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DTMKAAIVRTFDEPPHFGDFPDPTSSKPGELIVDVVATALHPRVRAQADGSHYTSTGELPFVPGIDAVVR DAEGTLYYAHLADTTLGTMAQRTIIDQQWAVALPDDADPVTVAAAVNPVLSSWVALRNRINFKPGSRVLI LGATGSSGGMAIQVAKRFGAAEVIAAGRNRQRLSELTSLGADRTLTLDQLGAAGDVDVVLDYVWGPPTAK GMVDLVTNRRDPHEELIWIQIGSTGGPSADIVSAALRSTRLQIVGSGIGSVSERDIRNDIPGIAQAVAAG EFEVRTQAMPLSDVTSAWTRPLGADRRVVFLP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0124 | - | - | 100% (313) | quinone oxidoreductase |
| M. marinum M | MMAR_0361 | - | 7e-12 | 29.28% (222) | quinone oxidoreductase |
| M. marinum M | MMAR_5313 | - | 1e-11 | 26.03% (315) | quinone oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0154 | - | 1e-13 | 27.52% (298) | putative quinone oxidoreductase (NADPH:quinone oxidoreductase) |
| M. gilvum PYR-GCK | Mflv_5154 | - | 4e-22 | 32.87% (216) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0149 | - | 1e-13 | 27.52% (298) | quinone oxidoreductase |
| M. leprae Br4923 | MLBr_00118 | - | 1e-07 | 23.90% (251) | putative oxidireductase |
| M. abscessus ATCC 19977 | MAB_1855c | - | 1e-47 | 36.81% (326) | putative zinc-binding alcohol dehydrogenase |
| M. avium 104 | MAV_0308 | - | 7e-15 | 31.00% (229) | alcohol dehydrogenase, zinc-binding |
| M. smegmatis MC2 155 | MSMEG_5778 | - | 3e-47 | 36.81% (326) | alcohol dehydrogenase, zinc-binding |
| M. thermoresistible (build 8) | TH_2952 | - | 4e-12 | 27.80% (295) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_4758 | - | 3e-12 | 29.28% (222) | quinone oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1864 | - | 2e-10 | 25.83% (271) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0154|M.bovis_AF2122/97 ---MKACVVKELSGPSGMVYTDIDEVSGDG-GKVVIDVRAAGVCFPDLLL
Rv0149|M.tuberculosis_H37Rv ---MKACVVKELSGPSGMVYTDIDEVSGDG-GKVVIDVRAAGVCFPDLLL
MUL_4758|M.ulcerans_Agy99 ---MKACVVQELSGPSGLVYTEVDDVSDGG-GNVVIDVRAAGVCLPDLLL
TH_2952|M.thermoresistible__bu ---VKALVAQELSGPSGLVYTDWEDPSEND-DVVVIDVRAAGLSFPDLLL
Mvan_1864|M.vanbaalenii_PYR-1 ---MRAIQIAELGGPQAAALVEIDEPMGDD-GTVLVDVHAAGVAFPDALQ
MAV_0308|M.avium_104 ---MRAVVCRSYGTPEDLVLDEVPDPVPGP-GQLLVRVRAAAVNFPDVLF
MLBr_00118|M.leprae_Br4923 ---MHAIVAESAN---QMVWREVPDVTAGP-GEVLIEVAASGVNRADVLQ
MAB_1855c|M.abscessus_ATCC_199 ---MKAAVVHEWG--QEPAYTDFPDPQPTG-GAEVATVEASALTNLTRAV
MSMEG_5778|M.smegmatis_MC2_155 ---MKAAVVRAWG--QSPVYTDLTDPQPGE-GTEIAEVEASALTNLTKGI
MMAR_0124|M.marinum_M MDTMKAAIVRTFD--EPPHFGDFPDPTSSKPGELIVDVVATALHPRVRAQ
Mflv_5154|M.gilvum_PYR-GCK ---MRAAVLEAVG--QPPTVREFDEP-----TRDVVRVSLAGCNPVDLAL
::* . : : : * :.
Mb0154|M.bovis_AF2122/97 TKGEYQLKLTPPFVPGMETAGVVRSAPSDA-GFHVGERVSAFGVLGG-YA
Rv0149|M.tuberculosis_H37Rv TKGEYQLKLTPPFVPGMETAGVVRSAPSDA-GFHVGERVSAFGVLGG-YA
MUL_4758|M.ulcerans_Agy99 TKGEYQLKLPPPFVPGLETAGVVRSAPARS-GFRVGERVSAFGVLGG-YA
TH_2952|M.thermoresistible__bu IRGEYQLRLDPPFIPGMEIAGEVRSAPQGS-GFRPGQRVSAFSMMGG-FA
Mvan_1864|M.vanbaalenii_PYR-1 SRGLYQYKPAMPYTPGAEVAGVVRSAPAGA-HVQPGDRVAGLTMLCGAMA
MAV_0308|M.avium_104 IAGKYQVKIPPPFIPGNEIAGEVIAAGEGA-RFLPGQRVAG-TTFGA-FA
MLBr_00118|M.leprae_Br4923 VAGKYPHPPGASAIIGMEVAGVVAAVSSGVTEWSVGQEVCALLAGGG-YA
MAB_1855c|M.abscessus_ATCC_199 ISGKHYSSKEITLPAIAGVDGVARLANGKR------VYSGSLAP-YGMMA
MSMEG_5778|M.smegmatis_MC2_155 ASGKHYAAKEIELPVVPGFDGVARLADGRR------VYTMSIGS-HGLMA
MMAR_0124|M.marinum_M ADGSHYTSTG-ELPFVPGIDAVVRDAEGTL------YYAHLADTTLGTMA
Mflv_5154|M.gilvum_PYR-GCK ASGEMG---DPVIPSVVGKEGIGRTADGTR------VYFDSPISPFGSWA
* . . . *
Mb0154|M.bovis_AF2122/97 EQIAVPVANVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVLV
Rv0149|M.tuberculosis_H37Rv EQIAVPVANVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVLV
MUL_4758|M.ulcerans_Agy99 EQVAVPVSNVVRSPAELDDAEAVSLLVNYNTMYFALARRAAMRPGETVLV
TH_2952|M.thermoresistible__bu ERVAVAPQNVIPTADGIDDASAAALLGNYYTMYFALARRAALRPGETVLV
Mvan_1864|M.vanbaalenii_PYR-1 EVVALQPERVFKLPDSVSFEAGAGILFNDLTVHFALRTRGRLQQGETLLV
MAV_0308|M.avium_104 EQALLDADQAEPIPDDADFASAAAFGVTYRTAYHALRSTAGVTAGDWVVV
MLBr_00118|M.leprae_Br4923 EYVAVPASQVMPIPKGVNVVDSAGIPEVACTVWSNLVMAAHLSAGQLLLL
MAB_1855c|M.abscessus_ATCC_199 ERTVVYPAGAVEVPEHVDSVTAAAIPNPGISAWVALSHGAAVQPGQHVLV
MSMEG_5778|M.smegmatis_MC2_155 ERTLVDPGRAVEIPERVDSVTAAALPNPGTSAWITLSYAAAVKPGDHVLV
MMAR_0124|M.marinum_M QRTIIDQQWAVALPDDADPVTVAAAVNPVLSSWVALRNRINFKPGSRVLI
Mflv_5154|M.gilvum_PYR-GCK ELTQLDPDLAFEVPDDVDDDLAVALGIAGLAAWLPLTRHADVSAGQSVLI
: : . . . .. : * . *. :::
Mb0154|M.bovis_AF2122/97 LGAAGGVGTAAVQIAK-AMQAGKVIAMVHREGAIDYVASLGADVVLP-LT
Rv0149|M.tuberculosis_H37Rv LGAAGGVGTAAVQIAK-AMQAGKVIAMVHREGAIDYVASLGADVVLP-LT
MUL_4758|M.ulcerans_Agy99 LGGAGGVGTAAIQIAK-AMGAGQVIAVVHREGAIDYVASVGADVVLP-LT
TH_2952|M.thermoresistible__bu FGSAGGVGTAAIQIAK-AMGA-RVIAMVRRARGTEYVESLGPDVVLP-LT
Mvan_1864|M.vanbaalenii_PYR-1 HGAAGGIGTSALRLAP-AFGASRTIAVVSSQDKAEVARAAGASEVV--LV
MAV_0308|M.avium_104 LGAAGGVGLAAVDLAV-AMQA-RVLAAASSPEKLELCRRRGAEATVDYDR
MLBr_00118|M.leprae_Br4923 HGGTSGIGSHGIQVAR-ALGA-KVAVTAGSEEKLEFCRALGAQITINYRD
MAB_1855c|M.abscessus_ATCC_199 LGATGVTGSLAVQLAKSVFGAGHVTVAGRNAERLDWLRTVGADDAIMLGS
MSMEG_5778|M.smegmatis_MC2_155 LGGTGVTGSTAVQLAGPMFGAESVVAVGRNAERLQWLRSAGAQTVIRLGD
MMAR_0124|M.marinum_M LGATGSSGGMAIQVAK-RFGAAEVIAAGRNRQRLSELTSLGADRTLTLD-
Mflv_5154|M.gilvum_PYR-GCK LGATGIVGNIAIQAAK-ILGAGRVVGAGRDAGALQKAQELGADAVVQLGT
*.:. * .: * : * . . *.. .:
Mb0154|M.bovis_AF2122/97 EGWAQQVRDHTYGQGVDIVVDPIGGPTFDDALGVLAIDG--------KLL
Rv0149|M.tuberculosis_H37Rv EGWAQQVRDHTYGQGVDIVVDPIGGPTFDDALGVLAIDG--------KLL
MUL_4758|M.ulcerans_Agy99 EGWVEEVHKHTHGRGVDIVVDPIGGPVFDDAIHALAVDG--------KLL
TH_2952|M.thermoresistible__bu EGWPQAVRDATDGRGVDVVVDPVGGDVFDDAIRVLATEG--------RLL
Mvan_1864|M.vanbaalenii_PYR-1 DGFKDAVKELTGGRGVDIVVDPVGGDRFTDSLRSLAPGG--------RLL
MAV_0308|M.avium_104 EDLKTRIRDLTGDR-ARVVLDPVGGPYSEPALRGLARGG--------TFV
MLBr_00118|M.leprae_Br4923 EDFVARLQQQ--NGGADVILDIMGAAYLDRNIDALAIDG--------QLI
MAB_1855c|M.abscessus_ATCC_199 DDLTEAITARHATRPFDAVLDYLWGSPAEQTLSALAASHPSAHFHATRFV
MSMEG_5778|M.smegmatis_MC2_155 DDLADRVAELHAARPFDAVLDYLWGEPAEHVLGALAAASPAGRFHSIRYV
MMAR_0124|M.marinum_M --------QLGAAGDVDVVLDYVWGPPTAKGMVDLVTNR-RDPHEELIWI
Mflv_5154|M.gilvum_PYR-GCK DDDAAALKSEVKDG-YDVVVDLIYGDPFLAALDATTVGA--------TLI
::* : . : . :
Mb0154|M.bovis_AF2122/97 LIGFAAGA-VPTLKVNRLLVRNISVVGVGWGEYLNAVPGS----AALFAW
Rv0149|M.tuberculosis_H37Rv LIGFAAGA-VPTLKVNRLLVRNISVVGVGWGEYLNAVPGS----AALFAW
MUL_4758|M.ulcerans_Agy99 AIGFAAGS-IPTLAVNRLLRRNVGVLGVAWGEYLNRVPGS----VYLFSW
TH_2952|M.thermoresistible__bu VLGFAAGQGIPTVKVNRLLLRNVGVIGVGYGEFVARNPGA----QQLFGS
Mvan_1864|M.vanbaalenii_PYR-1 VVGFTGGE-IPTVKVNRLLLNNVDAVGVGWGAWTMTHPGF----LQEQWA
MAV_0308|M.avium_104 TLGYASGT-IPAIPLNLVLLKDICVRGMEIRTFMTDRPDD----AVRDLT
MLBr_00118|M.leprae_Br4923 VIGLQGGV-KGELNLGKVLSKRARIIGSTLRARPVNGPNSKSEIVAAVTA
MAB_1855c|M.abscessus_ATCC_199 QIGAMTGE-TISVNASTLRSTGITLSGVGIGSVPPEALQHART---EALP
MSMEG_5778|M.smegmatis_MC2_155 QVGSMAGT-TLTLDAAVLRSIGITISGVGIGGVPDDVWHRART---EALP
MMAR_0124|M.marinum_M QIGSTGGP-SADIVSAALRSTRLQIVGSGIGSVS----ERDIR---NDIP
Mflv_5154|M.gilvum_PYR-GCK TVGQGAGT--PAIPFAKLMGR--THVGHMNNLLPASVMRQ-------AYA
:* * : : *
Mb0154|M.bovis_AF2122/97 GLNQLVFLG-LRPPPPQRYPLSEAQAALQSLDDGGVLGKVVLEP------
Rv0149|M.tuberculosis_H37Rv GLNQLVFLG-LRPPPPQRYPLSEAQAALQSLDDGGVLGKVVLEP------
MUL_4758|M.ulcerans_Agy99 GLNHLVSLG-LRPPPPQRFPLSEAQAALQSLAGGAVLGKIVLEP------
TH_2952|M.thermoresistible__bu GLRHLVEGG-LRPPPPVRFPLSEGRAAFEALAAGEVLGKAVLEP------
Mvan_1864|M.vanbaalenii_PYR-1 ELEPLLASGAVAAPEPVVYPLERAAEAIASLENRSARGKVVVAVR-----
MAV_0308|M.avium_104 ELSQMFAAGTVRPYIGARFPLARTAAALRHVADRKVLGKVVIDVA-----
MLBr_00118|M.leprae_Br4923 SIWPMIADGSVRPIIGARMAVQQAADAHQLLLSGKVSGKIVLTVAGSGTE
MAB_1855c|M.abscessus_ATCC_199 KLFAMVNNGDLQLQT-LARPLADIETIWAAKEPSGVR--VVVTPQ-----
MSMEG_5778|M.smegmatis_MC2_155 KLLSMVDAGELRLHT-LRRPLADIETVWSEKSPSGTR--VVVTP------
MMAR_0124|M.marinum_M GIAQAVAAGEFEVRT-QAMPLSDVTSAWTRPLGADRR--VVFLP------
Mflv_5154|M.gilvum_PYR-GCK ELVGLASEKRLTVET-TRYSLDDAEKAWDAQADSPHVKIGIAP-------
: . .: :
Mb0154|M.bovis_AF2122/97 -------
Rv0149|M.tuberculosis_H37Rv -------
MUL_4758|M.ulcerans_Agy99 -------
TH_2952|M.thermoresistible__bu -------
Mvan_1864|M.vanbaalenii_PYR-1 -------
MAV_0308|M.avium_104 -------
MLBr_00118|M.leprae_Br4923 TLLSRHH
MAB_1855c|M.abscessus_ATCC_199 -------
MSMEG_5778|M.smegmatis_MC2_155 -------
MMAR_0124|M.marinum_M -------
Mflv_5154|M.gilvum_PYR-GCK -------