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SERRFLVTGSSGHLGEALVRTLRRDGVDVVGIDIAAGPATDIVGSIADRGLVAEAMSGMTSVLHTATLHK PHIGSHPRTDFVETNIEGTLSVLEAAVAAGVRSFVYTSTTSAFGHALVGAREAAWITEAVASVPKNIYGA TKTAAEDIAHVVHQDSGLPVIVLRTSRFFPEQDDNDRVRNRYRDGNVKANEYLYRRVDLADVVDAHLLAA ERGPEIGWAKYVISATTPFSPGDAAQLRTDPGAVVARYFPEQPGLYAARGWSMFPTIDRVYVNARARDDL GWQPRYDYRRILDCLAAEQDFRSPLAREIGAKGYHDEPTGVYTT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1344c | - | - | 100% (325) | putative dTDP-glucose-4,6-dehydratase-related protein |
| M. abscessus ATCC 19977 | MAB_1682 | - | 7e-10 | 30.68% (176) | NAD-dependent epimerase/dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 2e-09 | 24.60% (313) | UDP-glucose 4-epimerase GalE1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3497c | rmlB2 | 2e-84 | 50.00% (316) | dTDP-glucose 4,6-dehydratase RmlB2 |
| M. gilvum PYR-GCK | Mflv_2075 | - | 4e-12 | 27.04% (355) | 3-beta hydroxysteroid dehydrogenase/isomerase |
| M. tuberculosis H37Rv | Rv3468c | - | 2e-84 | 49.68% (316) | dTDP-glucose 4,6-dehydratase |
| M. leprae Br4923 | MLBr_01942 | - | 5e-10 | 29.76% (168) | putative cholesterol dehydrogenase |
| M. marinum M | MMAR_3324 | - | 1e-16 | 32.73% (165) | nucleoside-diphosphate-sugar epimerase |
| M. avium 104 | MAV_1225 | - | 4e-13 | 26.33% (338) | 3-beta hydroxysteroid dehydrogenase/isomerase family protein |
| M. smegmatis MC2 155 | MSMEG_5976 | - | 9e-12 | 28.90% (173) | epimerase/dehydratase |
| M. thermoresistible (build 8) | TH_3827 | - | 3e-13 | 31.14% (167) | PUTATIVE putative dehydrogenase |
| M. ulcerans Agy99 | MUL_0172 | - | 2e-12 | 24.72% (352) | cholesterol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5705 | - | 1e-12 | 27.83% (327) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1225|M.avium_104 ---------------------MIGPMGDPSLTAELGRVLVTGGSGFVGAN
MUL_0172|M.ulcerans_Agy99 ---------------------MLRPMGDASLTTELGRVLVTGGSGFVGSN
MLBr_01942|M.leprae_Br4923 ---------------------MLRGVGNASLTTELGRVLVTGGSGFVGAN
Mflv_2075|M.gilvum_PYR-GCK ---------------------MLR--------TELGRVLVTGGSGFVGAN
MMAR_3324|M.marinum_M --------------------MSTDQSARPAPFFAQRKIFITGANGFIGAN
TH_3827|M.thermoresistible__bu ---------------------MTDEDRIPCGAMSRPSVFITGANGFIGRS
Mb3497c|M.bovis_AF2122/97 MGTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSGHLGEA
Rv3468c|M.tuberculosis_H37Rv MGTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSGHLGEA
MAB_1344c|M.abscessus_ATCC_199 --------------------------------MSERRFLVTGSSGHLGEA
Mvan_5705|M.vanbaalenii_PYR-1 -----------------------------------MTALVIGANGYLGSH
MSMEG_5976|M.smegmatis_MC2_155 -----------------------------------MRVLVTGHQGYLGTV
:: * .*.:*
MAV_1225|M.avium_104 LVTTLLERGYQVRSFDRA--PSPLPAHPHLEVLQGDITDAGVCAAAVEGI
MUL_0172|M.ulcerans_Agy99 LVTTLLDRGHHVRSFDRA--PSPLPPHPQLEVLQGDITDAATCATAVDGV
MLBr_01942|M.leprae_Br4923 LVTALLERGYQVRSFDRA--PMPLPQHPQLEVLQGDITDATVCTTAMDSI
Mflv_2075|M.gilvum_PYR-GCK LVTELLDRGLHVRSFDRV--ASALPAHARLEIVEGDITDADDVAAAVEGV
MMAR_3324|M.marinum_M LAARLRQLGARVTGVD-------LVADPANGIIAGSTADPAAWASALDGV
TH_3827|M.thermoresistible__bu LGAHFAENGYDVRGVD-------LAADPARNVVAGDVVNPRPWKSHLQGC
Mb3497c|M.bovis_AF2122/97 LVRTLRARGADVVSLD--------SRPSRYTNIVGCVSDRALLRDVMAGV
Rv3468c|M.tuberculosis_H37Rv LVRTLRARGADIVSLD--------SRPSRYTNIVGCVSDRALLRDVMAGV
MAB_1344c|M.abscessus_ATCC_199 LVRTLRRDGVDVVGID--------IAAGPATDIVGSIADRGLVAEAMSGM
Mvan_5705|M.vanbaalenii_PYR-1 VTRRLVADGQDVRVMVREGANTIGIDDLTVTRFVGDIWDDDVLREAMTGC
MSMEG_5976|M.smegmatis_MC2_155 MVPILQLAGHDVTGLDTGFFADCVLGPEPADPPAIQVDLRDVTVEQLAGF
: : * : . : .
MAV_1225|M.avium_104 DTIFHTAAIIDLMGGASVTEEYRQRSFAVNVGGTENLVRAGQA----AGV
MUL_0172|M.ulcerans_Agy99 DTVFHTAAIIELMGGASVTDEYRKRSFSVNVGGTENLVRAGQQ----AGV
MLBr_01942|M.leprae_Br4923 DTVFHTAAIIELMGGASVTDEYRQRSYTVNVGGTENLLRAGQK----SGV
Mflv_2075|M.gilvum_PYR-GCK DTVFHTAAIIDLMGGASVSEEYRQRSFAVNVTGTQNLVHAAQK----AGV
MMAR_3324|M.marinum_M DAVVHLAALVSTVVAVET-------AWDVNVLGTKKVIDAAVD----AGV
TH_3827|M.thermoresistible__bu AVVLHTAAVVSNAVAAGQ-------QWQANVLGTRRVLEAAAR----AGV
Mb3497c|M.bovis_AF2122/97 EVVFHAAAHHKPQLAFLP----RQAFLDTNIIGTQTVLDAAVA----ANV
Rv3468c|M.tuberculosis_H37Rv EVVFHAAAHHKPQLAFLP----RQAFLDTNIIGTQTVLDAAVA----ANV
MAB_1344c|M.abscessus_ATCC_199 TSVLHTATLHKPHIGSHP----RTDFVETNIEGTLSVLEAAVA----AGV
Mvan_5705|M.vanbaalenii_PYR-1 DVVYYCVVDTRGWLRDPAP------LFRTNVEGTRNVLNIAVEPAVAAGL
MSMEG_5976|M.smegmatis_MC2_155 DAVIHLAALSNDPLGALAP----QITYEINHLASVRLARLAKS----AGV
: : .. * .: : . :.:
MAV_1225|M.avium_104 QRFVYTSSNSVVMGGQNIVGGDETLPYTDRFN----DLYTETKVLAERFV
MUL_0172|M.ulcerans_Agy99 KRFVYTSSNSVVMGGQIIAGGDETLPYTNRFN----DLYTETKVVAEKFV
MLBr_01942|M.leprae_Br4923 KRFVYTASNSVVMGGTPITGGDETMPYTKRFN----DLYTETKVVAEKFV
Mflv_2075|M.gilvum_PYR-GCK TRFVYTASNSVVMGGQRIAGGDETLPYTERFN----DLYTETKVVAEKFV
MMAR_3324|M.marinum_M RRFVHLSSIAAYG-WDFPDHVTEDYPTRVTGGL---STYVDTKTNSELVA
TH_3827|M.thermoresistible__bu ERVVHFSSVRAYGDLGFPDGVKETWPLRADG-----RAYVDTKVAAEATA
Mb3497c|M.bovis_AF2122/97 RAFVMTSSTTVFGDALTPPADQPAAWIDESVTPIPKNIYGVTKASSEDLC
Rv3468c|M.tuberculosis_H37Rv RAFVMTSSTTVFGDALTPPADQPAAWIDESVTPIPKNIYGVTKASSEDLC
MAB_1344c|M.abscessus_ATCC_199 RSFVYTSTTSAFGHALVG--AREAAWITEAVASVPKNIYGATKTAAEDIA
Mvan_5705|M.vanbaalenii_PYR-1 RKFVFTSSYVTVGRRRGRVATEADVIADRGLTP-----YVRSRVQAENLV
MSMEG_5976|M.smegmatis_MC2_155 RRFLYASTCSVYG-SAGDDLVNEDAPLRPLTP------YAESKVRVEDDV
.: :: . * ::. *
MAV_1225|M.avium_104 LGQNGV---DGMLTCAIRPSGIWGRGDQTMFRKLFESVIAGHVKV----L
MUL_0172|M.ulcerans_Agy99 LSQNGN---NEMLTCAIRPSGIWGTGDQLMFRKLFESVIKGHVKV----L
MLBr_01942|M.leprae_Br4923 LSQNGVPDGETMLTCSIRPSGIWGRGDQTMFRKAFESVVSGHVKV----L
Mflv_2075|M.gilvum_PYR-GCK LSQNGV---SGLLTCSIRPSGIWGRGDQTMFRKVFESVLAGHVKV----L
MMAR_3324|M.marinum_M LAN-AN---RGMEMVVVRPADVYGPGS-VWIREPIAMAKANQLIL----P
TH_3827|M.thermoresistible__bu FAAHAS---GEIAVTVVRPGDVYGPGSRPWTIIPVEEIKKGRLIL----P
Mb3497c|M.bovis_AF2122/97 QLAHRN---DGLACVVLRVARFFVEGD------DMPDLYDGRSQD----N
Rv3468c|M.tuberculosis_H37Rv QLAHRN---DGLACVVLRVARFFVEGD------DMPDLYDGRSQD----N
MAB_1344c|M.abscessus_ATCC_199 HVVHQD---SGLPVIVLRTSRFFPEQD------DNDRVRNRYRDG----N
Mvan_5705|M.vanbaalenii_PYR-1 LEYART---RGLPAVAMCVSTTYGAGDWGRTPHGAIIAGAAFGKL----P
MSMEG_5976|M.smegmatis_MC2_155 AEMADD----SFTPVFLRNATAFGFSPRLRADIVLNNLVGHGFLTGEVRV
: : . :
MAV_1225|M.avium_104 IGRKSARLDNSYVHNLIHGFILAAQHLTPGGTAPGQAYFINDAEPINMFE
MUL_0172|M.ulcerans_Agy99 VGPKSVLLDNSYVDNLIHGFMLAAQHLVPGGSAPGQAYFINDAEPINMFD
MLBr_01942|M.leprae_Br4923 IGSKNAKLDNSYVHNLVHGLILAAEHLVPGGTAPGQAYFINDGEPINFFD
Mflv_2075|M.gilvum_PYR-GCK VGNKETKLDNSYVHNLVHGFILAAEHLVEGGSAPGQAYFINDGEPINMFE
MMAR_3324|M.marinum_M ERG-SGVFDVIYIDNFVDAMVLVLATEG----IAGEVFNLGEELAVSCQE
TH_3827|M.thermoresistible__bu AGG-QGVFSPVYIDDLIAGILLAATHPD----AAGQDFNLPGVEPVTCKT
Mb3497c|M.bovis_AF2122/97 IKANEYACRRVALEDAVDAHLNAAQRAP----QLGFGRYLVSATTPFTRD
Rv3468c|M.tuberculosis_H37Rv IKANEYACRRVALEDAVDAHLNAAQRAP----QLGFGRYLVSATTPFTRD
MAB_1344c|M.abscessus_ATCC_199 VKANEYLYRRVDLADVVDAHLLAAERGP----EIGWAKYVISATTPFSPG
Mvan_5705|M.vanbaalenii_PYR-1 FVLGGIELEAVGVEDAAHALLLAAEKGR------VGERYLISEKMISNAD
MSMEG_5976|M.smegmatis_MC2_155 LSDGTPWRPLVHARDIAAAFLLALEAPAKKVHCAAYNVGSESNNLTVAEI
: . : .
MAV_1225|M.avium_104 FARPVVEACGVNWPRVRVNGPIVRAAMTGWQRLHFRFGIPAPLLEPLAVE
MUL_0172|M.ulcerans_Agy99 FARPVVEACGEKWPRVRVSGPMVHRAMTGWQRLHFRFGLPAPLLEPLAVE
MLBr_01942|M.leprae_Br4923 FMGPIIKACGENWPRVRISGRLVRNVMAVWQRLHFGFGLPKPPMEPLAVE
Mflv_2075|M.gilvum_PYR-GCK FARPVVQACGEPFPKFRVPGRLVWFAMTIWQFLHFKFGLPKPLLEPLAVE
MMAR_3324|M.marinum_M YFGEVASWTG-AKVRS-VPIRIGAPALGAIGRIQRRLGMSSE-LGPALLH
TH_3827|M.thermoresistible__bu FFGHYTRMLNKPPPRT-VPTRVAIALATAAGTVERFRGRSSE-LNAETVY
Mb3497c|M.bovis_AF2122/97 DLTQLRTDAASVFARR-VPLAAAVWTQRGWRFPDR---LDRVYVNSRARR
Rv3468c|M.tuberculosis_H37Rv DLTQLRTDAASVFARR-VPLAAAVWTQRGWRFPDR---LDRVYVNSRARR
MAB_1344c|M.abscessus_ATCC_199 DAAQLRTDPGAVVARY-FPEQPGLYAARGWSMFPT---IDRVYVNARARD
Mvan_5705|M.vanbaalenii_PYR-1 VVRIAAEAAGVPAPSRTMPLP-LSYAMAALGSLKGRLKGTDERLSLDSLR
MSMEG_5976|M.smegmatis_MC2_155 AQAVVDVVPGSELMITGETGADPRSYRVDFSKVREELGFEAKWSIPDGAA
MAV_1225|M.avium_104 RLYLDNFFSIAKASRDLGYQPLFTTEQAMSECLPYYVGMFEQMKRQALAG
MUL_0172|M.ulcerans_Agy99 RLYLDNYFSVDKARRDLGYEPKFTTEQALKECLPYYVDLFRQMKSEVKAG
MLBr_01942|M.leprae_Br4923 RVYLDNYFSIEKAHKELGYRPLFTTEQAMAECLPYYTELFEQIKVAAKPH
Mflv_2075|M.gilvum_PYR-GCK RLYLDNYFSIAKAQRDLGYQPLFTTEQALAQCIPYYVELFDRMKREAGNP
MMAR_3324|M.marinum_M MLNRRYVVSNDKARDRLGFKPVVSYHEGMARSK-------EWARHEGLI-
TH_3827|M.thermoresistible__bu YLTRAGGYSRAKAERVLGWVPQVSLDEGMARTE-------AWLRTEGYLD
Mb3497c|M.bovis_AF2122/97 DLNWRPRFDLNAVAARLARGQSVHTPLSQLVGSKAYAHSSYHRGVFAPAR
Rv3468c|M.tuberculosis_H37Rv DLNWRPRFDLNAVAARLARGQSVHTPLSQLVGSKAYAHSSYHRGVFAPAR
MAB_1344c|M.abscessus_ATCC_199 DLGWQPRYDYRRILDCLAAEQDFRSPLAREIGAKGYHDEP--TGVYTT--
Mvan_5705|M.vanbaalenii_PYR-1 LMRAEAPVDCGKAKRELGWQP-RPVEESIREAAKFWVGLRAAKRAGKAAG
MSMEG_5976|M.smegmatis_MC2_155 ELYKEYDAAG---LTAVAFVKKFTRLAHLEELRDYGVIDKTLRRVRTYA-
: :.
MAV_1225|M.avium_104 KASA--------
MUL_0172|M.ulcerans_Agy99 GR----------
MLBr_01942|M.leprae_Br4923 LASIAATPRPE-
Mflv_2075|M.gilvum_PYR-GCK VVQAAAPAPPKG
MMAR_3324|M.marinum_M ------------
TH_3827|M.thermoresistible__bu ------------
Mb3497c|M.bovis_AF2122/97 P-----------
Rv3468c|M.tuberculosis_H37Rv P-----------
MAB_1344c|M.abscessus_ATCC_199 ------------
Mvan_5705|M.vanbaalenii_PYR-1 ------------
MSMEG_5976|M.smegmatis_MC2_155 ------------