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APRILVTGATGYLGSTILEALVRADERATILVQPGDPHVMSPELRSNVDVVRGDITDAQSVDEAMRGIAR VYHLAGIASPNSRLANQIWRTNVLGAYHVAQSAWRHGVQRLVHASSTAAIGYPPNGVIADEDFDPRDSVL DNVYSATKRAGEQLVLDFVDRGLDVVVVNPAAVFAPGFGPPRSWQGLLVSARKGLLRVVPPGGTAVCSAR DFAAGVTAAMNKGQPGRRYILSTDNLSYRQIAELLVRAVGRSHQVRVAPMRPFRALGMGKRIASDFSSRA HFDDPLVPENIDLMARKVYYDPTRAVRELGIPKVSVAELITEFVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4932 | - | - | 100% (326) | nucleoside-diphosphate-sugar epimerases |
| M. ulcerans Agy99 | MUL_4771 | - | 3e-18 | 27.16% (324) | oxidoreductase |
| M. ulcerans Agy99 | MUL_4328 | - | 4e-15 | 25.15% (326) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3752 | - | 9e-19 | 26.51% (332) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1564 | - | 1e-21 | 28.23% (333) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv3725 | - | 7e-16 | 28.63% (248) | oxidoreductase |
| M. leprae Br4923 | MLBr_01942 | - | 4e-12 | 22.99% (335) | putative cholesterol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1682 | - | 1e-132 | 72.31% (325) | NAD-dependent epimerase/dehydratase |
| M. marinum M | MMAR_0164 | - | 0.0 | 98.77% (326) | nucleoside-diphosphate-sugar epimerase |
| M. avium 104 | MAV_1849 | - | 6e-19 | 27.92% (308) | dihydroflavonol-4-reductase family protein |
| M. smegmatis MC2 155 | MSMEG_6563 | - | 1e-27 | 32.42% (327) | dihydrokaempferol 4-reductase |
| M. thermoresistible (build 8) | TH_2143 | - | 2e-20 | 26.54% (324) | POSSIBLE OXIDOREDUCTASE |
| M. vanbaalenii PYR-1 | Mvan_4271 | - | 6e-24 | 32.30% (322) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4932|M.ulcerans_Agy99 ------------MAPRILVTGATGYLGSTILEALVRADER-ATILVQPGD
MMAR_0164|M.marinum_M ------------MAPRILVTGATGYLGSTILEALVRAGER-ATILVQPGD
MAB_1682|M.abscessus_ATCC_1997 ------------MSGRTLVTGATGYLGSTLVASLVQAGER-VTVLMNPHE
MAV_1849|M.avium_104 -------------MAVKLVIGASGFLGSHVTRQLVERGER-VRVLLRRTS
TH_2143|M.thermoresistible__bu ------------VAKKKLVIGASGFLGSHVTRQLVREGHD-VRVMVRTTS
MSMEG_6563|M.smegmatis_MC2_155 ------------MTATKLVIGASGFLGSHVTRRLVERGED-VRILIRSTS
Mvan_4271|M.vanbaalenii_PYR-1 ------------MAGTKLVIGASGFLGSHVTKQLIAAGEDDVRVLIRTTS
Mb3752|M.bovis_AF2122/97 ---------MQNATMRVLVTGGTGFVGGWTAKAIADAGHS-VRFLVRNPA
Rv3725|M.tuberculosis_H37Rv ---------MQNATMRVLVTGGTGFVGGWTAKAIADAGHS-VRFLVRNPA
Mflv_1564|M.gilvum_PYR-GCK ----------MEGTIHIAVTGGIGYLGAHTVRALLEAGHS-VRLLVLPQE
MLBr_01942|M.leprae_Br4923 MLRGVGNASLTTELGRVLVTGGSGFVGANLVTALLERGYQ-----VRSFD
* *. *::*. : . :
MUL_4932|M.ulcerans_Agy99 PHVMSPELRS---NVDVVRGDITDAQSVDEAMRGIARVYHLAGIASPN--
MMAR_0164|M.marinum_M PHVMSPELRS---NVDVVRGDITDAQSVDEAMRGIARVYHLAGIASPN--
MAB_1682|M.abscessus_ATCC_1997 PAVLPGELRP---HVETAYADIADARAVDDVMRDVSHVYHLAGIASPN--
MAV_1849|M.avium_104 STVALDDLD-----IERRYGDVFDDAVLRDALDGCDDVYYCVVDTRAW--
TH_2143|M.thermoresistible__bu MTRGIDDLD-----VERCHGDVFDDAALRAAMTGVDDVYYCVVDARMW--
MSMEG_6563|M.smegmatis_MC2_155 STRGIDDVID---RVDVRHGDIFDAASVRDAADGCDTVYYCVVDARAW--
Mvan_4271|M.vanbaalenii_PYR-1 STRGIDGLP-----VQVHYGDIFDTGALRAAMAGCDVVYYCVVDARPW--
Mb3752|M.bovis_AF2122/97 RLKTSVAKLG-VDVSDFAVADISDRDSVREALNGCDAVVHSAALVATD--
Rv3725|M.tuberculosis_H37Rv RLKTSVAKLG-VDVSDFAVADISDRDSVREALNGCDAVVHSAALVATD--
Mflv_1564|M.gilvum_PYR-GCK QDAPVIDRLRALGEVSVVVGDIRSESTVTELLSGADAVLHAAGVVGTD--
MLBr_01942|M.leprae_Br4923 RAPMPLPQHP---QLEVLQGDITDATVCTTAMDSIDTVFHTAAIIELMGG
. .*: . . * : .
MUL_4932|M.ulcerans_Agy99 ----SRLANQIWRTNVLGAYHVAQSAWR----HGVQRLVHASSTAAIGYP
MMAR_0164|M.marinum_M ----SRLANQIWRTNVLGAYHVAQSAWR----HGVQRLVHVSSTAAIGYP
MAB_1682|M.abscessus_ATCC_1997 ----SRLGHRIWQTNVLGSYHVARAALR----HGVQRVVHVSSTAAIGYP
MAV_1849|M.avium_104 ----LRDPAPLFRTNVEGLRQVLDTAVG----ADLRRFVFTSTIGTIALS
TH_2143|M.thermoresistible__bu ----LRDPAPLFRTNVEGLRHVLDAAVE----ADLNRFLFTSTTGTMAIN
MSMEG_6563|M.smegmatis_MC2_155 ----LRDATPLWRTNVDGLSGVLDVMTEPEIASGVRRFVFTSSIATIGLP
Mvan_4271|M.vanbaalenii_PYR-1 ----LRDPAPMWRTNVDGLRNVLDVAVG----AGLHRFVFTSSIGTIGLA
Mb3752|M.bovis_AF2122/97 ----PRETSRMLSTNMAGAQNVLGQAVE----LGMDPIVHVSSFTALFRP
Rv3725|M.tuberculosis_H37Rv ----PRETSRMLSTNMAGAQNVLGQAVE----LGMDPIVHVSSFTALFRP
Mflv_1564|M.gilvum_PYR-GCK ----ERRSQLMWDINAYATEQILTRAVD----LGLDPVVSVSSYSALFPP
MLBr_01942|M.leprae_Br4923 ASVTDEYRQRSYTVNVGGTENLLRAGQK----SGVKRFVYTASN-SVVMG
. * . : .: .: .:: ::
MUL_4932|M.ulcerans_Agy99 PNGVIADEDFDPRDSVLDNVYSATKRAGEQLVLDFV-DRGLDVVVVNPAA
MMAR_0164|M.marinum_M PNGVIADEDFDPRDSVLDNVYSATKRAGEQLVLDFV-DRGLDVVVVNPAA
MAB_1682|M.abscessus_ATCC_1997 PNGVVADEDFDPCDSVLDNVYSATKRAGERLMLDFV-ERGLDVVVVNPAA
MAV_1849|M.avium_104 EDGLPVSEDEPFNWADRGGGYIRSRVEAENLVLQYARERGLPAVAMCVSN
TH_2143|M.thermoresistible__bu -PYRPVTEDDPHNWT-EGGAYIEARVAAEQLVLRYARERGLPAVALCIST
MSMEG_6563|M.smegmatis_MC2_155 -ESGPATEEIENNWLDRGGEYVRSRVRAEQLVLRYHKDRGLPAVAMCVSN
Mvan_4271|M.vanbaalenii_PYR-1 -ADGLADEDTAHNWLDKGGAYIRSRVEAEQMVLRYSAEKGLPAVAMCVAN
Mb3752|M.bovis_AF2122/97 NLATLSADLP---VAGGTDGYGQSKAQIEIYARGLQ-DAGAPVNITYPGM
Rv3725|M.tuberculosis_H37Rv NLATLSADLP---VAGGTDGYGQSKAQIEIYARGLQ-DAGAPVNITYPGM
Mflv_1564|M.gilvum_PYR-GCK KNGVISADSP---TADGRSSYAKTKGYADRAARRLQ-DAGAPVVVTYPSS
MLBr_01942|M.leprae_Br4923 GTPITGGDETMPYTKRFNDLYTETKVVAEKFVLSQNGVPDGETMLTCSIR
: . * :: : . .
MUL_4932|M.ulcerans_Agy99 VFAPGFG-PPRSWQGLLVSARKG-LLRVVPPGGTAVCS--ARDFAAGVTA
MMAR_0164|M.marinum_M VFAPGFG-PPRSWQGLLVAARKG-LLRVVPPGGTAVCS--ARDFAAGVTA
MAB_1682|M.abscessus_ATCC_1997 VFAPGAG-PARSWQGLLVAARKG-LLRVVPPGGTAVCS--ARDFVAGITT
MAV_1849|M.avium_104 TYGPGDF-QPTPHGSLVAAAGKGKMPVYVKDMSMEVVG--IEDAARALIL
TH_2143|M.thermoresistible__bu TYGPGDW-QPTPHGRLLAMVATGRFPFYLG-WSAEVVG--IEDAARAMLL
MSMEG_6563|M.smegmatis_MC2_155 TYGPGDW-QPTPHGGLVAAAVRGKMPFYIDGAEAEAVG--VADAAEALVL
Mvan_4271|M.vanbaalenii_PYR-1 TYGPGDF-LPTPHGGMLAAAVAGRLPFYIDGYDAEVVG--IEDAARAMIL
Mb3752|M.bovis_AF2122/97 VLGPPVG-DQFGEAGEGVRSALWMHVIPGRGAAWLIVD--VRDVAALHAA
Rv3725|M.tuberculosis_H37Rv VLGPPVG-DQFGEAGEGVRSALWMHVIPGRGAAWLIVD--VRDVAALHAA
Mflv_1564|M.gilvum_PYR-GCK VVGAAFGGTASGVTERGWAPIVRARVAPRVRAGMQMID--VRDVADVHTR
MLBr_01942|M.leprae_Br4923 PSGIWGRGDQTMFRKAFESVVSGHVKVLIGSKNAKLDNSYVHNLVHGLIL
. . : .
MUL_4932|M.ulcerans_Agy99 AMNKGQPG------RRYILSTDNLSYRQIAELLVRAVGRSHQVRVAPMRP
MMAR_0164|M.marinum_M AMNKGQPG------RRYILSTDNLSYRQIAELLVRAVGRSHQVRVAPMRP
MAB_1682|M.abscessus_ATCC_1997 AMAKGDNG------RRYILSTANLSYRQIGELLVAAVGRHHPVRPAPMGL
MAV_1849|M.avium_104 AAEKGRVG------ERYIVSERYISARELYTTAAEAGGARPPRIGIPLKV
TH_2143|M.thermoresistible__bu AAEQGRVG------ERYIISDRYLHTREVHAIAAEAVGRRAPWFGLPLPV
MSMEG_6563|M.smegmatis_MC2_155 AGERGTPG------ERYIVSERMMSAREIYEVACDAVGVEPPRRGVPIRV
Mvan_4271|M.vanbaalenii_PYR-1 AAERGRTG------ERYIVSERFMSTREIHEIGCAAVGVAPPKFGVPIRV
Mb3752|M.bovis_AF2122/97 LLESGRGP------RRYTAGGHRIPVPELAKILGEVAGTTMLAVPVPDSA
Rv3725|M.tuberculosis_H37Rv LLESGRGP------RRYTAGGHRIPVPELAKILGGSPAPRCWPSRCPIPR
Mflv_1564|M.gilvum_PYR-GCK LMSPGRGP------HRYVCGGVMLTFDEMIDALEEGLGRPVRRIPMSPKA
MLBr_01942|M.leprae_Br4923 AAEHLVPGGTAPGQAYFINDGEPINFFDFMGPIIKACGENWPRVRISGRL
: . : :. . .
MUL_4932|M.ulcerans_Agy99 FRALGMGKRIASDFSSRAHFDDPLVPENIDLMARKVYYDPTRAVRELGIP
MMAR_0164|M.marinum_M FRALGRGKRIASDFSSRAHFDDPLVPENIDLMARKVYYDPTRAVRELGIP
MAB_1682|M.abscessus_ATCC_1997 FRTAGRGNRLLRDLSGRFDPDDVLVAENLELMARELYYAPDRAVRELGIP
MAV_1849|M.avium_104 MYALGLCGDVAAKVLRR---DMLLSTLSVRLMHIMSPMDHSKAERELGWR
TH_2143|M.thermoresistible__bu LSVAARGNDLAARLLRR---DLMFAHVGLKMAELMSPLDHSKAERELGFK
MSMEG_6563|M.smegmatis_MC2_155 MAAAAGLSSAVARLRRR---ETRLSPLTVRLMHVMSPMDHGKAVRELGWK
Mvan_4271|M.vanbaalenii_PYR-1 MSAAGYLSEGVARLRGK---DTMLTPLNIRLMHIMSPMDHSKAVRELDWH
Mb3752|M.bovis_AF2122/97 LRVAGSVLDQAGPYLPF---NTPFTAAGMQYYTQMPEPDDSPSEKELGIT
Rv3725|M.tuberculosis_H37Rv CVSRDRCWIKPGP----------------ICLSILRSPRQVCS-----TT
Mflv_1564|M.gilvum_PYR-GCK LLAVGRISDVAGRYVPL---GDGLSYEAALLLTSATPTDDSVTRQDLGLS
MLBr_01942|M.leprae_Br4923 VRNVMAVWQRLHFGFGLP--KPPMEPLAVERVYLDNYFSIEKAHKELGYR
:
MUL_4932|M.ulcerans_Agy99 KVSV-AELITEFVG---------------------------
MMAR_0164|M.marinum_M KVSV-AELITEFVG---------------------------
MAB_1682|M.abscessus_ATCC_1997 KVST-HELIAEFVR---------------------------
MAV_1849|M.avium_104 PEPI-HDAIRRAVAFYQTR----------------------
TH_2143|M.thermoresistible__bu PEPV-EDSIAKAARFFLEQHR--------------------
MSMEG_6563|M.smegmatis_MC2_155 PAPA-PESIAQAARFFASRRRT-------------------
Mvan_4271|M.vanbaalenii_PYR-1 PQPT-SEAIVAAAHFFRDRRQRAAQGAR-------------
Mb3752|M.bovis_AF2122/97 YRDP-RDTVADTVTALRGLGS--------------------
Rv3725|M.tuberculosis_H37Rv HRCR-SPTIRRAKKN--------------------------
Mflv_1564|M.gilvum_PYR-GCK WRSP-RAAIVESFAAARVSAGRGIA----------------
MLBr_01942|M.leprae_Br4923 PLFTTEQAMAECLPYYTELFEQIKVAAKPHLASIAATPRPE
: