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MKAAVVRAWGQSPVYTDLTDPQPGEGTEIAEVEASALTNLTKGIASGKHYAAKEIELPVVPGFDGVARLA DGRRVYTMSIGSHGLMAERTLVDPGRAVEIPERVDSVTAAALPNPGTSAWITLSYAAAVKPGDHVLVLGG TGVTGSTAVQLAGPMFGAESVVAVGRNAERLQWLRSAGAQTVIRLGDDDLADRVAELHAARPFDAVLDYL WGEPAEHVLGALAAASPAGRFHSIRYVQVGSMAGTTLTLDAAVLRSIGITISGVGIGGVPDDVWHRARTE ALPKLLSMVDAGELRLHTLRRPLADIETVWSEKSPSGTRVVVTP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5778 | - | - | 100% (324) | alcohol dehydrogenase, zinc-binding |
| M. smegmatis MC2 155 | MSMEG_0303 | - | 1e-16 | 28.66% (307) | alcohol dehydrogenase, zinc-containing |
| M. smegmatis MC2 155 | MSMEG_4828 | - | 3e-15 | 30.03% (293) | alcohol dehydrogenase, zinc-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0154 | - | 2e-16 | 29.14% (278) | putative quinone oxidoreductase (NADPH:quinone oxidoreductase) |
| M. gilvum PYR-GCK | Mflv_5154 | - | 1e-31 | 33.65% (318) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0149 | - | 2e-16 | 29.14% (278) | quinone oxidoreductase |
| M. leprae Br4923 | MLBr_00118 | - | 2e-14 | 27.19% (228) | putative oxidireductase |
| M. abscessus ATCC 19977 | MAB_1855c | - | 1e-121 | 64.51% (324) | putative zinc-binding alcohol dehydrogenase |
| M. marinum M | MMAR_0124 | - | 3e-47 | 36.81% (326) | quinone oxidoreductase |
| M. avium 104 | MAV_0308 | - | 1e-18 | 29.38% (320) | alcohol dehydrogenase, zinc-binding |
| M. thermoresistible (build 8) | TH_2952 | - | 4e-17 | 28.57% (266) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_4387 | - | 6e-20 | 31.78% (321) | quinone oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4202 | - | 8e-16 | 29.90% (301) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0308|M.avium_104 ---MRAVVCRSYGTPEDLVLDEVPDPVPGP-GQLLVRVRAAAVNFPDVLF
MUL_4387|M.ulcerans_Agy99 ---MRAIVCDAYGPPEDLVLDEVPDPVPAP-GQVLVRVRAVAVNFPDVLF
Mvan_4202|M.vanbaalenii_PYR-1 ---MRAAVCPQYGPPEVVRVEERPEPSAGP-GQVVVRVEAAAVNFPDVLL
Mb0154|M.bovis_AF2122/97 ---MKACVVKELSGPSGMVYTDIDEVSGDG-GKVVIDVRAAGVCFPDLLL
Rv0149|M.tuberculosis_H37Rv ---MKACVVKELSGPSGMVYTDIDEVSGDG-GKVVIDVRAAGVCFPDLLL
TH_2952|M.thermoresistible__bu ---VKALVAQELSGPSGLVYTDWEDPSEND-DVVVIDVRAAGLSFPDLLL
MSMEG_5778|M.smegmatis_MC2_155 ---MKAAVVRAWGQSP--VYTDLTDPQPGE-GTEIAEVEASALTNLTKGI
MAB_1855c|M.abscessus_ATCC_199 ---MKAAVVHEWGQEP--AYTDFPDPQPTG-GAEVATVEASALTNLTRAV
MMAR_0124|M.marinum_M MDTMKAAIVRTFDEPP--HFGDFPDPTSSKPGELIVDVVATALHPRVRAQ
Mflv_5154|M.gilvum_PYR-GCK ---MRAAVLEAVGQPP--TVREFDEP-----TRDVVRVSLAGCNPVDLAL
MLBr_00118|M.leprae_Br4923 ---MHAIVAES---ANQMVWREVPDVTAGP-GEVLIEVAASGVNRADVLQ
::* : : : : * .
MAV_0308|M.avium_104 IAGKYQ--VKIPPPFIPGNEIAGEVIAAGEGAR-FLPGQRVAGT-TFGAF
MUL_4387|M.ulcerans_Agy99 IAGKYQ--IKIPPPFVPGNEIAGEVVGAGAGVI-LVPGQRVFGT-TFGAF
Mvan_4202|M.vanbaalenii_PYR-1 VADSYQ--VSVAPPFVPGSEFTGVVDEIGPHTTGFTVGERVAGTGMFGAF
Mb0154|M.bovis_AF2122/97 TKGEYQ--LKLTPPFVPGMETAGVVRSAPSDAG-FHVGERVSAFGVLGGY
Rv0149|M.tuberculosis_H37Rv TKGEYQ--LKLTPPFVPGMETAGVVRSAPSDAG-FHVGERVSAFGVLGGY
TH_2952|M.thermoresistible__bu IRGEYQ--LRLDPPFIPGMEIAGEVRSAPQGSG-FRPGQRVSAFSMMGGF
MSMEG_5778|M.smegmatis_MC2_155 ASGKHYAAKEIELPVVPG---FDGVARLADGRRVYT----MSIGS-HGLM
MAB_1855c|M.abscessus_ATCC_199 ISGKHYSSKEITLPAIAG---VDGVARLANGKRVYS----GSLAP-YGMM
MMAR_0124|M.marinum_M ADGSHYTSTG-ELPFVPG---IDAVVRDAEGTLYYA----HLADTTLGTM
Mflv_5154|M.gilvum_PYR-GCK ASGEMG------DPVIPSVVGKEGIGRTADGTRVYFD----SPISPFGSW
MLBr_00118|M.leprae_Br4923 VAGKYP--HPPGASAIIGMEVAGVVAAVSSGVTEWSVGQEVCALLAGGGY
.. . : . : *
MAV_0308|M.avium_104 AEQALLDADQAEPIPDDADFASAAAFGVTYRTAYHALRSTAGVTAGDWVV
MUL_4387|M.ulcerans_Agy99 AELALLDGAAAQPIPDDADFASAAAFGVTYRTAYHALRSVAQVSQGDWVV
Mvan_4202|M.vanbaalenii_PYR-1 AERVVADAAGLTPVPDGVDARTAAAFGVAHRTAYHALRSTARLSAGDELV
Mb0154|M.bovis_AF2122/97 AEQIAVPVANVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVL
Rv0149|M.tuberculosis_H37Rv AEQIAVPVANVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVL
TH_2952|M.thermoresistible__bu AERVAVAPQNVIPTADGIDDASAAALLGNYYTMYFALARRAALRPGETVL
MSMEG_5778|M.smegmatis_MC2_155 AERTLVDPGRAVEIPERVDSVTAAALPNPGTSAWITLSYAAAVKPGDHVL
MAB_1855c|M.abscessus_ATCC_199 AERTVVYPAGAVEVPEHVDSVTAAAIPNPGISAWVALSHGAAVQPGQHVL
MMAR_0124|M.marinum_M AQRTIIDQQWAVALPDDADPVTVAAAVNPVLSSWVALRNRINFKPGSRVL
Mflv_5154|M.gilvum_PYR-GCK AELTQLDPDLAFEVPDDVDDDLAVALGIAGLAAWLPLTRHADVSAGQSVL
MLBr_00118|M.leprae_Br4923 AEYVAVPASQVMPIPKGVNVVDSAGIPEVACTVWSNLVMAAHLSAGQLLL
*: . : .. : : * . *. ::
MAV_0308|M.avium_104 VLGAAGGVGLAAVDLAV-AMQA-RVLAAASSPEKLELCRRRGAEATVDYD
MUL_4387|M.ulcerans_Agy99 VLGAAGGVGLAAVDLAV-AMGA-RVLAAASSPEKLGLCRQRGAEAVVDYD
Mvan_4202|M.vanbaalenii_PYR-1 VLGAGGGVGLATVQLGV-ALGA-RVTAVASSNEKLAVAGGYGAATLINHR
Mb0154|M.bovis_AF2122/97 VLGAAGGVGTAAVQIAK-AMQAGKVIAMVHREGAIDYVASLGADVVLPLT
Rv0149|M.tuberculosis_H37Rv VLGAAGGVGTAAVQIAK-AMQAGKVIAMVHREGAIDYVASLGADVVLPLT
TH_2952|M.thermoresistible__bu VFGSAGGVGTAAIQIAK-AMGA-RVIAMVRRARGTEYVESLGPDVVLPLT
MSMEG_5778|M.smegmatis_MC2_155 VLGGTGVTGSTAVQLAGPMFGAESVVAVGRNAERLQWLRSAGAQTVIRLG
MAB_1855c|M.abscessus_ATCC_199 VLGATGVTGSLAVQLAKSVFGAGHVTVAGRNAERLDWLRTVGADDAIMLG
MMAR_0124|M.marinum_M ILGATGSSGGMAIQVAK-RFGAAEVIAAGRNRQRLSELTSLGADRTLTLD
Mflv_5154|M.gilvum_PYR-GCK ILGATGIVGNIAIQAAK-ILGAGRVVGAGRDAGALQKAQELGADAVVQLG
MLBr_00118|M.leprae_Br4923 LHGGTSGIGSHGIQVAR-ALGA-KVAVTAGSEEKLEFCRALGAQITINYR
: *. . * :: . : * * *. :
MAV_0308|M.avium_104 REDLKTRIRDLT-GDRARVVLDPVGGPYSEPALRGLARGG--------TF
MUL_4387|M.ulcerans_Agy99 QEDLKLRIRELT-GESARVVLDPVGGSYAEPALRGLARGG--------IF
Mvan_4202|M.vanbaalenii_PYR-1 DGELRQALRQAI-PDGADVVVDPVGGDVSEPALRSLGRGG--------RF
Mb0154|M.bovis_AF2122/97 EG-WAQQVRDHTYGQGVDIVVDPIGGPTFDDALGVLAIDG--------KL
Rv0149|M.tuberculosis_H37Rv EG-WAQQVRDHTYGQGVDIVVDPIGGPTFDDALGVLAIDG--------KL
TH_2952|M.thermoresistible__bu EG-WPQAVRDATDGRGVDVVVDPVGGDVFDDAIRVLATEG--------RL
MSMEG_5778|M.smegmatis_MC2_155 DDDLADRVAELHAARPFDAVLDYLWGEPAEHVLGALAAASPAGRFHSIRY
MAB_1855c|M.abscessus_ATCC_199 SDDLTEAITARHATRPFDAVLDYLWGSPAEQTLSALAASHPSAHFHATRF
MMAR_0124|M.marinum_M ---------QLGAAGDVDVVLDYVWGPPTAKGMVDLVTNR-RDPHEELIW
Mflv_5154|M.gilvum_PYR-GCK TDDDAAALKSEV-KDGYDVVVDLIYGDPFLAALDATTVGA--------TL
MLBr_00118|M.leprae_Br4923 DEDFVARLQQQN--GGADVILDIMGAAYLDRNIDALAIDG--------QL
::* : . :
MAV_0308|M.avium_104 VTLGYASG-TIPAIPLNLVLLKDICVRGMEIRTFMTDRPDDAVRDLTELS
MUL_4387|M.ulcerans_Agy99 VTLGYAAG-SIPAIPLNLVMLKNLTIRGMEIRTFMGDYPDECARDVAELS
Mvan_4202|M.vanbaalenii_PYR-1 VSVGFASG-VIPRIPLNLVLIKGVHVLGFQFQDVP---ADEFTRNEVELR
Mb0154|M.bovis_AF2122/97 LLIGFAAG-AVPTLKVNRLLVRNISVVGVGWGEYLNAVPGSAALFAWGLN
Rv0149|M.tuberculosis_H37Rv LLIGFAAG-AVPTLKVNRLLVRNISVVGVGWGEYLNAVPGSAALFAWGLN
TH_2952|M.thermoresistible__bu LVLGFAAGQGIPTVKVNRLLLRNVGVIGVGYGEFVARNPGAQQLFGSGLR
MSMEG_5778|M.smegmatis_MC2_155 VQVGSMAG-TTLTLDAAVLRSIGITISGVGIGGVPDDVWHRARTEALPKL
MAB_1855c|M.abscessus_ATCC_199 VQIGAMTG-ETISVNASTLRSTGITLSGVGIGSVPPEALQHARTEALPKL
MMAR_0124|M.marinum_M IQIGSTGG-PSADIVSAALRSTRLQIVGSGIGSVS----ERDIRNDIPGI
Mflv_5154|M.gilvum_PYR-GCK ITVGQGAG--TPAIPFAKLMGR------THVGHMNNLLPASVMRQAYAEL
MLBr_00118|M.leprae_Br4923 IVIGLQGG-VKGELNLGKVLSKRARIIGSTLRARPVNGPNSKSEIVAAVT
: :* * : :
MAV_0308|M.avium_104 Q----MFAAGTVRPYIGARFPLARTAAALRHVADRKVLGKVVIDVA----
MUL_4387|M.ulcerans_Agy99 Q----MFAAGKIRPHIGARFPLADTPAALRYVAERKVLGKVVIDVA----
Mvan_4202|M.vanbaalenii_PYR-1 E----LLVSGRVKPHVGAVYSLDDTVAALRHVSDGRAIGKVVIDLS----
Mb0154|M.bovis_AF2122/97 Q----LVFLG-LRPPPPQRYPLSEAQAALQSLDDGGVLGKVVLEP-----
Rv0149|M.tuberculosis_H37Rv Q----LVFLG-LRPPPPQRYPLSEAQAALQSLDDGGVLGKVVLEP-----
TH_2952|M.thermoresistible__bu H----LVEGG-LRPPPPVRFPLSEGRAAFEALAAGEVLGKAVLEP-----
MSMEG_5778|M.smegmatis_MC2_155 L----SMVDAGELRLHTLRRPLADIETVWSEKSPSGTR--VVVTP-----
MAB_1855c|M.abscessus_ATCC_199 F----AMVNNGDLQLQTLARPLADIETIWAAKEPSGVR--VVVTPQ----
MMAR_0124|M.marinum_M A----QAVAAGEFEVRTQAMPLSDVTSAWTRPLGADRR--VVFLP-----
Mflv_5154|M.gilvum_PYR-GCK V----GLASEKRLTVETTRYSLDDAEKAWDAQADSPHVKIGIAP------
MLBr_00118|M.leprae_Br4923 ASIWPMIADGSVRPIIGARMAVQQAADAHQLLLSGKVSGKIVLTVAGSGT
.: :
MAV_0308|M.avium_104 --------
MUL_4387|M.ulcerans_Agy99 --------
Mvan_4202|M.vanbaalenii_PYR-1 --------
Mb0154|M.bovis_AF2122/97 --------
Rv0149|M.tuberculosis_H37Rv --------
TH_2952|M.thermoresistible__bu --------
MSMEG_5778|M.smegmatis_MC2_155 --------
MAB_1855c|M.abscessus_ATCC_199 --------
MMAR_0124|M.marinum_M --------
Mflv_5154|M.gilvum_PYR-GCK --------
MLBr_00118|M.leprae_Br4923 ETLLSRHH