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MSQLLELLPRPLDPLRSFKFKTAVLVGVALLIATCLLWITAEWKLRYALTLALFVSFGVTWFLAHGMTSP LRDMTAAARSMAQGDYSRRIRSTSRDEVGQLATAFNHMAAELQSAERYRRELVGNVSHELRTPITALQAV LENIVDGVAEPDPQTLKTALAQTERLGRLVDDLLDLSKLENGSVPVQRESFAVREFVDDAVAEAKTTGRQ VRYHVTVEPFDLAAVADTARLHQVVANLLDNASRHSPPGGQVSVFARTENDALLLEVADTGPGIAPHERS RVFERFTHGGSRDGGTGLGLAIAQWAVDLHGGRIEIVDAPGCRVRVTLPQFDNEEGNS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1721 | - | - | 100% (338) | putative histidine kinase sensor of two-component system |
| M. abscessus ATCC 19977 | MAB_3340 | - | 2e-39 | 34.80% (296) | sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_0674 | - | 1e-37 | 34.89% (321) | putative sensor histidine kinase PhoR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0781 | phoR | 6e-36 | 32.54% (338) | two component system response sensor kinase membrane |
| M. gilvum PYR-GCK | Mflv_0892 | - | 2e-45 | 37.84% (296) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0758 | phoR | 2e-35 | 32.54% (338) | two component system response sensor kinase membrane |
| M. leprae Br4923 | MLBr_00175 | - | 3e-31 | 33.12% (311) | putative two-component system sensor kinase |
| M. marinum M | MMAR_4941 | phoR | 2e-37 | 35.56% (284) | two-component system response phosphate sensor kinase, PhoR |
| M. avium 104 | MAV_0703 | - | 1e-37 | 34.50% (313) | sensor histidine kinase PhoR |
| M. smegmatis MC2 155 | MSMEG_4989 | - | 5e-37 | 34.15% (325) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2428 | - | 5e-33 | 33.94% (327) | PUTATIVE integral membrane sensor signal transduction histidine |
| M. ulcerans Agy99 | MUL_0464 | phoR | 9e-38 | 35.56% (284) | two component system response phosphate sensor kinase, PhoR |
| M. vanbaalenii PYR-1 | Mvan_1833 | - | 1e-42 | 37.33% (292) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0892|M.gilvum_PYR-GCK ----------------MTPGPAATARRRRRWGRPGIGLRLLAAQVIVLVA
Mvan_1833|M.vanbaalenii_PYR-1 ----------------MARTEEELRPRRRMLRRPGIGLRLLAAQAIVLVA
MAB_1721|M.abscessus_ATCC_1997 -----------------------MSQLLELLPRPLDPLRSFKFKTAVLVG
Mb0781|M.bovis_AF2122/97 ----------------MARHLRGRLPLRVRLVAATLILVATGLVASGIAV
Rv0758|M.tuberculosis_H37Rv ----------------MARHLRGRLPLRVRLVAATLILVATGLVASGIAV
MMAR_4941|M.marinum_M ----------------MAERLPRAVPLRVGLVAATLALVLCGLLASGVAV
MUL_0464|M.ulcerans_Agy99 ----------------MAERLPRAVQLRVGLVAATLALVLCGLLASGVAV
MAV_0703|M.avium_104 ---------------MVVTRPRRGLPLRVGLVAATLALVACGLAVSGIAV
MSMEG_4989|M.smegmatis_MC2_155 MFFVPRADAPRAAVGGTRWWSPRTWPLRARLVGTQVALLAVVCLSIGLAT
MLBr_00175|M.leprae_Br4923 MVRFAW-------RRRASLRATSSLSLRWRVMLLAMSMVAMVVVLMAFAV
TH_2428|M.thermoresistible__bu -MTFAQPYPPSPPQRQATSQPASSLSLRWRVMLLAMSMVAMVVVLMSIAL
: ..
Mflv_0892|M.gilvum_PYR-GCK GAATTAVVAAVVGPPLFREHLHLAGVPTDSPEE-----------------
Mvan_1833|M.vanbaalenii_PYR-1 GAVTTSVVAAIVGPPLFHDHLHQAGISAGSPEE-----------------
MAB_1721|M.abscessus_ATCC_1997 -------VALLIATCLLWITAEWK--------------------------
Mb0781|M.bovis_AF2122/97 TSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPD-----------------
Rv0758|M.tuberculosis_H37Rv TSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPD-----------------
MMAR_4941|M.marinum_M TSILRHSLVSRIDSTLLEASRTWAQASWRHSMP-----------------
MUL_0464|M.ulcerans_Agy99 TSILRHSLVSRIDSTLLEASRTWAQASWRHSMP-----------------
MAV_0703|M.avium_104 TSILRHSLVSRIDSTLLDASRGWAQAPRRQSSS-----------------
MSMEG_4989|M.smegmatis_MC2_155 EFALQRFLMHQLDEQLLEAGRRSAAIYELPPPPRGFLPLFPPGMGPPGRH
MLBr_00175|M.leprae_Br4923 YVVISAALYSDIDNQLQSRAQLLIASGSLAADP-----------------
TH_2428|M.thermoresistible__bu YAVVSRALYNDIDNQLHSRARLLIESGSLAADP-----------------
: : *
Mflv_0892|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1833|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1721|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0781|M.bovis_AF2122/97 -----PYPIHNP---DRP--PSRFYVRVISPDG----QSYTALNDNTAIP
Rv0758|M.tuberculosis_H37Rv -----PYPGHNP---DRP--PSRFYVRVISPDG----QSYTALNDNTAIP
MMAR_4941|M.marinum_M -----SVEGPDP---ARP--PSKFYVRSISPDG----RAMTAINDRNAEP
MUL_0464|M.ulcerans_Agy99 -----SVEGPDP---ARP--PSKFYVRSISPDG----RAMTAINDRNAEP
MAV_0703|M.avium_104 -----AYEGPDP---GRP--PSKFYVRGVSTDG----TPFTAINDRNAEP
MSMEG_4989|M.smegmatis_MC2_155 LRVFDPEQGPGPGFLNAPGQAARTVGAVVSPDGSVDAGVITSDGDRQEVS
MLBr_00175|M.leprae_Br4923 ----------------GKAIEGTAYSDVNAMLVNPGHSIYTANQPGQTLP
TH_2428|M.thermoresistible__bu ----------------GRAIEGTAYSDVNAMLVNPGRSIYTANQQGEALP
Mflv_0892|M.gilvum_PYR-GCK ----------------------------------------------IHAE
Mvan_1833|M.vanbaalenii_PYR-1 ----------------------------------------------MHAE
MAB_1721|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0781|M.bovis_AF2122/97 AVPANNDVGRHPTTLPSIGGSK--TLWRAVSVRASDGYLTTVAIDLAD--
Rv0758|M.tuberculosis_H37Rv AVPANNDVGRHPTTLPSIGGSK--TLWRAVSVRASDGYLTTVAIDLAD--
MMAR_4941|M.marinum_M ALPADNDVGSDPTTLPSVNGSN--IEWRAVSVHGPQGGLTTVAIDLSD--
MUL_0464|M.ulcerans_Agy99 ALPADNDVGSDPTTLPSVNGSN--IEWRAVSVHGPQGGLTTVAIDLSD--
MAV_0703|M.avium_104 ALPADNDVGPNPTTLPSVNGSD--IQWRAVSVRGPHG-LTTVAIDLSD--
MSMEG_4989|M.smegmatis_MC2_155 AAAARQLAAIPATREPQTIDLDGLGRYRLIGLHPRHGGPQTIVTGLPNSV
MLBr_00175|M.leprae_Br4923 VGTAEKAVIRGELFMSQRTASD----QRILAIHLPNDSSLLISKSLRP--
TH_2428|M.thermoresistible__bu LGEPERQVLSGELVMSLRTADQ----QRVLAIHLSNGSSLLISKSLAP--
Mflv_0892|M.gilvum_PYR-GCK EAYGYATVMSIGGALAVSALAALAVS-FYVSRRLQRSITEVASAATDVAQ
Mvan_1833|M.vanbaalenii_PYR-1 EAYTYATVISIGGALAVSALAALAVS-WYISRRLQRSVTEVAEAASSVAE
MAB_1721|M.abscessus_ATCC_1997 ----------LRYALTLALFVSFGVT-WFLAHGMTSPLRDMTAAARSMAQ
Mb0781|M.bovis_AF2122/97 VRSTVRSLVLLQVGIGSAVLVVLGVAGYAVVRRSLRPLAEFEQTAAAIGA
Rv0758|M.tuberculosis_H37Rv VRSTVRSLVLLQVGIGSAVLVVPGVAGYAVVRRSLRPLAEFEQTAAAIGA
MMAR_4941|M.marinum_M VQHTVRSLVWLQIGIGAGVLVVVGLAGFAVVQRSLRPLSEVEQTAAAIAS
MUL_0464|M.ulcerans_Agy99 VQHTVRSLVWLQIGIGAGVLVVVGLAGFAVVQRSLRPLSEVEQTAAAIAS
MAV_0703|M.avium_104 VQHTVSSLVWLQIGIGVAVLAVVGIASFAVVQRSLRPLVEVEQTAAAIAA
MSMEG_4989|M.smegmatis_MC2_155 VDDTLLWVLGMFCVIAAVALIAAITAGTLLIRRQFAPLARVSATAREVAD
MLBr_00175|M.leprae_Br4923 TEAVMTKLRWVLLIVGSLGVAVAAVAGGMVTRAGLRPVGRLTEAAERVAR
TH_2428|M.thermoresistible__bu TMEVLRRLGTVLLIVGGIGVAVAAIAGGMVARAGLRPVSRLTEAAERVAR
: : . : : : .: . :* :.
Mflv_0892|M.gilvum_PYR-GCK GNYEI---RVSP-------PGLGDDFDALSTAFNQMASRLQAVESTR---
Mvan_1833|M.vanbaalenii_PYR-1 GHYDV---RVSS-------PQLGDDFDALADAFNQMASRLQTVESTR---
MAB_1721|M.abscessus_ATCC_1997 GDYSR---RIRS-------TSR-DEVGQLATAFNHMAAELQSAERYR---
Mb0781|M.bovis_AF2122/97 GQLDR---RVPQ-------WHPRTEVGRLSLALNGMLAQIQRAVASAESS
Rv0758|M.tuberculosis_H37Rv GQLDR---RVPQ-------WHPRTEVGRLSLALNGMLAQIQRAVASAESS
MMAR_4941|M.marinum_M GQLDR---RVPE-------RDPRTEVGQLSLAMNGMLSQIQVALAASEDS
MUL_0464|M.ulcerans_Agy99 GQLDR---RVPE-------RDPRTEVGQLSLAMNGMLSQIQVALAASEDS
MAV_0703|M.avium_104 GQLDR---RVPE-------RDPRTEVGRLSLALNGMLAQIQQALASSESS
MSMEG_4989|M.smegmatis_MC2_155 LELERGEVRLPTPIVPVDPAVAHTEVGQLGTSLNRMLDRIASALSAR---
MLBr_00175|M.leprae_Br4923 TDDLR---PIPVFG--------SDELARLTEAFNLMLRALAESRERQ---
TH_2428|M.thermoresistible__bu TDDLR---PIPVVG--------SDELARLTEAFNMMLRALAESRERQ---
. : :. * ::* * :
Mflv_0892|M.gilvum_PYR-GCK -----------QRLFGDLAHEIRTPVAVLEAYIEALEDG--------VRT
Mvan_1833|M.vanbaalenii_PYR-1 -----------QRLFSDLAHEIRTPVAVLEAYIEALEDG--------VRT
MAB_1721|M.abscessus_ATCC_1997 -----------RELVGNVSHELRTPITALQAVLENIVDG--------VAE
Mb0781|M.bovis_AF2122/97 AEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQG--------AAR
Rv0758|M.tuberculosis_H37Rv AEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQG--------AAR
MMAR_4941|M.marinum_M AEKARSSEERMRRFITDASHELRTPLTTIRGFAELYRQG--------AAR
MUL_0464|M.ulcerans_Agy99 AEKARSSEERMRRFITDASHELRTPLTTIRGFAELYRQG--------AAR
MAV_0703|M.avium_104 AEKARGSEDRMRRFITDASHELRTPLTTIRGFAELYRQG--------AAR
MSMEG_4989|M.smegmatis_MC2_155 ----HASETRVRQFVADASHELRTPLAAIRGYTELAQRKRGE-----LPD
MLBr_00175|M.leprae_Br4923 -----------ARLVTDAGHELRTPLTSLRTNVELLIASMAPEAPRLPDQ
TH_2428|M.thermoresistible__bu -----------ARLVADAGHELRTPLTSLRTNVELLMASQQPGAPGLPEE
.:. : .**:***:: :. *
Mflv_0892|M.gilvum_PYR-GCK LTPQTAAMLRDQTRRLVRFSDDVAALAKAEESSVSMSYATIDVDRLTRQY
Mvan_1833|M.vanbaalenii_PYR-1 LTPQTAAMLRDQTRRLVRFSDDVAALAKAEESSASMACSFVDVPRLAHHC
MAB_1721|M.abscessus_ATCC_1997 PDPQTLKTALAQTERLGRLVDDLLDLSKLENGSVPVQRESFAVREFVDDA
Mb0781|M.bovis_AF2122/97 DVGMLLSRIESEASRMGLLVDDLLLLARLD-AHRPLELCRVDLLALASDA
Rv0758|M.tuberculosis_H37Rv DVGMLLSRIESEASRMGLLVDDLLLLARLD-AHRPLELCRVDLLALASDA
MMAR_4941|M.marinum_M DVAMLLSRIESEASRMGLLVDDLLTLARLD-VQRPLERNRVDLLVLAADA
MUL_0464|M.ulcerans_Agy99 DVAMLLSRIESEASRMGLLVDDLLTLARLD-VQRPLERNRVDLLVLAADA
MAV_0703|M.avium_104 DVAMLLSRIESEASRMGLLVDDLLLLARLD-VQRPLEHHRVDLLALASDA
MSMEG_4989|M.smegmatis_MC2_155 DVAHAMSRVESETSRMTQLVEDMLLLARLD-AGRPLERDRVELSRLVVDT
MLBr_00175|M.leprae_Br4923 EMADLRADVLAQIEELSTLVGDLVDLTRDD--AGQVVHEPIDMSEVLYRS
TH_2428|M.thermoresistible__bu EMAGLRADVIAQIEELSTLVGDLVDLTRDD--AGGVIHEPVDIADVVDRS
: .: : *: *:: : : . : .
Mflv_0892|M.gilvum_PYR-GCK VAAAQKRYDSKGVALRVRLQTTLPPLWADEQRLSQVLGNLLENALRHTPS
Mvan_1833|M.vanbaalenii_PYR-1 AAAAQERFDSKNVTLAVRVAEGLPPLWADEQRLAQVVGNLVDNALRHTPA
MAB_1721|M.abscessus_ATCC_1997 VAEAKT--TGRQVRYHVTVEPFDLAAVADTARLHQVVANLLDNASRHSPP
Mb0781|M.bovis_AF2122/97 AHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPE
Rv0758|M.tuberculosis_H37Rv AHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPE
MMAR_4941|M.marinum_M VHDARAIDRKRAITVEVLEGPGTPEVLGDEPRLRQVLSNLVGNALQHTPD
MUL_0464|M.ulcerans_Agy99 VHDARAIDRKRAITVEVLEGPGTPEVLGDEPRLRQVLSNLVGNALQHTPD
MAV_0703|M.avium_104 VHDAQAMDPKRTITLEVLDGPGTPEVFGDEPRIRQVLGNLIANALQHTPE
MSMEG_4989|M.smegmatis_MC2_155 VSDAHVAGPQHKWSLDLPED--AVVIDGDEARLHQVMANLLANARTHTPP
MLBr_00175|M.leprae_Br4923 LERVRR----RRNDIHFDVQAIGWQIYGDAAGLSRAVLNLMDNAAKWSPS
TH_2428|M.thermoresistible__bu LERVRR----RRNDIDFDIEVVPWQVYGDAAGLSRAVMNLLDNAAKWSPS
.: : . .* : :.: **: ** :*
Mflv_0892|M.gilvum_PYR-GCK GGSVELTGVRDGD-RLRIAVADTGEGIAPEHLPRLFERFYRADAARDREH
Mvan_1833|M.vanbaalenii_PYR-1 GGRVEVSWEREGA-ELALRVADNGAGIAAEHLPRLFERFYRADTARDREH
MAB_1721|M.abscessus_ATCC_1997 GGQVSVFARTEND-ALLLEVADTGPGIAPHERSRVFERFTHGGSR----D
Mb0781|M.bovis_AF2122/97 SADVTVRVGTEGD-DAILEVADDGPGMSQEDALRVFERFYRADSSRARAS
Rv0758|M.tuberculosis_H37Rv SADVTVRVGTEGD-DAILEVADDGPGMSQEDALRVFERFYRADSSRARAS
MMAR_4941|M.marinum_M SADVTVRVGTAGQ-NAVLEVADKGPGMPAEDAARVFERFYRTDSSRARAS
MUL_0464|M.ulcerans_Agy99 SADVTVRVGTAGE-NAVLEVADKGPGMPAEDAARVFERFYRTDSSRARAS
MAV_0703|M.avium_104 SADVTVRVGTDGD-DAVLEVADRGPGMNEQDASRVFERFYRTDSSRARAS
MSMEG_4989|M.smegmatis_MC2_155 GTSVTVALSADAEGWVTVAVTDDGPGIAPELLPDVFERFARGDSSRSRRE
MLBr_00175|M.leprae_Br4923 GGRVVVTMRQFDPSHVELVVSDYGPGIPPQERRLVFERFYR--STTARSL
TH_2428|M.thermoresistible__bu GGRVGVRLTQVDPVHAELVVSDHGPGIPPQERRLVFERFYR--STTARSM
. * : : *:* * *: . :**** : :
Mflv_0892|M.gilvum_PYR-GCK GGAGLGLAIAKALVEAHGGSISVASAGLG---AGATFTVDLPVAQVRADD
Mvan_1833|M.vanbaalenii_PYR-1 GGAGIGLAITRALVEAHGGTISVASAGPG---TGATFTVTLPLAPARDEL
MAB_1721|M.abscessus_ATCC_1997 GGTGLGLAIAQWAVDLHGGRIEIVDA------PGCRVRVTLPQFDNEEGN
Mb0781|M.bovis_AF2122/97 GGTGLGLSIVDSLVAAHGGAVTVTTA-LG---EGCCFRVSLPRVSDVDQL
Rv0758|M.tuberculosis_H37Rv GGTGLGLSIVDSLVAAHGGAVTVTTA-LG---EGCCFRVSLPRVSDVDQL
MMAR_4941|M.marinum_M GGTGLGLSIVHSLVKAHGGDVTLTTA-PG---EGCCFRVTLPRVSEAAVE
MUL_0464|M.ulcerans_Agy99 GGTGLGLSIVHSLVKAHGGDVTLTTA-PG---EGCCFRVTLPRVSEAAVE
MAV_0703|M.avium_104 GGTGLGLSIVESLVRAHGGTVGVTTA-PG---QGCCFRVTLPRISDVPAV
MSMEG_4989|M.smegmatis_MC2_155 GSTGLGLAIVAAVVKAHGGVIDVTSR-PG---E-TRFVVRLPGAAHS---
MLBr_00175|M.leprae_Br4923 PGSGLGLAIVKQVVINHGGLLRVEDTAPGVQPPGTSIYVLLPGRPMPVSA
TH_2428|M.thermoresistible__bu PGSGLGLAIVKQVVLKHGGTLRVEDTVPGGQPPGTSIHVVLPGRPLSGVP
.:*:**:*. * *** : : . * **
Mflv_0892|M.gilvum_PYR-GCK VPVTGASART--------------------------------------
Mvan_1833|M.vanbaalenii_PYR-1 VALGVARPAAQ-------------------------------------
MAB_1721|M.abscessus_ATCC_1997 S-----------------------------------------------
Mb0781|M.bovis_AF2122/97 SLTPVVPGPP--------------------------------------
Rv0758|M.tuberculosis_H37Rv SLTPVVPGPP--------------------------------------
MMAR_4941|M.marinum_M LTEPVS------------------------------------------
MUL_0464|M.ulcerans_Agy99 LTEPVS------------------------------------------
MAV_0703|M.avium_104 QAS---------------------------------------------
MSMEG_4989|M.smegmatis_MC2_155 ------------------------------------------------
MLBr_00175|M.leprae_Br4923 YSTLADQDMGEANFQDKIGPAVQVSGKSANFRDSAHVISVDYQSARAR
TH_2428|M.thermoresistible__bu PASQEPQPP-----QHAPGADPHAPTQTGN-DAVQSVFTAENK-----