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FFDLSVRDFLDRAELVYPERVGVVDEPVQPAPSWGQLTYRQLAARARGQAAALDALGVGPGERVAIVSQN SARLLTSFFGVSGWGRILVPINFRLAPAEIEYIVGHSGASVLVVDPEVRGLLDTVRATHNFVLGEDDAAV FGELDSPHAVTPDPWSGSETGTATLNYTSGTTSRPKGVQLTHRNIWINAVVFGLHATLRDDDVLLHTLPM FHCNGWGWPYAATGMGARHIVLRKVDGDEILRRVEQHGVTVMCAAPTVVDSILDAAARWRGPIPGRDRVR IIVAGAPPPTRTIARVRTELGWEFIQIYGLTETAPLITMNRFRSEWAGLDVQEQARMLGRAGAPAIGVRV SVAEDGEVLTQSNTNLDGYWDQPQATAEALAGNWFHTGDRGSVDDGYLTISDRKKDIIITGGENVTSIEV EDALISHPGVREAAVVGVPDEKWGELVTAVVVVVTLDDPPSGADLIAHCRERLAGYKCPKRVEFVDSLPR TATGKVQKFRLREQLARD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3592c | - | - | 100% (509) | putative medium-chain acyl-CoA ligase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 6e-67 | 34.30% (519) | putative long-chain-fatty-acid CoA ligase |
| M. abscessus ATCC 19977 | MAB_4569c | - | 7e-63 | 33.86% (502) | fatty-acid-CoA ligase FadD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3116 | fadD13 | 5e-65 | 34.02% (485) | chain-fatty-acid-CoA ligase |
| M. gilvum PYR-GCK | Mflv_0027 | - | 1e-77 | 38.29% (504) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv3089 | fadD13 | 5e-65 | 34.02% (485) | chain-fatty-acid-CoA ligase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 9e-39 | 27.52% (516) | acyl-CoA synthetase |
| M. marinum M | MMAR_2597 | fadD13 | 5e-63 | 32.91% (477) | fatty-acid-CoA ligase FadD13 |
| M. avium 104 | MAV_3523 | - | 1e-65 | 36.38% (514) | acyl-CoA synthase |
| M. smegmatis MC2 155 | MSMEG_1982 | - | 4e-85 | 38.99% (536) | acyl-CoA synthase |
| M. thermoresistible (build 8) | TH_3031 | - | 7e-80 | 36.10% (518) | PUTATIVE acyl-CoA synthase |
| M. ulcerans Agy99 | MUL_0229 | fadD14 | 3e-55 | 32.29% (511) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 2e-74 | 38.09% (512) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3116|M.bovis_AF2122/97 --------------MKNIGWMLRQRAT----------------------V
Rv3089|M.tuberculosis_H37Rv --------------MKNIGWMLRQRAT----------------------V
MMAR_2597|M.marinum_M --------------MKNIGAMLKQRAH----------------------I
Mflv_0027|M.gilvum_PYR-GCK -------------MFHNLADIVRSHGR----------------------N
Mvan_0943|M.vanbaalenii_PYR-1 -------------MIHNLADIIRVHGR----------------------E
MAV_3523|M.avium_104 --------MPAAETRETLAGIVERHAQ----------------------R
MSMEG_1982|M.smegmatis_MC2_155 ---MAVF----TFAELTPTSLLQRSAQ----------------------A
TH_3031|M.thermoresistible__bu VDMMATIGVPPCATALTPTDFLRRSAT----------------------I
MAB_3592c|M.abscessus_ATCC_199 -----------MFFDLSVRDFLDRAEL----------------------V
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
MUL_0229|M.ulcerans_Agy99 ------MYSTMQDFPLTITAIMRHGCG----------------------V
:.
Mb3116|M.bovis_AF2122/97 SPRLQAYVEPSTDVRMT------YAQMNALANRCADVLTALGIAKGDRVA
Rv3089|M.tuberculosis_H37Rv SPRLQAYVEPSTDVRMT------YAQMNALANRCADVLTALGIAKGDRVA
MMAR_2597|M.marinum_M SPRLQAYVEPSTNVRMD------YTELNMLTNRCASVLRALGVGKGDRVA
Mflv_0027|M.gilvum_PYR-GCK RPDAPALIVG--DRTVS------YRELDERSNRTAQAFSRTGVGPGDRVA
Mvan_0943|M.vanbaalenii_PYR-1 RPGAPALVVG--DRTVT------YGELDDRSSRAAQAFAQAGVGVGDRVA
MAV_3523|M.avium_104 RPDAIAIRYG--ERQWS------WAEWSSRIRRAAGALRGDGIERGQCVA
MSMEG_1982|M.smegmatis_MC2_155 FPDRLAIVDGELR--------LTYTQFAERCGRVTSALAAAGVQPGDRVA
TH_3031|M.thermoresistible__bu FPDRVAVIDGADR--------TSYIGWYHRVRRMAGLLRKCGVQQGDCVA
MAB_3592c|M.abscessus_ATCC_199 YPERVGVVDEPVQPAPSW-GQLTYRQLAARARGQAAALDALGVGPGERVA
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
MUL_0229|M.ulcerans_Agy99 HGSRQVITATGDAYRQT-----TYREVGQRAAQLANALRGLGISGDQRVA
: : : *: .: :*
Mb3116|M.bovis_AF2122/97 LLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVIYG
Rv3089|M.tuberculosis_H37Rv LLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVIYG
MMAR_2597|M.marinum_M LLMPNSVAFCCLFYGAAKLGAVAVPLNTRLAAPELGFILADSGSTVLIYH
Mflv_0027|M.gilvum_PYR-GCK FVERNGIEFFDVAFGSAKLGAVAVPVNWRLTAPEMRHVIADCGASVVVVG
Mvan_0943|M.vanbaalenii_PYR-1 FVDKNGAEFFEVTFGLAKVGAVGVPVNWRLAAPEMRHIIADSGAKIVVVG
MAV_3523|M.avium_104 FLDKNHPACLEVLIGGASVGAVTTVVNWRVIGDELVHVLADSGARVLVVG
MSMEG_1982|M.smegmatis_MC2_155 ALCTNSHVMLELHQAVPARGAVLVPLNTRLAFEEMQYIIGHAGARILIAT
TH_3031|M.thermoresistible__bu VLAPNTSMLLDAHYGVPMAGAVLLTLNIRLTVEDLTYISRHAGAKAVLFD
MAB_3592c|M.abscessus_ATCC_199 IVSQNSARLLTSFFGVSGWGRILVPINFRLAPAEIEYIVGHSGASVLVVD
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
MUL_0229|M.ulcerans_Agy99 TFMWNNAEHLVTYLAVPSMGAVLHTLNIRLFAEQIAYVANEAEDQVVLVD
. * . . * :* .. :: : ::
Mb3116|M.bovis_AF2122/97 APSAPVIDAIRAQADPPGTVTDWI------------GADSLAERLRSAAA
Rv3089|M.tuberculosis_H37Rv APSAPVIDAIRAQADPPGTVTDWI------------GADSLAERLRSAAA
MMAR_2597|M.marinum_M QSLEPVVTAIKTATERSHNVISWVPL--------SDGEGALAQRLETADA
Mflv_0027|M.gilvum_PYR-GCK QEFTGRIEAIADDLDVEVVVIGKHR-----------HWPTFDDLLAAAPA
Mvan_0943|M.vanbaalenii_PYR-1 QDFAGHLEAIEDGLDADIVVIGDHP-----------RWPAFDDWVASHPP
MAV_3523|M.avium_104 AELRPAAEAAARRVPSLERIIEVG--------------DEYESLLAAAEP
MSMEG_1982|M.smegmatis_MC2_155 REFADRARELADDAG---IDVVIE-------------GDGYEEWLPDVAS
TH_3031|M.thermoresistible__bu DSLAHIAAQLP-------IPIQLS-------------ATEYRRRVADAPE
MAB_3592c|M.abscessus_ATCC_199 PEVRGLLDTVRATHN---FVLGEDD------------AAVFGELDSPHAV
MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGKLRALGVNPDE--------EEPPGSTDETLAELIA
MUL_0229|M.ulcerans_Agy99 LSLTNLLAPVLPNLDTVHTVIAVGEGDTAALEESGKTVLRYDELLDGQST
Mb3116|M.bovis_AF2122/97 --DEPAVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWAST--I
Rv3089|M.tuberculosis_H37Rv --DEPAVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWAST--I
MMAR_2597|M.marinum_M --GEPICDSGGSDNLFIMYTSGTTGNPKGVVHTHDSVHTAASSWSLT--V
Mflv_0027|M.gilvum_PYR-GCK --VDPGVVTGPDDLVFLMYTSGTTGAPKGVMLSNANVVCKTAGVGGP--W
Mvan_0943|M.vanbaalenii_PYR-1 --VDPGVVTGPDDVVLLMYTSGTTGAPKGVMLSNTNYVYKTGGVAGP--W
MAV_3523|M.avium_104 --APSDAGVDTDETALVIYSSGTTGRPKGVLLSQRALVNHAANLAPA--F
MSMEG_1982|M.smegmatis_MC2_155 --PEDRVAVGERDLLAINYTSGTTGRPKGVMYHHRGAYLQAVAMAYH--T
TH_3031|M.thermoresistible__bu --VEHQVDD-ELALLSLNYTSGTTGRPRGVMYHHRGAYLQALATAYH--S
MAB_3592c|M.abscessus_ATCC_199 --TPDPWSGSETGTATLNYTSGTTSRPKGVQLTHRNIWINAVVFGLH--A
MLBr_02546|M.leprae_Br4923 RSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSK--V
MUL_0229|M.ulcerans_Agy99 --EFDWPHIDENSAAAMCYTSGTTGHPKGVVYSHRSSFLHSMATCTANGI
: :****. *:*.
Mb3116|M.bovis_AF2122/97 DVRYRDRLLLPLPMFHVAALTTVIFSAMRGVTLISMP-QFDATKVWSLIV
Rv3089|M.tuberculosis_H37Rv DVRYRDRLLLPLPMFHVAALTTVIFSAMRGVTLISMP-QFDATKVWSLIV
MMAR_2597|M.marinum_M DVRYQDRLLLPLPMFHVAALTTVIMCAMRGVTLVSMP-QFDPAKAWSLIV
Mflv_0027|M.gilvum_PYR-GCK KFDADSVSLAVMPLFHMAGFGWALAGLWEGAVTVVLR-DVDPGAILDAVA
Mvan_0943|M.vanbaalenii_PYR-1 QFDADAVSLAVMPLFHMAGSGWALAGLWQGATTVVLR-DVEPAAILDAIA
MAV_3523|M.avium_104 PFGDGDANLVAMPLFHVGGIGYALFGIRAGAPTIMTR-EPDAAALIGAVR
MSMEG_1982|M.smegmatis_MC2_155 RLDPSTGYLWTLPMFHCNGWCFTWAVGAAGGTHICLR-KIDSAEIWRWLR
TH_3031|M.thermoresistible__bu GLSPQTVHLWTLPMFHCHGWSFTWSVTAAGGTHVCLP-KVEPSAIWRHLH
MAB_3592c|M.abscessus_ATCC_199 TLRDDDVLLHTLPMFHCNGWGWPYAATGMGARHIVLR-KVDGDEILRRVE
MLBr_02546|M.leprae_Br4923 PFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRR-RFKPATVLEDIE
MUL_0229|M.ulcerans_Agy99 GLGSSDRVLPIVPMFHANAWGLPYAALMAGADLVLPDRHLDARSLVHMVE
. * *:** . * : . :
Mb3116|M.bovis_AF2122/97 EERVCIGGAVPAILNFMRQVPEFAELDAPDFR-YFITGGAPMPEALIKIY
Rv3089|M.tuberculosis_H37Rv EERVCIGGAVPAILNFMRQVPEFAELDAPDFR-YFITGGAPMPEALIKIY
MMAR_2597|M.marinum_M DERVSLAGAVPAILNFMRLVPEFTELDAPEFR-CFITGGAPMPEALIRMY
Mflv_0027|M.gilvum_PYR-GCK RHRVTNMLLVPAVIQFLLDTTGLDDTDLSRLR-IVVYGASPITDDVLMRG
Mvan_0943|M.vanbaalenii_PYR-1 RHRITNMLLVPAVIQFLLDTDGVAEVDLSTLR-VIVYGASPISDDVLVRG
MAV_3523|M.avium_104 AG-ATHAFFVPPVIARFLDAGEAARASIAGLR-YIVYGAAPMPLPLLHRA
MSMEG_1982|M.smegmatis_MC2_155 GGGITHFSAAPTVLTMIAEDPSAQP--LPAR--VHVDTGGAPPSPALLAR
TH_3031|M.thermoresistible__bu DDGVNSLNAAPTVLIDLASHHDARR--VAHG--VRVGTGGAPPSPTLLQR
MAB_3592c|M.abscessus_ATCC_199 QHGVTVMCAAPTVVDSILDAAARWRGPIPGRDRVRIIVAGAPPPTRTIAR
MLBr_02546|M.leprae_Br4923 KHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATR
MUL_0229|M.ulcerans_Agy99 NLRPTRAGAVPTIWNDVMHYLEKNPGHDVSSLGLVACGGSAVP-ESLMRT
.* : . ...
Mb3116|M.bovis_AF2122/97 AAKN--IEVVQGYALTESCGGGTLLLSEDA----------LRKAGSAGRA
Rv3089|M.tuberculosis_H37Rv AAKN--IEVVQGYALTESCGGGTLLLSEDA----------LRKAGSAGRA
MMAR_2597|M.marinum_M AAKN--MQVVQGYALTESCGGGTLLLGEDA----------LAKVGSAGRA
Mflv_0027|M.gilvum_PYR-GCK IDRF-GGIFAQVYGMTESTGSVTQLDGDEH---------LPQLLRSCGRP
Mvan_0943|M.vanbaalenii_PYR-1 IERF-GPIFAQVYGMTETTGSITQLDGPDH---------VPALLRSCGRP
MAV_3523|M.avium_104 LSTWPGTKFVQVYGQTELCGAVTALSDDDHRDAA-----RPQLQLSAGKA
MSMEG_1982|M.smegmatis_MC2_155 L-TPLGFDVTHLYGLTETYGPVAVNVWQPEWDELPDDEQARLRARQGVGN
TH_3031|M.thermoresistible__bu L-SELGFDITHYYGLTETYGPAVICEFPAERADSPMIEQARFKARQGNCN
MAB_3592c|M.abscessus_ATCC_199 VRTELGWEFIQIYGLTETAPLITMNRFRSEWAGLDVQEQARMLGRAG-AP
MLBr_02546|M.leprae_Br4923 ALEELGPVIYNMYGSTEIAFATIAGPKDLQ-----------INSATVGPV
MUL_0229|M.ulcerans_Agy99 FEEKYGVQIRQLWGMTETSPLATMAWPPPGTPPD----RHWAIRSTQGQP
. : :. **
Mb3116|M.bovis_AF2122/97 TMFTDVAVRGDDG---VIREHGEGEVVIKSDILLKEYWNRPEATRDAFDN
Rv3089|M.tuberculosis_H37Rv TMFTDVAVRGDDG---VIREHGEGEVVIKSDILLKEYWNRPEATRDAFDN
MMAR_2597|M.marinum_M TMFADVRVRTDDG---MIAERGQGEVVIKSDFLLKEYWNRPDATRDAFHG
Mflv_0027|M.gilvum_PYR-GCK YPWVQIRVVDPTG--RDVAPGTVGEVWTRSDQNMLGYWNNPEATAATLTP
Mvan_0943|M.vanbaalenii_PYR-1 YPWVQIRIVDETG--ADAVAGTVGEVWTRSEQNMLGYWNNPDATASTLTA
MAV_3523|M.avium_104 VQGCEIRIVDPNNC-AELPAGRSGEVWVRSNQNMSGYLNRAEATAETITA
MSMEG_1982|M.smegmatis_MC2_155 IIANPLRVVDLGGDDVPRDGTTIGEIAARGNDVMLGYYNDDAATSAATRD
TH_3031|M.thermoresistible__bu IVGQPLRVVDDRGDDVPADATTMGEIVIRGNTVATGYYRDEEATREAFGS
MAB_3592c|M.abscessus_ATCC_199 AIGVRVSVAED------------GEVLTQSNTNLDGYWDQPQATAEALAG
MLBr_02546|M.leprae_Br4923 VKGVKVKILDDSGK--EVPRGQVGRIFVGNAFPFEGYTG---GGGKQIID
MUL_0229|M.ulcerans_Agy99 VCGVETRIVDDNGEALPNDGQAVGEVEVRGPWITGAYYLG--YDQSEFDS
: *.: . *
Mb3116|M.bovis_AF2122/97 G-WFRTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGV
Rv3089|M.tuberculosis_H37Rv G-WFRTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGV
MMAR_2597|M.marinum_M D-WFRTGDIGEIDSDGYLYIKDRIKDMIISGGENIYPAEIENVITGIPGV
Mflv_0027|M.gilvum_PYR-GCK DGWLRTGDAGYLDRDGYLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAV
Mvan_0943|M.vanbaalenii_PYR-1 DGWLKTGDAGYVDDDGYLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAV
MAV_3523|M.avium_104 DGWVRTGDVGRLDADGYVYIEDRLKDMIITGGENVYGPEVESVLIEHPAV
MSMEG_1982|M.smegmatis_MC2_155 G-YFLTGDLAAMHPDGYVEIRDRAKDVIISGGENIASIEIEKVIDSHPEV
TH_3031|M.thermoresistible__bu G-WFRTGDLGVMHPDNYVELRDRAKDVIISGGENISSVEVEQVLDTHPAV
MAB_3592c|M.abscessus_ATCC_199 N-WFHTGDRGSVD-DGYLTISDRKKDIIITGGENVTSIEVEDALISHPGV
MLBr_02546|M.leprae_Br4923 G-LLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEV
MUL_0229|M.ulcerans_Agy99 G-WLRTGDVGRIDELGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDV
. . :** . .. . : : .* .::* :*.* : *:*. : * *
Mb3116|M.bovis_AF2122/97 SEVAVIGLPDEKWGEIAAAIVVADQ-NEVSEQQ-IVEYCGTRLARYKLPK
Rv3089|M.tuberculosis_H37Rv SEVAVIGLPDEKWGEIAAAIVVADQ-NEVSEQQ-IVEYCGTRLARYKLPK
MMAR_2597|M.marinum_M AEVAVIGLPDQKWGEIACAIVVSDQ-GAVSEAG-IVEFCAARLARYKLPK
Mflv_0027|M.gilvum_PYR-GCK TDVAVIGIPDTRWGEAVKAVVVAG--APVTEAE-LIAFAREQLAGFKLPK
Mvan_0943|M.vanbaalenii_PYR-1 ADAAVIGVPDRRWGEAVKAVVVAARGAQLTEAE-LIAFARDRIGGFKLPK
MAV_3523|M.avium_104 VDAAVIGVPDDFWGESVKAIVVAD--GDVDAAD-VIEFCRRHLAGFKCPR
MSMEG_1982|M.smegmatis_MC2_155 VESAVVGVADEKWGEVPVAFITRRDGSD-VTFDQLTTFLREHLAGFKVPR
TH_3031|M.thermoresistible__bu RECAVVAGPHPRWGEVPVAFVDLEPGAN-ATVEDLIAYARTRLPGFKTPK
MAB_3592c|M.abscessus_ATCC_199 REAAVVGVPDEKWGELVTAVVVVVTLDDPPSGADLIAHCRERLAGYKCPK
MLBr_02546|M.leprae_Br4923 VEATAIGVDDKEWGARLRAFVVKKQ-DATIDEDAIKAYVRDHLARYKVPR
MUL_0229|M.ulcerans_Agy99 VEAAVVGVPDERWQERPLAVVVRRE-GATVSAAELRKFLADRVVRWWLPE
: :.:. . * *.: : . :: : *.
Mb3116|M.bovis_AF2122/97 KVIFAEAIPRNPTGKILKTVLREQYSATVPK------
Rv3089|M.tuberculosis_H37Rv KVIFAEAIPRNPTGKILKTVLREQYSATVPK------
MMAR_2597|M.marinum_M RLIFTATLPRNPAGKVLKRELRELYR-----------
Mflv_0027|M.gilvum_PYR-GCK SVDFVDALPRNPSGKLLKRQLREPYWTDEDRHIG---
Mvan_0943|M.vanbaalenii_PYR-1 SVDFVDVLPRNPSGKLLKRALREPYWDGADRHIG---
MAV_3523|M.avium_104 TVDFVAELPRNASGKILKTQLREPFWRDRDRRV----
MSMEG_1982|M.smegmatis_MC2_155 -TMVFDHLPKTSTGKIQKNVLRARAEQDKAN------
TH_3031|M.thermoresistible__bu -TVYIGPLPKTGTGKIQKFRLRDRARHGKYSSDV---
MAB_3592c|M.abscessus_ATCC_199 RVEFVDSLPRTATGKVQKFRLREQLARD---------
MLBr_02546|M.leprae_Br4923 EVIFLEELPRNPTGKVLKRELRDFEVH----------
MUL_0229|M.ulcerans_Agy99 RWAFADQVPRTSVGKYDKKTIRAGYAESVYQVTDVHN
:*:. ** * :*