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TTSEYGSRRSDDDQWDIVSGVGYTALLVAGWRALDTVGPQPLAPDEYAKYFIAASGDAYLNDQLAHPPTS VDETAFPRLYGVQTRFFDDFFRSAAAAGTKQAVIVAAGLDSRAYRLEWPSGTTVFEIDLPQVLEFKARVL QRHGVEPKARRNEVAADLRTDWPATLHAAGFEPGQPSAWSVEGLLPYLTADAQDALFARIDDLCAPGSRI ATGALGSRLDHDQLVALEQTHPGVNLSGDVNFSALTYDDKTNPAQWLAARGWVVEPVRNTLELEAGYGMT PPAVDVRLDAIMHSEYIVATKP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2791 | - | - | 100% (303) | hypothetical protein MMAR_2791 |
| M. marinum M | MMAR_0539 | - | 9e-59 | 42.72% (302) | O-methyltransferase |
| M. marinum M | MMAR_0356 | - | 9e-59 | 46.26% (281) | hypothetical protein MMAR_0356 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1931c | - | 1e-130 | 73.84% (302) | hypothetical protein Mb1931c |
| M. gilvum PYR-GCK | Mflv_0743 | - | 5e-58 | 44.20% (276) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv1896c | - | 1e-130 | 73.84% (302) | hypothetical protein Rv1896c |
| M. leprae Br4923 | MLBr_02020 | - | 1e-131 | 75.33% (300) | hypothetical protein MLBr_02020 |
| M. abscessus ATCC 19977 | MAB_4585c | - | 2e-65 | 45.51% (312) | hypothetical protein MAB_4585c |
| M. avium 104 | MAV_2803 | - | 1e-126 | 72.52% (302) | methyltransferase, putative, family protein |
| M. smegmatis MC2 155 | MSMEG_0614 | - | 1e-60 | 48.46% (260) | methyltransferase |
| M. thermoresistible (build 8) | TH_2759 | - | 1e-60 | 47.51% (301) | PUTATIVE methyltransferase |
| M. ulcerans Agy99 | MUL_2961 | - | 1e-173 | 98.68% (303) | hypothetical protein MUL_2961 |
| M. vanbaalenii PYR-1 | Mvan_0104 | - | 1e-60 | 45.74% (282) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2791|M.marinum_M ---MTTSEYGSR-RSDDDQWDIVSGVGYTALLVAGWRALDTVGPQPLAPD
MUL_2961|M.ulcerans_Agy99 ---MTTSEYGSR-RSDDDQWDIVSGVGYTALLVAGWRALDTVGPQPLAPD
MLBr_02020|M.leprae_Br4923 -MMAATPEFGSL-RSDDDHWDIVSSVGYTALLVAGWRALHAVGPQPLVRD
MAV_2803|M.avium_104 ---MTTPQFGSQ-RSDDDNWDIVSSVGYTALLVAGWRALHAVSPRPLVRD
Mb1931c|M.bovis_AF2122/97 ---MTTPEYGSL-RSDDDHWDIVSNVGYTALLVAGWRALHTTGPKPLVQD
Rv1896c|M.tuberculosis_H37Rv ---MTTPEYGSL-RSDDDHWDIVSNVGYTALLVAGWRALHTTGPKPLVQD
MAB_4585c|M.abscessus_ATCC_199 ---MTSTDQGSWARSEGDSWDIVSSVGYTALGVSAQRAVESERPDALIDD
Mflv_0743|M.gilvum_PYR-GCK ---------MSSLRTDDDTWDIASSVGATAVMVAAARAAETERHDALIND
Mvan_0104|M.vanbaalenii_PYR-1 ---------MSSLRTDNDTWDIASSVGATAVMVAAARAAETERPEPLIDD
TH_2759|M.thermoresistible__bu MVMMFDVTEAASARSEGDSWDITESVGATALGVAAERALETSQPDPLIRD
MSMEG_0614|M.smegmatis_MC2_155 ------------MRTDNDQWDITISVGQTALFVAASRALEARKPHPLAVD
*::.* ***. .** **: *:. ** .: .* *
MMAR_2791|M.marinum_M EYAKYFIAASGDAYLNDQLAH---------PPTSVDE-TAFPRLYGVQTR
MUL_2961|M.ulcerans_Agy99 EYAKYFIAASGDAYLNDQLAH---------PPTSVDE-TAFPRLYGVQTR
MLBr_02020|M.leprae_Br4923 EYAKYFITASRDPYLMNLLAN---------PGTSLNE-TAFPRLYGVQTR
MAV_2803|M.avium_104 DYAKTFIAASGDPYLTGVLAN---------PGTSEDE-LAFPRLYGVQTR
Mb1931c|M.bovis_AF2122/97 EYAKHFITASADPYLEGLLAN---------PRTSEDG-TAFPRLYGVQTR
Rv1896c|M.tuberculosis_H37Rv EYAKHFITASADPYLEGLLAN---------PRTSEDG-TAFPRLYGVQTR
MAB_4585c|M.abscessus_ATCC_199 PFAKHFVLAAGEPHLIETITK---------RDAPQASPFEYLRGMGMRSR
Mflv_0743|M.gilvum_PYR-GCK PYAKVLVEGAGAGAWRFIADEDLVAKASESDTEVGALFEHMKNYQAVRTH
Mvan_0104|M.vanbaalenii_PYR-1 PYAKILVAGAGNGAWQYIADDGFVAKVTESDPEIGPLFEHMKNYQAVRTH
TH_2759|M.thermoresistible__bu EYAFLLVSAAGP-PWTQLASSDLSWLG--DDETARRMHLMSRDYQAVRTH
MSMEG_0614|M.smegmatis_MC2_155 HYAEVFCRAAGG-DWVAAVEG-----TDPEHPLQTEFGVDFVNFQGARTK
:* : .: . :::
MMAR_2791|M.marinum_M FFDDFFRSAAAAGTKQAVIVAAGLDSRAYRLEWPSGTTVFEIDLPQVLEF
MUL_2961|M.ulcerans_Agy99 FFDDFFR-SAAAGTKQAVIVAAGLDSRAYRLEWPSGTTVFEIDLAQVLEF
MLBr_02020|M.leprae_Br4923 FFDDFFSSAGDTGIRQAVIVAAGLDSRAYRLKWPNGATVFEIDLPKVLEF
MAV_2803|M.avium_104 FFDDFFDAAGAAGIRQAVIIAAGLDSRAYRLEWPPATTVFEVDLAKVLEF
Mb1931c|M.bovis_AF2122/97 FFDDFFNCADEAGIRQAVIVAAGLDCRAYRLDWQPGTTVFEIDVPKVLEF
Rv1896c|M.tuberculosis_H37Rv FFDDFFNCADEAGIRQAVIVAAGLDCRAYRLDWQPGTTVFEIDVPKVLEF
MAB_4585c|M.abscessus_ATCC_199 FFDEFFLEAAASGITQAVILAAGLDARAHRLAWPAGVTVYELDQPQVLAF
Mflv_0743|M.gilvum_PYR-GCK FFDAFFSAAVDAGVRQIVILASGLDSRAFRLPWPAGTVVYEIDQPLVLDY
Mvan_0104|M.vanbaalenii_PYR-1 FFDAFFAAAVDAGIRQIVILASGLDSRAFRLPWPAGTTVFEIDQPLVLAY
TH_2759|M.thermoresistible__bu YFDRYFAAAARAGIRQIVLLAAGLDSRAYRLDWPAGTVVYELDQPRVLDF
MSMEG_0614|M.smegmatis_MC2_155 YFDDYFRRVADAGVRQVVLLAAGLDSRAYRLPWADGTVVYELDVPKVLEF
:** :* :* * *::*:***.**.** * ...*:*:* . ** :
MMAR_2791|M.marinum_M KARVLQRHGVEPKARRNEVAADLRTDWPATLHAAGFEPGQPSAWSVEGLL
MUL_2961|M.ulcerans_Agy99 KARVLQRHGVEPKARRNAVAADLRTDWPATLHAAGFEPGQPSAWSVEGLL
MLBr_02020|M.leprae_Br4923 KARVLAEQGAIPNAGRSEVAADLRADWPRALKAAGFDPQRSSAWSVEGLL
MAV_2803|M.avium_104 KARVLGEQGAVPKARRVEVAADLRADWSRPLEAAGFDVESPSAWSVEGLL
Mb1931c|M.bovis_AF2122/97 KARVLSERGAVPKAHRVAVPADLRTDWPTPLTAAGFDPQRPSAWSVEGLL
Rv1896c|M.tuberculosis_H37Rv KARVLSERGAVPKAHRVAVPADLRTDWPTPLTAAGFDPQRPSAWSVEGLL
MAB_4585c|M.abscessus_ATCC_199 KDGVYAQQGAEPTCDRRTVAVDLRDDWPAALKEAGFDAGRPTAWSAEGLL
Mflv_0743|M.gilvum_PYR-GCK KSSTLAAHGVAPTAERREVPIDLRQDWPAALVATGFDPARPTAWLAEGLL
Mvan_0104|M.vanbaalenii_PYR-1 KSSTLASHGVQPTADRREVPIDLRQDWPTALTHAGFDADQPTAWLAEGLL
TH_2759|M.thermoresistible__bu KNRTLQAHGAVAKADRRTVAVDLRDDWPAALRHAGFDSAAPTAWLAEGLL
MSMEG_0614|M.smegmatis_MC2_155 KREVLRRHGATPTAERREVPVDLRDDWPAALRANGFDASQPSAWIAEGLL
* . :*. ... * *. *** **. .* **: .:** .****
MMAR_2791|M.marinum_M PYLTADAQDALFARIDDLCAPGSRIATGALGSRLDH---DQLVALEQTHP
MUL_2961|M.ulcerans_Agy99 PYLTADAQDALFARIDDLCAPGSRIATGALGSRLDH---DQLVALEQTHP
MLBr_02020|M.leprae_Br4923 PYLTNDAQSALFTRIGELCAPGSRIAVGALGSRLDR---KQLAALEATHP
MAV_2803|M.avium_104 PYLTDEAQHALFTRISGLSAPGSRIAIGALGSRLDH---DQLHALEESHP
Mb1931c|M.bovis_AF2122/97 PYLTGDAQYALFARIDELCAPGSRVALGALGSRLDH---EQLAALETAHP
Rv1896c|M.tuberculosis_H37Rv PYLTGDAQYALFARIDELCAPGSRVALGALGSRLDH---EQLAALETAHP
MAB_4585c|M.abscessus_ATCC_199 PYLPAAAQELLFERMVELSAPGSRAAIEGPTGTLGM---SQFAKVEQKYR
Mflv_0743|M.gilvum_PYR-GCK MYLPADAQDRLFAQITELSAPGSQVAAESMGVHAP----DRRERMRERFA
Mvan_0104|M.vanbaalenii_PYR-1 MYLPADAQDRLFAQITELSAPGSRVAAESMGIHAQ----DRRERMRERFA
TH_2759|M.thermoresistible__bu CYLPADAQDRLFERITALSAPGSWLAVEAFHHDPQRATERRRAEWRDRTA
MSMEG_0614|M.smegmatis_MC2_155 IYLPADAQELLFAGIDALSAPGSFVAIEESAPMPM-------DVFEVKRA
**. ** ** : *.**** * .
MMAR_2791|M.marinum_M G-VNLSGDVN---FSALTYDD-KTNPA-QWLAARGWVVEPVRNTLELEAG
MUL_2961|M.ulcerans_Agy99 G-VNLFGDVN---FSALTYDD-KTNPA-QWLAARGWVVEPVRNTLELEAG
MLBr_02020|M.leprae_Br4923 G-VNISGDVD---FSALTYEP-KTDSA-QWLAAHGWAVEPVRNTLELQTS
MAV_2803|M.avium_104 G-VDVSGNVD---FSALTYEP-QSDPA-EWLAAHGWVVDPVRNTLDLQAG
Mb1931c|M.bovis_AF2122/97 G-VNMSGDVN---FSALTYDD-KTDPV-EWLVEHGWAVDPVRSTLELQVG
Rv1896c|M.tuberculosis_H37Rv G-VNMSGDVN---FSALTYDD-KTDPV-EWLVEHGWAVDPVRSTLELQVG
MAB_4585c|M.abscessus_ATCC_199 SEKDTFGKID---ITELFYDEEKTPPV-EWFSVRGWSTQGL-DMFDLAER
Mflv_0743|M.gilvum_PYR-GCK S-IASQIDIEPMDITELTYEDPDRAEVAEWLAAHGWTAQAVPSQDAMRR-
Mvan_0104|M.vanbaalenii_PYR-1 S-ITAQFDVEPMDITELTYEDPDRADVAQWLTAHGWRAEAVPSQDEMRR-
TH_2759|M.thermoresistible__bu R-MKAALDLN-LDFEALTYDDPDRADAGEWLAAHGWHPDSVPGTEEMAR-
MSMEG_0614|M.smegmatis_MC2_155 E-ALASGDPN--SFFALVFN-EQCAPGEQWFSERGWTASTTTLNECLHE-
. : : * :: . :*: :** . :
MMAR_2791|M.marinum_M YGMTPPAVDVRLDAIMHS-EYIVATKP----
MUL_2961|M.ulcerans_Agy99 YGMTPPAVDVRLDAIMHS-EYIVATKP----
MLBr_02020|M.leprae_Br4923 YGMTPPDVDVQMDSFMHS-QYITATR-----
MAV_2803|M.avium_104 YGMTPPEVDVKIDGFMRS-QYITAAR-----
Mb1931c|M.bovis_AF2122/97 YGLTPPDVDVKIDSFMRS-QYITAVRA----
Rv1896c|M.tuberculosis_H37Rv YGLTPPDVDVKIDSFMRS-QYITAVRA----
MAB_4585c|M.abscessus_ATCC_199 YGVRHPEVPEDIRELAGAMHYLTCTLPA---
Mflv_0743|M.gilvum_PYR-GCK LDRYVEVADSDGQSFS---TFTTGTKL----
Mvan_0104|M.vanbaalenii_PYR-1 LHRLVEIADGDDQSFS---TFTTAVKR----
TH_2759|M.thermoresistible__bu MGRPVPADLLDVAVPS---TLLRAHLNGASR
MSMEG_0614|M.smegmatis_MC2_155 VGRPAPAPDSEAAQMTGSISLMWARKG----