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RVLVTGHQGYLGTVMVPILQLAGHDVTGLDTGFFADCVLGPEPADPPAIQVDLRDVTVEQLAGFDAVIHL AALSNDPLGALAPQITYEINHLASVRLARLAKSAGVRRFLYASTCSVYGSAGDDLVNEDAPLRPLTPYAE SKVRVEDDVAEMADDSFTPVFLRNATAFGFSPRLRADIVLNNLVGHGFLTGEVRVLSDGTPWRPLVHARD IAAAFLLALEAPAKKVHCAAYNVGSESNNLTVAEIAQAVVDVVPGSELMITGETGADPRSYRVDFSKVRE ELGFEAKWSIPDGAAELYKEYDAAGLTAVAFVKKFTRLAHLEELRDYGVIDKTLRRVRTYA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5976 | - | - | 100% (342) | epimerase/dehydratase |
| M. smegmatis MC2 155 | MSMEG_6142 | - | 2e-16 | 28.48% (309) | nucleoside-diphosphate-sugar epimerase |
| M. smegmatis MC2 155 | MSMEG_0991 | - | 1e-14 | 27.49% (342) | NAD-dependent epimerase/dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0550 | galE3 | 6e-21 | 30.43% (345) | UDP-glucose 4-epimerase |
| M. gilvum PYR-GCK | Mflv_1401 | - | 7e-14 | 25.39% (323) | UDP-glucose 4-epimerase |
| M. tuberculosis H37Rv | Rv0536 | galE3 | 6e-21 | 30.43% (345) | UDP-glucose 4-epimerase |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 4e-14 | 29.31% (232) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 6e-15 | 29.24% (236) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_0882 | galE3 | 2e-17 | 30.15% (335) | UDP-glucose 4-epimerase, GalE3 |
| M. avium 104 | MAV_4609 | - | 2e-18 | 30.50% (341) | NAD-dependent epimerase/dehydratase |
| M. thermoresistible (build 8) | TH_3729 | - | 4e-16 | 28.87% (336) | PUTATIVE UDP-galactose 4-epimerase |
| M. ulcerans Agy99 | MUL_0635 | galE3 | 1e-17 | 30.15% (335) | UDP-glucose 4-epimerase, GalE3 |
| M. vanbaalenii PYR-1 | Mvan_0214 | - | 1e-149 | 75.73% (342) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0550|M.bovis_AF2122/97 -----MRVLLTGAAGFIGSRVDAALRAAGHDVVGVDALLPAAHGPNPVLP
Rv0536|M.tuberculosis_H37Rv -----MRVLLTGAAGFIGSRVDAALRAAGHDVVGVDALLPAAHGPNPVLP
MAV_4609|M.avium_104 -------MLVTGAAGFIGSRVAAALRAAGHDVVAVDALLAAAHGPNPLPP
MMAR_0882|M.marinum_M -----MKVLLTGAAGFIGSRVGAALSAAGHEVVGVDVLLPAAHGPNPVLP
MUL_0635|M.ulcerans_Agy99 -----MKVLLTGAAGFIGSRVGAALSAAGHEVVGVDVLLPAAHGPNPVLP
Mflv_1401|M.gilvum_PYR-GCK -----MSWLITGGAGYIGSHVARAMLEAGRDVVVIDDLSSGFESFVPDGA
TH_3729|M.thermoresistible__bu -----MTWLVTGGAGYIGSHVVRALLEADLPVVVIDDLSTGLEKFVPSEV
MLBr_00204|M.leprae_Br4923 MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANLEHLA
MAB_0503|M.abscessus_ATCC_1997 -----MRAMVTGAAGFIGSTLVDRLLADGHEVTGLDNLATGKVANLEAAE
MSMEG_5976|M.smegmatis_MC2_155 -----MRVLVTGHQGYLGTVMVPILQLAGHDVTGLDTGFFADCVLGPEPA
Mvan_0214|M.vanbaalenii_PYR-1 -----MKVLVTGHQGYLGTVMVPVLQAAGHDVTGLDSGLFEQCVLGPAPL
::** *::*: : : . *. :*
Mb0550|M.bovis_AF2122/97 PGCQRVDVRDASALAPLLAG-----VDLVCHQAAMVGAGVNAADAPAYGG
Rv0536|M.tuberculosis_H37Rv PGCQRVDVRDASALAPLLAG-----VDLVCHQAAMVGAGVNAADAPAYGG
MAV_4609|M.avium_104 NGCHRVDVRDADALAPLLAG-----VDVVCHQAAMVGAGVDAADAPAYGG
MMAR_0882|M.marinum_M PGCHRVDVRDADAMAPLLAG-----VDLVCHQAAMVGAGVDAADAPAYGG
MUL_0635|M.ulcerans_Agy99 PGCHRVDVRDADAMAPLLAG-----VDLVCHQAAMVGAGVDAADAPAYGG
Mflv_1401|M.gilvum_PYR-GCK AFVEGTLLDAALVDDTLA----RFDVDGVIHIAGYKYAGESVKRPLHTYE
TH_3729|M.thermoresistible__bu PLVRGTLLDADLVARALR----EHRVSGVIHIAGFKYAGVSVQQPLHTYE
MLBr_00204|M.leprae_Br4923 STPALAFVEADIVTADLQTILDEHRPEVVFHLAAQIDVRHSVVDPQFDAS
MAB_0503|M.abscessus_ATCC_1997 ANAKFTFVKDDIVEADLDAVVAEYSPEVIFHLAAQIDVRHSVADPQFDSS
MSMEG_5976|M.smegmatis_MC2_155 DPPAIQVDLRDVTVEQLAG------FDAVIHLAALSNDPLGALAPQITYE
Mvan_0214|M.vanbaalenii_PYR-1 DPPGIEQDLRDVSVTQLAG------FDAVVHLAALSNDPLGALAPEITYA
* . : * *. .. .
Mb0550|M.bovis_AF2122/97 HNDFATTVLLAQMFAAGVRRLVLASS-MVVYGQGRYDCPQHGPVDPLPRR
Rv0536|M.tuberculosis_H37Rv HNDFATTVLLAQMFAAGVRRLVLASS-MVVYGQGRYDCPQHGPVDPLPRR
MAV_4609|M.avium_104 HNDLATTVLLAQMFAAGVRRLVLASS-MVVYGQGGYRCERHGPVHPLPRR
MMAR_0882|M.marinum_M HNDLATTVLLAQMFAAGVRRLVLASS-MVVYGQGRYDCPEHGRIDPLPRR
MUL_0635|M.ulcerans_Agy99 HNDLATTVLLAQMFAAGVRRLVLASS-MVVYGQGHYDCPEHGRIDPLPRR
Mflv_1401|M.gilvum_PYR-GCK QNVSTTVILLQAMEARGVGQIVFSSS-AATFG------------------
TH_3729|M.thermoresistible__bu QNVSAMVTLLKAMQDTGVDMMVFSSS-AATFG------------------
MLBr_00204|M.leprae_Br4923 VNVIGTVRLAEAARHTGVRKIVHTSSGGSIYG------------------
MAB_0503|M.abscessus_ATCC_1997 VNVVGTVRLAEAARKAGVRKIVHTSSGGSIYG------------------
MSMEG_5976|M.smegmatis_MC2_155 INHLASVRLARLAKSAGVRRFLYAST-CSVYG------------------
Mvan_0214|M.vanbaalenii_PYR-1 INHRGSVRLARLAKEAGVRRFLYAST-CSVYG------------------
* . * ** :: :*: :*
Mb0550|M.bovis_AF2122/97 RADLDNGVFEHRCPGCGEPVIWQLVDEDAPLRPRSLYAASKTAQEHYALA
Rv0536|M.tuberculosis_H37Rv RADLDNGVFEHRCPGCGEPVIWQLVDEDAPLRPRSLYAASKTAQEHYALA
MAV_4609|M.avium_104 RADLDAGVFEHRCPIGGEELRWQLVDEDACLRPRSLYAASKTAQEHYALA
MMAR_0882|M.marinum_M HSDLDAGVFEHRCPLCAEPVRWRLVGEEAELRPRSLYAASKTAQEHYALA
MUL_0635|M.ulcerans_Agy99 HSDLDAGVFEHRCPLCAEPVRWRLVGEEAELRPRSLYAASKTAQEHYALA
Mflv_1401|M.gilvum_PYR-GCK ------------------TPDVDIVDESTPTTPESPYGETKLIGEWLLRD
TH_3729|M.thermoresistible__bu ------------------TPDVDLVTETTPTRPESPYGESKLIGEWLLAD
MLBr_00204|M.leprae_Br4923 ------------------TPSQYPTPETVPTDPTSPYAAGKVAGEIYLNT
MAB_0503|M.abscessus_ATCC_1997 ------------------TPKQIPTSETVPTDPHSPYAAGKVAGEIYLNT
MSMEG_5976|M.smegmatis_MC2_155 ------------------SAGDDLVNEDAPLRPLTPYAESKVRVEDDVAE
Mvan_0214|M.vanbaalenii_PYR-1 ------------------AADDGLVNEDTALRPLTPYAESKVRVEDDVAA
. * . * : *. * *
Mb0550|M.bovis_AF2122/97 WSEASGGSVVALRYHNVYGPGMP--RDTPYSGVAAIFRSAVEKGKPPKVF
Rv0536|M.tuberculosis_H37Rv WSEASGGSVVALRYHNVYGPGMP--RDTPYSGVAAIFRSAVEKGKPPKVF
MAV_4609|M.avium_104 WSEATGGSVVALRYHNVYGPGMP--RDTPYSGVAAIFRSALEKGEPPRVF
MMAR_0882|M.marinum_M WSESTGGSVVALRYHNVYGPGMP--RDTPYSGVAAIFRSSLEKGEPPKVF
MUL_0635|M.ulcerans_Agy99 WSESTGGSVVALRYHNVYGPGMP--RDTPYSGVAAIFRSSLEKGEPPKVF
Mflv_1401|M.gilvum_PYR-GCK AGRASGLRHTSLRYFNVVGSGAVELFDASPHNLFPLVFDMLFRGETPRIN
TH_3729|M.thermoresistible__bu VGRATGLRHTSLRYFNVVGSGSPELFDVSPHNLFPLVFDMLYRGETPRIN
MLBr_00204|M.leprae_Br4923 FRHLCGLDCSHIAPANVYGPRQDPYGEAG---VVAIFVQALLSDRPTKVF
MAB_0503|M.abscessus_ATCC_1997 FRHLYGLECSHIAPANVYGPRQDPHGEAG---VVAIFAQALLSGRSTKVF
MSMEG_5976|M.smegmatis_MC2_155 MADDS-FTPVFLRNATAFGFSPR---LRADIVLNNLVGHGFLTG-EVRVL
Mvan_0214|M.vanbaalenii_PYR-1 IADDW-FSPVFLRNATAFGFSPR---LRADIVVNNLVAHAVLTG-VVRVL
: .. * : :. . . ::
Mb0550|M.bovis_AF2122/97 ED------GGQMRDFVHVDDVAAANLAAVHLGEADRDGFTAVNVCSGRP-
Rv0536|M.tuberculosis_H37Rv ED------GGQMRDFVHVDDVAAANLAAVHLGEADRDGFTAVNVCSGRP-
MAV_4609|M.avium_104 ED------GGQMRDFVHVDDVAAANLAALAC----RDGFTAVNVCSGQP-
MMAR_0882|M.marinum_M ED------GGQMRDFVHVDDIAAANLAAAQLGEVDRHGFVAANVCSGRP-
MUL_0635|M.ulcerans_Agy99 ED------GGQMRDFVHVDDIAAANLAAAQLGEVDRHGFVAANVCSGRP-
Mflv_1401|M.gilvum_PYR-GCK GDDYPTPDGTCVRDYIHVSDLALAHVAAAQRLAAGEPVEPVYNLGSGAG-
TH_3729|M.thermoresistible__bu GDDYPTPDGTCVRDYIHVADLALAHVAAARRLQAGEPVEPVYNLGSGSG-
MLBr_00204|M.leprae_Br4923 GD------GTHTRDYVFVDDVVDAFIKASGDAGGGQ----RFNIGTGIE-
MAB_0503|M.abscessus_ATCC_1997 GD------GGNTRDYVFVDDVVEAFVRASGPDGGGQ----RFNVGTGVE-
MSMEG_5976|M.smegmatis_MC2_155 SD------GTPWRPLVHARDIAAAFLLALEAP-AKKVHCAAYNVGSESNN
Mvan_0214|M.vanbaalenii_PYR-1 SD------GTPWRPLVHAQDIAVAFLTALEAP-IHKIHCAAFNVGTETNN
* * * :.. *:. * : * . *: :
Mb0550|M.bovis_AF2122/97 ISILQVATAICDARGGSMSPAITGHYRSGDVRHIVADPARAARVLGFRAA
Rv0536|M.tuberculosis_H37Rv ISILQVATAICDARGGSMSPAITGHYRSGDVRHIVADPARAARVLGFRAA
MAV_4609|M.avium_104 ISILQVATALCDARGGAVAPVVTGQYRSGDVRHIVADPSRAARLLGFRAA
MMAR_0882|M.marinum_M ISILQVASALCQARGDALSPVITGQYRSGDVRHIVADPSRAAEVLGFRAA
MUL_0635|M.ulcerans_Agy99 ISILQVASALCQARGDALSPVITGQYRSGDVRHIVADPSRAAEVLGFRAA
Mflv_1401|M.gilvum_PYR-GCK TSVREIMTAMRTVTGVDFEPVVMPR-RPGDPARIVAAGDLAARDLGWSNR
TH_3729|M.thermoresistible__bu TSVREIMTAIRKVTGVDFVPEIAPR-RPGDPARIVASGELAARDLGWRMR
MLBr_00204|M.leprae_Br4923 TSDRQLHTAVSAAVGGPDDPEFHPP-RLGDLKRSCLDIGLATTVLGWSPQ
MAB_0503|M.abscessus_ATCC_1997 TSDRQLHSLVAAAAGAPDDPEFHPP-RLGDLRQSCLDVGLAKRVLGWEPR
MSMEG_5976|M.smegmatis_MC2_155 LTVAEIAQAVVDVVPGSE--LMITGETGADPRSYRVDFSKVREELGFEAK
Mvan_0214|M.vanbaalenii_PYR-1 LTVAEIAEAVVGAVPSSH--LLITGETGPDPRSYRVDFSRFRDTLGYEAT
: :: : . . * **:
Mb0550|M.bovis_AF2122/97 VDPGEGLREFAFAPLR----------------------------------
Rv0536|M.tuberculosis_H37Rv VDPGEGLREFAFAPLR----------------------------------
MAV_4609|M.avium_104 VQPGDGLREFAFAPLR----------------------------------
MMAR_0882|M.marinum_M VEPLEGLRGFAFAPLR----------------------------------
MUL_0635|M.ulcerans_Agy99 VEPLEGLRGFAFAPLR----------------------------------
Mflv_1401|M.gilvum_PYR-GCK HSLEEMVASAWRARQHAGDAYPR---------------------------
TH_3729|M.thermoresistible__bu HTLEDMVKSAWEARQRAGDAYPR---------------------------
MLBr_00204|M.leprae_Br4923 VQLDDGVRRTVEYFRAAQRS------------------------------
MAB_0503|M.abscessus_ATCC_1997 VPLADGIRRTVDFFRS----------------------------------
MSMEG_5976|M.smegmatis_MC2_155 WSIPDGAAELYKEYDAAGLTAVAFVKKFTRLAHLEELRDYGVIDKTLRRV
Mvan_0214|M.vanbaalenii_PYR-1 WSVADGATQLYRAYLAYGLNQHDFAHKFTRLPHLDALRSAGLLDESMRWI
:
Mb0550|M.bovis_AF2122/97 ----
Rv0536|M.tuberculosis_H37Rv ----
MAV_4609|M.avium_104 ----
MMAR_0882|M.marinum_M ----
MUL_0635|M.ulcerans_Agy99 ----
Mflv_1401|M.gilvum_PYR-GCK ----
TH_3729|M.thermoresistible__bu ----
MLBr_00204|M.leprae_Br4923 ----
MAB_0503|M.abscessus_ATCC_1997 ----
MSMEG_5976|M.smegmatis_MC2_155 RTYA
Mvan_0214|M.vanbaalenii_PYR-1 RTAA