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MAKVLYGNGTEIVDPRTGEGYEFQPDSTHGEVDAAFSAAHEGWRNWRGTTPAERQIALIAFADAIESQSD QLVAIEQRNTGKTREQASDELSGALDEMRFMAGAQRALQGPLAGSYVPGTVSTSSRESLGVCAQILPWNY PLASAISKLAPALAMGNTSVLKPAAPTPCSVQALLAIASETLPPGVVNAVFGGRETGQYMVAHHIPALIS LTGSVRAGHEITRAAGLKVLHLELGGNCPVIVLGDVDVEAVAHEIAEAALYNAGQDCTAAARLIVASEVV DEFVAALTREFLASRTVPLATREHLDRITALLARVPKTARVECGGRRADAPGLYVEPTVVTNVAQDDEIV TEEIFGPVVTVQQFESADEAVALANDTEYGLAASIWTTEHSSAVALSQRIDAGTVWINTHGVYATEMPFG GFKSSGYGKDLSPLALENYSRVKHIMTGSMG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0817 | - | - | 100% (451) | putative aldehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4203 | - | e-103 | 46.01% (439) | putative aldehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 1e-85 | 38.79% (464) | gamma-aminobutyraldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0467 | - | 2e-67 | 35.53% (470) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3819 | - | 1e-111 | 45.23% (451) | gamma-aminobutyraldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0458 | - | 2e-67 | 35.53% (470) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-57 | 31.40% (449) | succinic semialdehyde dehydrogenase |
| M. marinum M | MMAR_2610 | - | 1e-113 | 45.37% (454) | aldehyde dehydrogenase |
| M. avium 104 | MAV_4691 | - | 1e-65 | 35.45% (457) | eptc-inducible aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1665 | - | 1e-88 | 40.04% (462) | gamma-aminobutyraldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3284 | - | 8e-69 | 36.40% (467) | PUTATIVE eptc-inducible aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2789 | - | 9e-84 | 38.53% (462) | gamma-aminobutyraldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2580 | - | 1e-110 | 45.01% (451) | gamma-aminobutyraldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0467|M.bovis_AF2122/97 MTVFSRPGSAGALMSYESRYQNFIGGQWVAPVHGRYFENPTPVTGQPFCE
Rv0458|M.tuberculosis_H37Rv MTVFSRPGSAGALMSYESRYQNFIGGQWVAPVHGRYFENPTPVTGQPFCE
MAV_4691|M.avium_104 MTVFARPGSAGALMSYESRYDNFIGGQWVAPARGRYFENPTPVTGQTFCE
TH_3284|M.thermoresistible__bu -------------MSFESRYDNFIGGEWVAPVGGEYFENPSPVTGQPFCE
Mflv_3819|M.gilvum_PYR-GCK ----------------MTTVKNFIGGELVDSTGGATMPLIDPSTGEQYGT
Mvan_2580|M.vanbaalenii_PYR-1 ----------------MTTVQNFIDGQLVDSTSGATMPLVDPSTGEQYGT
MMAR_2610|M.marinum_M -------------MVEKKVFHNIIGGEIQATPDGNTMDIVNPSTGEVYAS
MAB_0817|M.abscessus_ATCC_1997 ---------------------------MAKVLYGNGTEIVDPRTGEGYEF
MSMEG_1665|M.smegmatis_MC2_155 --------------MAVKVASSWING-ASVETSGETHQIIDPATGKSVSE
MUL_2789|M.ulcerans_Agy99 ------------MTTTVSVAGSWING-AAHSTGGRQHAVINPATQETIAE
MLBr_02573|M.leprae_Br4923 ----------------------------------MSIATINPATGETVKT
* * :
Mb0467|M.bovis_AF2122/97 VPRSDAADIDKALDAAHAAAPGWGKTAPAERAAILNMIADRIDKNAAALA
Rv0458|M.tuberculosis_H37Rv VPRSDAADIDKALDAAHAAAPGWGKTAPAERAAILNMIADRIDKNAAALA
MAV_4691|M.avium_104 VARSDEADVDKALDAAHAAAPAWGKTAPPERAAILNKIADRIEENLESLA
TH_3284|M.thermoresistible__bu VARSTEADIDKALDAAHAAAPAWGKTAPAERALILNRIADRIEANLESIA
Mflv_3819|M.gilvum_PYR-GCK APVSNEQDIDNAYAAASGAFKEWKKTTPSQRQKALLDFADEVERNADALV
Mvan_2580|M.vanbaalenii_PYR-1 APVSNEQDIDNAYAAAARAFKEWKKTTPSQRQKALLDFADEVERNADALV
MMAR_2610|M.marinum_M APNSSGKDVDDAFTAAAKAFESWRWSTPSERQRALLRLADLIEDNAEELV
MAB_0817|M.abscessus_ATCC_1997 QPDSTHGEVDAAFSAAHEGWRNWRGTTPAERQIALIAFADAIESQSDQLV
MSMEG_1665|M.smegmatis_MC2_155 YNLATAADVDTAVAAARAAFPAWAGATPAERSAVLAKLAKLADEHAEQFV
MUL_2789|M.ulcerans_Agy99 LALATPADVDHAVVAARRALPQWAGVTTAERSAVLAELADLLEQRAPELI
MLBr_02573|M.leprae_Br4923 FTPTTQDEVEDAIARAYARFDNYRHTTFTQRAKWANATADLLEAEANQSA
: ::: * * : : .:* *. : .
Mb0467|M.bovis_AF2122/97 VAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEG--ALSQIDEDTV
Rv0458|M.tuberculosis_H37Rv VAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEG--ALSQIDEDTV
MAV_4691|M.avium_104 VAEVWDNGKPIREALAADIPLAADHFRYFAGALRAQEG--SLSQIDDDTV
TH_3284|M.thermoresistible__bu LAESWDNGKPIRETLNADIPLAVDHFRYFAGAIRAQEG--SLSQIDDDTV
Mflv_3819|M.gilvum_PYR-GCK AAEGRNTGKPNHVTTVEEIPPMVDQIRFFAGAARVLEGK-SAGEYMADHT
Mvan_2580|M.vanbaalenii_PYR-1 AAEGRNTGKPDHVTAAEEIPPMVDQIRFFAGAARVLEGK-SAGEYMADHT
MMAR_2610|M.marinum_M ALECENTGKPISLTMSEEIPPMVDQIRFFAGAARVLEGR-SQGEYMRGHT
MAB_0817|M.abscessus_ATCC_1997 AIEQRNTGKT-REQASDELSGALDEMRFMAGAQRALQGP-LAGSYVPGTV
MSMEG_1665|M.smegmatis_MC2_155 AEEVSQTGKPVRLATEFDVPGSVDNIDFFAGAARHLEGK-ATAEYSGDHT
MUL_2789|M.ulcerans_Agy99 AEEVCQTGKPLRLAEEFDVPGSVDNIRFFAGAARRLPGQ-ATAEYSADHT
MLBr_02573|M.leprae_Br4923 ALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVGASK
: **. : . : * . .
Mb0467|M.bovis_AF2122/97 AYHFHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVLKPAEQTPASV
Rv0458|M.tuberculosis_H37Rv AYHFHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVLKPAEQTPASV
MAV_4691|M.avium_104 AYHFHEPLGVVGQIIPWNFPILMGAWKLAPALAAGNAVVLKPAEQTPVSV
TH_3284|M.thermoresistible__bu AYHFHEPLGVVGQIIPWNFPILMATWKLAPALAAGNAVVLKPAEQTPASV
Mflv_3819|M.gilvum_PYR-GCK SWIRREPVGVIGQVAPWNYPMMMAIWKICPAVAAGNTVVIKPSDTTPVTT
Mvan_2580|M.vanbaalenii_PYR-1 SWIRREPIGVIGQVAPWNYPMMMAIWKICPAIAAGNTVVIKPSDTTPVTT
MMAR_2610|M.marinum_M SSIRREPVGPVAQVAPWNYPMMMAVWKFAPALAAGCTVVLKPSDTTPASS
MAB_0817|M.abscessus_ATCC_1997 STSSRESLGVCAQILPWNYPLASAISKLAPALAMGNTSVLKPAAPTPCSV
MSMEG_1665|M.smegmatis_MC2_155 SSIRREAVGVVATITPWNYPLQMAVWKVIPALAAGCAVVIKPAEITPLTT
MUL_2789|M.ulcerans_Agy99 SSIRREAIGVVATITPWNYPLQMAVWKVMPALAAGCTVVIKPSELTPLTT
MLBr_02573|M.leprae_Br4923 ALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCA
: :.:* : ***:*: **: * . ::* : .*
Mb0467|M.bovis_AF2122/97 LYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKVAFTGETTTGR
Rv0458|M.tuberculosis_H37Rv LYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKVAFTGETTTGR
MAV_4691|M.avium_104 LYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSNRIAKIAFTGETTTGR
TH_3284|M.thermoresistible__bu MYLMSLIGDL-LPPGVVNVVNGFGVEAGKPLASSNRIAKIAFTGETTTGR
Mflv_3819|M.gilvum_PYR-GCK VMLAELAAKH-LPPGVLNVVTG-DRVTGANLVSHPTPEMVAITGSVAAGK
Mvan_2580|M.vanbaalenii_PYR-1 VMLAELAAKY-LPAGVLNVVTG-DRVTGASLVAHPTPEMVAITGSVAAGK
MMAR_2610|M.marinum_M YWMVEKMQEI-FPPGVCNLVCG-DRDTGAALVAHPVPQLVSITGSTRAGM
MAB_0817|M.abscessus_ATCC_1997 QALLAIASET-LPPGVVNAVFG-GRETGQYMVAHHIPALISLTGSVRAGH
MSMEG_1665|M.smegmatis_MC2_155 LTLARLASEAGLPDGVFNVVTGSGAEVGTALAGHRDVDVVTFTGSTAVGR
MUL_2789|M.ulcerans_Agy99 LTLARLAAEAGLPDGVLNVVTGLGADVGAALAAHPGVDLVTFTGSTAVGR
MLBr_02573|M.leprae_Br4923 LYLADVIARGGFPEDCFQTLLISANGVEAILR-DPRVAAATLTGSEPAGQ
: :* . : : . : ::**. .*
Mb0467|M.bovis_AF2122/97 LIMQYASHNLIPVTLELGGKSPNIFFADVLAAHDDFCDKALEGFTMFALN
Rv0458|M.tuberculosis_H37Rv LIMQYASHNLIPVTLELGGKSPNIFFADVLAAHDDFCDKALEGFTMFALN
MAV_4691|M.avium_104 LIMQYASQNLIPVTLELGGKSPNIFFSDVMAKADDYQDKALEGFTMFALN
TH_3284|M.thermoresistible__bu LIMQYASQNLIPVTLELGGKSPNIFFADVMAASDDFCDKALEGFTMFALN
Mflv_3819|M.gilvum_PYR-GCK AVAVSAGGNLKRTHLELGGKAPVIVFDDADLAATAEGIATAG-----YFN
Mvan_2580|M.vanbaalenii_PYR-1 AVAVSAGGNLKRTHLELGGKAPVIVFDDADLAAAAEGIATAG-----YFN
MMAR_2610|M.marinum_M AVAASAANDLKRAHLELGGKAPVVIFNDADIAAAVEGLTAAG-----YFN
MAB_0817|M.abscessus_ATCC_1997 EITRAAG--LKVLHLELGGNCPVIVLGDVDVEAVAHEIAEAA-----LYN
MSMEG_1665|M.smegmatis_MC2_155 KVMASAAVHGHRTQLELGGKAPFVVFSDADLDAAVQGAVAGA-----LIN
MUL_2789|M.ulcerans_Agy99 KVMAAAATHGRRTQLELGGKAPFVVFDDADLDAAIQGAVAGA-----VIN
MLBr_02573|M.leprae_Br4923 AVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGR-----VQN
: *. *****. * :.: .. *
Mb0467|M.bovis_AF2122/97 QGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQG---DPLDTETMLGSQ
Rv0458|M.tuberculosis_H37Rv QGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQG---DPLDTETMLGSQ
MAV_4691|M.avium_104 QGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQG---DPLDSETMLGSQ
TH_3284|M.thermoresistible__bu QGEVCTCPSRSLIQADIYDEFLELATIRTKAVRQG---DPLDTETMVGAQ
Mflv_3819|M.gilvum_PYR-GCK AGQDCTAATRVLASASIAADLTAALAEQAKGATTTFGRPADDEDAWVPPV
Mvan_2580|M.vanbaalenii_PYR-1 AGQDCTAATRVLASASIAADLTAALAEQAKGATTTFGRAAGDEDAWVPPV
MMAR_2610|M.marinum_M AGQDCTAATRLIIQDGIYDEFLSAMAESVAGTRT--GYDPADEDILFGPI
MAB_0817|M.abscessus_ATCC_1997 AGQDCTAAARLIVASEVVDEFVAALTREFLASRT-------------VPL
MSMEG_1665|M.smegmatis_MC2_155 TGQDCTAATRAIVARELYDDFVAGVAEVMGKIVVG---DPHDPDTDLGPL
MUL_2789|M.ulcerans_Agy99 SGQDCTAATRAIVARELCHDFVAGVADVMSTVVIG---DPMDPDTDIGPL
MLBr_02573|M.leprae_Br4923 NGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVG---DPTDPDTDVGPL
*: * .. * : : :: . .
Mb0467|M.bovis_AF2122/97 ASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYMQPTIFTGT
Rv0458|M.tuberculosis_H37Rv ASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYMQPTIFTGT
MAV_4691|M.avium_104 ASNDQLEKVLSYIAIGKDEGATIITGGERAELGGDLSGGFYMQPTIFAGN
TH_3284|M.thermoresistible__bu ASNDQLEKILSYIDIGRSEGATVVTGGERAELGGDLSGGYYVQPTIFTGD
Mflv_3819|M.gilvum_PYR-GCK NNVNQMERVLSFFSDIPSH-ATVAVGGNRQGDK-----GFYVEPTVVGGL
Mvan_2580|M.vanbaalenii_PYR-1 NNVNQMERVLSFFSDIPSH-ATVAVGGNRQGDK-----GFYVEPTVIGGL
MMAR_2610|M.marinum_M NNSNQMRHIDGLVSRAPAH-ARILAGGKQKDCA-----GFFYEPTLIVDL
MAB_0817|M.abscessus_ATCC_1997 ATREHLDRITALLARVPKT-ARVECGGRRADAP-----GLYVEPTVVTNV
MSMEG_1665|M.smegmatis_MC2_155 ISYAHRDKVAGMVARAPQQGGRVVTGGEAPDLP-----GAFYRPTLIADV
MUL_2789|M.ulcerans_Agy99 ISLAHRDRVADILAKAPAQGARIVVGGRIPDLA-----GAFYLPTLLADV
MLBr_02573|M.leprae_Br4923 ATESGRAQVEQQVDAAAAAGAVIRCGGKRPDRP-----GWFYPPTVITDI
. :: . . : **. * : **:. .
Mb0467|M.bovis_AF2122/97 -NNMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGVWSRDGNTA
Rv0458|M.tuberculosis_H37Rv -NNMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGVWSRDGNTA
MAV_4691|M.avium_104 -NKMRIFQEEIFGPVVAVTSFTDYDDAISIANDTLYGLGAGVWSRDGNTA
TH_3284|M.thermoresistible__bu -NSMRIFQEEIFGPVVAVTSFTDYDDAIRIANDTLYGLGAGVWSRDGNTA
Mflv_3819|M.gilvum_PYR-GCK RQDDRLIQQEIFGPVITVQSFTDEDEAIGYANGVEYGLASSVWTKDVSRA
Mvan_2580|M.vanbaalenii_PYR-1 RQADRLIQQEIFGPVITVQSFSDEEEAIGWANGVEYGLASSVWTKDVSRA
MMAR_2610|M.marinum_M QQDDELIQTEIFGPVVTAQRFSDEQQALSFANGTEYGLASSVWTKDVDTA
MAB_0817|M.abscessus_ATCC_1997 AQDDEIVTEEIFGPVVTVQQFESADEAVALANDTEYGLAASIWTTEHSSA
MSMEG_1665|M.smegmatis_MC2_155 DESSEVYRDEIFGPVLTVRSFTDDDDALRQANDTEYGLAASAWTRDVYRA
MUL_2789|M.ulcerans_Agy99 GEQSQAYREEIFGPVLTVRAHDGDDDALRQANDTDYGLAASAWTRDVYRA
MLBr_02573|M.leprae_Br4923 TKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQ
: *:**** :. . ::*: ** . :**.:. *: :
Mb0467|M.bovis_AF2122/97 YRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGREGHQMMLQHYQHTK
Rv0458|M.tuberculosis_H37Rv YRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGREGHQMMLQHYQHTK
MAV_4691|M.avium_104 YRAGRDIQAGRVWVNCYHAYPAHAAFGGYKQSGIGRENHKMMLDHYQQTK
TH_3284|M.thermoresistible__bu YRAGRDIKAGRVWTNCYHVYPAHAAFGGYKQSGIGRENHTMMLDHYQQTK
Mflv_3819|M.gilvum_PYR-GCK LRVSNALDFGCVWINTHIPLVAEMPHGGFKSSGHGKDLSMYGLEDYTRIK
Mvan_2580|M.vanbaalenii_PYR-1 LRVSNALDFGCVWINTHIPLVAEMPHGGFKSSGHGKDLSMYGLEDYTRIK
MMAR_2610|M.marinum_M ARMGARLDFGCVWINTHIPLVAEMPHGGFKHSGYGKDLSMYGFEDYTRIK
MAB_0817|M.abscessus_ATCC_1997 VALSQRIDAGTVWINTHGVYATEMPFGGFKSSGYGKDLSPLALENYSRVK
MSMEG_1665|M.smegmatis_MC2_155 QRASREINAGCVWINDHIPIISEMPHGGVGASGFGKDMSDYSFEEYLTIK
MUL_2789|M.ulcerans_Agy99 QRASREISAGCVWINDHIPIVSEMPHGGVAASGFGNDMSEYSFDEYLTIK
MLBr_02573|M.leprae_Br4923 RHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIK
: * *: * .. ..** ** *.: : .: *
Mb0467|M.bovis_AF2122/97 NLLVSYSDKALGFF---------
Rv0458|M.tuberculosis_H37Rv NLLVSYSDKALGFF---------
MAV_4691|M.avium_104 NMLVSYSNKAQGFF---------
TH_3284|M.thermoresistible__bu NLLVSYSTKAQGFF---------
Mflv_3819|M.gilvum_PYR-GCK HVMAYTG----------------
Mvan_2580|M.vanbaalenii_PYR-1 HVMAYTG----------------
MMAR_2610|M.marinum_M HVMHYHGFEG-------------
MAB_0817|M.abscessus_ATCC_1997 HIMTGSMG---------------
MSMEG_1665|M.smegmatis_MC2_155 HVMSDITGVAEKEWHRTIFNKR-
MUL_2789|M.ulcerans_Agy99 HVMSDITGVAEKPWHRTIFSTRI
MLBr_02573|M.leprae_Br4923 TVWIA------------------
: