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TVVIAGAGPTGLTLACELTRRGIACRVLDKAPDLFPGSRGKGLSPRTQEVFDDLGIAPAINSGGMAMPPF RIYAGHEVVAERSLVEMLGTDIPSGPGIPYPGFWLVPQWRTDEILLDRLRQFGGDVEFNCEVVGFTQRSD AVSVMVSQGGAPELLHASYLVGADGGRSTVRKMLGVGFAGETFERERTLIGDVRADGLEGSFCHVLTRDG QVSERFSLWNLPGSEHYQFVANMATEDVPALTLDAVQKLVVDRSGRDDIVLRDLRWISLYRVNARMVDRF RVGRVILAGDAAHVHSSAGGQGLNTSVQDAYNLGWKLAAVIYGAPEKLLDTYEEERMPVAASVLGLSTDL HHRNFAPAKGPAPQLHQMDITYRGCSLAVDDRVFQGNLRAGDRAPDALLDNGVRLFDVLRGTHFTLLTFG AQAPVIADVCIQQMTPSPDYDVTATTLVLVRPDGYIGVMTESGRTVLEYLARVV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1496c | - | - | 100% (475) | putative FAD-binding monooxygenase |
| M. abscessus ATCC 19977 | MAB_0857 | - | 7e-48 | 34.34% (498) | hypothetical protein MAB_0857 |
| M. abscessus ATCC 19977 | MAB_3483 | - | 2e-42 | 38.26% (345) | hypothetical protein MAB_3483 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1780 | - | 5e-10 | 22.31% (399) | hypothetical protein Mb1780 |
| M. gilvum PYR-GCK | Mflv_5009 | - | 6e-40 | 33.33% (354) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1751 | - | 2e-10 | 22.31% (399) | hypothetical protein Rv1751 |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4271 | - | 1e-38 | 37.78% (352) | hypothetical protein MMAR_4271 |
| M. avium 104 | MAV_2736 | - | 3e-40 | 31.45% (496) | hypothetical protein MAV_2736 |
| M. smegmatis MC2 155 | MSMEG_2252 | - | 2e-53 | 36.09% (471) | flavin-type hydroxylase |
| M. thermoresistible (build 8) | TH_1880 | - | 3e-46 | 35.26% (363) | flavin-type hydroxylase |
| M. ulcerans Agy99 | MUL_3663 | - | 8e-11 | 24.85% (338) | hypothetical protein MUL_3663 |
| M. vanbaalenii PYR-1 | Mvan_0779 | - | 4e-38 | 29.80% (500) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4271|M.marinum_M -------------------------------------------------M
MAV_2736|M.avium_104 ---------------------------------------MRGVRFSERSV
MSMEG_2252|M.smegmatis_MC2_155 -------------------------------MADAESLAAHGSRVAGKGI
TH_1880|M.thermoresistible__bu --------------------------------------------------
Mflv_5009|M.gilvum_PYR-GCK ----------------------------------------------MPGA
Mvan_0779|M.vanbaalenii_PYR-1 -------------------------------------------------M
Mb1780|M.bovis_AF2122/97 MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Rv1751|M.tuberculosis_H37Rv MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
MUL_3663|M.ulcerans_Agy99 -------------------------------------MPQPS--------
MAB_1496c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4271|M.marinum_M ADHAVVVVGAGPTGLMLAGELALAGVDVAVVERRVSQDLVGSRAGGLHSR
MAV_2736|M.avium_104 RGHAVLVAGAGPTGLMLAGELGLAGVDVALVERRADQQLIGSRAGGLHAR
MSMEG_2252|M.smegmatis_MC2_155 SVKDVVIVGGGPTGAMLAGELRLYEVDVMVLDKDIEPTKV-VRSLGLHAR
TH_1880|M.thermoresistible__bu -VYDVIVVGGGPTGMMLAGELRLHGVRVLVVEKNSEPPAH-VRSLGLHVR
Mflv_5009|M.gilvum_PYR-GCK HRSDVVVVGAGPTGLTLACCLRLHGVSVRVLDAAAGPATT-SRANFLHAR
Mvan_0779|M.vanbaalenii_PYR-1 TDTDVVVVGAGPTGLTLACALRLHGLTVQVVDRAAGPATT-SRANFLHAR
Mb1780|M.bovis_AF2122/97 ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRD-FRGDTVHPT
Rv1751|M.tuberculosis_H37Rv ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRD-FRGDTVHPT
MUL_3663|M.ulcerans_Agy99 ETTSVLVAGGGPAGMVLGLLLARAGVDVTVMEKHADFLRD-SRGDTVHAS
MAB_1496c|M.abscessus_ATCC_199 --MTVVIAGAGPTGLTLACELTRRGIACRVLDKAPDLFPG-SRGKGLSPR
: *.**:* *. * : ::: *. :
MMAR_4271|M.marinum_M TIEVLDQRGIADRFLAQ-GTATQVAR-FAAIPL-DISDFP----TRHNYG
MAV_2736|M.avium_104 TLEILDQRGIVDRFLAE-GQVAQVAG-FAQIRL-DISDFP----TRHPYG
MSMEG_2252|M.smegmatis_MC2_155 SIEIMDQRGLLDRFLEV-GRRHPVGGYFAGITKAPPRTLD----TAHPYV
TH_1880|M.thermoresistible__bu SIEMLDQRGLLDRFLAH-GQRHPVGGFFAAIAK-PPAELD----TAHGYV
Mflv_5009|M.gilvum_PYR-GCK GSEVLDRMGALGTLPQE-SLRALRITNYLGDRPLATLEFGDPGMRTAAPP
Mvan_0779|M.vanbaalenii_PYR-1 GSEVLGRIGALGTLPDE-SLRAMRITNYLGDRPLVTLEFGDPRMRTAAPP
Mb1780|M.bovis_AF2122/97 TMRLLDELGLWERFAALPYSEVRTATLHSNGRAVTYIDFERLHQPYPYVA
Rv1751|M.tuberculosis_H37Rv TMRLLDELGLWERFAALPYSEVRTATLHSNGRAVTYIDFERLHQPYPYVA
MUL_3663|M.ulcerans_Agy99 TLRLLDELGLGSQFAQIPHRLIDTISMKVQGQPVD-LDLKHLPGAHQHIA
MAB_1496c|M.abscessus_ATCC_199 TQEVFDDLGIAPAINSG-GMAMPPFRIYAGHEVVAERSLVEMLGTDIPSG
.::. * : :
MMAR_4271|M.marinum_M LALWQN--------RIERILAEWVAELRVRIYRGCEVTDITQ-------D
MAV_2736|M.avium_104 LALWQN--------HIERILADWVGELGVPIYRGHRIATCTQ-------D
MSMEG_2252|M.smegmatis_MC2_155 LGIPQP--------VTDRILVEHAVASGAVLRRGCEAVGLAQ-------D
TH_1880|M.thermoresistible__bu LGIRQP--------VTDRLLAEWAAERGAVIRRGCAVVGLDQ-------D
Mflv_5009|M.gilvum_PYR-GCK MVVSQA--------KVEAALRARLADLDVEPEWGRKVIDVRE-------D
Mvan_0779|M.vanbaalenii_PYR-1 MVISQA--------KVEASLRSRLADLGAEPQWGNGLAALHR-------N
Mb1780|M.bovis_AF2122/97 MVPQWD--------LLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGK
Rv1751|M.tuberculosis_H37Rv MVPQWD--------LLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGK
MUL_3663|M.ulcerans_Agy99 LVPQWD--------FLELLAAAAEAEPTFRLLRSTEVTGVLWGDGPDPGR
MAB_1496c|M.abscessus_ATCC_199 PGIPYPGFWLVPQWRTDEILLDRLRQFGGDVEFNCEVVGFTQ-------R
:
MMAR_4271|M.marinum_M DNGVDLTLSDG---PPLRADYVVGCDGGRSLVRRAVGIDFPGWDP-TTSS
MAV_2736|M.avium_104 DTGVDVVASDG---RTLRGQYLVGCDGGRSVIRKAAGIDFPGWEA-TTSY
MSMEG_2252|M.smegmatis_MC2_155 DDGVSVTLADG---TQVRARYVVGCDGGRSTVRKLMGVGFPGEPS-RVDT
TH_1880|M.thermoresistible__bu AAGITVELADG---SVQRARYLVGCDGGRSTVRKLAGIGFPGEPA-RSET
Mflv_5009|M.gilvum_PYR-GCK ADGVVADLADG---ARVRGQWLVGCDGTTSVVRRQTGIEFPGVRL-SERF
Mvan_0779|M.vanbaalenii_PYR-1 DDTVVAELDDG---TSVEARWLVGCDGTASTTRKLAGIGFPGVKL-TERW
Mb1780|M.bovis_AF2122/97 VTGVRYQGAEG-P-GELRAELTVACDGRWSIARHEAGLKAREFPV-NFDV
Rv1751|M.tuberculosis_H37Rv VTGVRYQGAEG-P-GELRAELTVACDGRWSIARHEAGLKAREFPV-NFDV
MUL_3663|M.ulcerans_Agy99 VVSATYRAQSGET-KHMHADLTVACDGRGSTVRSALGMATRSFGA-PMDV
MAB_1496c|M.abscessus_ATCC_199 SDAVSVMVSQGGAPELLHASYLVGADGGRSTVRKMLGVGFAGETFERERT
.* .. *..** * * *:
MMAR_4271|M.marinum_M LIAEVEVAVGSESG-PNLGEVRHDALGVHGFTRLPD---GGPLRVVVTER
MAV_2736|M.avium_104 LLAEAEMDWRTGQP-PQWG-IHHDSLGVHALSETEP---AGGVRVLVTER
MSMEG_2252|M.smegmatis_MC2_155 LIGEMQVGVTPEQVTAVVAEVRKMQLRFGAGPLGDG---LYRVMVPAAEV
TH_1880|M.thermoresistible__bu LLGEMSLSADPATVAAVVAEVRKTQLRFGAMPLGDG---VYRVIVPAEGV
Mflv_5009|M.gilvum_PYR-GCK LLADIHLDWAVDRAGTTGWIHPDGVVGAMPMPSTDGRDDLWRLFVYDPSL
Mvan_0779|M.vanbaalenii_PYR-1 LLADLHLDWDLDRGGTTGWIHPGGLLGAMPMPDSSGAHDLWRVFAYDPGH
Mb1780|M.bovis_AF2122/97 WWFKLPREGDAEFS---FLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQ
Rv1751|M.tuberculosis_H37Rv WWFKLPREGDAEFS---FLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQ
MUL_3663|M.ulcerans_Agy99 WWFRLPRRPDDPTG---LAGIFNSGHGGIAIDRGDYYQIAYIIPKGSDAQ
MAB_1496c|M.abscessus_ATCC_199 LIGDVRADGLEGSFCHVLTRDGQVSERFSLWNLPGS-----EHYQFVANM
MMAR_4271|M.marinum_M QLDAGGEPSLGDLSAALTAVYGTD-YGIHSPTWISRFTDLTRQAATYRQG
MAV_2736|M.avium_104 QLRSAAEPNLDDLRQALIAVYRTD-YGIHSPRWISRFTDAARQAARYRDR
MSMEG_2252|M.smegmatis_MC2_155 VEDRSATPTLDEFRQQLRATAGTD-LGVHSPRWLSRFGDGTRLADRYRTG
TH_1880|M.thermoresistible__bu AGDR-AEPTLDEFRRRLKAFAGTD-FGAHTPRWLSRFGDATRLAERYRAG
Mflv_5009|M.gilvum_PYR-GCK DRKPTDSEILDRISELVPYRTGRR-VKIGDAEWLSMFTVHRRLADTYRRG
Mvan_0779|M.vanbaalenii_PYR-1 TEKPAESEILERMRQVIPQRSGRR-VHVGDPEWLSVFTVHRRLADRYRQG
Mb1780|M.bovis_AF2122/97 LRERGIEEFRRDVSELLPEATASV-AALASTDEVKHLNVKVNRLRRWHID
Rv1751|M.tuberculosis_H37Rv LRERGIEEFRRDVSELLPEATASV-AALASMDEVKHLNVKVNRLRRWHID
MUL_3663|M.ulcerans_Agy99 LRAQGIEALHRALADLMPWLADRV-DALKSFDDVKLLDVQLNRLRRWYCD
MAB_1496c|M.abscessus_ATCC_199 ATEDVPALTLDAVQKLVVDRSGRDDIVLRDLRWISLYRVNARMVDRFRVG
. : :. . :
MMAR_4271|M.marinum_M RVLIAGDAAHVHDPVGGQGLNTGVQDAVNLGWKLAQVVNRRSPESLLDTY
MAV_2736|M.avium_104 RVLLAGDAAHIHHPVGGQGLNTGVQDAVNLGWKLALVVGGASPPALLDTY
MSMEG_2252|M.smegmatis_MC2_155 RVLLAGDAAHVHPPVGGQGLNLGVQDAFNLGWKLAASINGWAPDGLLDSY
TH_1880|M.thermoresistible__bu RVFLAGDAAHVHPPAGGQGLNLGIQDAFNLGWKLAAAVGGWAPDGLLDTY
Mflv_5009|M.gilvum_PYR-GCK RVLIAGDAAHVHAPFGGQGMLTGIGDAENVGFKLALVVRGLAADDLLDTY
Mvan_0779|M.vanbaalenii_PYR-1 RILIAGDAAHAHAPFGGQGMLTGIGDAENLAFKLALVTRGLAADPFVDTY
Mb1780|M.bovis_AF2122/97 GLLCIGDAAHAMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAA
Rv1751|M.tuberculosis_H37Rv GLLCIGDAAHAMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAA
MUL_3663|M.ulcerans_Agy99 GALCIGDAAHAMSPVGGVGINLALADAVATARMLAPSLRVGRVSTGQLAR
MAB_1496c|M.abscessus_ATCC_199 RVILAGDAAHVHSSAGGQGLNTSVQDAYNLGWKLAAVIYG-APEKLLDTY
: ***** . .* *: .: ** . ** :
MMAR_4271|M.marinum_M HAERHPVAARVLR--TTMAQVALRRLDYRKKALSDTISELLMMDEPRKRF
MAV_2736|M.avium_104 HAERHPVGERVLR--NAIAQMALLRPDERTRALRDLVTELLGMDEPRKRF
MSMEG_2252|M.smegmatis_MC2_155 EAERRPVAAAVLD--NTRAQMELLSPEPGPQAVRRLLAQLMAFEEVNRYL
TH_1880|M.thermoresistible__bu HAERHPVAADVLN--NTRAQMELMSPEPGPRAVRWLLAELMDFEEVNRYL
Mflv_5009|M.gilvum_PYR-GCK EAERRPLATQVLRGTSAITRVNVAGNPIVRFLRDRVAPRVFGLPAVQRWT
Mvan_0779|M.vanbaalenii_PYR-1 EAERRPLATEVLRGTSAVTRVNIAGNPVGRFLRDRVAPKVFGLAPVQRWT
Mb1780|M.bovis_AF2122/97 VRRRRAFPTAVTQAVQRVLHRRLLGPLLQGRDPTPPAALLGLVERLPWLS
Rv1751|M.tuberculosis_H37Rv VRRRRAFPTAVTQAVQRVLHRRLLGPLLQGRDPTPPAALLGLVERLPWLS
MUL_3663|M.ulcerans_Agy99 VQARRWAPTAFLQGIQRAIHAAIVAVAVTGGPPQPPPVVR-LVSRSVPVR
MAB_1496c|M.abscessus_ATCC_199 EEERMPVAASVLGLSTDLHHRNFAP-------AKGPAPQLHQMDITYRGC
* . : . .
MMAR_4271|M.marinum_M AAMMSGLDIRYH-----LGGGHPLLGRRMPDLDLTTADGPRRVFTHLHAA
MAV_2736|M.avium_104 AAMISGLDVRYD-----LGPGHPLLGRRMPDLDLVTADGASRVFALLRNA
MSMEG_2252|M.smegmatis_MC2_155 TEMITATGIRYD-----FGAEDDLVGRRLRDIRLRRG----RLYELTRTG
TH_1880|M.thermoresistible__bu TEKITAIGVRYHT----MGDGHGLLGRRMRDIPLTGG----RLYARMHAG
Mflv_5009|M.gilvum_PYR-GCK TYTASQLWVSYRNGPLGGRGSKPRPGDRIDDAPCSRPDGTATRLHGELGG
Mvan_0779|M.vanbaalenii_PYR-1 TYTASQLWVSYRKGPLGGRGPKPRAGDRIPDVACVRPDGTPSLLHRELSG
Mb1780|M.bovis_AF2122/97 AVPAYFVGVGVRP------EHAPAFARRGPGNRKGP--------------
Rv1751|M.tuberculosis_H37Rv AVPAYFVGVGVRP------EHAPAFARRGPGNRKGP--------------
MUL_3663|M.ulcerans_Agy99 RIMGYLVAIGPLP------EHAPKYPRRAR--------------------
MAB_1496c|M.abscessus_ATCC_199 SLAVDDRVFQGN----------LRAGDRAPDALLDNG---VRLFDVLRGT
. *
MMAR_4271|M.marinum_M RPVLLNLAEPGRFDIAGWRHRVLLIDAKYVGVWELPVLGAIAAPAAALIR
MAV_2736|M.avium_104 RPVLLNFAGAGRRSVAGWADRVRVVDAKCVADWELPVLGRVSAPPAVLIR
MSMEG_2252|M.smegmatis_MC2_155 RGLLLDQT--GQLSAAGWSDRVDHVVD----------VSDELDVPAVLLR
TH_1880|M.thermoresistible__bu RGVLLDRT--GTLSVSGWADRVDHIVD----------PGAALDVPAVLLR
Mflv_5009|M.gilvum_PYR-GCK RWALLLPRGVPAVGAAAVRGPAGYLAD-------HVVTLHHDRDDVMLVR
Mvan_0779|M.vanbaalenii_PYR-1 RWALLAPPDAPAGCADVAR---RHLGD-------FVEPLTFDGDEAMLIR
Mb1780|M.bovis_AF2122/97 --------------------------------------------------
Rv1751|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3663|M.ulcerans_Agy99 --------------------------------------------------
MAB_1496c|M.abscessus_ATCC_199 HFTLLTFGAQAPVIADVCIQQMTPSPD-----------YDVTATTLVLVR
MMAR_4271|M.marinum_M PDGYVAWVGDD-LTDRGLFDALTAWFGRPAVPSPRLRASAP
MAV_2736|M.avium_104 PDGHVAWAGD--PNDPGLHDALTTWCGPPAAGG--------
MSMEG_2252|M.smegmatis_MC2_155 PDGHIAWVGDE---QGDLEGCLVRWFGVPA-----------
TH_1880|M.thermoresistible__bu PDGHVAWVGADHPGQQDLTARLSRWFGAPA-----------
Mflv_5009|M.gilvum_PYR-GCK PDAHLAWRGAH-----DDPTGLDRWLATALHPGGTQ-----
Mvan_0779|M.vanbaalenii_PYR-1 PDGHLAWRGDA-----GDADGVNLWLTRALTTGNAR-----
Mb1780|M.bovis_AF2122/97 -----------------------------------------
Rv1751|M.tuberculosis_H37Rv -----------------------------------------
MUL_3663|M.ulcerans_Agy99 -----------------------------------------
MAB_1496c|M.abscessus_ATCC_199 PDGYIGVMTES-------GRTVLEYLARVV-----------