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MKFRGPLIGLSLFMVVAVALTWMVYVSLRREVAGKTVAYAAVFTDVYGLREGDGVRMAGVRVGRVEKIDL EGKLAKVRFVVQNEQRLFGNTVASVTYQNIVGQRYLGLSLGKKGSPDQLAPGSVIPVQRTEPSFDVTALL NGYEPLFSLLNPRDADNLTKGIIESLQGDTASLATLVSQTSTLTETFAGRDQALGDVITNLNKVIYNLAQ QNDNLDGVITDTREVVSTLDQRRPELVSSIGSLARVLERLSASANDVYPQLREFIDRQPGATRHILSVEP QVAFFGDNIPLLLKGLTRVGNRGAYGNAYVCDINAFGFFPGLNDVMPIIVNAATPGNQARHTPRCRSMAD G
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3797 | mce5B | - | 100% (351) | Mce family protein, Mce5B |
| M. ulcerans Agy99 | MUL_4918 | mce6B | e-114 | 57.89% (342) | MCE-family protein Mce6B |
| M. ulcerans Agy99 | MUL_1063 | mce1B | 2e-40 | 28.62% (318) | MCE-family protein Mce1B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0605 | mce2B | 3e-40 | 32.60% (319) | MCE-family protein MCE2B |
| M. gilvum PYR-GCK | Mflv_0009 | - | 1e-138 | 66.67% (351) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0170 | mce1B | 3e-39 | 28.08% (317) | MCE-family protein MCE1B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 2e-41 | 29.34% (317) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_1009c | - | 1e-143 | 69.89% (352) | putative MCE family protein |
| M. marinum M | MMAR_3865 | mce5B | 0.0 | 99.72% (351) | Mce family protein, Mce5B |
| M. avium 104 | MAV_2387 | - | 1e-167 | 81.48% (351) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_1144 | - | 1e-138 | 66.95% (351) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3156 | - | 1e-135 | 65.81% (351) | PUTATIVE virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0960 | - | 1e-140 | 68.95% (351) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3797|M.ulcerans_Agy99 MKFRGPLIGLSLFMVVAVALTWMVYVSLRREVAGKTVAYAAVFTDVYGLR
MMAR_3865|M.marinum_M MKFRGPLIGLSLFMVVAVALTWMVYVSLRREVAGKTVAYAAVFTDVYGLR
MAV_2387|M.avium_104 MRFRGPLIALTLFMIVSLTLTWLVYVSLRRDVAGDTARYSAVFSDVYGLR
MAB_1009c|M.abscessus_ATCC_199 MKFRGPLIALTVFMAVALALTWLVYATLRRDVAGGTTSYSAIFTDVYGLR
Mflv_0009|M.gilvum_PYR-GCK MKYRGPLIGLSLFMIVAITLTWLVYVTLRRDVAGEKVPYSAMFTDVFGLR
Mvan_0960|M.vanbaalenii_PYR-1 MKYRGALVGLSLFMVVAVTLTWLVYVTLRRDVAGSTAPYAAVFTDVFGLR
MSMEG_1144|M.smegmatis_MC2_155 MKIRGALIGLSLFMVVALTLTWMVYVTLRRDVAGRTVPYTAVFTDVFGLR
TH_3156|M.thermoresistible__bu MRSRGALIGLSLFMAVAVVLTWLVYVTLRRDVAGSTVPYSAVFTDVFGLR
Rv0170|M.tuberculosis_H37Rv MKITGTVVKLGIVSVVLLFFTVMIIVIFGQMRFDRTNGYTAEFSNVSGLR
MLBr_02590|M.leprae_Br4923 MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRTNGYTAEFTNISGLR
Mb0605|M.bovis_AF2122/97 MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHTTGYSAVFTHVSGLR
*: *. : * :. * :* :: . : : . *:* *:.: ***
MUL_3797|M.ulcerans_Agy99 EGDGVRMAGVRVGRVEKIDLEG--KLAKVRFVVQNEQRLFGNTVASVTYQ
MMAR_3865|M.marinum_M EGDDVRMAGVRVGRVEKIDLEG--KLAKVRFVVQNEQRLFGNTVASVTYQ
MAV_2387|M.avium_104 EGDDVRMAGVRVGRVEKIELDG--KLAKVSFVVQSEQRLYGNTLASVTYQ
MAB_1009c|M.abscessus_ATCC_199 DGDDVRMAGVRVGRVEKIELVNN-KQAKVDFVVQNDQKLYGNTLASVTYQ
Mflv_0009|M.gilvum_PYR-GCK EGDDVRMAGVRVGRVEKIELDG--KLAKVSFVVQGDQQVLGTTVASVTYQ
Mvan_0960|M.vanbaalenii_PYR-1 EGDDVRMAGVRVGRVEKIELQG--DLAKVSFVVQNDQQVLGTTVASVTYQ
MSMEG_1144|M.smegmatis_MC2_155 EGDDVRMAGVRVGRVEKIELDG--KHAKVSFVVQADQQVFGNTVASVTYQ
TH_3156|M.thermoresistible__bu EGDDVRMAGVRVGRVERIELDG--KYAKVSFVVQSDQQVLGNTVASVTYQ
Rv0170|M.tuberculosis_H37Rv QGQFVRASGVEIGKVKALHLVDGGRRVRVEFNIDRSVPLYQSTTAQIRYS
MLBr_02590|M.leprae_Br4923 TGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTTAQIRYL
Mb0605|M.bovis_AF2122/97 AGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATTASIRYL
*: ** :**.:*:* : * . . * * :: . : * *.: *
MUL_3797|M.ulcerans_Agy99 NIVGQRYLGLSLGK-KGSPDQLAPGSVIPVQRTEPSFDVTALLNGYEPLF
MMAR_3865|M.marinum_M NIVGQRYLGLSLGK-KGSPDQLAPGSVIPVQRTEPSFDVTALLNGYEPLF
MAV_2387|M.avium_104 NIVGQRYLGLSLGK-EGNPAQLPPGSTIPLERTEPSFDVTTLLNGYEPLF
MAB_1009c|M.abscessus_ATCC_199 NIVGQRYLGLSLGK-TGDTNVLAGGSTIPVERTDPSFDVTTLLNGYEPLF
Mflv_0009|M.gilvum_PYR-GCK NIVGQRYLGLTLGS-QGEPVPLPAGSVLPLERSDPSFDVTTLLNGYEPLF
Mvan_0960|M.vanbaalenii_PYR-1 NIVGQRYLGLSLGN-TGDPRPLPAGSVIPLERSEASFDVTTLLNGYEPLF
MSMEG_1144|M.smegmatis_MC2_155 NIVGQRYLGLSLGK-EGDPTLLAAGSVIPLERTDPSFDVGTLLNGYEPLF
TH_3156|M.thermoresistible__bu NIVGQRYLGLSLGN-LGDPHPLPPGATIPVEQTDPSFDVGALLNGYEPLF
Rv0170|M.tuberculosis_H37Rv DLIGNRYVELKRGEGKGANDLLPPGGLIPLSRTSPALDLDALIGGFKPVF
MLBr_02590|M.leprae_Br4923 DLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIGGFKPLF
Mb0605|M.bovis_AF2122/97 NLIGDRYLELGRG---HSGQRLAPGATIPLEHTHPALDLDALLGGFRPLF
:::*:**: * * :. *. :*:.:: .::*: :*:.*:.*:*
MUL_3797|M.ulcerans_Agy99 SLLNPRDADNLTKGIIESLQGDTASLATLVSQTSTLTETFAGRDQALGDV
MMAR_3865|M.marinum_M SLLNPRDADNLTKGIIESLQGDTASLATLVSQTSTLTETFAGRDQALGDV
MAV_2387|M.avium_104 SLLNPHDADNLTKGIIASLQGDTSSLATLVGQTSTLTQTFAGRDQALGNV
MAB_1009c|M.abscessus_ATCC_199 STLSPEQADNLTKGVIQSLQGDQASITSLVDQTSTLTKTFAGRDQVLGNV
Mflv_0009|M.gilvum_PYR-GCK SLLDPQAADDLTQGVIQSLQGDEASLVALVDQTSQLTESFAGHDEELGAV
Mvan_0960|M.vanbaalenii_PYR-1 SLLNPRDADNLTQGVIQSLQGDEASIVGLVDQTSQLTESLAGRDEELGTV
MSMEG_1144|M.smegmatis_MC2_155 SVLDPKYANNLTEGVIQSLQGDQGSITALIDQTAQLTEAFAGREEELGSV
TH_3156|M.thermoresistible__bu SVLDPKHADNLTKGVIESLQGDEASITALVDQTAQLTEAFAGRDEELGAV
Rv0170|M.tuberculosis_H37Rv RALDPAKVNNIANALITVFQGQGGTINDILDQTAQLTSQIAERDQAIGEV
MLBr_02590|M.leprae_Br4923 RALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERDQAIGEV
Mb0605|M.bovis_AF2122/97 QTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRDHAIGEV
*.* : ::..:: :**: .:: ::.**: ** :. ::. :* *
MUL_3797|M.ulcerans_Agy99 ITNLNKVIYNLAQQNDNLDGVITDTREVVSTLDQRRPELVSSIGSLARVL
MMAR_3865|M.marinum_M ITNLNKVIYNLAQQNDNLDGVITDTREVVSTLDQRRPELVSSIGSLARVL
MAV_2387|M.avium_104 ITNLNKVVGNLAAQNDNLDGVITQTRSVVGELDRRRPDLVASVGSLARLS
MAB_1009c|M.abscessus_ATCC_199 ITSLSTVTGNLAQQNDSLDKAITNTRKVVADFDSRRPELVNSVGSLAQTM
Mflv_0009|M.gilvum_PYR-GCK ITDLNTVMSNLAKHNDSMDQVLTETQAAVSIFDAQRQELVDSTGSISRVV
Mvan_0960|M.vanbaalenii_PYR-1 ITDLNAVMGNLARHNDSLDQVLTQVQSAVTTFDGQRQELVDSTGSMARVV
MSMEG_1144|M.smegmatis_MC2_155 ITDLNAVAANLARHNDDLDHIVSEAQSVVATFEARRPELVESMGSIAKVV
TH_3156|M.thermoresistible__bu ITDLNTVVANLARHNDDLDHVIGEARSVVSTFDDRRDQLIDSMGSAAKVI
Rv0170|M.tuberculosis_H37Rv VKNLNIVLDTTVKHRKEFDETVNNLENLITGLRNHSDQLAGGLAHISNGA
MLBr_02590|M.leprae_Br4923 VKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFAHISNAA
Mb0605|M.bovis_AF2122/97 VNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAAHISSAA
:..*. * . . :. .:* : . . : : : * . . :
MUL_3797|M.ulcerans_Agy99 ERLSASANDVYPQLREFIDRQPGATRHILSVEPQVAFFGDNIPLLLKGLT
MMAR_3865|M.marinum_M ERLSASANDVYPQLREFIDRQPGATRHILSVEPQVAFFGDNIPLLLKGLT
MAV_2387|M.avium_104 DRLSASAADVYPALREFIDRQPGVTKHIMDVEPQVAFFGDNIPLLLKGLT
MAB_1009c|M.abscessus_ATCC_199 RRLSKITDEVYPSLDELITRQPGFAKHMVQIEPKLAFLGGNLPLLLKGLA
Mflv_0009|M.gilvum_PYR-GCK SRLSTVSDDVYPSLNELIEREPGFAQHLVSIEPQLAFTGANLPLLLKGFA
Mvan_0960|M.vanbaalenii_PYR-1 RQLSTISDEVYPSLNELITREPGFTQHMVSIEPQLAFTGANLPLLLKGFA
MSMEG_1144|M.smegmatis_MC2_155 RQLSTISDEVYPSLSEMVQRQPGFAAHMLGIEPQLAFVGANLPLMLKGFA
TH_3156|M.thermoresistible__bu RQLSAISDEVYQPLNEMVQREPGFAKHMLGIEPQLAFVGANLPLMLKGFA
Rv0170|M.tuberculosis_H37Rv GTVADLLAENRTLVRKAVSYLDAIQQPVIDQRVELDDLLHKTPTALTALG
MLBr_02590|M.leprae_Br4923 GTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPTVLNQIG
Mb0605|M.bovis_AF2122/97 GTLADLLGADRPLLHSSFGHLEGIQQPLIDELAELDHVLGKLPDAYRIIG
:: : . . . :: :: : * :
MUL_3797|M.ulcerans_Agy99 RVG-NRGAYGNAYVCDINAFGFFPGLNDVMPIIVNAATPGNQARHTPRCR
MMAR_3865|M.marinum_M RVG-NRGAYGNAYVCDINAFGFFPGLNDVMPIIVNAATPGNQARHTPRCR
MAV_2387|M.avium_104 RVG-NQGAYGNAYVCDVNFMGFFPGLNDVVPIIINAATPGNRAWHTPRCR
MAB_1009c|M.abscessus_ATCC_199 RIT-GDGAYGNAYICDLNITGFFPGLNDVVPIIVNAATPGNVAQHTPRCR
Mflv_0009|M.gilvum_PYR-GCK RIT-SEGAYANAYACDLNATGFFPGLNDVTPIIVDAATPGNDAQYSPKCR
Mvan_0960|M.vanbaalenii_PYR-1 RIT-GEGAYANAYACDLNIQGFFPGLNDVVPIIVDAATPGNDARYTPKCR
MSMEG_1144|M.smegmatis_MC2_155 RIT-QEGTYANAYLCDLNATAFFPGLNDVTPIIVDAATPGNKAQHTPKCR
TH_3156|M.thermoresistible__bu RVT-GEGTYANAYACNLDGTAFFPGLNDITPIIVAAATPGNKARYTPKCR
Rv0170|M.tuberculosis_H37Rv RANGTYGDFQNFYLCDLQIK--WNGFQAGGPVRTVKLFSQPTGRCTPQ--
MLBr_02590|M.leprae_Br4923 RTIGSYGDFVNFYSCDITLK--INGLQPGGPVRTVRLFQQPTGRCTPQ--
Mb0605|M.bovis_AF2122/97 RAGGIYGDFFNFYLCDISLK--VNGLQPGGPVRTVKLFGQPTGRCTPQ--
* * : * * *:: *:: *: . :*:
MUL_3797|M.ulcerans_Agy99 SMADG
MMAR_3865|M.marinum_M SMADG
MAV_2387|M.avium_104 STVDG
MAB_1009c|M.abscessus_ATCC_199 NLANG
Mflv_0009|M.gilvum_PYR-GCK NMANG
Mvan_0960|M.vanbaalenii_PYR-1 NMANG
MSMEG_1144|M.smegmatis_MC2_155 SMANG
TH_3156|M.thermoresistible__bu NLANG
Rv0170|M.tuberculosis_H37Rv -----
MLBr_02590|M.leprae_Br4923 -----
Mb0605|M.bovis_AF2122/97 -----