: . :. : * *. :
MSMEG_1144|M.smegmatis_MC2_155 ARIT-QEGTYANAYLCDLNATAFFPGLNDVTPIIVDAATPGNKAQHTPKC
TH_3156|M.thermoresistible__bu ARVT-GEGTYANAYACNLDGTAFFPGLNDITPIIVAAATPGNKARYTPKC
Mflv_0009|M.gilvum_PYR-GCK ARIT-SEGAYANAYACDLNATGFFPGLNDVTPIIVDAATPGNDAQYSPKC
Mvan_0960|M.vanbaalenii_PYR-1 ARIT-GEGAYANAYACDLNIQGFFPGLNDVVPIIVDAATPGNDARYTPKC
MMAR_3865|M.marinum_M TRVG-NRGAYGNAYVCDINAFGFFPGLNDVMPIIVNAATPGNQARHTPRC
MUL_3797|M.ulcerans_Agy99 TRVG-NRGAYGNAYVCDINAFGFFPGLNDVMPIIVNAATPGNQARHTPRC
MAV_2387|M.avium_104 TRVG-NQGAYGNAYVCDVNFMGFFPGLNDVVPIIINAATPGNRAWHTPRC
MAB_4598c|M.abscessus_ATCC_199 ARTT-QDGAYGNSYACQLNINGFFPGLNDLVPEIVRRATHGNVAKYTPKC
Mb0176|M.bovis_AF2122/97 GRANGTYGDFQNFYLCDLQIK--WNGFQAGGPVRTVKLFSQPTGRCTPQ-
Rv0170|M.tuberculosis_H37Rv GRANGTYGDFQNFYLCDLQIK--WNGFQAGGPVRTVKLFSQPTGRCTPQ-
MLBr_02590|M.leprae_Br4923 GRTIGSYGDFVNFYSCDITLK--INGLQPGGPVRTVRLFQQPTGRCTPQ-
* * : * * *:: *:: * . :*:
MSMEG_1144|M.smegmatis_MC2_155 RSMANG
TH_3156|M.thermoresistible__bu RNLANG
Mflv_0009|M.gilvum_PYR-GCK RNMANG
Mvan_0960|M.vanbaalenii_PYR-1 RNMANG
MMAR_3865|M.marinum_M RSMADG
MUL_3797|M.ulcerans_Agy99 RSMADG
MAV_2387|M.avium_104 RSTVDG
MAB_4598c|M.abscessus_ATCC_199 RGIE--
Mb0176|M.bovis_AF2122/97 ------
Rv0170|M.tuberculosis_H37Rv ------
MLBr_02590|M.leprae_Br4923 ------