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KAAVVHEWGQEPAYTDFPDPQPTGGAEVATVEASALTNLTRAVISGKHYSSKEITLPAIAGVDGVARLAN GKRVYSGSLAPYGMMAERTVVYPAGAVEVPEHVDSVTAAAIPNPGISAWVALSHGAAVQPGQHVLVLGAT GVTGSLAVQLAKSVFGAGHVTVAGRNAERLDWLRTVGADDAIMLGSDDLTEAITARHATRPFDAVLDYLW GSPAEQTLSALAASHPSAHFHATRFVQIGAMTGETISVNASTLRSTGITLSGVGIGSVPPEALQHARTEA LPKLFAMVNNGDLQLQTLARPLADIETIWAAKEPSGVRVVVTPQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1855c | - | - | 100% (325) | putative zinc-binding alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0285 | - | 4e-14 | 29.52% (210) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4603c | - | 2e-11 | 27.27% (264) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0154 | - | 1e-14 | 27.70% (278) | putative quinone oxidoreductase (NADPH:quinone oxidoreductase) |
| M. gilvum PYR-GCK | Mflv_5154 | - | 2e-33 | 32.21% (326) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0149 | - | 1e-14 | 27.70% (278) | quinone oxidoreductase |
| M. leprae Br4923 | MLBr_00118 | - | 1e-11 | 25.00% (228) | putative oxidireductase |
| M. marinum M | MMAR_0124 | - | 1e-47 | 36.81% (326) | quinone oxidoreductase |
| M. avium 104 | MAV_0308 | - | 4e-13 | 27.90% (276) | alcohol dehydrogenase, zinc-binding |
| M. smegmatis MC2 155 | MSMEG_5778 | - | 1e-121 | 64.51% (324) | alcohol dehydrogenase, zinc-binding |
| M. thermoresistible (build 8) | TH_2952 | - | 8e-17 | 27.92% (265) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_4758 | - | 1e-15 | 29.04% (272) | quinone oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0107 | - | 7e-12 | 27.00% (263) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0154|M.bovis_AF2122/97 ---MKACVVKELSGPSGMVYTDIDEVSGDG-GKVVIDVRAAGVCFPDLLL
Rv0149|M.tuberculosis_H37Rv ---MKACVVKELSGPSGMVYTDIDEVSGDG-GKVVIDVRAAGVCFPDLLL
MUL_4758|M.ulcerans_Agy99 ---MKACVVQELSGPSGLVYTEVDDVSDGG-GNVVIDVRAAGVCLPDLLL
TH_2952|M.thermoresistible__bu ---VKALVAQELSGPSGLVYTDWEDPSEND-DVVVIDVRAAGLSFPDLLL
Mvan_0107|M.vanbaalenii_PYR-1 ---MKALVAQELTGPAGLAYTDVEDVHGG--DAVVLDVGAAGVCFPDLLM
MAV_0308|M.avium_104 ---MRAVVCRSYGTPEDLVLDEVPDPVPGP-GQLLVRVRAAAVNFPDVLF
MAB_1855c|M.abscessus_ATCC_199 ---MKAAVVHEWGQEP--AYTDFPDPQPTG-GAEVATVEASALTNLTRAV
MSMEG_5778|M.smegmatis_MC2_155 ---MKAAVVRAWGQSP--VYTDLTDPQPGE-GTEIAEVEASALTNLTKGI
MMAR_0124|M.marinum_M MDTMKAAIVRTFDEPP--HFGDFPDPTSSKPGELIVDVVATALHPRVRAQ
Mflv_5154|M.gilvum_PYR-GCK ---MRAAVLEAVGQPP--TVREFDEPTRD-----VVRVSLAGCNPVDLAL
MLBr_00118|M.leprae_Br4923 ---MHAIVAES---ANQMVWREVPDVTAGP-GEVLIEVAASGVNRADVLQ
::* : . : : : * :.
Mb0154|M.bovis_AF2122/97 TKGEYQ--LKLTPPFVPGMETAGVVRSAPS-DAGFHVGERVSAFGVLGGY
Rv0149|M.tuberculosis_H37Rv TKGEYQ--LKLTPPFVPGMETAGVVRSAPS-DAGFHVGERVSAFGVLGGY
MUL_4758|M.ulcerans_Agy99 TKGEYQ--LKLPPPFVPGLETAGVVRSAPA-RSGFRVGERVSAFGVLGGY
TH_2952|M.thermoresistible__bu IRGEYQ--LRLDPPFIPGMEIAGEVRSAPQ-GSGFRPGQRVSAFSMMGGF
Mvan_0107|M.vanbaalenii_PYR-1 LRGEYQ--MKVPAPFVPGLEVAGTVRSAPA-ESGFVAGQRVSAFSLLGAW
MAV_0308|M.avium_104 IAGKYQ--VKIPPPFIPGNEIAGEVIAAGE-GARFLPGQRVAG-TTFGAF
MAB_1855c|M.abscessus_ATCC_199 ISGKHYSSKEITLPAIAG--VDGVARLANG-KRVYS----GSLAP-YGMM
MSMEG_5778|M.smegmatis_MC2_155 ASGKHYAAKEIELPVVPG--FDGVARLADG-RRVYT----MSIGS-HGLM
MMAR_0124|M.marinum_M ADGSHYTSTG-ELPFVPG--IDAVVRDAEG-TLYYA----HLADTTLGTM
Mflv_5154|M.gilvum_PYR-GCK ASGEMG---DPVIPSVVG--KEGIGRTADG-TRVYFD----SPISPFGSW
MLBr_00118|M.leprae_Br4923 VAGKYP--HPPGASAIIGMEVAGVVAAVSSGVTEWSVGQEVCALLAGGGY
*. . : * . . : *
Mb0154|M.bovis_AF2122/97 AEQIAVPVANVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVL
Rv0149|M.tuberculosis_H37Rv AEQIAVPVANVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVL
MUL_4758|M.ulcerans_Agy99 AEQVAVPVSNVVRSPAELDDAEAVSLLVNYNTMYFALARRAAMRPGETVL
TH_2952|M.thermoresistible__bu AERVAVAPQNVIPTADGIDDASAAALLGNYYTMYFALARRAALRPGETVL
Mvan_0107|M.vanbaalenii_PYR-1 AEQVAVPVGSVVPTNDALDDGSAVCLLGNYYTMHFALQRRGALQAGETVL
MAV_0308|M.avium_104 AEQALLDADQAEPIPDDADFASAAAFGVTYRTAYHALRSTAGVTAGDWVV
MAB_1855c|M.abscessus_ATCC_199 AERTVVYPAGAVEVPEHVDSVTAAAIPNPGISAWVALSHGAAVQPGQHVL
MSMEG_5778|M.smegmatis_MC2_155 AERTLVDPGRAVEIPERVDSVTAAALPNPGTSAWITLSYAAAVKPGDHVL
MMAR_0124|M.marinum_M AQRTIIDQQWAVALPDDADPVTVAAAVNPVLSSWVALRNRINFKPGSRVL
Mflv_5154|M.gilvum_PYR-GCK AELTQLDPDLAFEVPDDVDDDLAVALGIAGLAAWLPLTRHADVSAGQSVL
MLBr_00118|M.leprae_Br4923 AEYVAVPASQVMPIPKGVNVVDSAGIPEVACTVWSNLVMAAHLSAGQLLL
*: : . : . : * . .*. ::
Mb0154|M.bovis_AF2122/97 VLGAAGGVGTAAVQIAK-AMQAGKVIAMVHREGAIDYVASLGADVVLPLT
Rv0149|M.tuberculosis_H37Rv VLGAAGGVGTAAVQIAK-AMQAGKVIAMVHREGAIDYVASLGADVVLPLT
MUL_4758|M.ulcerans_Agy99 VLGGAGGVGTAAIQIAK-AMGAGQVIAVVHREGAIDYVASVGADVVLPLT
TH_2952|M.thermoresistible__bu VFGSAGGVGTAAIQIAK-AMGA-RVIAMVRRARGTEYVESLGPDVVLPLT
Mvan_0107|M.vanbaalenii_PYR-1 VLGSGGGVGTASVQIAK-ALGA-RVIAMVHRPSAIEFVESLGADVVLPLT
MAV_0308|M.avium_104 VLGAAGGVGLAAVDLAV-AMQA-RVLAAASSPEKLELCRRRGAEATVDYD
MAB_1855c|M.abscessus_ATCC_199 VLGATGVTGSLAVQLAKSVFGAGHVTVAGRNAERLDWLRTVGADDAIMLG
MSMEG_5778|M.smegmatis_MC2_155 VLGGTGVTGSTAVQLAGPMFGAESVVAVGRNAERLQWLRSAGAQTVIRLG
MMAR_0124|M.marinum_M ILGATGSSGGMAIQVAK-RFGAAEVIAAGRNRQRLSELTSLGADRTLTLD
Mflv_5154|M.gilvum_PYR-GCK ILGATGIVGNIAIQAAK-ILGAGRVVGAGRDAGALQKAQELGADAVVQLG
MLBr_00118|M.leprae_Br4923 LHGGTSGIGSHGIQVAR-ALGAKVAVTAG-SEEKLEFCRALGAQITINYR
: *. . * .:: * : * . . *.: .:
Mb0154|M.bovis_AF2122/97 -EGWAQQVRDHTYGQGVDIVVDPIGGPTFDDALGVLAIDG--------KL
Rv0149|M.tuberculosis_H37Rv -EGWAQQVRDHTYGQGVDIVVDPIGGPTFDDALGVLAIDG--------KL
MUL_4758|M.ulcerans_Agy99 -EGWVEEVHKHTHGRGVDIVVDPIGGPVFDDAIHALAVDG--------KL
TH_2952|M.thermoresistible__bu -EGWPQAVRDATDGRGVDVVVDPVGGDVFDDAIRVLATEG--------RL
Mvan_0107|M.vanbaalenii_PYR-1 -EGWLDAVKAETGGRGVDLVVDPIGGPAFDDAIRALATEG--------RL
MAV_0308|M.avium_104 REDLKTRIRDLTGDR-ARVVLDPVGGPYSEPALRGLARGG--------TF
MAB_1855c|M.abscessus_ATCC_199 SDDLTEAITARHATRPFDAVLDYLWGSPAEQTLSALAASHPSAHFHATRF
MSMEG_5778|M.smegmatis_MC2_155 DDDLADRVAELHAARPFDAVLDYLWGEPAEHVLGALAAASPAGRFHSIRY
MMAR_0124|M.marinum_M ---------QLGAAGDVDVVLDYVWGPPTAKGMVDLVTNR-RDPHEELIW
Mflv_5154|M.gilvum_PYR-GCK -TDDDAAALKSEVKDGYDVVVDLIYGDPFLAALDATTVGA--------TL
MLBr_00118|M.leprae_Br4923 --DEDFVARLQQQNGGADVILDIMGAAYLDRNIDALAIDG--------QL
::* : . : .
Mb0154|M.bovis_AF2122/97 LLIGFAAG-AVPTLKVNRLLVRNISVVGVGWGEYLNAV----PGSAALFA
Rv0149|M.tuberculosis_H37Rv LLIGFAAG-AVPTLKVNRLLVRNISVVGVGWGEYLNAV----PGSAALFA
MUL_4758|M.ulcerans_Agy99 LAIGFAAG-SIPTLAVNRLLRRNVGVLGVAWGEYLNRV----PGSVYLFS
TH_2952|M.thermoresistible__bu LVLGFAAGQGIPTVKVNRLLLRNVGVIGVGYGEFVARN----PGAQQLFG
Mvan_0107|M.vanbaalenii_PYR-1 LVIGFAAG-GIPTVKVNRLLLRNVSVVGVGWGEFVNRT----PGAQAQVG
MAV_0308|M.avium_104 VTLGYASG-TIPAIPLNLVLLKDICVRGMEIRTFMTDR----PDDAVRDL
MAB_1855c|M.abscessus_ATCC_199 VQIGAMTG-ETISVNASTLRSTGITLSGVGIGSVPPEAL---QHARTEAL
MSMEG_5778|M.smegmatis_MC2_155 VQVGSMAG-TTLTLDAAVLRSIGITISGVGIGGVPDDVW---HRARTEAL
MMAR_0124|M.marinum_M IQIGSTGG-PSADIVSAALRSTRLQIVGSGIGSVS-------ERDIRNDI
Mflv_5154|M.gilvum_PYR-GCK ITVGQGAG--TPAIPFAKLMGR------THVGHMNNLLP---ASVMRQAY
MLBr_00118|M.leprae_Br4923 IVIGLQGG-VKGELNLGKVLSKRARIIGSTLRARPVNGPNSKSEIVAAVT
: :* * : :
Mb0154|M.bovis_AF2122/97 WGLNQLVFLG-LRPPPPQRYPLSEAQAALQSLDDGGVLGKVVLEP-----
Rv0149|M.tuberculosis_H37Rv WGLNQLVFLG-LRPPPPQRYPLSEAQAALQSLDDGGVLGKVVLEP-----
MUL_4758|M.ulcerans_Agy99 WGLNHLVSLG-LRPPPPQRFPLSEAQAALQSLAGGAVLGKIVLEP-----
TH_2952|M.thermoresistible__bu SGLRHLVEGG-LRPPPPVRFPLSEGRAAFEALAAGEVLGKAVLEP-----
Mvan_0107|M.vanbaalenii_PYR-1 AALATLVDQG-LRPPEPVRFSLSDGVAALQAFADRAVNGKLVLEPDR---
MAV_0308|M.avium_104 TELSQMFAAGTVRPYIGARFPLARTAAALRHVADRKVLGKVVIDVA----
MAB_1855c|M.abscessus_ATCC_199 PKLFAMVNNG-DLQLQTLARPLADIETIWAAKEPSGVR--VVVTPQ----
MSMEG_5778|M.smegmatis_MC2_155 PKLLSMVDAG-ELRLHTLRRPLADIETVWSEKSPSGTR--VVVTP-----
MMAR_0124|M.marinum_M PGIAQAVAAG-EFEVRTQAMPLSDVTSAWTRPLGADRR--VVFLP-----
Mflv_5154|M.gilvum_PYR-GCK AELVGLASEK-RLTVETTRYSLDDAEKAWDAQADSPHVKIGIAP------
MLBr_00118|M.leprae_Br4923 ASIWPMIADGSVRPIIGARMAVQQAADAHQLLLSGKVSGKIVLTVAGSGT
: .: :
Mb0154|M.bovis_AF2122/97 --------
Rv0149|M.tuberculosis_H37Rv --------
MUL_4758|M.ulcerans_Agy99 --------
TH_2952|M.thermoresistible__bu --------
Mvan_0107|M.vanbaalenii_PYR-1 --------
MAV_0308|M.avium_104 --------
MAB_1855c|M.abscessus_ATCC_199 --------
MSMEG_5778|M.smegmatis_MC2_155 --------
MMAR_0124|M.marinum_M --------
Mflv_5154|M.gilvum_PYR-GCK --------
MLBr_00118|M.leprae_Br4923 ETLLSRHH