For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_3031 | - | - | 100% (521) | acyl-CoA synthase |
| M. thermoresistible (build 8) | TH_2961 | - | 8e-63 | 32.90% (535) | PUTATIVE AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_2591 | - | 1e-61 | 32.69% (520) | PUTATIVE feruloyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1087 | fadD14 | 4e-59 | 31.71% (533) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_1585 | - | 5e-67 | 33.46% (517) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv1058 | fadD14 | 4e-59 | 31.71% (533) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_01051 | xclC | 5e-35 | 30.40% (500) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_3592c | - | 8e-80 | 36.10% (518) | putative medium-chain acyl-CoA ligase |
| M. marinum M | MMAR_3151 | - | 1e-60 | 32.58% (534) | medium chain fatty-acid-CoA ligase |
| M. avium 104 | MAV_1186 | - | 6e-62 | 33.33% (534) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_1982 | - | 1e-149 | 53.07% (505) | acyl-CoA synthase |
| M. ulcerans Agy99 | MUL_0229 | fadD14 | 2e-54 | 30.61% (526) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_5172 | - | 2e-68 | 33.85% (514) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1087|M.bovis_AF2122/97 ------MYGTMQDFPLTITAIMRHGCGVHGRRTVTTATG-EGYRH---SS
Rv1058|M.tuberculosis_H37Rv ------MYGTMQDFPLTITAIMRHGCGVHGRRTVTTATG-EGYRH---SS
MUL_0229|M.ulcerans_Agy99 ------MYSTMQDFPLTITAIMRHGCGVHGSRQVITATG-DAYRQ---TT
MAV_1186|M.avium_104 ------MDGTMQDFPLTITAIMRHGCSVHGARTVTTATG-DGYRR---TS
MMAR_3151|M.marinum_M ------MRSTMQDVALTVPAIVAHASAVHGDREVLTARGPRQISG---VS
Mflv_1585|M.gilvum_PYR-GCK ------MLGLMQDRPLMISSLIEHAAAFHGDTEIVSRLPEGPVRR---TT
Mvan_5172|M.vanbaalenii_PYR-1 ------MFGLMQDRPLMISSLIEHAAAFHGDTEIVSRLPEGPVRR---TT
TH_3031|M.thermoresistible__bu VDMMATIGVPPCATALTPTDFLRRSATIFPDRVAVIDGADR-------TS
MSMEG_1982|M.smegmatis_MC2_155 ---MAVF----TFAELTPTSLLQRSAQAFPDRLAIVDGELR-------LT
MAB_3592c|M.abscessus_ATCC_199 -----------MFFDLSVRDFLDRAELVYPERVGVVDEPVQPAPSWGQLT
MLBr_01051|M.leprae_Br4923 --------MLLASLNPSVVTATDIADAVCVDGVVLSRSG-----------
.
Mb1087|M.bovis_AF2122/97 YRDVGQRAGQLANALRRLGVTGDQRVATFMWNNTEHLVTYFAVPSMGAVL
Rv1058|M.tuberculosis_H37Rv YRDVGQRAGQLANALRRLGVTGDQRVATFMWNNTEHLVTYFAVPSMGAVL
MUL_0229|M.ulcerans_Agy99 YREVGQRAAQLANALRGLGISGDQRVATFMWNNAEHLVTYLAVPSMGAVL
MAV_1186|M.avium_104 YRELGDRAAQLANALRGLGVTGDQRVATFMWNNAEHLAAYLAVPSMGAVL
MMAR_3151|M.marinum_M YREVGERAARLANALRQIGIRGDERVATLQWSNQEHLDCYAAVPSMGAVL
Mflv_1585|M.gilvum_PYR-GCK WREIGERAKQVANALAELGVRHGDRVATLAWNSDRHLALYFGVSGTGAVM
Mvan_5172|M.vanbaalenii_PYR-1 WREINEHSKQVANALAELGIEQGDRVATLAWNSDRHLALYFGVSGSGAVM
TH_3031|M.thermoresistible__bu YIGWYHRVRRMAGLLRKCGVQQGDCVAVLAPNTSMLLDAHYGVPMAGAVL
MSMEG_1982|M.smegmatis_MC2_155 YTQFAERCGRVTSALAAAGVQPGDRVAALCTNSHVMLELHQAVPARGAVL
MAB_3592c|M.abscessus_ATCC_199 YRQLAARARGQAAALDALGVGPGERVAIVSQNSARLLTSFFGVSGWGRIL
MLBr_01051|M.leprae_Br4923 -------LVGAATSVAER-VGGARLVAVLATPTASTVLAITGCLIAGVPV
: : : ** . . : . * :
Mb1087|M.bovis_AF2122/97 HTLNIRLFPEQIAYVTNEAEDRVILVDLSLARLLAPVLPKLDTVHTVIAV
Rv1058|M.tuberculosis_H37Rv HTLNIRLFPEQIAYVTNEAEDRVILVDLSLARLLAPVLPKLDTVHTVIAV
MUL_0229|M.ulcerans_Agy99 HTLNIRLFAEQIAYVANEAEDQVVLVDLSLTNLLAPVLPNLDTVHTVIAV
MAV_1186|M.avium_104 HTLNIRLFPEQIAYVANEAGDQVVLVDASLVKLLAPVLPGLHTVHTVIVV
MMAR_3151|M.marinum_M HTLNLRLPPEQLTWIANHAEDRVIIVDSTVLALLAAALPSMTSVRTVLVT
Mflv_1585|M.gilvum_PYR-GCK HTVNPRLFPEQISYIVNHAEDRVLFFDITFAPLVSGLASSFDSVEYFVAM
Mvan_5172|M.vanbaalenii_PYR-1 HTVNPRLFPEQIAYIVNHAEDRVLFFDITFAPLVAQLAGELGTVETFVAM
TH_3031|M.thermoresistible__bu LTLNIRLTVEDLTYISRHAGAKAVLFDDSLAHIAAQLP----IPIQLS--
MSMEG_1982|M.smegmatis_MC2_155 VPLNTRLAFEEMQYIIGHAGARILIATREFADRARELADDAGIDVVIE--
MAB_3592c|M.abscessus_ATCC_199 VPINFRLAPAEIEYIVGHSGASVLVVDPEVRGLLDTVRATHNFVLGEDD-
MLBr_01051|M.leprae_Br4923 VPVPADIGVVERRHMLTDSGAQAWLGPGPSADSAPDGLP-----------
.: : : : .: .
Mb1087|M.bovis_AF2122/97 GEGDTTPLRE--AGKTVLRFAELIDAESPDFGWPQIDENSAAAMCYTSGT
Rv1058|M.tuberculosis_H37Rv GEGDTTPLRE--AGKTVLRFAELIDAESPDFGWPQIDENSAAAMCYTSGT
MUL_0229|M.ulcerans_Agy99 GEGDTAALEE--SGKTVLRYDELLDGQSTEFDWPHIDENSAAAMCYTSGT
MAV_1186|M.avium_104 GDGDTEPLRA--SGKTVLRYADVIGAEPAEFDWPRIDENSAAAMCYTSGT
MMAR_3151|M.marinum_M GTGDLAAVEG--CGKDVLRYDDVVAAQSSTFEWPDVDERSAAAMCYTSGT
Mflv_1585|M.gilvum_PYR-GCK TDREHMPDVPGISADRLLCWEDVIGRQSTHYEWPEFDECSASSLCYTSGT
Mvan_5172|M.vanbaalenii_PYR-1 TDRDHMPDIPQIPDGRLRCWDDFIGGQSTAFDWPEFDERSASSLCYTSGT
TH_3031|M.thermoresistible__bu ----------------ATEYRRRVADAPEVEHQVDD-ELALLSLNYTSGT
MSMEG_1982|M.smegmatis_MC2_155 ----------------GDGYEEWLPDVASPEDRVAVGERDLLAINYTSGT
MAB_3592c|M.abscessus_ATCC_199 ----------------AAVFGELDSPHAVTPDPWSGSETGTATLNYTSGT
MLBr_01051|M.leprae_Br4923 -------------------HIPVQLDARSWNRYPEPSPDATAMVIYTSGT
: *****
Mb1087|M.bovis_AF2122/97 TGNPKGVVYSHRSSFLHTMAACTTNGIGVGSSDKVLPIVPMFHANGWGLP
Rv1058|M.tuberculosis_H37Rv TGNPKGVVYSHRSSFLHTMAACTTNGIGVGSSDKVLPIVPMFHANGWGLP
MUL_0229|M.ulcerans_Agy99 TGHPKGVVYSHRSSFLHSMATCTANGIGLGSSDRVLPIVPMFHANAWGLP
MAV_1186|M.avium_104 TGNPKGVVYSHRSSFLHTMAACTANGIGIGATDSLLPIVPMFHANAWGLP
MMAR_3151|M.marinum_M TGHPKGVVYSHRSTWLHSQAACTSNALGIGHDDTVLAIVPMFHANAWGLP
Mflv_1585|M.gilvum_PYR-GCK TGNPKGVLYSHRSTMLHTLMAAARDTIDIHSGSVILLVVPMFHANAWGSP
Mvan_5172|M.vanbaalenii_PYR-1 TGNPKGVLYSHRSTMLHTLMIAARDAIDIHSGSVILLVVPMFHANAWGTP
TH_3031|M.thermoresistible__bu TGRPRGVMYHHRGAYLQALATAYHSGLSP--QTVHLWTLPMFHCHGWSFT
MSMEG_1982|M.smegmatis_MC2_155 TGRPKGVMYHHRGAYLQAVAMAYHTRLDP--STGYLWTLPMFHCNGWCFT
MAB_3592c|M.abscessus_ATCC_199 TSRPKGVQLTHRNIWINAVVFGLHATLRD--DDVLLHTLPMFHCNGWGWP
MLBr_01051|M.leprae_Br4923 TGPPKGVLLSRRAIAVDLDALAQAWQWTA--DDVLVHGLPLFHVHGLVLG
*. *:** :* :. : :*:** :.
Mb1087|M.bovis_AF2122/97 YAALMAGADLVLPDRHLDARSLIHMVETLKPTLAGAVPTIWNDVMHYLEK
Rv1058|M.tuberculosis_H37Rv YAALMAGADLVLPDRHLDARSLIHMVETLKPTLAGAVPTIWNDVMHYLEK
MUL_0229|M.ulcerans_Agy99 YAALMAGADLVLPDRHLDARSLVHMVENLRPTRAGAVPTIWNDVMHYLEK
MAV_1186|M.avium_104 YAALMAGADLVLPDCHLDPRSLVRMVEDLRPTVTGAVPTIWNAVLHHLED
MMAR_3151|M.marinum_M YAAMMAGAQLLLPDRFLQAGPLVEMIEAVRPTMAGAVPTIWTDVLHYLRD
Mflv_1585|M.gilvum_PYR-GCK YTAAMVGAKLVMPGPHLDGESVYQLMKAEGVNQSQGVPTVWMMLFAYLDE
Mvan_5172|M.vanbaalenii_PYR-1 YTAAMVGAKLVMPGPHLDGQSVYELMKAEGVNQSQGVPTVWMMLFSYLDE
TH_3031|M.thermoresistible__bu WSVTAAGGTHVCLP-KVEPSAIWRHLHDDGVNSLNAAPTVLIDLASHHD-
MSMEG_1982|M.smegmatis_MC2_155 WAVGAAGGTHICLR-KIDSAEIWRWLRGGGITHFSAAPTVLTMIAEDPS-
MAB_3592c|M.abscessus_ATCC_199 YAATGMGARHIVLR-KVDGDEILRRVEQHGVTVMCAAPTVVDSILDAAAR
MLBr_01051|M.leprae_Br4923 LLGSLRIGNRFVHTGKPTPTAYAQACSEAGGSLYFGVPTVWSRLV--ADE
. . . . ..**: :
Mb1087|M.bovis_AF2122/97 DPDHDMSSLRLVACG--GSAVPESLMRTFEDKHDVQIRQLWGMTETSPLA
Rv1058|M.tuberculosis_H37Rv DPDHDMSSLRLVACG--GSAVPESLMRTFEDKHDVQIRQLWGMTETSPLA
MUL_0229|M.ulcerans_Agy99 NPGHDVSSLGLVACG--GSAVPESLMRTFEEKYGVQIRQLWGMTETSPLA
MAV_1186|M.avium_104 DPDHDMSSLRLVVCG--GSAVPVSLMRTFEEKHGVQIRQLWGMTETSPLA
MMAR_3151|M.marinum_M NPGHDVSSLKMVACG--GSAVPRSLMTAYDELG-IRIVQAWGMTETSPLA
Mflv_1585|M.gilvum_PYR-GCK HPEIDAHELGLRYAGTGGAALPLSMIERFEKDFGAEAYQGWGMTETSPLC
Mvan_5172|M.vanbaalenii_PYR-1 HPEIDAHELGLRVAGTGGAALPLSMIERFHRDFGAESMQGWGMTETSPLC
TH_3031|M.thermoresistible__bu --ARRVAHG--VRVGTGGAPPSPTLLQRL-SELGFDITHYYGLTETYGPA
MSMEG_1982|M.smegmatis_MC2_155 --AQPLPAR--VHVDTGGAPPSPALLARL-TPLGFDVTHLYGLTETYGPV
MAB_3592c|M.abscessus_ATCC_199 W-RGPIPGRDRVRIIVAGAPPPTRTIARVRTELGWEFIQIYGLTETAPLI
MLBr_01051|M.leprae_Br4923 AVARALRPARLLVSG--SASLPVPVFDRLAHLTGHRPIERYGSTES--LI
.:. . : . :* **:
Mb1087|M.bovis_AF2122/97 TMAWPPP---GTPDDQHWAFRITQG-QPVCGVETRIVDDDGQVLPNDGNA
Rv1058|M.tuberculosis_H37Rv TMAWPPP---GTPDDQHWAFRITQG-QPVCGVETRIVDDDGQVLPNDGNA
MUL_0229|M.ulcerans_Agy99 TMAWPPP---GTPPDRHWAIRSTQG-QPVCGVETRIVDDNGEALPNDGQA
MAV_1186|M.avium_104 TMAWPPP---GTPEDQHWAYRGTQG-QPVCGVQMRIVDDDGRVLPNDGTA
MMAR_3151|M.marinum_M SVALPRS---SDTPERSLHLRATQG-RVVAGVQARIVDDSGAEQPWDGKS
Mflv_1585|M.gilvum_PYR-GCK VVGRPLPKHDALDPADRRSLRLKQG-RGIWGVEIKIVDDDGNRLPWDGKA
Mvan_5172|M.vanbaalenii_PYR-1 VVGRLLPKHEGLSDAEKNQIRLKQG-RGVWGVDLKIVDDDGNRLPWDGKA
TH_3031|M.thermoresistible__bu VICEFPAERADSPMIEQARFKARQGNCNIVGQPLRVVDDRGDDVPADATT
MSMEG_1982|M.smegmatis_MC2_155 AVNVWQPEWDELPDDEQARLRARQGVGNIIANPLRVVDLGGDDVPRDGTT
MAB_3592c|M.abscessus_ATCC_199 TMNRFRSEWAGLDVQEQARMLGRAG-APAIGVRVSVAED-----------
MLBr_01051|M.leprae_Br4923 TLSTLAD---------GERRAGWVG-LPLAGVQTRLVDESGGPVPYDGET
: * . :.:
Mb1087|M.bovis_AF2122/97 VGEVEVRGPWIAGSYYGGRDESKFD---SGWLRTGDVGRIDEQGFITLTD
Rv1058|M.tuberculosis_H37Rv VGEVEVRGPWIAGSYYGGRDESKFD---SGWLRTGDVGRIDEQGFITLTD
MUL_0229|M.ulcerans_Agy99 VGEVEVRGPWITGAYYLGYDQSEFD---SGWLRTGDVGRIDELGFITLTD
MAV_1186|M.avium_104 VGEVEVRGPWIAGSYYLGRDDSKFD---SGWLRTGDVGRIDERGFVTLTD
MMAR_3151|M.marinum_M VGEIQVRGPWITQSYYENDSPAASP---DGWLRTGDVGTISADALIALTD
Mflv_1585|M.gilvum_PYR-GCK FGEVWVRGPWIASGYYRGEGGDKLDG--EGFFPTGDVATIDPDGYLQLVD
Mvan_5172|M.vanbaalenii_PYR-1 FGEVWVRGPWIASGYFRGEGGEKLDA--EGFFPTGDVATIDPDGYLQLVD
TH_3031|M.thermoresistible__bu MGEIVIRGNTVATGYYRDEEATREAFG-SGWFRTGDLGVMHPDNYVELRD
MSMEG_1982|M.smegmatis_MC2_155 IGEIAARGNDVMLGYYNDDAATSAATR-DGYFLTGDLAAMHPDGYVEIRD
MAB_3592c|M.abscessus_ATCC_199 -GEVLTQSNTNLDGYWDQPQATAEALA-GNWFHTGDRGSVD-DGYLTISD
MLBr_01051|M.leprae_Br4923 VGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGMHRIVG
*.: :. .* .: *** . : : .
Mb1087|M.bovis_AF2122/97 R-AKDVIKSGGEWISSVELENCLIAHPDVLEAAVVGVPDERWQERPLAVV
Rv1058|M.tuberculosis_H37Rv R-AKDVIKSGGEWISSVELENCLIAHPDVLEAAVVGVPDERWQERPLAVV
MUL_0229|M.ulcerans_Agy99 R-AKDVIKSGGEWISSVELENCLIAHPDVVEAAVVGVPDERWQERPLAVV
MAV_1186|M.avium_104 R-AKDVIKSGGEWISSVELENCLIGHPDVVEAAVVGVPDERWEERPLAVV
MMAR_3151|M.marinum_M R-SKDVIKSGGEWISSVELENELAAHPAVRTATVIGVPDDKWQERPLAVV
Mflv_1585|M.gilvum_PYR-GCK R-TKDVIKSGGEWVSSIDLENAAMGHPAIAEAAVIGVPHPKWQERPLLVA
Mvan_5172|M.vanbaalenii_PYR-1 R-AKDVIKSGGEWVSSIDLENAALGHPAVAEAAVIGVPHPKWQERPLLIV
TH_3031|M.thermoresistible__bu R-AKDVIISGGENISSVEVEQVLDTHPAVRECAVVAGPHPRWGEVPVAFV
MSMEG_1982|M.smegmatis_MC2_155 R-AKDVIISGGENIASIEIEKVIDSHPEVVESAVVGVADEKWGEVPVAFI
MAB_3592c|M.abscessus_ATCC_199 R-KKDIIITGGENVTSIEVEDALISHPGVREAAVVGVPDEKWGELVTAVV
MLBr_01051|M.leprae_Br4923 RESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQRIVAFV
* *:* ** : : ::* ** : :*:. .. : .
Mb1087|M.bovis_AF2122/97 VVREGAT-VSAGDLRAFLADKVVRWWLPERWAFVDEIPRTSVGKYDKKAI
Rv1058|M.tuberculosis_H37Rv VVREGAT-VSAGDLRAFLADKVVRWWLPERWAFVDEIPRTSVGKYDKKAI
MUL_0229|M.ulcerans_Agy99 VRREGAT-VSAAELRKFLADRVVRWWLPERWAFADQVPRTSVGKYDKKTI
MAV_1186|M.avium_104 VVKDGAS-VDADQLRKFLADKVVRWWLPERWTFVDEIPRTSVGKYDKKAV
MMAR_3151|M.marinum_M VLAADRT-ATAAELTEFLRARVAKWWLPERWAFVTDIPLTSTGKFDKKKL
Mflv_1585|M.gilvum_PYR-GCK VLRKGHS-ATREDILEFLAERVVRWWLPDDVVFVDELPHTATGKVLKITL
Mvan_5172|M.vanbaalenii_PYR-1 VLRKGHH-ATREDILEYLAGEVVKWWLPDDVVFVDELPHTATGKVLKLKL
TH_3031|M.thermoresistible__bu DLEPGAN-ATVEDLIAYARTRLPGFKTPK-TVYIGPLPKTGTGKIQKFRL
MSMEG_1982|M.smegmatis_MC2_155 TRRDGSD-VTFDQLTTFLREHLAGFKVPR-TMVFDHLPKTSTGKIQKNVL
MAB_3592c|M.abscessus_ATCC_199 VVVTLDDPPSGADLIAHCRERLAGYKCPKRVEFVDSLPRTATGKVQKFRL
MLBr_01051|M.leprae_Br4923 VGAEALD---ADELINYVAQQLSIHKRPREVRFVDALPRNAMGKVLKKQL
:: . .: * :* .. ** * :
Mb1087|M.bovis_AF2122/97 RSRYAEGAYQITEVHT
Rv1058|M.tuberculosis_H37Rv RSRYAEGAYQITEVHT
MUL_0229|M.ulcerans_Agy99 RAGYAESVYQVTDVHN
MAV_1186|M.avium_104 RSRYADGGYRVIEARD
MMAR_3151|M.marinum_M RRQFADGDLIIETLA-
Mflv_1585|M.gilvum_PYR-GCK REQYRDHELSQPE---
Mvan_5172|M.vanbaalenii_PYR-1 REQYRDHRLSQPE---
TH_3031|M.thermoresistible__bu RDRARHGKYSSDV---
MSMEG_1982|M.smegmatis_MC2_155 RARAEQDKAN------
MAB_3592c|M.abscessus_ATCC_199 REQLARD---------
MLBr_01051|M.leprae_Br4923 LFEG------------