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MAVFTFAELTPTSLLQRSAQAFPDRLAIVDGELRLTYTQFAERCGRVTSALAAAGVQPGDRVAALCTNSH VMLELHQAVPARGAVLVPLNTRLAFEEMQYIIGHAGARILIATREFADRARELADDAGIDVVIEGDGYEE WLPDVASPEDRVAVGERDLLAINYTSGTTGRPKGVMYHHRGAYLQAVAMAYHTRLDPSTGYLWTLPMFHC NGWCFTWAVGAAGGTHICLRKIDSAEIWRWLRGGGITHFSAAPTVLTMIAEDPSAQPLPARVHVDTGGAP PSPALLARLTPLGFDVTHLYGLTETYGPVAVNVWQPEWDELPDDEQARLRARQGVGNIIANPLRVVDLGG DDVPRDGTTIGEIAARGNDVMLGYYNDDAATSAATRDGYFLTGDLAAMHPDGYVEIRDRAKDVIISGGEN IASIEIEKVIDSHPEVVESAVVGVADEKWGEVPVAFITRRDGSDVTFDQLTTFLREHLAGFKVPRTMVFD HLPKTSTGKIQKNVLRARAEQDKAN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1982 | - | - | 100% (515) | acyl-CoA synthase |
| M. smegmatis MC2 155 | MSMEG_4065 | - | 1e-61 | 33.27% (520) | feruloyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_2883 | - | 1e-58 | 32.09% (511) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3116 | fadD13 | 5e-60 | 33.07% (502) | chain-fatty-acid-CoA ligase |
| M. gilvum PYR-GCK | Mflv_0027 | - | 3e-66 | 32.86% (496) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv3089 | fadD13 | 5e-60 | 33.07% (502) | chain-fatty-acid-CoA ligase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-35 | 25.64% (507) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_3592c | - | 3e-85 | 38.99% (536) | putative medium-chain acyl-CoA ligase |
| M. marinum M | MMAR_4412 | fadD14 | 1e-61 | 30.61% (526) | medium chain fatty-acid-CoA ligase FadD14 |
| M. avium 104 | MAV_1186 | - | 3e-64 | 33.08% (529) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3031 | - | 1e-149 | 53.07% (505) | PUTATIVE acyl-CoA synthase |
| M. ulcerans Agy99 | MUL_0229 | fadD14 | 1e-61 | 30.99% (526) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 3e-67 | 33.40% (494) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0027|M.gilvum_PYR-GCK -------------MFHNLADIVRSHGRNRPDAPALIVG--DRT-------
Mvan_0943|M.vanbaalenii_PYR-1 -------------MIHNLADIIRVHGRERPGAPALVVG--DRT-------
Mb3116|M.bovis_AF2122/97 --------------MKNIGWMLRQRATVSPRLQAYVEPSTDVR-------
Rv3089|M.tuberculosis_H37Rv --------------MKNIGWMLRQRATVSPRLQAYVEPSTDVR-------
MSMEG_1982|M.smegmatis_MC2_155 ---MAVF----TFAELTPTSLLQRSAQAFPDRLAIVDGELR---------
TH_3031|M.thermoresistible__bu VDMMATIGVPPCATALTPTDFLRRSATIFPDRVAVIDGADR---------
MAB_3592c|M.abscessus_ATCC_199 -----------MFFDLSVRDFLDRAELVYPERVGVVDEPVQPAPS-----
MMAR_4412|M.marinum_M ------MYSTMQDFPLTITAIMRHGCGVHGSRQVITATGDAYR-------
MUL_0229|M.ulcerans_Agy99 ------MYSTMQDFPLTITAIMRHGCGVHGSRQVITATGDAYR-------
MAV_1186|M.avium_104 ------MDGTMQDFPLTITAIMRHGCSVHGARTVTTATGDGYR-------
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
:.
Mflv_0027|M.gilvum_PYR-GCK ---------------------VSYRELDERSNRTAQAFSRTGVGPGDRVA
Mvan_0943|M.vanbaalenii_PYR-1 ---------------------VTYGELDDRSSRAAQAFAQAGVGVGDRVA
Mb3116|M.bovis_AF2122/97 ---------------------MTYAQMNALANRCADVLTALGIAKGDRVA
Rv3089|M.tuberculosis_H37Rv ---------------------MTYAQMNALANRCADVLTALGIAKGDRVA
MSMEG_1982|M.smegmatis_MC2_155 ---------------------LTYTQFAERCGRVTSALAAAGVQPGDRVA
TH_3031|M.thermoresistible__bu ---------------------TSYIGWYHRVRRMAGLLRKCGVQQGDCVA
MAB_3592c|M.abscessus_ATCC_199 ------------------WGQLTYRQLAARARGQAAALDALGVGPGERVA
MMAR_4412|M.marinum_M --------------------QTTYREVGQRAAQLANALRGLGISGDQRVA
MUL_0229|M.ulcerans_Agy99 --------------------QTTYREVGQRAAQLANALRGLGISGDQRVA
MAV_1186|M.avium_104 --------------------RTSYRELGDRAAQLANALRGLGVTGDQRVA
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
:* : : *: .: :*
Mflv_0027|M.gilvum_PYR-GCK FVERNGIEFFDVAFGSAKLGAVAVPVNWRLTAPEMRHVIADCGASVVVVG
Mvan_0943|M.vanbaalenii_PYR-1 FVDKNGAEFFEVTFGLAKVGAVGVPVNWRLAAPEMRHIIADSGAKIVVVG
Mb3116|M.bovis_AF2122/97 LLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVIYG
Rv3089|M.tuberculosis_H37Rv LLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVIYG
MSMEG_1982|M.smegmatis_MC2_155 ALCTNSHVMLELHQAVPARGAVLVPLNTRLAFEEMQYIIGHAGARILIAT
TH_3031|M.thermoresistible__bu VLAPNTSMLLDAHYGVPMAGAVLLTLNIRLTVEDLTYISRHAGAKAVLFD
MAB_3592c|M.abscessus_ATCC_199 IVSQNSARLLTSFFGVSGWGRILVPINFRLAPAEIEYIVGHSGASVLVVD
MMAR_4412|M.marinum_M TFMWNNAEHLVAYLAVPSMGAVLHTLNIRLFAEQIAYVANEAEDQVVLVD
MUL_0229|M.ulcerans_Agy99 TFMWNNAEHLVTYLAVPSMGAVLHTLNIRLFAEQIAYVANEAEDQVVLVD
MAV_1186|M.avium_104 TFMWNNAEHLAAYLAVPSMGAVLHTLNIRLFPEQIAYVANEAGDQVVLVD
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
. * . . * :* .: :: : ::
Mflv_0027|M.gilvum_PYR-GCK QEFTGRIEAIADDLDV-----------EVVVIGKHRHWPTFDDLLAAAPA
Mvan_0943|M.vanbaalenii_PYR-1 QDFAGHLEAIEDGLDA-----------DIVVIGDHPRWPAFDDWVASHPP
Mb3116|M.bovis_AF2122/97 APSAPVIDAIRAQADP-----------PGTVT-DWIGADSLAERLRSAAA
Rv3089|M.tuberculosis_H37Rv APSAPVIDAIRAQADP-----------PGTVT-DWIGADSLAERLRSAAA
MSMEG_1982|M.smegmatis_MC2_155 REFADRARELAD---------------DAGIDVVIE-GDGYEEWLPDVAS
TH_3031|M.thermoresistible__bu DSLAHIAAQLP-------------------IPIQLS-ATEYRRRVADAPE
MAB_3592c|M.abscessus_ATCC_199 PEVRGLLDTVRA---------------THNFVLGEDDAAVFGELDSPHAV
MMAR_4412|M.marinum_M LSLTNLLAPVLPDLGTVHTVIAVGEGDTAPLEESGKTVLRYDELLDGQPT
MUL_0229|M.ulcerans_Agy99 LSLTNLLAPVLPNLDTVHTVIAVGEGDTAALEESGKTVLRYDELLDGQST
MAV_1186|M.avium_104 ASLVKLLAPVLPGLHTVHTVIVVGDGDTEPLRASGKTVLRYADVIGAEPA
MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGKLRALG----VNPDEEEPPGSTDETLAELIARSSS
.
Mflv_0027|M.gilvum_PYR-GCK VDPGVVTGPDDLVFLMYTSGTTGAPKGVMLSNAN--VVCKTAGVGGPWKF
Mvan_0943|M.vanbaalenii_PYR-1 VDPGVVTGPDDVVLLMYTSGTTGAPKGVMLSNTN--YVYKTGGVAGPWQF
Mb3116|M.bovis_AF2122/97 DEPAVECGGDDNLFIMYTSGTTGHPKGVVHTHES--VHSAASSWASTIDV
Rv3089|M.tuberculosis_H37Rv DEPAVECGGDDNLFIMYTSGTTGHPKGVVHTHES--VHSAASSWASTIDV
MSMEG_1982|M.smegmatis_MC2_155 PEDRVAVGERDLLAINYTSGTTGRPKGVMYHHRGAYLQAVAMAYHT--RL
TH_3031|M.thermoresistible__bu VEHQVDD-ELALLSLNYTSGTTGRPRGVMYHHRGAYLQALATAYHS--GL
MAB_3592c|M.abscessus_ATCC_199 TPDPWSGSETGTATLNYTSGTTSRPKGVQLTHRNIWINAVVFGLHA--TL
MMAR_4412|M.marinum_M EFDWPHIDENSAAAMCYTSGTTGHPKGVVYSHRSSFLHSMATCTANGIGV
MUL_0229|M.ulcerans_Agy99 EFDWPHIDENSAAAMCYTSGTTGHPKGVVYSHRSSFLHSMATCTANGIGL
MAV_1186|M.avium_104 EFDWPRIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTANGIGI
MLBr_02546|M.leprae_Br4923 AP--APKVRKRASIIILTSGTTGTPKGANRNTPAS--LAPLGGILSKVPF
: *****. *:*. .
Mflv_0027|M.gilvum_PYR-GCK DADSVSLAVMPLFHMAGFGWALAGLWEGAVTVVLR-DVDPGAILDAVARH
Mvan_0943|M.vanbaalenii_PYR-1 DADAVSLAVMPLFHMAGSGWALAGLWQGATTVVLR-DVEPAAILDAIARH
Mb3116|M.bovis_AF2122/97 RYRDRLLLPLPMFHVAALTTVIFSAMRGVTLISMP-QFDATKVWSLIVEE
Rv3089|M.tuberculosis_H37Rv RYRDRLLLPLPMFHVAALTTVIFSAMRGVTLISMP-QFDATKVWSLIVEE
MSMEG_1982|M.smegmatis_MC2_155 DPSTGYLWTLPMFHCNGWCFTWAVGAAGGTHICLR-KIDSAEIWRWLRGG
TH_3031|M.thermoresistible__bu SPQTVHLWTLPMFHCHGWSFTWSVTAAGGTHVCLP-KVEPSAIWRHLHDD
MAB_3592c|M.abscessus_ATCC_199 RDDDVLLHTLPMFHCNGWGWPYAATGMGARHIVLR-KVDGDEILRRVEQH
MMAR_4412|M.marinum_M GSNDRVLPIVPMFHANAWGLPYAALMAGADLVLPDRHLDARSLVHMVENL
MUL_0229|M.ulcerans_Agy99 GSSDRVLPIVPMFHANAWGLPYAALMAGADLVLPDRHLDARSLVHMVENL
MAV_1186|M.avium_104 GATDSLLPIVPMFHANAWGLPYAALMAGADLVLPDCHLDPRSLVRMVEDL
MLBr_02546|M.leprae_Br4923 RAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRR-RFKPATVLEDIEKH
* *:** . * : .. : :
Mflv_0027|M.gilvum_PYR-GCK RVTNMLLVPAVIQFLLDTTGLDDT--DLSRLRIVVYGASPITDDVLMRGI
Mvan_0943|M.vanbaalenii_PYR-1 RITNMLLVPAVIQFLLDTDGVAEV--DLSTLRVIVYGASPISDDVLVRGI
Mb3116|M.bovis_AF2122/97 RVCIGGAVPAILNFMRQVPEFAEL--DAPDFRYFITGGAPMP-EALIKIY
Rv3089|M.tuberculosis_H37Rv RVCIGGAVPAILNFMRQVPEFAEL--DAPDFRYFITGGAPMP-EALIKIY
MSMEG_1982|M.smegmatis_MC2_155 GITHFSAAPTVLTMIAEDPSAQP--LPAR--VHVDTGGAPPSPALLARL-
TH_3031|M.thermoresistible__bu GVNSLNAAPTVLIDLASHHDARR--VAHG--VRVGTGGAPPSPTLLQRL-
MAB_3592c|M.abscessus_ATCC_199 GVTVMCAAPTVVDSILDAAARWRGPIPGRDRVRIIVAGAPPPTRTIARVR
MMAR_4412|M.marinum_M RPTRAGAVPTIWNDVMHYLEKNPG-HDVSSLGLVACGGSAVPESLMRTFE
MUL_0229|M.ulcerans_Agy99 RPTRAGAVPTIWNDVMHYLEKNPG-HDVSSLGLVACGGSAVPESLMRTFE
MAV_1186|M.avium_104 RPTVTGAVPTIWNAVLHHLEDDPD-HDMSSLRLVVCGGSAVPVSLMRTFE
MLBr_02546|M.leprae_Br4923 QATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRAL
.*.: : . ..:
Mflv_0027|M.gilvum_PYR-GCK DRFGGIFAQVYGMTESTGSVTQLDGD---------EHLPQLLRSCGRPYP
Mvan_0943|M.vanbaalenii_PYR-1 ERFGPIFAQVYGMTETTGSITQLDGP---------DHVPALLRSCGRPYP
Mb3116|M.bovis_AF2122/97 AAKNIEVVQGYALTESCGGGTLLLSE---------DALRKAG-SAGRATM
Rv3089|M.tuberculosis_H37Rv AAKNIEVVQGYALTESCGGGTLLLSE---------DALRKAG-SAGRATM
MSMEG_1982|M.smegmatis_MC2_155 TPLGFDVTHLYGLTETYGPVAVNVWQPEWDELPDDEQARLRARQGVGNII
TH_3031|M.thermoresistible__bu SELGFDITHYYGLTETYGPAVICEFPAERADSPMIEQARFKARQGNCNIV
MAB_3592c|M.abscessus_ATCC_199 TELGWEFIQIYGLTETAPLITMNRFRSEWAGLDVQEQARMLGRAG-APAI
MMAR_4412|M.marinum_M EKYGVQIRQLWGMTETSPLATMAWPP---PGTPPDRHWAIRSTQG-QPVC
MUL_0229|M.ulcerans_Agy99 EKYGVQIRQLWGMTETSPLATMAWPP---PGTPPDRHWAIRSTQG-QPVC
MAV_1186|M.avium_104 EKHGVQIRQLWGMTETSPLATMAWPP---PGTPEDQHWAYRGTQG-QPVC
MLBr_02546|M.leprae_Br4923 EELGPVIYNMYGSTEIAFATIAGPKD-----------LQINSATVGPVVK
. . : :. **
Mflv_0027|M.gilvum_PYR-GCK WVQIRVVDPTG--RDVAPGTVGEVWTRSDQNMLGYWNNPEATAATLTPDG
Mvan_0943|M.vanbaalenii_PYR-1 WVQIRIVDETG--ADAVAGTVGEVWTRSEQNMLGYWNNPDATASTLTADG
Mb3116|M.bovis_AF2122/97 FTDVAVRGDDG--VIREHG-EGEVVIKSDILLKEYWNRPEATRDAFDN-G
Rv3089|M.tuberculosis_H37Rv FTDVAVRGDDG--VIREHG-EGEVVIKSDILLKEYWNRPEATRDAFDN-G
MSMEG_1982|M.smegmatis_MC2_155 ANPLRVVDLGGDDVPRDGTTIGEIAARGNDVMLGYYNDDAATSAATRD-G
TH_3031|M.thermoresistible__bu GQPLRVVDDRGDDVPADATTMGEIVIRGNTVATGYYRDEEATREAFGS-G
MAB_3592c|M.abscessus_ATCC_199 GVRVSVAED------------GEVLTQSNTNLDGYWDQPQATAEALAG-N
MMAR_4412|M.marinum_M GVETRIVDDNGEALPNDGQAVGEVEVRGPWITGAYYLG--YDQSKFDS-G
MUL_0229|M.ulcerans_Agy99 GVETRIVDDNGEALPNDGQAVGEVEVRGPWITGAYYLG--YDQSEFDS-G
MAV_1186|M.avium_104 GVQMRIVDDDGRVLPNDGTAVGEVEVRGPWIAGSYYLG--RDDSKFDS-G
MLBr_02546|M.leprae_Br4923 GVKVKILDDSG--KEVPRGQVGRIFVGNAFPFEGYTGG--GGKQIIDG--
: *.: . *
Mflv_0027|M.gilvum_PYR-GCK WLRTGDAGYLDRDGYLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAVTD
Mvan_0943|M.vanbaalenii_PYR-1 WLKTGDAGYVDDDGYLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAVAD
Mb3116|M.bovis_AF2122/97 WFRTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSE
Rv3089|M.tuberculosis_H37Rv WFRTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSE
MSMEG_1982|M.smegmatis_MC2_155 YFLTGDLAAMHPDGYVEIRDRAKDVIISGGENIASIEIEKVIDSHPEVVE
TH_3031|M.thermoresistible__bu WFRTGDLGVMHPDNYVELRDRAKDVIISGGENISSVEVEQVLDTHPAVRE
MAB_3592c|M.abscessus_ATCC_199 WFHTGDRGSVD-DGYLTISDRKKDIIITGGENVTSIEVEDALISHPGVRE
MMAR_4412|M.marinum_M WLRTGDVGRIDELGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVVE
MUL_0229|M.ulcerans_Agy99 WLRTGDVGRIDELGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVVE
MAV_1186|M.avium_104 WLRTGDVGRIDERGFVTLTDRAKDVIKSGGEWISSVELENCLIGHPDVVE
MLBr_02546|M.leprae_Br4923 LLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVE
: :** . .. . : : .* .::* :*.* : . *:*. : * * :
Mflv_0027|M.gilvum_PYR-GCK VAVIGIPDTRWG-EAVKAVVVAG--APVTEAELIAFAREQLAGFKLPKSV
Mvan_0943|M.vanbaalenii_PYR-1 AAVIGVPDRRWG-EAVKAVVVAARGAQLTEAELIAFARDRIGGFKLPKSV
Mb3116|M.bovis_AF2122/97 VAVIGLPDEKWG-EIAAAIVVADQ-NEVSEQQIVEYCGTRLARYKLPKKV
Rv3089|M.tuberculosis_H37Rv VAVIGLPDEKWG-EIAAAIVVADQ-NEVSEQQIVEYCGTRLARYKLPKKV
MSMEG_1982|M.smegmatis_MC2_155 SAVVGVADEKWGEVPVAFITRRDGSD-VTFDQLTTFLREHLAGFKVPR-T
TH_3031|M.thermoresistible__bu CAVVAGPHPRWGEVPVAFVDLEPGAN-ATVEDLIAYARTRLPGFKTPK-T
MAB_3592c|M.abscessus_ATCC_199 AAVVGVPDEKWGELVTAVVVVVTLDDPPSGADLIAHCRERLAGYKCPKRV
MMAR_4412|M.marinum_M AAVVGVPDERWQERPLAVVVRREGAT-VSAAELRKFLADRVVRWWLPERW
MUL_0229|M.ulcerans_Agy99 AAVVGVPDERWQERPLAVVVRREGAT-VSAAELRKFLADRVVRWWLPERW
MAV_1186|M.avium_104 AAVVGVPDERWEERPLAVVVVKDGAS-VDADQLRKFLADKVVRWWLPERW
MLBr_02546|M.leprae_Br4923 ATAIGVDDKEWG-ARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREV
:.:. . .* . : . :: : *.
Mflv_0027|M.gilvum_PYR-GCK DFVDALPRNPSGKLLKRQLREPYWTDEDRHIG---
Mvan_0943|M.vanbaalenii_PYR-1 DFVDVLPRNPSGKLLKRALREPYWDGADRHIG---
Mb3116|M.bovis_AF2122/97 IFAEAIPRNPTGKILKTVLREQYSATVPK------
Rv3089|M.tuberculosis_H37Rv IFAEAIPRNPTGKILKTVLREQYSATVPK------
MSMEG_1982|M.smegmatis_MC2_155 MVFDHLPKTSTGKIQKNVLRARAEQDKAN------
TH_3031|M.thermoresistible__bu VYIGPLPKTGTGKIQKFRLRDRARHGKYSSDV---
MAB_3592c|M.abscessus_ATCC_199 EFVDSLPRTATGKVQKFRLREQLARD---------
MMAR_4412|M.marinum_M AFADQVPRTSVGKYDKKTIRAGYAEGVYQVTEVHN
MUL_0229|M.ulcerans_Agy99 AFADQVPRTSVGKYDKKTIRAGYAESVYQVTDVHN
MAV_1186|M.avium_104 TFVDEIPRTSVGKYDKKAVRSRYADGGYRVIEARD
MLBr_02546|M.leprae_Br4923 IFLEELPRNPTGKVLKRELRDFEVH----------
:*:. ** * :*