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AHTLGASAMLGLPDGRALHYMRAGGGPGPTVVFESGLGASRSEWGLVAPLVAQHFPTVVYDRANLGRSDP DPAPRTLEHLAGDLGELLAALDAGPYILVGHSYGGTIALAAANRDQSCIAGLVLVDHSDEQLDVCCGSSL KHLRRLVLAGRWTMSVLRWLHLLGWVVRRAASGLPDDVLGDLIAEDLTVSAQQAADAEERFFLSGLASMR QHRRDLGNIPVTVISGVKTTLLDRSIRAAFLAAHRRSAQRLGARHVLAQKSGHLVVFTEPQLVADEIRRI AERIAAAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0470c | - | - | 100% (289) | putative hydrolase (alpha/beta hydrolase fold) |
| M. abscessus ATCC 19977 | MAB_1510 | - | 2e-79 | 57.84% (268) | Alpha/beta hydrolase fold precursor |
| M. abscessus ATCC 19977 | MAB_3034 | - | 2e-09 | 31.86% (113) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 1e-10 | 26.22% (286) | hydrolase |
| M. gilvum PYR-GCK | Mflv_3856 | - | 2e-11 | 27.08% (288) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2715 | - | 1e-10 | 26.22% (286) | hydrolase |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-10 | 24.41% (299) | short chain dehydrogenase |
| M. marinum M | MMAR_2050 | - | 1e-09 | 26.06% (307) | hypothetical protein MMAR_2050 |
| M. avium 104 | MAV_3609 | - | 1e-12 | 27.40% (292) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_1587 | - | 4e-12 | 25.08% (315) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_4323 | - | 1e-10 | 27.62% (286) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3299 | - | 1e-09 | 30.19% (159) | hypothetical protein MUL_3299 |
| M. vanbaalenii PYR-1 | Mvan_2445 | - | 7e-10 | 30.28% (109) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2050|M.marinum_M MRPTLAAAALAGASGLVGWGGARALARRIERNPDPFPRERLLAEPQGERV
MUL_3299|M.ulcerans_Agy99 MRPTLAAAALAGASGLVGWGGARALARRIERNPDPFPRERLLAEPQGERV
Mb2734|M.bovis_AF2122/97 ---------------------------MTERKRN----LRPVRDVAPPTL
Rv2715|M.tuberculosis_H37Rv ---------------------------MTERKRN----LRPVRDVAPPTL
MAV_3609|M.avium_104 ---------------------------MTERKRKNT--LRPVREVSAPRL
Mvan_2445|M.vanbaalenii_PYR-1 ---------------------------MTERKPN----LRPVRELT-PTL
MLBr_00862|M.leprae_Br4923 -------------------------------------MPATQSIHKVPHQ
TH_4323|M.thermoresistible__bu ---------------------------------------------MATEH
MAB_0470c|M.abscessus_ATCC_199 -----------------------------------------MAHTLGASA
Mflv_3856|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1587|M.smegmatis_MC2_155 -------MSRHHRRNHLRLSRIAAVACVAWVAALFCGPPSAIAVPEDVAG
MMAR_2050|M.marinum_M AITRPDGTVLHALVAGR--GTPVILVHGYCASLTEWNFVWDELLARGLRV
MUL_3299|M.ulcerans_Agy99 AITRPDGTVLHALVAGR--GTPVILVHGYCASLTEWNFVWDELLARGLRV
Mb2734|M.bovis_AF2122/97 QFRTVHGYRRAFRIAGS--GPAILLIHGIGDNSTTWNGVHAKLAQR-FTV
Rv2715|M.tuberculosis_H37Rv QFRTVHGYRRAFRIAGS--GPAILLIHGIGDNSTTWNGVHAKLAQR-FTV
MAV_3609|M.avium_104 EFRTIHGYRRAYRIAGS--GPAILLIHGIGDNSTTWNTVQAKLAQR-FTV
Mvan_2445|M.vanbaalenii_PYR-1 KFCTIHGYRRAFRVAGS--GPAILLIHGIGDNSTTWSTVQTQLAQR-FTV
MLBr_00862|M.leprae_Br4923 FVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWDGVVPLLAKR-FRI
TH_4323|M.thermoresistible__bu FIDSSGGVRIAAYEEGNPDGPTVVLVHGWPDSHVVWDSVAPLLADR-FRI
MAB_0470c|M.abscessus_ATCC_199 MLGLPDGRALHYMRAGGGPGPTVVFESGLGASRSEWGLVAPLVAQH-FPT
Mflv_3856|M.gilvum_PYR-GCK ---MDVRIRNSVRVVGRPDGRPLMLAHGFGCDQNLWRLVVPLLSDR-FRI
MSMEG_1587|M.smegmatis_MC2_155 LLDIGGGRAIFLECRGSG-SPTVVLMAGKGNGADDWLQVLAPGDPE--QD
* . .::: * . * * .
MMAR_2050|M.marinum_M IAFDQRGHGRSTLGA----EGIGSEPMADDLAAVLQHFDIRD--GVLVGH
MUL_3299|M.ulcerans_Agy99 IAFDQRGHGRSTLGA----EGIGSEPMADDLAAVLQHFDLRD--GVLVGH
Mb2734|M.bovis_AF2122/97 IAPDLLGHGQSDKPR----ADYSVAAYANGMRDLLSVLDIER--VTIVGH
Rv2715|M.tuberculosis_H37Rv IAPDLLGHGQSDKPR----ADYSVAAYANGMRDLLSVLDIER--VTIVGH
MAV_3609|M.avium_104 IAPDLLGHGQSDKPR----ADYSVAAYANGMRDLLAVLDIER--VTIVGH
Mvan_2445|M.vanbaalenii_PYR-1 IAPDLLGHGRSDKPR----ADYSVAAYANGMRDLLSVLDIDD--VTVIGH
MLBr_00862|M.leprae_Br4923 VRYDNRGVGQSSVPKP--VSAYTMTRFADDFAAVIDELSPDRP-VHVLAH
TH_4323|M.thermoresistible__bu IRYDNRGVGRTTAPRR--VADHTMARYADDFGAVIDALAPGQR-VHVLAH
MAB_0470c|M.abscessus_ATCC_199 VVYDRANLGRSDPDP----APRTLEHLAGDLGELLAALDAGP--YILVGH
Mflv_3856|M.gilvum_PYR-GCK VLFDHVGSGSSDAGAWTAKRYADLQQYADDILEIVDDMRLRE--VVYVGH
MSMEG_1587|M.smegmatis_MC2_155 APGDNLPFGRGDLIH-------SSEAVLPAIARFTRVCAYDRPDVRMGGS
* * : . .
MMAR_2050|M.marinum_M SMGGFVSIRALLDHGALAQRLRAVVLFATWAGR----VLDGAP-------
MUL_3299|M.ulcerans_Agy99 SMGGFVSIRALLDHGALAQRLRAVVLFATWAGR----VLDGAP-------
Mb2734|M.bovis_AF2122/97 SLGGGVAMQFAYQFPQLVDRLILVSAGGVTKDVNIVFRLASLP-------
Rv2715|M.tuberculosis_H37Rv SLGGGVAMQFAYQFPQLVDRLILVSAGGVTKDVNIVFRLASLP-------
MAV_3609|M.avium_104 SLGGGVAMQFAYQFPHLVERLILVGAGGVTKDVNFVLRWASLP-------
Mvan_2445|M.vanbaalenii_PYR-1 SLGGGVAMQFAYQFPQLVNRLILVGAGGVTKDVNIALRLASLP-------
MLBr_00862|M.leprae_Br4923 DWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSGLRRPWRPRT
TH_4323|M.thermoresistible__bu DWGSAGVWEYLARPEAEDRIASFTSVSGPSGDHLARYVLDGLAAPYRPRR
MAB_0470c|M.abscessus_ATCC_199 SYGGTIALAAANRDQSCIAGLVLVDHSDEQLDVCCGSSLKHLR-------
Mflv_3856|M.gilvum_PYR-GCK SVAAMMGVLAAAKNPGAFAGLVLLTPSPRYLDD--ADYRGGFT-------
MSMEG_1587|M.smegmatis_MC2_155 DISTPRAQPHSVDLDVDDLHALLTALGEPAPYVLVAHSYSGLIAD-----
. .
MMAR_2050|M.marinum_M -------------QNRLQIPLLERGILQRLLR--SRTIAVLFG-------
MUL_3299|M.ulcerans_Agy99 -------------QNRLQIPLLERGILQRLLR--SRTIAVLFG-------
Mb2734|M.bovis_AF2122/97 -------------MGSEAMALLRLPLVLPAVQIAGRIVGKAIG-------
Rv2715|M.tuberculosis_H37Rv -------------MGSEAMALLRLPLVLPAVQIAGRIVGKAIG-------
MAV_3609|M.avium_104 -------------LGSEAIALLRLPLVLPAVQLMGRVLGTALG-------
Mvan_2445|M.vanbaalenii_PYR-1 -------------MGSEALALLRLPLVLPALQVLGRVSGTVFG-------
MLBr_00862|M.leprae_Br4923 FARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIR-RTMVDNISTDQI
TH_4323|M.thermoresistible__bu FLRSLTQLLRLSYMGFFSIPVLAPLLVRGVLSKALRRSLRLRDGVPADRL
MAB_0470c|M.abscessus_ATCC_199 ---------RLVLAGRWTMSVLRWLHLLGWVVRRAAS-------------
Mflv_3856|M.gilvum_PYR-GCK ---------------RSEIDELLDSIESNYLGWSRAMAPVIMG-------
MSMEG_1587|M.smegmatis_MC2_155 ------------LYARMHPETVGALVMVDAVSEQMAD-------------
: :
MMAR_2050|M.marinum_M --AAQCG-------------------------------------------
MUL_3299|M.ulcerans_Agy99 --AAQCG-------------------------------------------
Mb2734|M.bovis_AF2122/97 --TTSLGHDLPNVLRIL---------------------------------
Rv2715|M.tuberculosis_H37Rv --TTSLGHDLPNVLRIL---------------------------------
MAV_3609|M.avium_104 --STGLGRDLPNVLRIL---------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --STGVGRDIPDMLRIL---------------------------------
MLBr_00862|M.leprae_Br4923 HHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDR
TH_4323|M.thermoresistible__bu HHSDTFAADAARSIKVYGANFLRTLRHARTDH---FVRVPVQLIVNTRDP
MAB_0470c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3856|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1587|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2050|M.marinum_M ----------------------------ARPSPAMISVFLEWFHQHLDRH
MUL_3299|M.ulcerans_Agy99 ----------------------------ARPSPAMISG-IPRVVPSTSRP
Mb2734|M.bovis_AF2122/97 ---------------------------DDLPEPTASAAFGRTLRAVVDWR
Rv2715|M.tuberculosis_H37Rv ---------------------------DDLPEPTASAAFGRTLRAVVDWR
MAV_3609|M.avium_104 ---------------------------DDLPEPTASAAFSRTLRAVVDWR
Mvan_2445|M.vanbaalenii_PYR-1 ---------------------------ADLPEPTASSAFARTLRAVVDWR
MLBr_00862|M.leprae_Br4923 YVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHDLADLVDGK
TH_4323|M.thermoresistible__bu YVRPHVYDETDRWVSRLWRRDIKAGHWSPMSHPQVLATAVTELADHLAGA
MAB_0470c|M.abscessus_ATCC_199 ----------------------------GLPDDVLGDLIAEDLTVSAQQA
Mflv_3856|M.gilvum_PYR-GCK ----------------------------TPERPDLEGELADTFCRTDPQR
MSMEG_1587|M.smegmatis_MC2_155 -----------------------------VVNPAALANWDASNATTSDQV
MMAR_2050|M.marinum_M GPHLPIVRA------------------FSRED------------------
MUL_3299|M.ulcerans_Agy99 ARTAPTHRAGV----------------LARGS------------------
Mb2734|M.bovis_AF2122/97 GQMVTMLDRCY----------------LTEAIPVQIIWGTKDVVLPVRHA
Rv2715|M.tuberculosis_H37Rv GQMVTMLDRCY----------------LTEAIPVQIIWGTKDVVLPVRHA
MAV_3609|M.avium_104 GQIVTMLDRCY----------------LTEAIPVQIVWGTKDVVVPVRHA
Mvan_2445|M.vanbaalenii_PYR-1 GQVVTMLDRCY----------------LTQSVPVQLIWGDCDAVIPVSHG
MLBr_00862|M.leprae_Br4923 QPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALARRGAEVVVS
TH_4323|M.thermoresistible__bu PAGRALLRAQVGRPREYFGDMLVAITGAGGGIGRETALAFAREGAEVIVS
MAB_0470c|M.abscessus_ATCC_199 ADAEERFFLSG-------------------------------------LA
Mflv_3856|M.gilvum_PYR-GCK ALAFARATFLS---------------------------------------
MSMEG_1587|M.smegmatis_MC2_155 REGVLLIDAFG-------------------------------RIAAAPGL
MMAR_2050|M.marinum_M ----RYPRLAEISVP--AVVMVGSSDRTTPPSHSHRLAAGIPG---ARLV
MUL_3299|M.ulcerans_Agy99 ----LSTAGRDLGAGGGDGGLLGSHHPAQPLAPAGRRNPGCPAGHRARRG
Mb2734|M.bovis_AF2122/97 HMAHAAMPGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAA
Rv2715|M.tuberculosis_H37Rv HMAHAAMPGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAA
MAV_3609|M.avium_104 WMAHAAMPGSRLEIFEGSGHFPFHDDPARFIDVVERFIDSTEPAAYDQEA
Mvan_2445|M.vanbaalenii_PYR-1 EMAHAAMPGSRLEVFEGSGHFPFHDDPDRFVEVVEKFIDTSEPAVYDHEY
MLBr_00862|M.leprae_Br4923 DIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVSAKHGVPDI
TH_4323|M.thermoresistible__bu DIDEATAKDTAAEIAARGGVAHAYQLDVSDAAAVDRFADEVCARHGVPDI
MAB_0470c|M.abscessus_ATCC_199 SMRQHRRDLGNIPVTVISGVKTTLLDRSIRAAFLAAHR-RSAQRLGARHV
Mflv_3856|M.gilvum_PYR-GCK ------DNRTDLARVTVPTVVIECARDTLAPREVGAYCHEQIAG--STLV
MSMEG_1587|M.smegmatis_MC2_155 PAVPAVVLSADKPWRTDLLPESARQGEQVTFADWLVAQDRLAAAIGAGHI
MMAR_2050|M.marinum_M T--VPGAGHLLN--WEAVDELAEVVESFAAQR------------------
MUL_3299|M.ulcerans_Agy99 TPAELGGGRRAGRSRRILCGAAVLMRGHAAGVWR----------------
Mb2734|M.bovis_AF2122/97 LRALLRRGGGEATVTGSADTRVAVLNAIGSNERSAT--------------
Rv2715|M.tuberculosis_H37Rv LRALLRRGGGEATVTGSADTRVAVLNAIGSNERSAT--------------
MAV_3609|M.avium_104 LRRLLRSGGGAQAVTGPAPTRVAVLSAMGSDERSAT--------------
Mvan_2445|M.vanbaalenii_PYR-1 LRGLLRAGISEGTISGPADTRVAVLDAMGADERSAT--------------
MLBr_00862|M.leprae_Br4923 VVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQRLVERGTGG
TH_4323|M.thermoresistible__bu VVNNAGIGHAGRFLDTPRDQWDRVLEVNLGGVVNGCRAFAPRLVERGTGG
MAB_0470c|M.abscessus_ATCC_199 LAQKSGHLVVFTEPQLVADEIRRIAERIAAAA------------------
Mflv_3856|M.gilvum_PYR-GCK TLDASGHCPHLSAPEDTAAAIADFALRL----------------------
MSMEG_1587|M.smegmatis_MC2_155 TETHSGHDIYLYSPALVVEAIRDVVAQVTRVHG-----------------
.
MMAR_2050|M.marinum_M --------------------------------------------------
MUL_3299|M.ulcerans_Agy99 --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3609|M.avium_104 --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 HIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVGVGLTTICP
TH_4323|M.thermoresistible__bu HIVNIASMASYAPLQSLNAYCTSKAAVYMFSDCLRAELDSAGIMLTTICP
MAB_0470c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3856|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1587|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2050|M.marinum_M --------------------------------------------------
MUL_3299|M.ulcerans_Agy99 --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3609|M.avium_104 --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRYGPDKVADTILS
TH_4323|M.thermoresistible__bu STVNTNIIGSTRFNAPDGLDDVVDTRREQLQKLFALRRFGPDKAAKAIVS
MAB_0470c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3856|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1587|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2050|M.marinum_M --------------------------------------
MUL_3299|M.ulcerans_Agy99 --------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------
MAV_3609|M.avium_104 --------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------
MLBr_00862|M.leprae_Br4923 AIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI
TH_4323|M.thermoresistible__bu AVKQNKPIRPVMPEAYFVYGVSRVLPQALRSTARGRVL
MAB_0470c|M.abscessus_ATCC_199 --------------------------------------
Mflv_3856|M.gilvum_PYR-GCK --------------------------------------
MSMEG_1587|M.smegmatis_MC2_155 --------------------------------------