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MSGRTLVTGATGYLGSTLVASLVQAGERVTVLMNPHEPAVLPGELRPHVETAYADIADARAVDDVMRDVS HVYHLAGIASPNSRLGHRIWQTNVLGSYHVARAALRHGVQRVVHVSSTAAIGYPPNGVVADEDFDPCDSV LDNVYSATKRAGERLMLDFVERGLDVVVVNPAAVFAPGAGPARSWQGLLVAARKGLLRVVPPGGTAVCSA RDFVAGITTAMAKGDNGRRYILSTANLSYRQIGELLVAAVGRHHPVRPAPMGLFRTAGRGNRLLRDLSGR FDPDDVLVAENLELMARELYYAPDRAVRELGIPKVSTHELIAEFVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1682 | - | - | 100% (326) | NAD-dependent epimerase/dehydratase |
| M. abscessus ATCC 19977 | MAB_0718c | - | 2e-23 | 29.31% (331) | NAD-dependent epimerase/dehydratase |
| M. abscessus ATCC 19977 | MAB_2971c | - | 1e-15 | 27.08% (336) | putative oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3752 | - | 1e-15 | 27.41% (270) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1564 | - | 1e-19 | 28.47% (288) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv3784 | - | 3e-14 | 32.39% (176) | dTDP-glucose 4,6-dehydratase |
| M. leprae Br4923 | MLBr_01942 | - | 1e-13 | 30.67% (163) | putative cholesterol dehydrogenase |
| M. marinum M | MMAR_0164 | - | 1e-134 | 73.54% (325) | nucleoside-diphosphate-sugar epimerase |
| M. avium 104 | MAV_1849 | - | 3e-18 | 28.00% (325) | dihydroflavonol-4-reductase family protein |
| M. smegmatis MC2 155 | MSMEG_6563 | - | 2e-21 | 28.74% (334) | dihydrokaempferol 4-reductase |
| M. thermoresistible (build 8) | TH_2143 | - | 1e-21 | 28.53% (326) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_4932 | - | 1e-132 | 72.31% (325) | nucleoside-diphosphate-sugar epimerases |
| M. vanbaalenii PYR-1 | Mvan_4271 | - | 7e-23 | 31.82% (330) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3752|M.bovis_AF2122/97 ---------MQNATMRVLVTGGTGFVGGWTAKAIADAGHS-VRFLVRNPA
Mflv_1564|M.gilvum_PYR-GCK ----------MEGTIHIAVTGGIGYLGAHTVRALLEAGHS-VRLLVLPQE
MMAR_0164|M.marinum_M ------------MAPRILVTGATGYLGSTILEALVRAGER-ATILVQPGD
MUL_4932|M.ulcerans_Agy99 ------------MAPRILVTGATGYLGSTILEALVRADER-ATILVQPGD
MAB_1682|M.abscessus_ATCC_1997 ------------MSGRTLVTGATGYLGSTLVASLVQAGER-VTVLMNPHE
MAV_1849|M.avium_104 -------------MAVKLVIGASGFLGSHVTRQLVERGER-VRVLLRRTS
TH_2143|M.thermoresistible__bu ------------VAKKKLVIGASGFLGSHVTRQLVREGHD-VRVMVRTTS
MSMEG_6563|M.smegmatis_MC2_155 ------------MTATKLVIGASGFLGSHVTRRLVERGED-VRILIRSTS
Mvan_4271|M.vanbaalenii_PYR-1 ------------MAGTKLVIGASGFLGSHVTKQLIAAGEDDVRVLIRTTS
MLBr_01942|M.leprae_Br4923 MLRGVGNASLTTELGRVLVTGGSGFVGANLVTALLERGYQ-VRSFDRAPM
Rv3784|M.tuberculosis_H37Rv --------------MEILVTGGAGFQGSHLTESLLANGHW-VTVLDKSSR
* *. *: *. : . . :
Mb3752|M.bovis_AF2122/97 RLKTSVAKL-GVDVSDFAVADISDRDSVREALNGCDAVVHSAALVATD--
Mflv_1564|M.gilvum_PYR-GCK QDAPVIDRLRALGEVSVVVGDIRSESTVTELLSGADAVLHAAGVVGTD--
MMAR_0164|M.marinum_M ---PHVMSPELRSNVDVVRGDITDAQSVDEAMRGIARVYHLAGIASPN--
MUL_4932|M.ulcerans_Agy99 ---PHVMSPELRSNVDVVRGDITDAQSVDEAMRGIARVYHLAGIASPN--
MAB_1682|M.abscessus_ATCC_1997 ---PAVLPGELRPHVETAYADIADARAVDDVMRDVSHVYHLAGIASPN--
MAV_1849|M.avium_104 ---STVALDDLD--IERRYGDVFDDAVLRDALDGCDDVYYCVVDTRAW--
TH_2143|M.thermoresistible__bu ---MTRGIDDLD--VERCHGDVFDDAALRAAMTGVDDVYYCVVDARMW--
MSMEG_6563|M.smegmatis_MC2_155 ---STRGIDDVIDRVDVRHGDIFDAASVRDAADGCDTVYYCVVDARAW--
Mvan_4271|M.vanbaalenii_PYR-1 ---STRGIDGLP--VQVHYGDIFDTGALRAAMAGCDVVYYCVVDARPW--
MLBr_01942|M.leprae_Br4923 P-------LPQHPQLEVLQGDITDATVCTTAMDSIDTVFHTAAIIELMGG
Rv3784|M.tuberculosis_H37Rv NAVRNMQGFRSHDRAAFISGSVTDGQTIDRAVRDHHVVFHLAAHVNVDQS
..: . . * : .
Mb3752|M.bovis_AF2122/97 ----PRETSRMLSTNMAGAQNVLGQAVE----LGMDPIVHVSSFTALFRP
Mflv_1564|M.gilvum_PYR-GCK ----ERRSQLMWDINAYATEQILTRAVD----LGLDPVVSVSSYSALFPP
MMAR_0164|M.marinum_M ----SRLANQIWRTNVLGAYHVAQSAWR----HGVQRLVHVSSTAAIGYP
MUL_4932|M.ulcerans_Agy99 ----SRLANQIWRTNVLGAYHVAQSAWR----HGVQRLVHASSTAAIGYP
MAB_1682|M.abscessus_ATCC_1997 ----SRLGHRIWQTNVLGSYHVARAALR----HGVQRVVHVSSTAAIGYP
MAV_1849|M.avium_104 ----LRDPAPLFRTNVEGLRQVLDTAVG----ADLRRFVFTSTIGTIALS
TH_2143|M.thermoresistible__bu ----LRDPAPLFRTNVEGLRHVLDAAVE----ADLNRFLFTSTTGTMAIN
MSMEG_6563|M.smegmatis_MC2_155 ----LRDATPLWRTNVDGLSGVLDVMTEPEIASGVRRFVFTSSIATIGLP
Mvan_4271|M.vanbaalenii_PYR-1 ----LRDPAPMWRTNVDGLRNVLDVAVG----AGLHRFVFTSSIGTIGLA
MLBr_01942|M.leprae_Br4923 ASVTDEYRQRSYTVNVGGTENLLRAGQK----SGVKRFVYTASNSVVMGG
Rv3784|M.tuberculosis_H37Rv ----LGDPESFLETNVMGTYRVLEAVRR-----YRNRLIYVSTCEVYGDG
* . : .: .:: .
Mb3752|M.bovis_AF2122/97 NLATLSADLP---VAGGTDGYGQSKAQIEIYARGLQ-DAGAPVNITYPGM
Mflv_1564|M.gilvum_PYR-GCK KNGVISADSP---TADGRSSYAKTKGYADRAARRLQ-DAGAPVVVTYPSS
MMAR_0164|M.marinum_M PNGVIADEDFDPRDSVLDNVYSATKRAGEQLVLDFV-DRGLDVVVVNPAA
MUL_4932|M.ulcerans_Agy99 PNGVIADEDFDPRDSVLDNVYSATKRAGEQLVLDFV-DRGLDVVVVNPAA
MAB_1682|M.abscessus_ATCC_1997 PNGVVADEDFDPCDSVLDNVYSATKRAGERLMLDFV-ERGLDVVVVNPAA
MAV_1849|M.avium_104 EDGLPVSEDEPFNWADRGGGYIRSRVEAENLVLQYARERGLPAVAMCVSN
TH_2143|M.thermoresistible__bu -PYRPVTEDDPHNWT-EGGAYIEARVAAEQLVLRYARERGLPAVALCIST
MSMEG_6563|M.smegmatis_MC2_155 -ESGPATEEIENNWLDRGGEYVRSRVRAEQLVLRYHKDRGLPAVAMCVSN
Mvan_4271|M.vanbaalenii_PYR-1 -ADGLADEDTAHNWLDKGGAYIRSRVEAEQMVLRYSAEKGLPAVAMCVAN
MLBr_01942|M.leprae_Br4923 -TPITGGDETMPYTKRFNDLYTETKVVAEKFVLSQNGVPDGETMLTCSIR
Rv3784|M.tuberculosis_H37Rv HNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFN
. * :: : . .
Mb3752|M.bovis_AF2122/97 VLGPPVG---DQFGEAGEGVRSALWMHVIPGRGAAWLIVD--VRDVAALH
Mflv_1564|M.gilvum_PYR-GCK VVGAAFGG--TASGVTERGWAPIVRARVAPRVRAGMQMID--VRDVADVH
MMAR_0164|M.marinum_M VFAPGFG---PPRSWQGLLVAARKG-LLRVVPPGGTAVCS--ARDFAAGV
MUL_4932|M.ulcerans_Agy99 VFAPGFG---PPRSWQGLLVSARKG-LLRVVPPGGTAVCS--ARDFAAGV
MAB_1682|M.abscessus_ATCC_1997 VFAPGAG---PARSWQGLLVAARKG-LLRVVPPGGTAVCS--ARDFVAGI
MAV_1849|M.avium_104 TYGPGDF---QPTPHGSLVAAAGKGKMPVYVKDMSMEVVG--IEDAARAL
TH_2143|M.thermoresistible__bu TYGPGDW---QPTPHGRLLAMVATGRFPFYLG-WSAEVVG--IEDAARAM
MSMEG_6563|M.smegmatis_MC2_155 TYGPGDW---QPTPHGGLVAAAVRGKMPFYIDGAEAEAVG--VADAAEAL
Mvan_4271|M.vanbaalenii_PYR-1 TYGPGDF---LPTPHGGMLAAAVAGRLPFYIDGYDAEVVG--IEDAARAM
MLBr_01942|M.leprae_Br4923 PSGIWGRG--DQTMFRKAFESVVSGHVKVLIGSKNAKLDNSYVHNLVHGL
Rv3784|M.tuberculosis_H37Rv IFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAY
. : .
Mb3752|M.bovis_AF2122/97 AALLESGRGP------RRYTAGGHRIPVPELAKILGEVAGTTMLAVPVPD
Mflv_1564|M.gilvum_PYR-GCK TRLMSPGRGP------HRYVCGGVMLTFDEMIDALEEGLGRPVRRIPMSP
MMAR_0164|M.marinum_M TAAMNKGQPG------RRYILSTDNLSYRQIAELLVRAVGRSHQVRVAPM
MUL_4932|M.ulcerans_Agy99 TAAMNKGQPG------RRYILSTDNLSYRQIAELLVRAVGRSHQVRVAPM
MAB_1682|M.abscessus_ATCC_1997 TTAMAKGDNG------RRYILSTANLSYRQIGELLVAAVGRHHPVRPAPM
MAV_1849|M.avium_104 ILAAEKGRVG------ERYIVSERYISARELYTTAAEAGGARPPRIGIPL
TH_2143|M.thermoresistible__bu LLAAEQGRVG------ERYIISDRYLHTREVHAIAAEAVGRRAPWFGLPL
MSMEG_6563|M.smegmatis_MC2_155 VLAGERGTPG------ERYIVSERMMSAREIYEVACDAVGVEPPRRGVPI
Mvan_4271|M.vanbaalenii_PYR-1 ILAAERGRTG------ERYIVSERFMSTREIHEIGCAAVGVAPPKFGVPI
MLBr_01942|M.leprae_Br4923 ILAAEHLVPGGTAPGQAYFINDGEPINFFDFMGPIIKACGENWPRVRISG
Rv3784|M.tuberculosis_H37Rv NLVLRTPTLRG----QAINFASGKDTRVRDIVEYVADKFGARIEHRDARP
. :. *
Mb3752|M.bovis_AF2122/97 SALRVAGSVLDQAGPYLPFN---TPFTAAGMQYYTQMPEPDDSPSEKELG
Mflv_1564|M.gilvum_PYR-GCK KALLAVGRISDVAGRYVPLG---DGLSYEAALLLTSATPTDDSVTRQDLG
MMAR_0164|M.marinum_M RPFRALGRGKRIASDFSSRAHFDDPLVPENIDLMARKVYYDPTRAVRELG
MUL_4932|M.ulcerans_Agy99 RPFRALGMGKRIASDFSSRAHFDDPLVPENIDLMARKVYYDPTRAVRELG
MAB_1682|M.abscessus_ATCC_1997 GLFRTAGRGNRLLRDLSGRFDPDDVLVAENLELMARELYYAPDRAVRELG
MAV_1849|M.avium_104 KVMYALGLCGDVAAKVLRR---DMLLSTLSVRLMHIMSPMDHSKAERELG
TH_2143|M.thermoresistible__bu PVLSVAARGNDLAARLLRR---DLMFAHVGLKMAELMSPLDHSKAERELG
MSMEG_6563|M.smegmatis_MC2_155 RVMAAAAGLSSAVARLRRR---ETRLSPLTVRLMHVMSPMDHGKAVRELG
Mvan_4271|M.vanbaalenii_PYR-1 RVMSAAGYLSEGVARLRGK---DTMLTPLNIRLMHIMSPMDHSKAVRELD
MLBr_01942|M.leprae_Br4923 RLVRNVMAVWQRLHFGFGLP--KPPMEPLAVERVYLDNYFSIEKAHKELG
Rv3784|M.tuberculosis_H37Rv GEVQRFPADISLAKS--------IGFQPQVEIWDGIDRYINWAKDQPQYP
. : :
Mb3752|M.bovis_AF2122/97 IT-YRDPRDTVADTVTALRGLGS--------------------
Mflv_1564|M.gilvum_PYR-GCK LS-WRSPRAAIVESFAAARVSAGRGIA----------------
MMAR_0164|M.marinum_M IP-KVSVAELITEFVG---------------------------
MUL_4932|M.ulcerans_Agy99 IP-KVSVAELITEFVG---------------------------
MAB_1682|M.abscessus_ATCC_1997 IP-KVSTHELIAEFVR---------------------------
MAV_1849|M.avium_104 WR-PEPIHDAIRRAVAFYQTR----------------------
TH_2143|M.thermoresistible__bu FK-PEPVEDSIAKAARFFLEQHR--------------------
MSMEG_6563|M.smegmatis_MC2_155 WK-PAPAPESIAQAARFFASRRRT-------------------
Mvan_4271|M.vanbaalenii_PYR-1 WH-PQPTSEAIVAAAHFFRDRRQRAAQGAR-------------
MLBr_01942|M.leprae_Br4923 YRPLFTTEQAMAECLPYYTELFEQIKVAAKPHLASIAATPRPE
Rv3784|M.tuberculosis_H37Rv YE-----QDGFSGSSVL--------------------------
.