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MAQIDLSGVAETAMWTLYTRANEAQRSDGVLKDPRCIELFESIDYPYESKFGKDQTGLHGEKSRIFDVVV RQWLAENPSGTIVELGAGLETQFHRLDNGTVLWICLDLDEVIAVREKFLAPTERCRYIAADACDVSWFEQ VGPGPVLITAQSFLMFLHEEQARHLLVAIIDRFPGVEIVFDTISPAISQKMVKGYKPTENYEFPAAPWGI KWDAIAPLLRRWHTGISSVEVQSFGAVHGALNVIKPLFLRIPALRGMLPAVAHLKA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2259 | - | - | 100% (266) | putative O-methyltransferase |
| M. abscessus ATCC 19977 | MAB_1292c | - | 9e-42 | 38.95% (267) | O-methyltransferase OMT |
| M. abscessus ATCC 19977 | MAB_0668c | - | 5e-36 | 34.66% (251) | O-methyltransferase OmT |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 2e-31 | 34.38% (224) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_2136 | - | 6e-34 | 35.68% (213) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 9e-32 | 34.38% (224) | O-methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_0262 | omt_1 | 3e-34 | 36.11% (252) | O-methyltransferase Omt_1 |
| M. avium 104 | MAV_2991 | - | 2e-20 | 31.07% (206) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. smegmatis MC2 155 | MSMEG_5173 | - | 3e-36 | 36.04% (222) | O-methyltransferase, putative |
| M. thermoresistible (build 8) | TH_0460 | omt | 2e-32 | 33.04% (224) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_4852 | omt_1 | 5e-33 | 35.71% (252) | O-methyltransferase Omt_1 |
| M. vanbaalenii PYR-1 | Mvan_0979 | - | 2e-31 | 33.33% (231) | O-methyltransferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2136|M.gilvum_PYR-GCK ---MSPTDKHSADLTGVSETALMTLLVRATEARRPDSLIDDPMAVKLVDS
MSMEG_5173|M.smegmatis_MC2_155 -MTTDATARTRVSLTGVSETALLTLQVRANEARRPDGLIKDPMAVQLVDS
TH_0460|M.thermoresistible__bu ---VSSGPLAKPELTGVSETALLTLLVRATEARRPDGIIDDPMAVRLVDS
Mvan_0979|M.vanbaalenii_PYR-1 --MDQDGKIDAGALAGVSETALLTLNGRAYQARHPNAIIDDPMAIRLVDA
Mb1184c|M.bovis_AF2122/97 -MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDTIIDDPMAVALVES
Rv1153c|M.tuberculosis_H37Rv -MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDAIIDDPMAVALVES
MMAR_0262|M.marinum_M -----MPVIDARHLDGISETALLTLHQRATEAARPDAIIDDPMAIALRND
MUL_4852|M.ulcerans_Agy99 -----MPVIDARHLDDISETALLTLHQRATEAARPDAIIDDPMAIALRND
MAB_2259|M.abscessus_ATCC_1997 --------MAQIDLSGVAETAMWTLYTRANEAQRSDGVLKDPRCIELFES
MAV_2991|M.avium_104 MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAAAEAVDR
.: * : ** ** :: : :: *. . :
Mflv_2136|M.gilvum_PYR-GCK LDFDRA-KFGFVRRQD----MAVRALVFDKWTRRYLVDHPRATVVALAEG
MSMEG_5173|M.smegmatis_MC2_155 IDFDFA-KFGHSHRQD----MALRSLIFDRATSDYLRDHPKATVVALAEG
TH_0460|M.thermoresistible__bu IDFDFA-KFGPSRRQD----MALRAKAFDTATRRYLRAHPKATVVALAEG
Mvan_0979|M.vanbaalenii_PYR-1 IDFDFD-KFGRRKGQE----MALRSLAFDRAATRYLSRHPAATVVALAEG
Mb1184c|M.bovis_AF2122/97 IDFGFA-KFG-PTGQG----FALRARAFDMAAQHYLDQHPAATVVALAEG
Rv1153c|M.tuberculosis_H37Rv IDFDFA-KFG-PTGQG----FALRARAFDMAAQHYLDQHPAATVVALAEG
MMAR_0262|M.marinum_M IDYPYH-HFG-RTHQA----TALRALAFDNSTRDFLRTHPGATVVALAEG
MUL_4852|M.ulcerans_Agy99 IDYPYH-HFG-RTHQA----TALRALAFDNSTRDFLQTRPGATVVALAEG
MAB_2259|M.abscessus_ATCC_1997 IDYPYESKFGKDQTGL----HGEKSRIFDVVVRQWLAENPSGTIVELGAG
MAV_2991|M.avium_104 IRYDFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLARHPDAVVLHLGCG
: : . . :: ** :* .* ..:: *. *
Mflv_2136|M.gilvum_PYR-GCK LQTSFYRLDSGPESVGHDFRWLTVDLPPMIDLRTKLLPPSDRVRTLAQSA
MSMEG_5173|M.smegmatis_MC2_155 LQTSFYRLN--EAGVGDQFCWLTVDLPPMVEIRNKLLPPSDRVRTCAQSA
TH_0460|M.thermoresistible__bu LQTSFFRLN--AADVGDEFRWVTVDLAPVIELRRQLLPADDRVTMLAQSA
Mvan_0979|M.vanbaalenii_PYR-1 LQTSFWRLD--AAIPDSRFRWVSIDLEPVIALRRRLLPDSPRITTLAQSA
Mb1184c|M.bovis_AF2122/97 LQTSFWRLD--VAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSA
Rv1153c|M.tuberculosis_H37Rv LQTSFWRLD--VAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSA
MMAR_0262|M.marinum_M LQTSFWRLD------NGELNWLSVDLAPIVRLREQLLPACDRLRYCAQSA
MUL_4852|M.ulcerans_Agy99 LQTSFWRLD------NGELNWLSVDLAPIVRLREQLLPACDRLRYCAQSA
MAB_2259|M.abscessus_ATCC_1997 LETQFHRLD------NGTVLWICLDLDEVIAVREKFLAPTERCRYIAADA
MAV_2991|M.avium_104 LDGRAFRVS-----VPPSLSWFDVDQPSVIGLRRRLYDDTENYRMIGSSV
*: *:. . *. :* :: :* :: . . ..
Mflv_2136|M.gilvum_PYR-GCK LDFSWMDQVDTSEGVFITAEGLLMYLQPAEAMSLITECAARFPGGQMIFD
MSMEG_5173|M.smegmatis_MC2_155 LDYSWMDQVDDSEGVFITAEGLLMYLQPEESMGLIKECARRFPGGQMIFD
TH_0460|M.thermoresistible__bu LDYSWMDRIDTSEGVFITAEGLLMYLQPDEAMGLIRECARRFPGGQMMFD
Mvan_0979|M.vanbaalenii_PYR-1 LDYSWMDAVDTTDGVFITAEGLLMYLQPDEAMDLITACASRFPGGQMIFD
Mb1184c|M.bovis_AF2122/97 LDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFD
Rv1153c|M.tuberculosis_H37Rv LDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFD
MMAR_0262|M.marinum_M FDYSWMEQVDDTNGVLITAEGLFQYLRRDVVFELIAACAKRFPHGQLVFD
MUL_4852|M.ulcerans_Agy99 FDYSWMEQVDDTNGVLITAEGLFQYLRRDVVFELIAACAKRVPHGQLVFD
MAB_2259|M.abscessus_ATCC_1997 CDVSWFEQVGP-GPVLITAQSFLMFLHEEQARHLLVAIIDRFPGVEIVFD
MAV_2991|M.avium_104 TELQWLDEVPAGRPTLMVAEGLLMYLREDEVRRLLQRLIDRFPGGEMHFD
: .*:: : .::.*:.:: :*: *: .* :: **
Mflv_2136|M.gilvum_PYR-GCK LPPSAFAFLVG-RGVRASLRYRVPPMPFSLTIAEAADLVNTVPGVRAVHD
MSMEG_5173|M.smegmatis_MC2_155 LPPSWFAAWAR-KGMRTSRRYRVPPMPFSLSPAEVADLVNTVPGVRVVHD
TH_0460|M.thermoresistible__bu LPPSFFAWLTR-RGFRTSLRYKVPPMPFTLSPEQAADLVNTVPGVQAVHD
Mvan_0979|M.vanbaalenii_PYR-1 LPPTMVKKIAP-KGMRSSARYRVPPMPFSLSPAQLAELVHTVPGVTAVHD
Mb1184c|M.bovis_AF2122/97 LPPRWFAGWSR-LGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRD
Rv1153c|M.tuberculosis_H37Rv LPPRWFAGWSR-LGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRD
MMAR_0262|M.marinum_M SIPWLLSVYSRRRGFRLSEHYTAPPMPFWFTADHYDELR-AIPGVRAVRE
MUL_4852|M.ulcerans_Agy99 SIPWLLSVYSRRRGFKLSEHYTAPPMPFWFTADHYDELR-AIPGVRAVRE
MAB_2259|M.abscessus_ATCC_1997 TISPAISQKMV-KGYKPTENYEFPAAPWGIKWDAIAPLLRRWHTGISSVE
MAV_2991|M.avium_104 TLSALAPLLSK--------VFTRGIITWGIR--DARRIADWNPRLRFLEQ
. : .: : : :
Mflv_2136|M.gilvum_PYR-GCK LPAEHARGRLINALLWTAQRVPLLDPIRPMFTLLEFG-------
MSMEG_5173|M.smegmatis_MC2_155 LPFPPARGKFMRTVVWGVQRLPLFDPIRPVMALLEFG-------
TH_0460|M.thermoresistible__bu VPIPRGRGVLVNTLIWAAQRTPLFDNVRGTYTLLEFGPPNSAST
Mvan_0979|M.vanbaalenii_PYR-1 LPMPRGRGFLFERVFPAFWQFKPTRNYRGAYTLLEFG-------
Mb1184c|M.bovis_AF2122/97 LRVPPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG--
Rv1153c|M.tuberculosis_H37Rv LRVPPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG--
MMAR_0262|M.marinum_M LPAPAGRGRFLRWALPVAYRLPGLGRLRAPVTLVEFG-------
MUL_4852|M.ulcerans_Agy99 LPAPAGRGRFLRWALPVAYRLPGLGRLRAPVTLVEFG-------
MAB_2259|M.abscessus_ATCC_1997 VQSFGAVHGALNVIKPLFLRIPALRGMLPAVAHLKA--------
MAV_2991|M.avium_104 SPALAGYQRIPSTVVRSIYRLTWLTGGRGYDVLNRFEY------
. : . .