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MIRPLDSYNKTWLGVAAVAVVAALIGGLLLVKQLGIGYRQFTAEFLQAAALRPGNIVTVAGVQVGSVTGV RLAGDRVEATFRVRDNMAVGTDSRAAIKITTLFGSRYVDLRPAGAGTPAGRRISLQHTEVPYDLQAALAD STRTFEQVDADRIASSLNVLGTQLDGLPGVVPQAMENVRALSAVIAQRREQLGTLLTSTENVTSMLRRQQ SDIGTFIRQGQELVGEFVARSAAFHAMMRSLQSIVASLRTIVVGDHRALDGVIHTLEELSGKLADQDALL RNLLQIAPVPIREIANATGFGNSIEGNPGGGALIDSWMCAISGRAKQFGMIEYFKDCQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1697 | - | - | 100% (338) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_4514c | - | e-115 | 60.42% (336) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_1008c | - | e-115 | 58.63% (336) | putative MCE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3527c | mce4C | 2e-27 | 27.51% (269) | MCE-family protein MCE4C |
| M. gilvum PYR-GCK | Mflv_0008 | - | 1e-109 | 56.85% (336) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3497c | mce4C | 2e-27 | 27.51% (269) | MCE-family protein MCE4C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 4e-21 | 25.17% (290) | putative secreted protein |
| M. marinum M | MMAR_0179 | mce6C | 1e-139 | 71.43% (336) | MCE-family protein Mce6C |
| M. avium 104 | MAV_2386 | - | 1e-111 | 59.52% (336) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_1145 | - | 1e-107 | 56.25% (336) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2869 | - | 1e-108 | 58.38% (334) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4917 | mce6C | 1e-138 | 70.83% (336) | MCE-family protein Mce6C |
| M. vanbaalenii PYR-1 | Mvan_0961 | - | 1e-112 | 58.33% (336) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0179|M.marinum_M MAERIKHLRPRLRPLASYNKTWLGFVGLSLAVVLIGALLLVKQAGIGYR-
MUL_4917|M.ulcerans_Agy99 MAERIKHLRPRLRPLASYNKTWLGFVGLSLAVVMIGALLLVKQGGIGYR-
MAB_1697|M.abscessus_ATCC_1997 ----------MIRPLDSYNKTWLGVAAVAVVAALIGGLLLVKQLGIGYR-
MSMEG_1145|M.smegmatis_MC2_155 MAE--ARKARRRKPLESYNRLWLGVVAVAVVSVLIGAMLLVRVADIGYT-
TH_2869|M.thermoresistible__bu --------------LETYSRTTLGVIAVAVVAVLVGALLVVKAAGIGYK-
Mflv_0008|M.gilvum_PYR-GCK MAE--QTK-RRRRRLESYHKAWLGTVAVVVVAVLVGALLLIKAADVGYR-
Mvan_0961|M.vanbaalenii_PYR-1 MAE--RRK-WPRRPLESYHSAWLGFAAVAVVAVLIGAMLLIKGADVGYR-
MAV_2386|M.avium_104 MRQ--RLSALTKRPLESYNKTWLGFVAVAVVAAVIAVMLVVHALGAGYR-
Mb3527c|M.bovis_AF2122/97 --------MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWP
Rv3497c|M.tuberculosis_H37Rv --------MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWP
MLBr_02591|M.leprae_Br4923 -----------MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFAR
. :. : . :
MMAR_0179|M.marinum_M ---RYTAEFLQAASLQPDNVVSVAGVPVGNVISVRLAGDHVEARLRVKDN
MUL_4917|M.ulcerans_Agy99 ---RYTAEFLQAASLQPDNVVSVAGVPVGNVISVRLAGNHVEARLRVKDN
MAB_1697|M.abscessus_ATCC_1997 ---QFTAEFLQAAALRPGNIVTVAGVQVGSVTGVRLAGDRVEATFRVRDN
MSMEG_1145|M.smegmatis_MC2_155 ---QYTARFLQAAALKAGNPVTVAGIPVGEVKSMRLAGDHVEAKIKVRND
TH_2869|M.thermoresistible__bu ---EYTARFLQAAALQPGNPITVAGIPVGEVLSMKLNGDHVEARLKVRGD
Mflv_0008|M.gilvum_PYR-GCK ---TFTAQFLQAAALQPGNPVSVAGIPVGEVTDMKLAGDHVEARFTVRND
Mvan_0961|M.vanbaalenii_PYR-1 ---KYTAQFLQAAALQPGNPVTVAGIPVGEVTGMELAGDHVVADFTVRND
MAV_2386|M.avium_104 ---HYTAEFAQAASLRAGNPIVVAGIPVGTVTSMKLVGDHVEAGLKVRDN
Mb3527c|M.bovis_AF2122/97 QGKTYDAYFTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRS
Rv3497c|M.tuberculosis_H37Rv QGKTYDAYFTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRS
MLBr_02591|M.leprae_Br4923 --PSYYGQFTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-T
: . * ::..: .: : ::*: ** * : : *: . : :
MMAR_0179|M.marinum_M IALGRDTRAAIKITTIFGSRYIDLHPTGAGVP-PGQTIDLAHTEVPYDLQ
MUL_4917|M.ulcerans_Agy99 IALGRDTRAAIKITTIFGSRYIDLHPTGAGVP-PGQTIDLAHTEVPYDLQ
MAB_1697|M.abscessus_ATCC_1997 MAVGTDSRAAIKITTLFGSRYVDLRPAGAGTP-AGRRISLQHTEVPYDLQ
MSMEG_1145|M.smegmatis_MC2_155 VGLGKDSRAKIMVTTILGSRYLSLEPAGDGTL-PDRTFDLSHTDVPYDLQ
TH_2869|M.thermoresistible__bu IRLGEHSRAVIKITTILGSRYLALYPDGPGTL-PDNTFDLKHTEVPYDLQ
Mflv_0008|M.gilvum_PYR-GCK VDLGEDSRAVIKVTTILGSRYLSLEPEGTGAL-PDRHFDLSHTEVPYDLQ
Mvan_0961|M.vanbaalenii_PYR-1 VALGEDSRAVIKVTTILGSRYLSLEPEGPGSL-PDRRFDLAHTEVPYDLQ
MAV_2386|M.avium_104 ISFGKDSRAQIRVTTILGSRYLALEPNGPARL-PGNTFDLAHTEVPYDLQ
Mb3527c|M.bovis_AF2122/97 IVVGDQSLAAIRTDTILGERSIAVSPAGSGK---STTIPLSRTTTPYTLN
Rv3497c|M.tuberculosis_H37Rv IVVGDQSLAAIRTDTILGERSIAVSPAGSGK---STTIPLSRTTTPYTLN
MLBr_02591|M.leprae_Br4923 NRIGTASRLGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSY
.* : * *::*.: : : . * . : * :: .**
MMAR_0179|M.marinum_M AALADSTRTFEQVDGDRIASSLTVLGQALNGLPDVFPQALENVRALSSVI
MUL_4917|M.ulcerans_Agy99 AALADSTRTFEQVDGDRIASSLTVLGQALNGLPDVFPQALENVRALSSVI
MAB_1697|M.abscessus_ATCC_1997 AALADSTRTFEQVDADRIASSLNVLGTQLDGLPGVVPQAMENVRALSAVI
MSMEG_1145|M.smegmatis_MC2_155 EALTDVTTTFEKVDSDKFAETLQILGSQLETLPPVIPQALENTHTLSTII
TH_2869|M.thermoresistible__bu EALADVATTYEQVDSDQFAESLAILGRQLETLPPVVPQALENTHTLSSII
Mflv_0008|M.gilvum_PYR-GCK EALTDVTTTFEQVDSDKFAETLSILGRQLQGMPEILPQALENTHTLSTII
Mvan_0961|M.vanbaalenii_PYR-1 EALTDVATTFEQVDSDKFAESLAILGRQLQGLPEVVPQALQNTHTLSTIL
MAV_2386|M.avium_104 AALQDATTTFEQVDSDRFAQSLAVLGKQLEGLPAVVPQAITNIDTLSSII
Mb3527c|M.bovis_AF2122/97 GVLQDLGRNANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRAL
Rv3497c|M.tuberculosis_H37Rv GVLQDLGRNANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRAL
MLBr_02591|M.leprae_Br4923 DAFFDATKVASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTI
.: * . : : .:* :. :. . *: . :* :
MMAR_0179|M.marinum_M SQRRDQLGTLLKSTQNVTDILRRQQSDLGSMIRQGQDLIGEFVAHSAAFH
MUL_4917|M.ulcerans_Agy99 SQRRDQLGTLLKSTQNVTDILRRQQSDLGSMIRQGQDLIGEFVAHSAAFH
MAB_1697|M.abscessus_ATCC_1997 AQRREQLGTLLTSTENVTSMLRRQQSDIGTFIRQGQELVGEFVARSAAFH
MSMEG_1145|M.smegmatis_MC2_155 AQRRDQLGELLKTTELISNTLYRQKSTIGSLMNQSNSLLAEFVARRATFH
TH_2869|M.thermoresistible__bu AQRRDQLGELLKTTEMVSTTLRRQQANIGNLVHQGNSLLGEFVARRATFH
Mflv_0008|M.gilvum_PYR-GCK ADRRDQLGSLLETTEVVSNTLRRQQANIGSLVRQGNDLVGEFVLRRASFQ
Mvan_0961|M.vanbaalenii_PYR-1 AQRRDQLGALLETTDVVSTTLKRQQSNIASMVRQGNDLVGEFVVRRASFH
MAV_2386|M.avium_104 ATRRDQLGQLLRSTEQVTNTLRRQQAGIGALVDQGQDLLGQFVARRAVFH
Mb3527c|M.bovis_AF2122/97 NRRDEALQGLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALS
Rv3497c|M.tuberculosis_H37Rv NRRDEALQGLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALS
MLBr_02591|M.leprae_Br4923 GARDKEIKHLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVD
* . : *: :. :: * : : :: : : *.. : : .
MMAR_0179|M.marinum_M AMMQALTQVVGSLRTIVVDDRAALEDVVQTMEQLSAKLAEQDALFRNLLE
MUL_4917|M.ulcerans_Agy99 AMMQALTQVVGSLRTIVVDDRAALEDVVQTMEQLSAKLAEQDALFRNLLE
MAB_1697|M.abscessus_ATCC_1997 AMMRSLQSIVASLRTIVVGDHRALDGVIHTLEELSGKLADQDALLRNLLQ
MSMEG_1145|M.smegmatis_MC2_155 AMMDALTNLVQTLSGIVIDDRPELEKLVEDLRQLSSLLSKNDGMLRSILQ
TH_2869|M.thermoresistible__bu AMMDALTVLVQRLSDIVIDDRPELEELLSNLRELSGLLADNDGMLRSILQ
Mflv_0008|M.gilvum_PYR-GCK AMMNAITNLVQTLGDIVIEDRPELEALLVNVRELSDMLGQHDDLLRSILQ
Mvan_0961|M.vanbaalenii_PYR-1 AMLAAITDLVQTLSDIVIGDRPELEALLVNVRELSDMLGQHDDLVRNILQ
MAV_2386|M.avium_104 AMMRSLSSLVDTLSRVVVNDRSGVDALLKDIRDFTGLVSAHDDLLHSLLQ
Mb3527c|M.bovis_AF2122/97 ALISGIDDVAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALK
Rv3497c|M.tuberculosis_H37Rv ALISGIDDVAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALK
MLBr_02591|M.leprae_Br4923 ALLGNVAAFAAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLI
*:: : .. : .: : . : :. . : . . . *
MMAR_0179|M.marinum_M IAPVPVRELANASGYGNALELNAA---AGPLVDSWMCAISGRA-------
MUL_4917|M.ulcerans_Agy99 IAPVPVRELANASGYGNALEINAA---AGPLVDSWMCAISGRA-------
MAB_1697|M.abscessus_ATCC_1997 IAPVPIREIANATGFGNSIEGNPG---GGALIDSWMCAISGRA-------
MSMEG_1145|M.smegmatis_MC2_155 TAPIALRNIANMTGTGNAIDFNSS---SGLLVDSWMCAISGRA-------
TH_2869|M.thermoresistible__bu TTPIAVRNLANITGTGNAIDFNAP---GGLLVDSWMCAISGRA-------
Mflv_0008|M.gilvum_PYR-GCK SGPPALRGLANATGMGNAVEFNAA---NGLLVDSWMCAISGRA-------
Mvan_0961|M.vanbaalenii_PYR-1 SGPLALRGLANATGSGNAVDFNAA---NGLLVDSWMCAISGRA-------
MAV_2386|M.avium_104 VSPIFFREAANLTGDGNAINFNAP---NVPLIDSWMCAISGRA-------
Mb3527c|M.bovis_AF2122/97 RLPTYATTLGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQPG-------
Rv3497c|M.tuberculosis_H37Rv RLPTYATTLGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQPG-------
MLBr_02591|M.leprae_Br4923 QVAAFLPSLNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENF
. : * * .. :: . .
MMAR_0179|M.marinum_M -KQFG-LIQYFKDCA-----------------------------------
MUL_4917|M.ulcerans_Agy99 -KQFG-LIQYFKDCA-----------------------------------
MAB_1697|M.abscessus_ATCC_1997 -KQFG-MIEYFKDCQ-----------------------------------
MSMEG_1145|M.smegmatis_MC2_155 -KQFG-MIQYFQDCK-----------------------------------
TH_2869|M.thermoresistible__bu -KQFG-MIEYFQDCK-----------------------------------
Mflv_0008|M.gilvum_PYR-GCK -KQFG-MIQYFQDCK-----------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 -KQFG-MIEYLKDCK-----------------------------------
MAV_2386|M.avium_104 -KQFG-MIQYFKDCK-----------------------------------
Mb3527c|M.bovis_AF2122/97 -KLPDSLADYLRGFIQERWIIRPKSP------------------------
Rv3497c|M.tuberculosis_H37Rv -KLPDSLADYLRGFIQERWIIRPKSP------------------------
MLBr_02591|M.leprae_Br4923 WRSAGLPEFRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSY
: . : .
MMAR_0179|M.marinum_M --------------------------------------------------
MUL_4917|M.ulcerans_Agy99 --------------------------------------------------
MAB_1697|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------------------
TH_2869|M.thermoresistible__bu --------------------------------------------------
Mflv_0008|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2386|M.avium_104 --------------------------------------------------
Mb3527c|M.bovis_AF2122/97 --------------------------------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02591|M.leprae_Br4923 TPAHPGGNNTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPP
MMAR_0179|M.marinum_M --------------------------------------------------
MUL_4917|M.ulcerans_Agy99 --------------------------------------------------
MAB_1697|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------------------
TH_2869|M.thermoresistible__bu --------------------------------------------------
Mflv_0008|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2386|M.avium_104 --------------------------------------------------
Mb3527c|M.bovis_AF2122/97 --------------------------------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02591|M.leprae_Br4923 NPDGLPLLPGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAPA
MMAR_0179|M.marinum_M ----------------------------------
MUL_4917|M.ulcerans_Agy99 ----------------------------------
MAB_1697|M.abscessus_ATCC_1997 ----------------------------------
MSMEG_1145|M.smegmatis_MC2_155 ----------------------------------
TH_2869|M.thermoresistible__bu ----------------------------------
Mflv_0008|M.gilvum_PYR-GCK ----------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 ----------------------------------
MAV_2386|M.avium_104 ----------------------------------
Mb3527c|M.bovis_AF2122/97 ----------------------------------
Rv3497c|M.tuberculosis_H37Rv ----------------------------------
MLBr_02591|M.leprae_Br4923 QDSSAPHEPREQLSAPLINPGGTGGSGGAGGSRN