For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MILLAVCLAVFMLLLDMTIVSSALADLQASLGADLSDLQWVIDAYALPMAGLLLTAATLGDRLGRRRLYL LGMALFTTASLVCALSGSAAMLIGVRAVQGTGGAILLAVSLPIIAAAYPQERRGGPIAIYGAVMGAGSAA GPLLGGFLVTHFGWQSIFLVNLPVGVIALIIAARHLPETRAEQTRPVDWVGTMLLTCGLLTGVFAVISLH GGGIGARACAALALCAVVALALFLWWEGRTPAPMLSLRLVTSPGFAGVWVAAAAASGTLIGATNYLALYF MNTLGYNAFETGLRAGPLTLATIAGAPLGILVGKRLPSVVTIPGGVALVAVGLWAATGAHAGTVWTHFIF GSALAGLGLGALSAVTSDAALQFVPLDDAGMATGSVSTGRQIGILLGVAGMGVAFGLAAAGQSGPRAAGA AAINSVLAWGALAAACAAFVSLILLSVATISRSHDPATGESLAI
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_1935 | - | - | 100% (464) | putative drug resistance transporter |
M. abscessus ATCC 19977 | MAB_0945 | - | 1e-60 | 33.42% (404) | EmrB/QacA family drug resistance transporter |
M. abscessus ATCC 19977 | MAB_1396 | - | 1e-58 | 34.07% (455) | EmrB/QacA family drug resistance transporter |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2361c | - | 2e-57 | 34.89% (407) | integral membrane transport protein |
M. gilvum PYR-GCK | Mflv_1730 | - | 3e-64 | 34.73% (455) | EmrB/QacA family drug resistance transporter |
M. tuberculosis H37Rv | Rv2333c | - | 4e-57 | 34.89% (407) | integral membrane transport protein |
M. leprae Br4923 | MLBr_01562 | - | 5e-39 | 27.31% (454) | putative transmembrane efflux protein |
M. marinum M | MMAR_1146 | - | 1e-64 | 35.59% (413) | integral membrane transport protein |
M. avium 104 | MAV_1387 | - | 1e-47 | 31.54% (447) | drug transporter |
M. smegmatis MC2 155 | MSMEG_5670 | - | 6e-63 | 34.60% (422) | efflux membrane protein |
M. thermoresistible (build 8) | TH_3965 | - | 1e-55 | 34.22% (450) | PUTATIVE drug transporter |
M. ulcerans Agy99 | MUL_0911 | - | 1e-64 | 34.66% (427) | integral membrane transport protein |
M. vanbaalenii PYR-1 | Mvan_5021 | - | 6e-62 | 34.67% (424) | EmrB/QacA family drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_1146|M.marinum_M --------------------------------------------MRIQPV MUL_0911|M.ulcerans_Agy99 --------------------------------------------MRIQPV MAB_1935|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_1387|M.avium_104 -------------------------------------------------- TH_3965|M.thermoresistible__bu ----------------------------VTSVDAGRSTMSEVFTAYAPRS Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------M Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------M MSMEG_5670|M.smegmatis_MC2_155 ------------------------------------------MNETVGAL Mb2361c|M.bovis_AF2122/97 -------------------------------------------------- Rv2333c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF MMAR_1146|M.marinum_M FRDHPIPALAVICLSVFVISVDATIVNVALPTLSRQLGADTAQLQWIVDA MUL_0911|M.ulcerans_Agy99 FRDHPILALAVICLSVFVISVDATIVNVALPTLSRELGADTAQLQWIVDA MAB_1935|M.abscessus_ATCC_1997 ------MILLAVCLAVFMLLLDMTIVSSALADLQASLGADLSDLQWVIDA MAV_1387|M.avium_104 -----------MMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVWVTSA TH_3965|M.thermoresistible__bu AAANPWHALWAMLIGFFMILVDATIVPVANLEIMADLGADYTAVIWVTSA Mflv_1730|M.gilvum_PYR-GCK TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRADLSASPAQMQWVVDI Mvan_5021|M.vanbaalenii_PYR-1 TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRDDLSATPAQMQWVVDV MSMEG_5670|M.smegmatis_MC2_155 SARRKAIILVSCCLSLLIVSMDATIVNVAIPSIRSDLGASPSQLQWVIDV Mb2361c|M.bovis_AF2122/97 MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS Rv2333c|M.tuberculosis_H37Rv MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA :: :* :. * : .: * MMAR_1146|M.marinum_M YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLIA MUL_0911|M.ulcerans_Agy99 YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLVA MAB_1935|M.abscessus_ATCC_1997 YALPMAGLLLTAATLGDRLGRRRLYLLGMALFTTASLVCALSGSAAMLIG MAV_1387|M.avium_104 YLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLIA TH_3965|M.thermoresistible__bu YLLAYAVPLLIAGRLGDRFGPRTMYLIGLAIFTAASLWCGLAGTIGMLIA Mflv_1730|M.gilvum_PYR-GCK YTLVLASLLMLSGATGDRFGRRRLFQIGLTVFALGSLACSLAPTIDTLIG Mvan_5021|M.vanbaalenii_PYR-1 YTLVLASLLMLSGATGDRFGRRRVFQIGLAVFALGSLACSLAPTIDALIG MSMEG_5670|M.smegmatis_MC2_155 YTLVLASLLLLAGATGDRFGRRRTFHLGLTVFAVASLLCSVAPNIETLIA Mb2361c|M.bovis_AF2122/97 YSLGMAVFIMSAATLADLYGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT Rv2333c|M.tuberculosis_H37Rv YSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI * * . :: .. .* * : *: :*: * .. * MMAR_1146|M.marinum_M ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI MUL_0911|M.ulcerans_Agy99 ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI MAB_1935|M.abscessus_ATCC_1997 VRAVQGTGGAILLAVSLPIIAAAYPQER-RGGPIAIYGAVMGAGSAAGPL MAV_1387|M.avium_104 ARVVQGVGAGVMTPQTLSTITRIFP-AERRGVAVSVWSATAGAASLAGPL TH_3965|M.thermoresistible__bu ARVLQGLGAALLTPQTLSMITRIFP-ADRRGVPMGVWGATAGVATLIGPL Mflv_1730|M.gilvum_PYR-GCK ARFLQGVGGSMLNPVALSIISQIFTKPVERARALGIWGGVTGISMAAGPI Mvan_5021|M.vanbaalenii_PYR-1 ARLLQGIGGSMLNPVALSIISQIFTQPVERARALGIWGGVTGISMAAGPI MSMEG_5670|M.smegmatis_MC2_155 ARLLQAIGGSMLNPVAMSIITQVFTGRVERARAIGVWGSVVGISMALGPL Mb2361c|M.bovis_AF2122/97 ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT Rv2333c|M.tuberculosis_H37Rv ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV .* . *.. : :: :. : . .:: . . . * MMAR_1146|M.marinum_M TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSRDPAAPRVDVPGLM MUL_0911|M.ulcerans_Agy99 TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSRDPAAPRVDVPGLM MAB_1935|M.abscessus_ATCC_1997 LGGFLVTHFGWQSIFLVNLPVGVIALIIAARHLPETRAEQTRPVDWVGTM MAV_1387|M.avium_104 AGGVLVDGLGWQWIFFVNVPIGVLGLVLAYWLVPVLPTQSHR-FDLVGVG TH_3965|M.thermoresistible__bu AGGVLVDGLGWQWIFIVNVPIGIAGLVLGARLMPRLPRQDQG-FDVLGMV Mflv_1730|M.gilvum_PYR-GCK VGGLLIETVGWRSVFWINLPICAAAIILTAVFVPESKSQTMRNVDPIGQG Mvan_5021|M.vanbaalenii_PYR-1 VGGLLIDTIGWRSVFWINLPICAAAILLTAIFVPESKSQTMRNVDPIGQG MSMEG_5670|M.smegmatis_MC2_155 VGGALIEYVDWRAVFWINLPICALAILLTAIFVRESKSSTMRDVDPVGQG Mb2361c|M.bovis_AF2122/97 LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL Rv2333c|M.tuberculosis_H37Rv LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKERMK-LDAAGAI ** * * * :*:*: : : .* * MMAR_1146|M.marinum_M LSAVGITALVYTIIEAPNWGWTSTRASGGFIAAAIVLVGFALWERRSSHP MUL_0911|M.ulcerans_Agy99 LSAVGITALVYTIIEAPNWGWTSTRASGGFIAAAIVLVGFALWERRSSHP MAB_1935|M.abscessus_ATCC_1997 LLTCGLLTGVFAVISLHGGGIGARACAALALCAVVALALFLWWEGRTPAP MAV_1387|M.avium_104 LSGVGMLLIVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVREP TH_3965|M.thermoresistible__bu LSAVGLFLIVFALQEAQTHRWAPWIWGTLAGGAGVMAMFVIWQSANRRHP Mflv_1730|M.gilvum_PYR-GCK LGILFLFGTVFTLIEGPVLGWTNPRVLAIAAVAVVALIAFLRFESRRHDP Mvan_5021|M.vanbaalenii_PYR-1 LAIMFLFGTVFTLIEGPVLGWTNPRVVVAAVVVALALVAFLRFESRRHDP MSMEG_5670|M.smegmatis_MC2_155 LGVAFLFGVVFVLIEGPGMGWTDPRTLAVAATALVAFLAFLRYESRRHDP Mb2361c|M.bovis_AF2122/97 LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP Rv2333c|M.tuberculosis_H37Rv LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAENP * *: . . . . . * MMAR_1146|M.marinum_M MLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQTGV MUL_0911|M.ulcerans_Agy99 MLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQTGV MAB_1935|M.abscessus_ATCC_1997 MLSLRLVTSPGFAGVWVAAAAASGTLIGATNYLALYFMNTLGYNAFETGL MAV_1387|M.avium_104 LIPLVIFSDRDFSLCNIGVAIISFAATAMMLPLTFYAQAVCGLSPTRSAL TH_3965|M.thermoresistible__bu LVPLQIFADRNFMLANVGVATIGFVVTAMVLPAMFFAQAVCGLSPTGSAL Mflv_1730|M.gilvum_PYR-GCK FLDLRFFRSIPFTTATINAISAFAAWGAFLFMMSLYLQGERGFSAMQTGL Mvan_5021|M.vanbaalenii_PYR-1 FLDLRFFRSIPFTTATVIAISAFAAWGAFLFLMSLYLQGERGFSAMHTGL MSMEG_5670|M.smegmatis_MC2_155 FIDLRFFRSVPFASATLVAVCAFAAYGAFLFMMSLYLQSERGYSAMFTGL Mb2361c|M.bovis_AF2122/97 MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL Rv2333c|M.tuberculosis_H37Rv MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL MLBr_01562|M.leprae_Br4923 VVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAGI .: . .. . . . : . .. :.: MMAR_1146|M.marinum_M RLLPVALSIALAAILGPRLVERVGTTAVVAAGLAVFAAALAWAS-TADAT MUL_0911|M.ulcerans_Agy99 RLLPVAFSIALAAILGPRLVERVGTTAVVAAGLAVFAAALAWAS-TADAT MAB_1935|M.abscessus_ATCC_1997 RAGPLTLATIAGAPLGILVGKRLPSVVTIPGGVALVAVGLWAAT-GAHAG MAV_1387|M.avium_104 LIAPMAIANGVFAPFVGKIVDRYHPRPVLGFGFSLLAIALTWLTFEMSPA TH_3965|M.thermoresistible__bu LIAPMAVASGVLAPMAGRIVDRSHPTPVVGFGFSVVAVGLTWLAVEMAPT Mflv_1730|M.gilvum_PYR-GCK IYLPIALGALFCSPLSGRLVGRYGARPSLVAAG-ILITTAATLLTLLTAT Mvan_5021|M.vanbaalenii_PYR-1 IYLPIAIGALLFSPLSGRLVGRYGARPSLVIAG-VTITAAATMLTFLTAT MSMEG_5670|M.smegmatis_MC2_155 IYLPIAIGALIFSPLSGRMVGRFGSRPSLVSAG-VLITAATVMLAQMTAT Mb2361c|M.bovis_AF2122/97 MILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEHRS Rv2333c|M.tuberculosis_H37Rv MILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEHRS MLBr_01562|M.leprae_Br4923 GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNRG *. . . : * . . : MMAR_1146|M.marinum_M TPYTQIALQMLLLG-GGLGLTTAPATEAIMGSLPADRAGVGSAVNDTTRE MUL_0911|M.ulcerans_Agy99 TPYTQITLQMLLLG-GGLGLTTAPATEAIMGSLPADRAGVGSAVNDTTRE MAB_1935|M.abscessus_ATCC_1997 TVWTHFIFGSALAG-LGLGALSAVTSDAALQFVPLDDAGMATGSVSTGRQ MAV_1387|M.avium_104 TPIWRLVLPFFAMG-VGMAFVWSPLTATATRNLSAQLAGAGSAVYNSVRQ TH_3965|M.thermoresistible__bu TPIWRLVLPFVAVG-VGMAFIWSPLATTATRQLPLHLSGAGSGVYNTTRQ Mflv_1730|M.gilvum_PYR-GCK TPVWHLLIVFAVFG-VGFSMVNAPITNAAVSGMPLDRAGAASAVTSTSRQ Mvan_5021|M.vanbaalenii_PYR-1 TPVWSLLMVFAVFG-IGFSMVNAPVTNAAVSGMPLDRAGAASAVTSTSRQ MSMEG_5670|M.smegmatis_MC2_155 TPVWLLLVIFAVFG-IGFALVNAPITTAAVSGMPLDRAGAASAVASTSRQ Mb2361c|M.bovis_AF2122/97 S--ALVLVGLGLCG-SGVALCLTPITTVAMTAVPAERAGMASGIMSAQRA Rv2333c|M.tuberculosis_H37Rv S--ALVLVGLGLCG-SGVALCLTPITTVAMTAVPAERAGMASGIMSAQRA MLBr_01562|M.leprae_Br4923 VPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQS . * *.. : : . * :. : MMAR_1146|M.marinum_M LGGTLGVAIAGSVFASVYSGQLGSASTLATLPSDVRS------------- MUL_0911|M.ulcerans_Agy99 LGGTLGVAIAGSVFASVYSGQLGSASALATLPSDVRS------------- MAB_1935|M.abscessus_ATCC_1997 IGILLGVAGMGVAFG----------------------------------- MAV_1387|M.avium_104 LGAVLGSAGMAAFMTWRIGAEMPGQPGGGGEDSAGPVLPEFLRGPFAAAM TH_3965|M.thermoresistible__bu IGSVLGSAGMAAFLTGRLSAELPFGATAVPAGEQTRVLPEFLHAPYAAAM Mflv_1730|M.gilvum_PYR-GCK VGVSIG----VALCGSVAGAAMAGSGTDFATAAR---------------- Mvan_5021|M.vanbaalenii_PYR-1 VGVSIG----VALCGSLAGSAMATGGADFAAAAR---------------- MSMEG_5670|M.smegmatis_MC2_155 VGVSIG----VALCGSVAGTALAGTGVDFAAASR---------------- Mb2361c|M.bovis_AF2122/97 IGSTIGFAVLGSVLAAWLSATLEPHLERAVPDPVQR-------------- Rv2333c|M.tuberculosis_H37Rv IGSTIGFAVLGSVLAAWLSATLEPHLERAVPDPVQR-------------- MLBr_01562|M.leprae_Br4923 LGGPLVLAVIQAVITSRTLYLGGTTG------------------------ :* : MMAR_1146|M.marinum_M ----AMKGSMAVAHKVIDQLPAGPAAGVRDAVN----------------- MUL_0911|M.ulcerans_Agy99 ----AMKGSMAVAHKVIDQLPAGPAAGVRDAVN----------------- MAB_1935|M.abscessus_ATCC_1997 -------------------LAAAGQSGPRAAGA----------------- MAV_1387|M.avium_104 SQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDYHDDY TH_3965|M.thermoresistible__bu AQSMLLPAFVALFGVLAAIFLAGIVLSTPQP---------DADAQYLDEH Mflv_1730|M.gilvum_PYR-GCK ------PLWFVCIALGLVILAVGFFSTSQRA------------------- Mvan_5021|M.vanbaalenii_PYR-1 ------PLWFVCMALGLVILGLGLFATSQRA------------------- MSMEG_5670|M.smegmatis_MC2_155 ------PLWLICTALGVVIVAIGIVSTSPWA------------------- Mb2361c|M.bovis_AF2122/97 ----HVLAEIIIDSANPRAHVGGIVPRRHIEHR----------------- Rv2333c|M.tuberculosis_H37Rv ----HVLAEIIIDSANPRAHVGGIVPRRHIEHR----------------- MLBr_01562|M.leprae_Br4923 -------PVKFMNDAQLRALDHGYTYG----------------------- . MMAR_1146|M.marinum_M -------------------------------------------------- MUL_0911|M.ulcerans_Agy99 -------------------------------------------------- MAB_1935|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_1387|M.avium_104 DDDDAYVELILVREPEPEAQQRAGQPRRPQPTPAPPADVRRRDPVESRRS TH_3965|M.thermoresistible__bu DD---YLVIELAR-----------------PDPNPRTDIAVTAVIPALRP Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- Mb2361c|M.bovis_AF2122/97 -------------------------------------------------- Rv2333c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01562|M.leprae_Br4923 -------------------------------------------------- MMAR_1146|M.marinum_M -----------------------------HAFLDGLQVATLVCAGIALAA MUL_0911|M.ulcerans_Agy99 -----------------------------HAFLDGLQVATLVCAGIALAA MAB_1935|M.abscessus_ATCC_1997 -----------------------------AAINSVLAWGALAAACAAFVS MAV_1387|M.avium_104 VLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPADRFTRPPR TH_3965|M.thermoresistible__bu TLRP--------------------------TLR--PSLGPPGGPVVQP-- Mflv_1730|M.gilvum_PYR-GCK -------------------------------VRSAERLAPLVAGAPDP-- Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------LRSAERLAPLVSGAPEP-- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------LRSAERLAPLIGQHHRP-- Mb2361c|M.bovis_AF2122/97 ----------------------DPVAIAEEDFIEGIRVALLVATATLAVV Rv2333c|M.tuberculosis_H37Rv ----------------------DPVAIAEEDFIEGIRVALLVATATLAVV MLBr_01562|M.leprae_Br4923 -------------------------------LLWVAGAVVIVGVAALFIG . MMAR_1146|M.marinum_M AIVVGWLLPARAGQPTPAQTEPALAQA-------------------- MUL_0911|M.ulcerans_Agy99 AIVVGWLLPARAGQPTPAQTEPALAQV-------------------- MAB_1935|M.abscessus_ATCC_1997 LILLSVATISRSHDPATGESLAI------------------------ MAV_1387|M.avium_104 RHHPGPAGHHLGEGESLRGQHHRPDPDDDPTGYGRHSSGN------- TH_3965|M.thermoresistible__bu -----------NNTAALR----------------------------- Mflv_1730|M.gilvum_PYR-GCK -----------VNGAHVR----------------------------- Mvan_5021|M.vanbaalenii_PYR-1 -----------VGGAHVR----------------------------- MSMEG_5670|M.smegmatis_MC2_155 -----------AEVAHAR----------------------------- Mb2361c|M.bovis_AF2122/97 FLAGWRWFPRDVQTAGSDAKR--EAAYSDDRRVRG------------ Rv2333c|M.tuberculosis_H37Rv FLAGWRWFPRDVHTAGSDLSERLPTAMTVECAVSHMPGATWCRLWPA MLBr_01562|M.leprae_Br4923 YTPEQVAYAQEVKEAVDAGEL--------------------------