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GTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSGHLGEALVRTLRARGADIVSLDSRPSR YTNIVGCVSDRALLRDVMAGVEVVFHAAAHHKPQLAFLPRQAFLDTNIIGTQTVLDAAVAANVRAFVMTS STTVFGDALTPPADQPAAWIDESVTPIPKNIYGVTKASSEDLCQLAHRNDGLACVVLRVARFFVEGDDMP DLYDGRSQDNIKANEYACRRVALEDAVDAHLNAAQRAPQLGFGRYLVSATTPFTRDDLTQLRTDAASVFA RRVPLAAAVWTQRGWRFPDRLDRVYVNSRARRDLNWRPRFDLNAVAARLARGQSVHTPLSQLVGSKAYAH SSYHRGVFAPARP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3468c | - | - | 100% (364) | POSSIBLE DTDP-GLUCOSE 4,6-DEHYDRATASE |
| M. tuberculosis H37Rv | Rv3784 | - | 3e-12 | 29.12% (182) | dTDP-glucose 4,6-dehydratase |
| M. tuberculosis H37Rv | Rv1106c | - | 2e-11 | 24.39% (328) | cholesterol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3497c | rmlB2 | 0.0 | 99.73% (364) | dTDP-glucose 4,6-dehydratase RmlB2 |
| M. gilvum PYR-GCK | Mflv_1108 | - | 6e-13 | 27.79% (331) | NAD-dependent epimerase/dehydratase |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 2e-08 | 28.74% (174) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_1344c | - | 3e-84 | 49.68% (316) | putative dTDP-glucose-4,6-dehydratase-related protein |
| M. marinum M | MMAR_3324 | - | 2e-12 | 32.18% (174) | nucleoside-diphosphate-sugar epimerase |
| M. avium 104 | MAV_1849 | - | 3e-13 | 29.17% (264) | dihydroflavonol-4-reductase family protein |
| M. smegmatis MC2 155 | MSMEG_1512 | rfbB | 4e-11 | 31.82% (176) | dTDP-glucose 4,6-dehydratase |
| M. thermoresistible (build 8) | TH_2143 | - | 3e-11 | 28.84% (267) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_0172 | - | 2e-12 | 23.69% (325) | cholesterol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4271 | - | 8e-15 | 26.38% (326) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3468c|M.tuberculosis_H37Rv MGTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSGHLGEA
Mb3497c|M.bovis_AF2122/97 MGTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSGHLGEA
MAB_1344c|M.abscessus_ATCC_199 --------------------------------MSERRFLVTGSSGHLGEA
MAV_1849|M.avium_104 ---------------------------------MA-VKLVIGASGFLGSH
Mvan_4271|M.vanbaalenii_PYR-1 ---------------------------------MAGTKLVIGASGFLGSH
TH_2143|M.thermoresistible__bu ---------------------------------VAKKKLVIGASGFLGSH
Mflv_1108|M.gilvum_PYR-GCK ---------------------------------MSAPVLVIGANGYLGSH
MLBr_00204|M.leprae_Br4923 ------------------------------MYGEPVRALVTGAAGFIGST
MSMEG_1512|M.smegmatis_MC2_155 -----------------------------------MRLLVTGGAGFIGAN
MMAR_3324|M.marinum_M --------------------MSTDQSARPAPFFAQRKIFITGANGFIGAN
MUL_0172|M.ulcerans_Agy99 ---------------------MLRPMGDASLTTELGRVLVTGGSGFVGSN
:: *. *.:*
Rv3468c|M.tuberculosis_H37Rv LVRTLRARGADIVSLDSRPSRYTN---------IVGCVSDRALLRDVMAG
Mb3497c|M.bovis_AF2122/97 LVRTLRARGADVVSLDSRPSRYTN---------IVGCVSDRALLRDVMAG
MAB_1344c|M.abscessus_ATCC_199 LVRTLRRDGVDVVGIDIAAGPATD---------IVGSIADRGLVAEAMSG
MAV_1849|M.avium_104 VTRQLVERGER-VRVLLRRTSSTVALDDLDIERRYGDVFDDAVLRDALDG
Mvan_4271|M.vanbaalenii_PYR-1 VTKQLIAAGEDDVRVLIRTTSSTRGIDGLPVQVHYGDIFDTGALRAAMAG
TH_2143|M.thermoresistible__bu VTRQLVREGHD-VRVMVRTTSMTRGIDDLDVERCHGDVFDDAALRAAMTG
Mflv_1108|M.gilvum_PYR-GCK VTRKLVAAGND-VRVMVRDGANTVGIDDLAVTRYVGDIWNTDVLREAMTG
MLBr_00204|M.leprae_Br4923 LVDRLLADGHTVVGLDNFATGHAANLEHLASTPALAFVEADIVTADLQTI
MSMEG_1512|M.smegmatis_MC2_155 FVHLALREARTSSITVLDALTYAGSRESLAPVADRIRLVQGDITDAALVG
MMAR_3324|M.marinum_M LAARLRQLGARVTGVDLVADPANG--------IIAGSTADPAAWASALDG
MUL_0172|M.ulcerans_Agy99 LVTTLLDRGHHVRSFDRAPSPLPP---HPQLEVLQGDITDAATCATAVDG
.. .
Rv3468c|M.tuberculosis_H37Rv -----VEVVFHAAAHHKPQ----LAFLPRQAFLDTNIIGTQTVLDAAVA-
Mb3497c|M.bovis_AF2122/97 -----VEVVFHAAAHHKPQ----LAFLPRQAFLDTNIIGTQTVLDAAVA-
MAB_1344c|M.abscessus_ATCC_199 -----MTSVLHTATLHKPH----IGSHPRTDFVETNIEGTLSVLEAAVA-
MAV_1849|M.avium_104 -----CDDVYYCVVDTRAW----LRDP--APLFRTNVEGLRQVLDTAVG-
Mvan_4271|M.vanbaalenii_PYR-1 -----CDVVYYCVVDARPW----LRDP--APMWRTNVDGLRNVLDVAVG-
TH_2143|M.thermoresistible__bu -----VDDVYYCVVDARMW----LRDP--APLFRTNVEGLRHVLDAAVE-
Mflv_1108|M.gilvum_PYR-GCK -----CEVVYYCVVDTRGW----LRDP--APLFRTNVEGTRNVLDVAVEP
MLBr_00204|M.leprae_Br4923 LDEHRPEVVFHLAAQIDVR----HSVVDPQFDASVNVIGTVRLAEAARH-
MSMEG_1512|M.smegmatis_MC2_155 DLVAESDAVVHFAAETHVD----NALADPEPFLHSNVVGTYTILEAVRR-
MMAR_3324|M.marinum_M -----VDAVVHLAALVSTV----VAVET---AWDVNVLGTKKVIDAAVD-
MUL_0172|M.ulcerans_Agy99 -----VDTVFHTAAIIELMGGASVTDEYRKRSFSVNVGGTENLVRAGQQ-
* : .. *: * : .
Rv3468c|M.tuberculosis_H37Rv ---ANVRAFVMTSSTTVFGDALTPPADQPAAWIDESVTPIPKNIYGVTKA
Mb3497c|M.bovis_AF2122/97 ---ANVRAFVMTSSTTVFGDALTPPADQPAAWIDESVTPIPKNIYGVTKA
MAB_1344c|M.abscessus_ATCC_199 ---AGVRSFVYTSTTSAFGHALVG--AREAAWITEAVASVPKNIYGATKT
MAV_1849|M.avium_104 ---ADLRRFVFTSTIGTIALSEDGLPVSEDEPFNWADRGGG---YIRSRV
Mvan_4271|M.vanbaalenii_PYR-1 ---AGLHRFVFTSSIGTIGLAADGL-ADEDTAHNWLDKGGA---YIRSRV
TH_2143|M.thermoresistible__bu ---ADLNRFLFTSTTGTMAINPYRP-VTEDDPHNWT-EGGA---YIEARV
Mflv_1108|M.gilvum_PYR-GCK GIAATLRKFVFTSSCVTVGRTRGRVATEADVISDPADLKSLT-PYVRSRV
MLBr_00204|M.leprae_Br4923 ---TGVRKIVHTSSGGSIYGTPSQYPTPETVPTDPTSP------YAAGKV
MSMEG_1512|M.smegmatis_MC2_155 ----HNVRLHHVSTDEVYG----DLELDNPARFNETTPYNPSSPYSSTKA
MMAR_3324|M.marinum_M ---AGVRRFVHLSSIAAYGWDFPDHVTEDYP----TRVTGGLSTYVDTKT
MUL_0172|M.ulcerans_Agy99 ---AGVKRFVYTSSNSVVMGGQIIAGGDETLPYTNRFN----DLYTETKV
: *: * :.
Rv3468c|M.tuberculosis_H37Rv SSEDLCQLAHRNDGLACVVLRVARFFVEGDDMPDLYDGRSQDN-------
Mb3497c|M.bovis_AF2122/97 SSEDLCQLAHRNDGLACVVLRVARFFVEGDDMPDLYDGRSQDN-------
MAB_1344c|M.abscessus_ATCC_199 AAEDIAHVVHQDSGLPVIVLRTSRFFPEQDDNDRVRNRYRDGN-------
MAV_1849|M.avium_104 EAENLVLQYARERGLPAVAMCVSNTYGPGDFQPTPHGSLVAAAGKGKMP-
Mvan_4271|M.vanbaalenii_PYR-1 EAEQMVLRYSAEKGLPAVAMCVANTYGPGDFLPTPHGGMLAAAVAGRLP-
TH_2143|M.thermoresistible__bu AAEQLVLRYARERGLPAVALCISTTYGPGDWQPTPHGRLLAMVATGRFP-
Mflv_1108|M.gilvum_PYR-GCK QAENLVMEYARERGLPAVAMCVSTTYGAGDWGRTPHGAIIAGAAFGKLP-
MLBr_00204|M.leprae_Br4923 AGEIYLNTFRHLCGLDCSHIAPANVYGPRQ---DPYG-------------
MSMEG_1512|M.smegmatis_MC2_155 AADLLVRAWVRSYGVRATISNCSNNYGPYQHVEKFIPRQITNVLTGRRPK
MMAR_3324|M.marinum_M NSELVALANAN-RGMEMVVVRPADVYGPGSVWIREPIAMAKANQLILPE-
MUL_0172|M.ulcerans_Agy99 VAEKFVLSQNGNNEMLTCAIRPSGIWGTGD--QLMFRKLFESVIKGHVKV
.: : : : .
Rv3468c|M.tuberculosis_H37Rv -IKANEYACRRVALEDAVDAHLNAAQ---RAPQLGFGRYLVSATTPFTRD
Mb3497c|M.bovis_AF2122/97 -IKANEYACRRVALEDAVDAHLNAAQ---RAPQLGFGRYLVSATTPFTRD
MAB_1344c|M.abscessus_ATCC_199 -VKANEYLYRRVDLADVVDAHLLAAE---RGPEIGWAKYVISATTPFSPG
MAV_1849|M.avium_104 -VYVKDMSMEVVGIEDAARALILAAE---KGRVG--ERYIVSERYISAR-
Mvan_4271|M.vanbaalenii_PYR-1 -FYIDGYDAEVVGIEDAARAMILAAE---RGRTG--ERYIVSERFMSTR-
TH_2143|M.thermoresistible__bu -FYLG-WSAEVVGIEDAARAMLLAAE---QGRVG--ERYIISDRYLHTR-
Mflv_1108|M.gilvum_PYR-GCK -FVMGGIELEAVGIDDAAQAMLLAAR---KGRAG--ERYLISEKMISNA-
MLBr_00204|M.leprae_Br4923 ----------EAGVVAIFVQALLSDR---PTKVFGDGTHTRDYVFVDDVV
MSMEG_1512|M.smegmatis_MC2_155 LYGAGANVRDWIHVDDHNSAVWRILT---DGTIG--RTYLIGAECERNNL
MMAR_3324|M.marinum_M ---RGSGVFDVIYIDNFVDAMVLVLA---TEGIAG-EVFNLGEELAVSCQ
MUL_0172|M.ulcerans_Agy99 LVGPKSVLLDNSYVDNLIHGFMLAAQHLVPGGSAPGQAYFINDAEPINMF
: . .
Rv3468c|M.tuberculosis_H37Rv DLTQLRTDAASVFARRVPLAAAVWTQRGWRFPDRLDRVYVNSRARRDLNW
Mb3497c|M.bovis_AF2122/97 DLTQLRTDAASVFARRVPLAAAVWTQRGWRFPDRLDRVYVNSRARRDLNW
MAB_1344c|M.abscessus_ATCC_199 DAAQLRTDPGAVVARYFPEQPGLYAARGWSMFPTIDRVYVNARARDDLGW
MAV_1849|M.avium_104 ELYTTAAEAGGARPPRIGIPLKVMYALGL-CGDVAAKVLRRDMLLSTLSV
Mvan_4271|M.vanbaalenii_PYR-1 EIHEIGCAAVGVAPPKFGVPIRVMSAAGY-LSEGVARLRGKDTMLTPLNI
TH_2143|M.thermoresistible__bu EVHAIAAEAVGRRAPWFGLPLPVLSVAAR-GNDLAARLLRRDLMFAHVGL
Mflv_1108|M.gilvum_PYR-GCK DVVRIAAEAAGVPAPTKKIPLVLSYAMAA-LGSAKSRLKGTDERMSLGSL
MLBr_00204|M.leprae_Br4923 DAFIKASGDAGG-GQRFNIGTGIETSDRQLHTAVSAAVGGPDDPEFHPPR
MSMEG_1512|M.smegmatis_MC2_155 TVMRTILKLMGRDPDDFDHVTDRAGHDLR--YAIDPSTLQDELGWAPKHT
MMAR_3324|M.marinum_M EYFGEVASWTGAKVRSVPIR---IGAPALGAIGRIQRRLGMSSELGPALL
MUL_0172|M.ulcerans_Agy99 DFARPVVEACGEKWPRVRVSGPMVHRAMTGWQRLHFRFGLPAPLLEPLAV
.
Rv3468c|M.tuberculosis_H37Rv RPRFDLNAVAARLARGQSVHTPLSQLVGSKAYAHSSYHRGVFAPARP---
Mb3497c|M.bovis_AF2122/97 RPRFDLNAVAARLARGQSVHTPLSQLVGSKAYAHSSYHRGVFAPARP---
MAB_1344c|M.abscessus_ATCC_199 QPRYDYRRILDCLAAEQDFRSPLAREIGAKGYHDEP--TGVYTT------
MAV_1849|M.avium_104 RLMHIMSPMDHSKAERELGWRPEPIHDAIRRAVAFYQTR-----------
Mvan_4271|M.vanbaalenii_PYR-1 RLMHIMSPMDHSKAVRELDWHPQPTSEAIVAAAHFFRDRRQRAAQGAR--
TH_2143|M.thermoresistible__bu KMAELMSPLDHSKAERELGFKPEPVEDSIAKAARFFLEQHR---------
Mflv_1108|M.gilvum_PYR-GCK RLMRAEAPVDCSKARRELGWQPRPVEESIREAAKFWVGLKAAKRQRTA--
MLBr_00204|M.leprae_Br4923 LGDLKRSCLDIGLATTVLGWSPQVQLDDGVRRTVEYFRAAQRS-------
MSMEG_1512|M.smegmatis_MC2_155 DFEAGLTDTIDWYRANESWWRPLKDTVEAKYQERGQ--------------
MMAR_3324|M.marinum_M HMLNRRYVVSNDKARDRLGFKPVVSYHEGMARSKEWARHEGLI-------
MUL_0172|M.ulcerans_Agy99 ERLYLDNYFSVDKARRDLGYEPKFTTEQALKECLPYYVDLFRQMKSEVKA
*
Rv3468c|M.tuberculosis_H37Rv ---
Mb3497c|M.bovis_AF2122/97 ---
MAB_1344c|M.abscessus_ATCC_199 ---
MAV_1849|M.avium_104 ---
Mvan_4271|M.vanbaalenii_PYR-1 ---
TH_2143|M.thermoresistible__bu ---
Mflv_1108|M.gilvum_PYR-GCK ---
MLBr_00204|M.leprae_Br4923 ---
MSMEG_1512|M.smegmatis_MC2_155 ---
MMAR_3324|M.marinum_M ---
MUL_0172|M.ulcerans_Agy99 GGR