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VRTEGDSWDIVTSVGYTALAVAAGRALDAKLDPPLAHDDHAAAFVAAAGAPQLAAAVATADMTSSAAFNA QWVGVRTRFFDNFFADAAGAGVRQHVILAAGLDSRAYRLPWPAITTVFELDQPKVLQFKDEVLKRSGAQP SARRVTVAVDLRDDWPAALREAGFDATQPTGWILEGLLPYLPGAAQDALFERLNDMSAPGSRVAAELGPE PGELERLAASIKTVVGETSDGETQPNLRDLWFDDPRLDTKTWLGERGWTVTEANLVDAAVAYGRPLRDLP PAFENFLSTKFFTAVQDHPRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4586c | - | - | 100% (302) | hypothetical protein MAB_4586c |
| M. abscessus ATCC 19977 | MAB_0027c | - | 4e-73 | 51.43% (280) | hypothetical protein MAB_0027c |
| M. abscessus ATCC 19977 | MAB_4585c | - | 7e-70 | 49.82% (273) | hypothetical protein MAB_4585c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0289 | - | 3e-64 | 48.75% (281) | hypothetical protein Mb0289 |
| M. gilvum PYR-GCK | Mflv_0743 | - | 1e-57 | 44.33% (282) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv0281 | - | 3e-64 | 48.75% (281) | hypothetical protein Rv0281 |
| M. leprae Br4923 | MLBr_02020 | - | 3e-62 | 43.10% (297) | hypothetical protein MLBr_02020 |
| M. marinum M | MMAR_2791 | - | 6e-64 | 47.54% (284) | hypothetical protein MMAR_2791 |
| M. avium 104 | MAV_4557 | - | 1e-67 | 44.87% (312) | methyltransferase, putative, family protein |
| M. smegmatis MC2 155 | MSMEG_1481 | - | 5e-63 | 47.02% (285) | methyltransferase |
| M. thermoresistible (build 8) | TH_2759 | - | 3e-62 | 48.25% (286) | PUTATIVE methyltransferase |
| M. ulcerans Agy99 | MUL_4402 | - | 1e-62 | 43.38% (302) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0104 | - | 3e-59 | 47.43% (272) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4557|M.avium_104 ---------MSTARTDDDSWEITESVGATALGVASARAAETRSENPLIKD
MUL_4402|M.ulcerans_Agy99 -----------MPRTDNDSWTITESVGATALGVAAARAAETESENPLIED
Mflv_0743|M.gilvum_PYR-GCK ---------MSSLRTDDDTWDIASSVGATAVMVAAARAAETERHDALIND
Mvan_0104|M.vanbaalenii_PYR-1 ---------MSSLRTDNDTWDIASSVGATAVMVAAARAAETERPEPLIDD
MSMEG_1481|M.smegmatis_MC2_155 -----------MARTDTDSWDLASSVGATATMVAAARAIASTEPNALIDD
TH_2759|M.thermoresistible__bu MVMMFDVTEAASARSEGDSWDITESVGATALGVAAERALETSQPDPLIRD
Mb0289|M.bovis_AF2122/97 ------------MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVD
Rv0281|M.tuberculosis_H37Rv ------------MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVD
MAB_4586c|M.abscessus_ATCC_199 -----------MVRTEGDSWDIVTSVGYTALAVAAGRALDAKLDPPLAHD
MLBr_02020|M.leprae_Br4923 --MMAATPEFGSLRSDDDHWDIVSSVGYTALLVAGWRALHAVGPQPLVRD
MMAR_2791|M.marinum_M ----MTTSEYGSRRSDDDQWDIVSGVGYTALLVAGWRALDTVGPQPLAPD
*:: * * :. .** ** ** ** : .* *
MAV_4557|M.avium_104 PFAQVFLDAAGDGVWNWHSAPQLPPELIEAEPTIPLQQQAMVSYMASRTA
MUL_4402|M.ulcerans_Agy99 PFARVFVDAAGDGMWSMFANPALLAGAPEIESQVGARVRQMIDFMATRTA
Mflv_0743|M.gilvum_PYR-GCK PYAKVLVEGAGAGAWRFIADEDLVAKASESDTEVGALFEHMKNYQAVRTH
Mvan_0104|M.vanbaalenii_PYR-1 PYAKILVAGAGNGAWQYIADDGFVAKVTESDPEIGPLFEHMKNYQAVRTH
MSMEG_1481|M.smegmatis_MC2_155 PYAADLVRKVGLEFFTKLVDGDIALDG--DDAAAAGLMVS---MMAVRTR
TH_2759|M.thermoresistible__bu EYAFLLVSAAGPP-WTQLASSDLSWLG--DDETARRMHLMSRDYQAVRTH
Mb0289|M.bovis_AF2122/97 PYAEAFCRAVGGS-WADVLDGKLPDHKLKSTDFG----EHFVNFQGARTK
Rv0281|M.tuberculosis_H37Rv PYAEAFCRAVGGS-WADVLDGKLPDHKLKSTDFG----EHFVNFQGARTK
MAB_4586c|M.abscessus_ATCC_199 DHAAAFVAAAGAP---QLAAAVATADMTSSAAFN-------AQWVGVRTR
MLBr_02020|M.leprae_Br4923 EYAKYFITASRDP----YLMNLLANPGTSLNETA------FPRLYGVQTR
MMAR_2791|M.marinum_M EYAKYFIAASGDA----YLNDQLAHPPTSVDETA------FPRLYGVQTR
.* : . :*
MAV_4557|M.avium_104 FFDSFFLEATGAGIRQAVILAAGLDARSWRLPWPAGTTVYELDQPRVLEF
MUL_4402|M.ulcerans_Agy99 FFDEFFLGAADAGVRQVVILASGLDSRAWRLPWPDGTVVYELDQPRVLEF
Mflv_0743|M.gilvum_PYR-GCK FFDAFFSAAVDAGVRQIVILASGLDSRAFRLPWPAGTVVYEIDQPLVLDY
Mvan_0104|M.vanbaalenii_PYR-1 FFDAFFAAAVDAGIRQIVILASGLDSRAFRLPWPAGTTVFEIDQPLVLAY
MSMEG_1481|M.smegmatis_MC2_155 FFDDFFCDAAGAGIRQSVILAAGLDSRAYRLGWPAGTVVYEIDQPRVIEA
TH_2759|M.thermoresistible__bu YFDRYFAAAARAGIRQIVLLAAGLDSRAYRLDWPAGTVVYELDQPRVLDF
Mb0289|M.bovis_AF2122/97 YFDEYFRRAAAAGARQVVILAAGLDSRAYRLPWPDGTTVFELDRPQVLDF
Rv0281|M.tuberculosis_H37Rv YFDEYFRRAAAAGARQVVILAAGLDSRAYRLPWPDGTTVFELDRPQVLDF
MAB_4586c|M.abscessus_ATCC_199 FFDNFFADAAGAGVRQHVILAAGLDSRAYRLPWPAITTVFELDQPKVLQF
MLBr_02020|M.leprae_Br4923 FFDDFFSSAGDTGIRQAVIVAAGLDSRAYRLKWPNGATVFEIDLPKVLEF
MMAR_2791|M.marinum_M FFDDFFRSAAAAGTKQAVIVAAGLDSRAYRLEWPSGTTVFEIDLPQVLEF
:** :* * :* :* *::*:***:*::** ** :.*:*:* * *:
MAV_4557|M.avium_104 KESTLAEHGAQPACNRVAVPVDLRHDWPEALRQAGFDASAPSVWSAEGLM
MUL_4402|M.ulcerans_Agy99 KSATLRQHGARPTAQLMNIPIDLRQDWPAALLDSGFDASKPTAWSAEGLV
Mflv_0743|M.gilvum_PYR-GCK KSSTLAAHGVAPTAERREVPIDLRQDWPAALVATGFDPARPTAWLAEGLL
Mvan_0104|M.vanbaalenii_PYR-1 KSSTLASHGVQPTADRREVPIDLRQDWPTALTHAGFDADQPTAWLAEGLL
MSMEG_1481|M.smegmatis_MC2_155 KTAAMAEIGASPTAERRTVAVDLRDDWPAALRAAGFDAATPTAWIAEGLL
TH_2759|M.thermoresistible__bu KNRTLQAHGAVAKADRRTVAVDLRDDWPAALRHAGFDSAAPTAWLAEGLL
Mb0289|M.bovis_AF2122/97 KREVLASHGAQPRALRREIAVDLRDDWPQALRDSGFDAAAPSAWIAEGLL
Rv0281|M.tuberculosis_H37Rv KREVLASHGAQPRALRREIAVDLRDDWPQALRDSGFDAAAPSAWIAEGLL
MAB_4586c|M.abscessus_ATCC_199 KDEVLKRSGAQPSARRVTVAVDLRDDWPAALREAGFDATQPTGWILEGLL
MLBr_02020|M.leprae_Br4923 KARVLAEQGAIPNAGRSEVAADLRADWPRALKAAGFDPQRSSAWSVEGLL
MMAR_2791|M.marinum_M KARVLQRHGVEPKARRNEVAADLRTDWPATLHAAGFEPGQPSAWSVEGLL
* .: *. . . :. *** *** :* :**:. .: * ***:
MAV_4557|M.avium_104 PYLPAAAQDLLFDRIQGLTVAGSRVAVEALGPKFLDPQARAKRRERMDRI
MUL_4402|M.ulcerans_Agy99 RYLPARAQDLLFERIDTLSPAGSWLATNVPQGGFLDPDLVRRQHEEMQRM
Mflv_0743|M.gilvum_PYR-GCK MYLPADAQDRLFAQITELSAPGSQVAAES-----MGVHAP----DRRERM
Mvan_0104|M.vanbaalenii_PYR-1 MYLPADAQDRLFAQITELSAPGSRVAAES-----MGIHAQ----DRRERM
MSMEG_1481|M.smegmatis_MC2_155 VYLPPEAQDRLFDNITALSARGSRLATE------YHPDITSTLRGRGQAM
TH_2759|M.thermoresistible__bu CYLPADAQDRLFERITALSAPGSWLAVEA-----FHHDPQRATERRRAEW
Mb0289|M.bovis_AF2122/97 IYLPATAQERLFTGIDALAGRRSHVAVED--------GAPMGPDEYAAKV
Rv0281|M.tuberculosis_H37Rv IYLPATAQERLFTGIDALAGRRSHVAVED--------GAPMGPDEYAAKV
MAB_4586c|M.abscessus_ATCC_199 PYLPGAAQDALFERLNDMSAPGSRVAAELG-------PEPGELERLAASI
MLBr_02020|M.leprae_Br4923 PYLTNDAQSALFTRIGELCAPGSRIAVGALG--------SRLDRKQLAAL
MMAR_2791|M.marinum_M PYLTADAQDALFARIDDLCAPGSRIATGALG--------SRLDHDQLVAL
**. **. ** : : * :*.
MAV_4557|M.avium_104 QALMARIDPDRAVP--RTDELWYFE-EREDVGEWFGRHGWDVRVTP-SDE
MUL_4402|M.ulcerans_Agy99 RAAAGRL-VEIQMP--AVEDLWYAE-ERTPVADWLGEHGWRASATT-SAE
Mflv_0743|M.gilvum_PYR-GCK RERFASIASQIDIEPMDITELTYEDPDRAEVAEWLAAHGWTAQAVP-SQD
Mvan_0104|M.vanbaalenii_PYR-1 RERFASITAQFDVEPMDITELTYEDPDRADVAQWLTAHGWRAEAVP-SQD
MSMEG_1481|M.smegmatis_MC2_155 SERWR----DHGFD-VDLSDLWYGG-DRNAADEYLAGHGWQVSTRP-RPE
TH_2759|M.thermoresistible__bu RDRTARMKAALDLN-LDFEALTYDDPDRADAGEWLAAHGWHPDSVP-GTE
Mb0289|M.bovis_AF2122/97 EEERAAIAEGAEEH--PFFQLVYNE-RCAPAAEWFGERGWTAVATL-LND
Rv0281|M.tuberculosis_H37Rv EEERAAIAEGAEEH--PFFQLVYNE-RCAPAAEWFGERGWTAVATL-LND
MAB_4586c|M.abscessus_ATCC_199 KTVVGETSDGETQP--NLRDLWFDD-PRLDTKTWLGERGWTVTEAN-LVD
MLBr_02020|M.leprae_Br4923 EATHPGVNISGDVD---FSALTYEP--KTDSAQWLAAHGWAVEPVRNTLE
MMAR_2791|M.marinum_M EQTHPGVNLSGDVN---FSALTYDD--KTNPAQWLAARGWVVEPVRNTLE
* : :: :** :
MAV_4557|M.avium_104 LMAGYGR-----PAPAEVRDFVPGNLFVAAQRR---
MUL_4402|M.ulcerans_Agy99 LLTRYGR-----PVPDDAEGPVPPTLFVSAHRPAA-
Mflv_0743|M.gilvum_PYR-GCK AMRRLDR-----YVEVADSDGQSFSTFTTGTKL---
Mvan_0104|M.vanbaalenii_PYR-1 EMRRLHR-----LVEIADGDDQSFSTFTTAVKR---
MSMEG_1481|M.smegmatis_MC2_155 VFAAYGRTFPDLTLTGDDNAAMRQSVAITATRS---
TH_2759|M.thermoresistible__bu EMARMGRPVPADLLDVAVPSTLLRAHLNGASR----
Mb0289|M.bovis_AF2122/97 YLEAVGRPVP--GPESEAGPMFARNTLVSAARV---
Rv0281|M.tuberculosis_H37Rv YLEAVGRPVP--GPESEAGPMFARNTLVSAARV---
MAB_4586c|M.abscessus_ATCC_199 AAVAYGRPLR--DLPPAFENFLSTKFFTAVQDHPRG
MLBr_02020|M.leprae_Br4923 LQTSYGMTPP--DVDVQMDSFMHSQYITATR-----
MMAR_2791|M.marinum_M LEAGYGMTPP--AVDVRLDAIMHSEYIVATKP----