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RFRGPLIALTLFMIVSLTLTWLVYVSLRRDVAGDTARYSAVFSDVYGLREGDDVRMAGVRVGRVEKIELD GKLAKVSFVVQSEQRLYGNTLASVTYQNIVGQRYLGLSLGKEGNPAQLPPGSTIPLERTEPSFDVTTLLN GYEPLFSLLNPHDADNLTKGIIASLQGDTSSLATLVGQTSTLTQTFAGRDQALGNVITNLNKVVGNLAAQ NDNLDGVITQTRSVVGELDRRRPDLVASVGSLARLSDRLSASAADVYPALREFIDRQPGVTKHIMDVEPQ VAFFGDNIPLLLKGLTRVGNQGAYGNAYVCDVNFMGFFPGLNDVVPIIINAATPGNRAWHTPRCRSTVDG *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2387 | - | - | 100% (351) | virulence factor Mce family protein |
| M. avium 104 | MAV_0103 | - | e-128 | 61.24% (356) | virulence factor Mce family protein |
| M. avium 104 | MAV_5014 | - | 4e-43 | 31.23% (317) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0605 | mce2B | 5e-41 | 32.52% (326) | MCE-family protein MCE2B |
| M. gilvum PYR-GCK | Mflv_0009 | - | 1e-135 | 65.24% (351) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1967 | mce3B | 3e-42 | 33.44% (314) | MCE-family protein MCE3B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 5e-42 | 29.66% (327) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_1009c | - | 1e-144 | 71.59% (352) | putative MCE family protein |
| M. marinum M | MMAR_3865 | mce5B | 1e-168 | 81.77% (351) | Mce family protein, Mce5B |
| M. smegmatis MC2 155 | MSMEG_1144 | - | 1e-134 | 64.39% (351) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3156 | - | 1e-131 | 64.67% (351) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3797 | mce5B | 1e-167 | 81.48% (351) | Mce family protein, Mce5B |
| M. vanbaalenii PYR-1 | Mvan_0960 | - | 1e-136 | 66.95% (351) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3865|M.marinum_M --MKFRGPLIGLSLFMVVAVALTWMVYVSLRREVAGKTVAYAAVFTDVYG
MUL_3797|M.ulcerans_Agy99 --MKFRGPLIGLSLFMVVAVALTWMVYVSLRREVAGKTVAYAAVFTDVYG
MAV_2387|M.avium_104 --MRFRGPLIALTLFMIVSLTLTWLVYVSLRRDVAGDTARYSAVFSDVYG
MAB_1009c|M.abscessus_ATCC_199 --MKFRGPLIALTVFMAVALALTWLVYATLRRDVAGGTTSYSAIFTDVYG
Mflv_0009|M.gilvum_PYR-GCK --MKYRGPLIGLSLFMIVAITLTWLVYVTLRRDVAGEKVPYSAMFTDVFG
Mvan_0960|M.vanbaalenii_PYR-1 --MKYRGALVGLSLFMVVAVTLTWLVYVTLRRDVAGSTAPYAAVFTDVFG
MSMEG_1144|M.smegmatis_MC2_155 --MKIRGALIGLSLFMVVALTLTWMVYVTLRRDVAGRTVPYTAVFTDVFG
TH_3156|M.thermoresistible__bu --MRSRGALIGLSLFMAVAVVLTWLVYVTLRRDVAGSTVPYSAVFTDVFG
Mb0605|M.bovis_AF2122/97 --MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHTTGYSAVFTHVSG
MLBr_02590|M.leprae_Br4923 --MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRTNGYTAEFTNISG
Rv1967|M.tuberculosis_H37Rv MRENLGGVVVRLGVFLAVCLLTAFLLIAVFGEVRFGDGKTYYAEFANVSN
. * : * :. * : :: . : . * * *:.: .
MMAR_3865|M.marinum_M LREGDDVRMAGVRVGRVEKIDLEG--KLAKVRFVVQNEQRLFGNTVASVT
MUL_3797|M.ulcerans_Agy99 LREGDGVRMAGVRVGRVEKIDLEG--KLAKVRFVVQNEQRLFGNTVASVT
MAV_2387|M.avium_104 LREGDDVRMAGVRVGRVEKIELDG--KLAKVSFVVQSEQRLYGNTLASVT
MAB_1009c|M.abscessus_ATCC_199 LRDGDDVRMAGVRVGRVEKIELVNN-KQAKVDFVVQNDQKLYGNTLASVT
Mflv_0009|M.gilvum_PYR-GCK LREGDDVRMAGVRVGRVEKIELDG--KLAKVSFVVQGDQQVLGTTVASVT
Mvan_0960|M.vanbaalenii_PYR-1 LREGDDVRMAGVRVGRVEKIELQG--DLAKVSFVVQNDQQVLGTTVASVT
MSMEG_1144|M.smegmatis_MC2_155 LREGDDVRMAGVRVGRVEKIELDG--KHAKVSFVVQADQQVFGNTVASVT
TH_3156|M.thermoresistible__bu LREGDDVRMAGVRVGRVERIELDG--KYAKVSFVVQSDQQVLGNTVASVT
Mb0605|M.bovis_AF2122/97 LRAGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATTASIR
MLBr_02590|M.leprae_Br4923 LRTGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTTAQIR
Rv1967|M.tuberculosis_H37Rv LRTGKLVRIAGVEVGKVTRIS-INPDATVRVQFTADNSVTLTRGTRAVIR
** *. ** :**.**:* : . . * * .: . : * * :
MMAR_3865|M.marinum_M YQNIVGQRYLGLSLGK-KGSPDQLAPGSVIPVQRTEPSFDVTALLNGYEP
MUL_3797|M.ulcerans_Agy99 YQNIVGQRYLGLSLGK-KGSPDQLAPGSVIPVQRTEPSFDVTALLNGYEP
MAV_2387|M.avium_104 YQNIVGQRYLGLSLGK-EGNPAQLPPGSTIPLERTEPSFDVTTLLNGYEP
MAB_1009c|M.abscessus_ATCC_199 YQNIVGQRYLGLSLGK-TGDTNVLAGGSTIPVERTDPSFDVTTLLNGYEP
Mflv_0009|M.gilvum_PYR-GCK YQNIVGQRYLGLTLGS-QGEPVPLPAGSVLPLERSDPSFDVTTLLNGYEP
Mvan_0960|M.vanbaalenii_PYR-1 YQNIVGQRYLGLSLGN-TGDPRPLPAGSVIPLERSEASFDVTTLLNGYEP
MSMEG_1144|M.smegmatis_MC2_155 YQNIVGQRYLGLSLGK-EGDPTLLAAGSVIPLERTDPSFDVGTLLNGYEP
TH_3156|M.thermoresistible__bu YQNIVGQRYLGLSLGN-LGDPHPLPPGATIPVEQTDPSFDVGALLNGYEP
Mb0605|M.bovis_AF2122/97 YLNLIGDRYLELGRG---HSGQRLAPGATIPLEHTHPALDLDALLGGFRP
MLBr_02590|M.leprae_Br4923 YLDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIGGFKP
Rv1967|M.tuberculosis_H37Rv YDNLFGDRYLALEEG--AGGLAVLRPGHTIPLARTQPALDLDALIGGFKP
* ::.*:*** * * : * :*: :: .::*: :*:.*:.*
MMAR_3865|M.marinum_M LFSLLNPRDADNLTKGIIESLQGDTASLATLVSQTSTLTETFAGRDQALG
MUL_3797|M.ulcerans_Agy99 LFSLLNPRDADNLTKGIIESLQGDTASLATLVSQTSTLTETFAGRDQALG
MAV_2387|M.avium_104 LFSLLNPHDADNLTKGIIASLQGDTSSLATLVGQTSTLTQTFAGRDQALG
MAB_1009c|M.abscessus_ATCC_199 LFSTLSPEQADNLTKGVIQSLQGDQASITSLVDQTSTLTKTFAGRDQVLG
Mflv_0009|M.gilvum_PYR-GCK LFSLLDPQAADDLTQGVIQSLQGDEASLVALVDQTSQLTESFAGHDEELG
Mvan_0960|M.vanbaalenii_PYR-1 LFSLLNPRDADNLTQGVIQSLQGDEASIVGLVDQTSQLTESLAGRDEELG
MSMEG_1144|M.smegmatis_MC2_155 LFSVLDPKYANNLTEGVIQSLQGDQGSITALIDQTAQLTEAFAGREEELG
TH_3156|M.thermoresistible__bu LFSVLDPKHADNLTKGVIESLQGDEASITALVDQTAQLTEAFAGRDEELG
Mb0605|M.bovis_AF2122/97 LFQTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRDHAIG
MLBr_02590|M.leprae_Br4923 LFRALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERDQAIG
Rv1967|M.tuberculosis_H37Rv LFRALNPEQVNALSEQLLHAFAGQGPTIGSLLAQSAAVTNTLADRDRLIG
** *.* : ::. :: : *: :: :: *:: :* ::. ::. :*
MMAR_3865|M.marinum_M DVITNLNKVIYNLAQQNDNLDGVITDTREVVSTLDQRRPELVSSIGSLAR
MUL_3797|M.ulcerans_Agy99 DVITNLNKVIYNLAQQNDNLDGVITDTREVVSTLDQRRPELVSSIGSLAR
MAV_2387|M.avium_104 NVITNLNKVVGNLAAQNDNLDGVITQTRSVVGELDRRRPDLVASVGSLAR
MAB_1009c|M.abscessus_ATCC_199 NVITSLSTVTGNLAQQNDSLDKAITNTRKVVADFDSRRPELVNSVGSLAQ
Mflv_0009|M.gilvum_PYR-GCK AVITDLNTVMSNLAKHNDSMDQVLTETQAAVSIFDAQRQELVDSTGSISR
Mvan_0960|M.vanbaalenii_PYR-1 TVITDLNAVMGNLARHNDSLDQVLTQVQSAVTTFDGQRQELVDSTGSMAR
MSMEG_1144|M.smegmatis_MC2_155 SVITDLNAVAANLARHNDDLDHIVSEAQSVVATFEARRPELVESMGSIAK
TH_3156|M.thermoresistible__bu AVITDLNTVVANLARHNDDLDHVIGEARSVVSTFDDRRDQLIDSMGSAAK
Mb0605|M.bovis_AF2122/97 EVVNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAAHISS
MLBr_02590|M.leprae_Br4923 EVVKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFAHISN
Rv1967|M.tuberculosis_H37Rv QVITNLNVVLGSLGAHTDRLDQAVTSLSALIHRLAQRKTDISNAVAYTNA
*:..*. * . : :* : . : : : : : .
MMAR_3865|M.marinum_M VLERLSASANDVYPQLREFIDRQPGATRHILSVEPQVAFFGDNIPLLLKG
MUL_3797|M.ulcerans_Agy99 VLERLSASANDVYPQLREFIDRQPGATRHILSVEPQVAFFGDNIPLLLKG
MAV_2387|M.avium_104 LSDRLSASAADVYPALREFIDRQPGVTKHIMDVEPQVAFFGDNIPLLLKG
MAB_1009c|M.abscessus_ATCC_199 TMRRLSKITDEVYPSLDELITRQPGFAKHMVQIEPKLAFLGGNLPLLLKG
Mflv_0009|M.gilvum_PYR-GCK VVSRLSTVSDDVYPSLNELIEREPGFAQHLVSIEPQLAFTGANLPLLLKG
Mvan_0960|M.vanbaalenii_PYR-1 VVRQLSTISDEVYPSLNELITREPGFTQHMVSIEPQLAFTGANLPLLLKG
MSMEG_1144|M.smegmatis_MC2_155 VVRQLSTISDEVYPSLSEMVQRQPGFAAHMLGIEPQLAFVGANLPLMLKG
TH_3156|M.thermoresistible__bu VIRQLSAISDEVYQPLNEMVQREPGFAKHMLGIEPQLAFVGANLPLMLKG
Mb0605|M.bovis_AF2122/97 AAGTLADLLGADRPLLHSSFGHLEGIQQPLIDELAELDHVLGKLPDAYRI
MLBr_02590|M.leprae_Br4923 AAGTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPTVLNQ
Rv1967|M.tuberculosis_H37Rv AAGSVADLLSQARAPLAKVVRETDRVAGIAAADHDYLDNLLNTLPDKYQA
:: * . . : .:* .
MMAR_3865|M.marinum_M LTRVG-NRGAYGNAYVCDINAFGFFPGLNDVMPIIVNAATPGNQARHTPR
MUL_3797|M.ulcerans_Agy99 LTRVG-NRGAYGNAYVCDINAFGFFPGLNDVMPIIVNAATPGNQARHTPR
MAV_2387|M.avium_104 LTRVG-NQGAYGNAYVCDVNFMGFFPGLNDVVPIIINAATPGNRAWHTPR
MAB_1009c|M.abscessus_ATCC_199 LARIT-GDGAYGNAYICDLNITGFFPGLNDVVPIIVNAATPGNVAQHTPR
Mflv_0009|M.gilvum_PYR-GCK FARIT-SEGAYANAYACDLNATGFFPGLNDVTPIIVDAATPGNDAQYSPK
Mvan_0960|M.vanbaalenii_PYR-1 FARIT-GEGAYANAYACDLNIQGFFPGLNDVVPIIVDAATPGNDARYTPK
MSMEG_1144|M.smegmatis_MC2_155 FARIT-QEGTYANAYLCDLNATAFFPGLNDVTPIIVDAATPGNKAQHTPK
TH_3156|M.thermoresistible__bu FARVT-GEGTYANAYACNLDGTAFFPGLNDITPIIVAAATPGNKARYTPK
Mb0605|M.bovis_AF2122/97 IGRAGGIYGDFFNFYLCDISLK--VNGLQPGGPVRTVKLFGQPTGRCTPQ
MLBr_02590|M.leprae_Br4923 IGRTIGSYGDFVNFYSCDITLK--INGLQPGGPVRTVRLFQQPTGRCTPQ
Rv1967|M.tuberculosis_H37Rv LVRQG-MYGDFFAFYLCDVVLK--VNGK--GGQPVYIKLAGQDSGRCAPK
: * * : * *:: . * . :*:
MMAR_3865|M.marinum_M CRSMADG
MUL_3797|M.ulcerans_Agy99 CRSMADG
MAV_2387|M.avium_104 CRSTVDG
MAB_1009c|M.abscessus_ATCC_199 CRNLANG
Mflv_0009|M.gilvum_PYR-GCK CRNMANG
Mvan_0960|M.vanbaalenii_PYR-1 CRNMANG
MSMEG_1144|M.smegmatis_MC2_155 CRSMANG
TH_3156|M.thermoresistible__bu CRNLANG
Mb0605|M.bovis_AF2122/97 -------
MLBr_02590|M.leprae_Br4923 -------
Rv1967|M.tuberculosis_H37Rv -------