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STDQSARPAPFFAQRKIFITGANGFIGANLAARLRQLGARVTGVDLVADPANGIIAGSTADPAAWASALD GVDAVVHLAALVSTVVAVETAWDVNVLGTKKVIDAAVDAGVRRFVHLSSIAAYGWDFPDHVTEDYPTRVT GGLSTYVDTKTNSELVALANANRGMEMVVVRPADVYGPGSVWIREPIAMAKANQLILPERGSGVFDVIYI DNFVDAMVLVLATEGIAGEVFNLGEELAVSCQEYFGEVASWTGAKVRSVPIRIGAPALGAIGRIQRRLGM SSELGPALLHMLNRRYVVSNDKARDRLGFKPVVSYHEGMARSKEWARHEGLI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3324 | - | - | 100% (333) | nucleoside-diphosphate-sugar epimerase |
| M. marinum M | MMAR_3319 | - | 1e-89 | 49.41% (338) | dehydrogenase |
| M. marinum M | MMAR_4359 | - | 1e-20 | 27.74% (328) | cholesterol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1136c | - | 2e-19 | 26.89% (331) | cholesterol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2075 | - | 7e-16 | 25.66% (339) | 3-beta hydroxysteroid dehydrogenase/isomerase |
| M. tuberculosis H37Rv | Rv1106c | - | 2e-19 | 26.89% (331) | cholesterol dehydrogenase |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 2e-16 | 27.43% (339) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_4385 | - | 2e-57 | 40.06% (322) | putative oxidoreductase |
| M. avium 104 | MAV_1225 | - | 7e-18 | 25.60% (332) | 3-beta hydroxysteroid dehydrogenase/isomerase family protein |
| M. smegmatis MC2 155 | MSMEG_6142 | - | 1e-18 | 28.53% (340) | nucleoside-diphosphate-sugar epimerase |
| M. thermoresistible (build 8) | TH_3827 | - | 1e-65 | 42.69% (335) | PUTATIVE putative dehydrogenase |
| M. ulcerans Agy99 | MUL_0172 | - | 2e-20 | 27.74% (328) | cholesterol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4914 | - | 9e-20 | 26.83% (328) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4385|M.abscessus_ATCC_1997 -MTD--------MTQR-AFVTGANGFVGRSLSLRLRTLGWQVSGVD----
TH_3827|M.thermoresistible__bu -MTDEDRIPCGAMSRPSVFITGANGFIGRSLGAHFAENGYDVRGVD----
MMAR_3324|M.marinum_M MSTDQSARPAPFFAQRKIFITGANGFIGANLAARLRQLGARVTGVD----
Mb1136c|M.bovis_AF2122/97 -MLRRMGDASLTTELGRVLVTGGAGFVGANLVTTLLDRGHWVRSFDRAPS
Rv1106c|M.tuberculosis_H37Rv -MLRRMGDASLTTELGRVLVTGGAGFVGANLVTTLLDRGHWVRSFDRAPS
MAV_1225|M.avium_104 -MIGPMGDPSLTAELGRVLVTGGSGFVGANLVTTLLERGYQVRSFDRAPS
MUL_0172|M.ulcerans_Agy99 -MLRPMGDASLTTELGRVLVTGGSGFVGSNLVTTLLDRGHHVRSFDRAPS
Mflv_2075|M.gilvum_PYR-GCK -MLR--------TELGRVLVTGGSGFVGANLVTELLDRGLHVRSFDRVAS
MLBr_00204|M.leprae_Br4923 ----------MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFAT
MSMEG_6142|M.smegmatis_MC2_155 -------------MAVRTLVTGAAGFIGSTLVDRLLADGHGVVGLDDLSS
Mvan_4914|M.vanbaalenii_PYR-1 ---------------MQLFVTGGSGFVGQHLIRRLVGAGHEVRALARTDS
::**. **:* * : * * ..
MAB_4385|M.abscessus_ATCC_1997 --------LVADPAHNIQGGDINT--AGPWMTEAAA-ADAIFHTAAVVSN
TH_3827|M.thermoresistible__bu --------LAADPARNVVAGDVVN--PRPWKSHLQG-CAVVLHTAAVVSN
MMAR_3324|M.marinum_M --------LVADPANGIIAGSTAD--PAAWASALDG-VDAVVHLAALVST
Mb1136c|M.bovis_AF2122/97 -------LLPAHPQLEVLQGDITD--ADVCAAAVDG-IDTIFHTAAIIEL
Rv1106c|M.tuberculosis_H37Rv -------LLPAHPQLEVLQGDITD--ADVCAAAVDG-IDTIFHTAAIIEL
MAV_1225|M.avium_104 -------PLPAHPHLEVLQGDITD--AGVCAAAVEG-IDTIFHTAAIIDL
MUL_0172|M.ulcerans_Agy99 -------PLPPHPQLEVLQGDITD--AATCATAVDG-VDTVFHTAAIIEL
Mflv_2075|M.gilvum_PYR-GCK -------ALPAHARLEIVEGDITD--ADDVAAAVEG-VDTVFHTAAIIDL
MLBr_00204|M.leprae_Br4923 GHAANLEHLASTPALAFVEADIVT--ADLQTILDEHRPEVVFHLAAQIDV
MSMEG_6142|M.smegmatis_MC2_155 GRAENLHSAENSDKFEFVKADIVD--ADLTGLLAEFKPEVIFHLAAQISV
Mvan_4914|M.vanbaalenii_PYR-1 AAG-LVGRVGAEPVLGDLSDLVNSDPPPLWASALRG-VDAVVHGAAYMAF
. .:.* ** :
MAB_4385|M.abscessus_ATCC_1997 IADS-------DTAWRVNVLGTKKVIDATAPG--AVFVHLSSVRAFSDLD
TH_3827|M.thermoresistible__bu AVAA-------GQQWQANVLGTRRVLEAAARAGVERVVHFSSVRAYGDLG
MMAR_3324|M.marinum_M VVAV-------ETAWDVNVLGTKKVIDAAVDAGVRRFVHLSSIAAYG-WD
Mb1136c|M.bovis_AF2122/97 MGGASVTDEYRQRSFAVNVGGTENLLHAGQRAGVQRFVYTSSNSVVMGGQ
Rv1106c|M.tuberculosis_H37Rv MGGASVTDEYRQRSFAVNVGGTENLLHAGQRAGVQRFVYTSSNSVVMGGQ
MAV_1225|M.avium_104 MGGASVTEEYRQRSFAVNVGGTENLVRAGQAAGVQRFVYTSSNSVVMGGQ
MUL_0172|M.ulcerans_Agy99 MGGASVTDEYRKRSFSVNVGGTENLVRAGQQAGVKRFVYTSSNSVVMGGQ
Mflv_2075|M.gilvum_PYR-GCK MGGASVSEEYRQRSFAVNVTGTQNLVHAAQKAGVTRFVYTASNSVVMGGQ
MLBr_00204|M.leprae_Br4923 RHSVVDP----QFDASVNVIGTVRLAEAARHTGVRKIVHTSSGGSIYGTP
MSMEG_6142|M.smegmatis_MC2_155 KRSVDDP----PFDATVNVVGTVRLAEAARLAGVRKVVHTSSGGSVYGTP
Mvan_4914|M.vanbaalenii_PYR-1 WGPD-------DVFRRANLEPSVALHQVAASSGVTRFVLISAASVATGTQ
.*: : : . .* ::
MAB_4385|M.abscessus_ATCC_1997 FPDMVTEEHPVRTDG--NAYVDTKVASEQVVLQAHGAGRIDARIARPGDI
TH_3827|M.thermoresistible__bu FPDGVKETWPLRADG--RAYVDTKVAAEATAFAAHASGEIAVTVVRPGDV
MMAR_3324|M.marinum_M FPDHVTEDYPTRVTGGLSTYVDTKTNSELVALANANRG-MEMVVVRPADV
Mb1136c|M.bovis_AF2122/97 NIAGGDETLPYTDRFN-DLYTETKVVAERFVLAQNGVDGMLTCAIRPSGI
Rv1106c|M.tuberculosis_H37Rv NIAGGDETLPYTDRFN-DLYTETKVVAERFVLAQNGVDGMLTCAIRPSGI
MAV_1225|M.avium_104 NIVGGDETLPYTDRFN-DLYTETKVLAERFVLGQNGVDGMLTCAIRPSGI
MUL_0172|M.ulcerans_Agy99 IIAGGDETLPYTNRFN-DLYTETKVVAEKFVLSQNGNNEMLTCAIRPSGI
Mflv_2075|M.gilvum_PYR-GCK RIAGGDETLPYTERFN-DLYTETKVVAEKFVLSQNGVSGLLTCSIRPSGI
MLBr_00204|M.leprae_Br4923 SQYPTPETVPTDPTSP---YAAGKVAGEIYLNTFRHLCGLDCSHIAPANV
MSMEG_6142|M.smegmatis_MC2_155 PAYPTSEDMPVNPASP---YAAGKVAGEVYLNMYRNLYDLDCSHIAPANV
Mvan_4914|M.vanbaalenii_PYR-1 RAPVVDERTDEGRPNI--AYSRVKLATERILLN-AVTPTMTTVALRPPFI
* * * * : * :
MAB_4385|M.abscessus_ATCC_1997 YG-----PGSRPWTILPVEMIRS-RQFVLPAMGRGVFSPIYIDDLVEGVV
TH_3827|M.thermoresistible__bu YG-----PGSRPWTIIPVEEIKK-GRLILPAGGQGVFSPVYIDDLIAGIL
MMAR_3324|M.marinum_M YG-----PGS-VWIREPIAMAKA-NQLILPERGSGVFDVIYIDNFVDAMV
Mb1136c|M.bovis_AF2122/97 WG-----NGDQTMFRKLFESVLKGHVKVLVGRKSARLDNSYVHNLIHGFI
Rv1106c|M.tuberculosis_H37Rv WG-----NGDQTMFRKLFESVLKGHVKVLVGRKSARLDNSYVHNLIHGFI
MAV_1225|M.avium_104 WG-----RGDQTMFRKLFESVIAGHVKVLIGRKSARLDNSYVHNLIHGFI
MUL_0172|M.ulcerans_Agy99 WG-----TGDQLMFRKLFESVIKGHVKVLVGPKSVLLDNSYVDNLIHGFM
Mflv_2075|M.gilvum_PYR-GCK WG-----RGDQTMFRKVFESVLAGHVKVLVGNKETKLDNSYVHNLVHGFI
MLBr_00204|M.leprae_Br4923 YGPRQDPYGEAGVVAIFVQALLSDRPTKVFGDGTHTRDYVFVDDVVDAFI
MSMEG_6142|M.smegmatis_MC2_155 YGPRQDPHGEAGVVAIFSEALLAGRTTKIFGDGSDTRDYVFVDDVVDAFV
Mvan_4914|M.vanbaalenii_PYR-1 WG-------AGMSTLADFVAAVEAGRFSWIDNGKHTVDFVHVDNLAKAVG
:* . .:.:. ..
MAB_4385|M.abscessus_ATCC_1997 ALGS----GGAASGQVFTISGGVGVTCAQFFGHYHRMLDRRGPLV-LPTA
TH_3827|M.thermoresistible__bu LAAT----HPDAAGQDFNLPGVEPVTCKTFFGHYTRMLNKPPPRT-VPTR
MMAR_3324|M.marinum_M LVLA----TEGIAGEVFNLGEELAVSCQEYFGEVASWTG-AKVRS-VPIR
Mb1136c|M.bovis_AF2122/97 LAAAHLVPDGTAPGQAYFINDAEPINMFEFARPVLEACGQRWPKMRISGP
Rv1106c|M.tuberculosis_H37Rv LAAAHLVPDGTAPGQAYFINDAEPINMFEFARPVLEACGQRWPKMRISGP
MAV_1225|M.avium_104 LAAQHLTPGGTAPGQAYFINDAEPINMFEFARPVVEACGVNWPRVRVNGP
MUL_0172|M.ulcerans_Agy99 LAAQHLVPGGSAPGQAYFINDAEPINMFDFARPVVEACGEKWPRVRVSGP
Mflv_2075|M.gilvum_PYR-GCK LAAEHLVEGGSAPGQAYFINDGEPINMFEFARPVVQACGEPFPKFRVPGR
MLBr_00204|M.leprae_Br4923 KASG-----DAGGGQRFNIGTGIETSDRQLHTAVSAAVG-----------
MSMEG_6142|M.smegmatis_MC2_155 RAGG-----PAGGGQRFNVGTGVETSTRELHTAIAGAVG-----------
Mvan_4914|M.vanbaalenii_PYR-1 LALT-----RGRAGRAYYITDGAPMPTRDFFTPLLATQGVDVSAARSVPF
*. : : .
MAB_4385|M.abscessus_ATCC_1997 AAVGLATVKARV--LALSGK-ATEANAISVRYLARTGSYSIAKAQRILGF
TH_3827|M.thermoresistible__bu VAIALATAAGTV--ERFRGR-SSELNAETVYYLTRAGGYSRAKAERVLGW
MMAR_3324|M.marinum_M IGAPALGAIGRI--QRRLGM-SSELGPALLHMLNRRYVVSNDKARDRLGF
Mb1136c|M.bovis_AF2122/97 AVRWVMTGWQRL--HFRFGFPAPLLEPLAVERLYLDNYFSIAKARRDLGY
Rv1106c|M.tuberculosis_H37Rv AVRWVMTGWQRL--HFRFGFPAPLLEPLAVERLYLDNYFSIAKARRDLGY
MAV_1225|M.avium_104 IVRAAMTGWQRL--HFRFGIPAPLLEPLAVERLYLDNFFSIAKASRDLGY
MUL_0172|M.ulcerans_Agy99 MVHRAMTGWQRL--HFRFGLPAPLLEPLAVERLYLDNYFSVDKARRDLGY
Mflv_2075|M.gilvum_PYR-GCK LVWFAMTIWQFL--HFKFGLPKPLLEPLAVERLYLDNYFSIAKAQRDLGY
MLBr_00204|M.leprae_Br4923 ------------------GPDDPEFHPPRLGDLKRS-CLDIGLATTVLGW
MSMEG_6142|M.smegmatis_MC2_155 ------------------APDEPEFHPPRLGDLRRS-RLDNTRAREVLGW
Mvan_4914|M.vanbaalenii_PYR-1 ALAAPLGALLEAGARLLRRPEPPMLTNWITTFMGRDRSYDITAARSELDY
. : . * *.:
MAB_4385|M.abscessus_ATCC_1997 EPRFSLDAGMRATEIWLRDQGYLD-------------------
TH_3827|M.thermoresistible__bu VPQVSLDEGMARTEAWLRTEGYLD-------------------
MMAR_3324|M.marinum_M KPVVSYHEGMARSKEWARHEGLI--------------------
Mb1136c|M.bovis_AF2122/97 EPLFTTQQALTECLPYYVSLFEQMKNEAR--AEKTAATVKP--
Rv1106c|M.tuberculosis_H37Rv EPLFTTQQALTECLPYYVSLFEQMKNEAR--AEKTAATVKP--
MAV_1225|M.avium_104 QPLFTTEQAMSECLPYYVGMFEQMKRQAL--AGKASA------
MUL_0172|M.ulcerans_Agy99 EPKFTTEQALKECLPYYVDLFRQMKSEVK--AGGR--------
Mflv_2075|M.gilvum_PYR-GCK QPLFTTEQALAQCIPYYVELFDRMKREAGNPVVQAAAPAPPKG
MLBr_00204|M.leprae_Br4923 SPQVQLDDGVRRTVEYFRAAQRS--------------------
MSMEG_6142|M.smegmatis_MC2_155 QPQVALAEGIAKTVEFFRNKSQ---------------------
Mvan_4914|M.vanbaalenii_PYR-1 TPSVNLADGLAEMADSLSR------------------------
* . .: