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MDVRIRNSVRVVGRPDGRPLMLAHGFGCDQNLWRLVVPLLSDRFRIVLFDHVGSGSSDAGAWTAKRYADL QQYADDILEIVDDMRLREVVYVGHSVAAMMGVLAAAKNPGAFAGLVLLTPSPRYLDDADYRGGFTRSEID ELLDSIESNYLGWSRAMAPVIMGTPERPDLEGELADTFCRTDPQRALAFARATFLSDNRTDLARVTVPTV VIECARDTLAPREVGAYCHEQIAGSTLVTLDASGHCPHLSAPEDTAAAIADFALRL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3856 | - | - | 100% (266) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_1348 | - | 4e-13 | 23.26% (258) | 3-oxoadipate enol-lactonase |
| M. gilvum PYR-GCK | Mflv_4502 | - | 8e-12 | 27.21% (283) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 9e-11 | 26.37% (292) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2214c | ephD | 9e-11 | 26.37% (292) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-09 | 35.87% (92) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0470c | - | 2e-11 | 27.08% (288) | putative hydrolase (alpha/beta hydrolase fold) |
| M. marinum M | MMAR_3505 | - | 2e-12 | 28.51% (228) | hydrolase |
| M. avium 104 | MAV_4984 | - | 9e-12 | 29.20% (250) | alpha/beta hydrolase fold-1 |
| M. smegmatis MC2 155 | MSMEG_4707 | - | 1e-12 | 25.10% (255) | non-heme bromoperoxidase BPO-A2 |
| M. thermoresistible (build 8) | TH_2963 | - | 1e-09 | 23.83% (256) | PUTATIVE putative 3-oxoadipate enol-lactonase |
| M. ulcerans Agy99 | MUL_4838 | lipJ | 5e-12 | 28.37% (208) | lignin peroxidase LipJ |
| M. vanbaalenii PYR-1 | Mvan_2912 | - | 2e-11 | 25.83% (271) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3505|M.marinum_M --MSDD----RVRYARNGD-VHLAYRVFGQSGPTVIWVPGWMVSNVDTID
MUL_4838|M.ulcerans_Agy99 --MSQAPRTPRTRYARCGD-LDIAYQVIGDHPIDLLVIPGASIP-VDTID
Mb2237c|M.bovis_AF2122/97 MPATQQMS----RLVDSPDGVRIAVYHEGNP-------DGPTVVLVHGFP
Rv2214c|M.tuberculosis_H37Rv MPATQQMS----RLVDSPDGVRIAVYHEGNP-------DGPTVVLVHGFP
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQP-------EGPAIVLVHGFP
Mflv_3856|M.gilvum_PYR-GCK ----------------MDVRIRNSVRVVGRP-------DGRPLMLAHGFG
MAV_4984|M.avium_104 -----------MATVVSPDGTVIGYESVGAG---------PPLLLVHGST
MAB_0470c|M.abscessus_ATCC_199 ----MAHTLGASAMLGLPDGRALHYMRAGGG-------PGPTVVFESGLG
MSMEG_4707|M.smegmatis_MC2_155 -------MAAITAYRGLLRSIELHVEDTGGA--------GRPVVLVHGWP
TH_2963|M.thermoresistible__bu ------------MPRFSRAGTTIDYTDTGAPAG---RLEAPTILFGHGLL
Mvan_2912|M.vanbaalenii_PYR-1 --------MHDDVKYLDLHGDRVAYREAGQG---------PAVLLIHGMG
* :
MMAR_3505|M.marinum_M EPGSPYAPGIERASQQ-VRLVVWDRRGTGLS--DPATHLLSLDER--LED
MUL_4838|M.ulcerans_Agy99 SEPSMYR-FHRRLASF-SRLIRFDHRGVGLS--SRVSSPDALGPRFWAED
Mb2237c|M.bovis_AF2122/97 DSHVLWDGVVPLLAER-FRIVRYDNRGVGRS--SVPKPISAYTMAHFADD
Rv2214c|M.tuberculosis_H37Rv DSHVLWDGVVPLLAER-FRIVRYDNRGVGRS--SVPKPISAYTMAHFADD
MLBr_00862|M.leprae_Br4923 DSHVLWDGVVPLLAKR-FRIVRYDNRGVGQS--SVPKPVSAYTMTRFADD
Mflv_3856|M.gilvum_PYR-GCK CDQNLWRLVVPLLSDR-FRIVLFDHVGSGSSDAGAWTAKRYADLQQYADD
MAV_4984|M.avium_104 GTRARWRPVTPELARR-YTVHAMDRRGRGLS----TAEAEPYSLGREAED
MAB_0470c|M.abscessus_ATCC_199 ASRSEWGLVAPLVAQH-FPTVVYDRANLGRS----DPDPAPRTLEHLAGD
MSMEG_4707|M.smegmatis_MC2_155 LTGESWGAQVEALTAAGHRVITYDRRGFGRS----DTSLVGYTYEALSDD
TH_2963|M.thermoresistible__bu FSGWQFNLQIYALRRY-YRCLAIDWRGQGAS----SGAARPYDMDTLTED
Mvan_2912|M.vanbaalenii_PYR-1 GSSLTWKALLPHLATR-YRVIAPDLLGHGQS----DKPRGDYSLGAFAVW
: * . * *
MMAR_3505|M.marinum_M LRAIVDSVGLDR---------------AALWGTSEGG-AVSILFAATYPD
MUL_4838|M.ulcerans_Agy99 AIAVMDAAGCQQ---------------ATILASGFTA-TTALVLAADYPE
Mb2237c|M.bovis_AF2122/97 FDAVIGELSPGEPVHVLAHDWGSVGVWEYLRRPGASD-RVASFTSVSGPS
Rv2214c|M.tuberculosis_H37Rv FDAVIGELSPGEPVHVLAHDWGSVGVWEYLRRPGASD-RVASFTSVSGPS
MLBr_00862|M.leprae_Br4923 FAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASD-RVASFTSVSGPS
Mflv_3856|M.gilvum_PYR-GCK ILEIVDDMRLRE---------------VVYVGHSVAA-MMGVLAAAKNPG
MAV_4984|M.avium_104 VAAVAEAVGGDV----------------YVVGHSYG--ALAVLDAAPITR
MAB_0470c|M.abscessus_ATCC_199 LGELLAALDAGP---------------YILVGHSYGG-TIALAAANRDQS
MSMEG_4707|M.smegmatis_MC2_155 LAAVLDELDVRD---------------ATLVGFSMGTGEVAAYCARKGTE
TH_2963|M.thermoresistible__bu AAHLVRSLGVAP---------------AHYVGLSMGG-FVGIRLAARHPE
Mvan_2912|M.vanbaalenii_PYR-1 LRDLLDLLGIAR---------------VTLVGHSLGG-GVAMQFVHQHPD
: . .
MMAR_3505|M.marinum_M RVGLLSLFGTAARFSQDLPDFPWGFTPAEVQS-QLCAIEDDWGR------
MUL_4838|M.ulcerans_Agy99 RVRSLVLINASAR-TLHAPDYELGIRSNTAEP-FLTLGTDPDAV------
Mb2237c|M.bovis_AF2122/97 QDHLVNYVYGGLRRPWRPRTFLRAISQTLRLS-YMALFSVPVVAPLLLRV
Rv2214c|M.tuberculosis_H37Rv QDHLVNYVYGGLRRPWRPRTFLRAISQTLRLS-YMALFSVPVVAPLLLRV
MLBr_00862|M.leprae_Br4923 QDQLVDYILSGLRRPWRPRTFARAVSQLFRLT-YMVLFSIPVLVPMVLWI
Mflv_3856|M.gilvum_PYR-GCK AFAGLVLLTPSPR-YLDDADYRGGFTRSEIDE-LLDSIESNYLG------
MAV_4984|M.avium_104 AFRRIVLYEPPIPSLGLDVGSPGGWARITALS-DPRDILEAFYR------
MAB_0470c|M.abscessus_ATCC_199 CIAGLVLVDHSDEQLDVCCGSSLKHLRRLVLAGRWTMSVLRWLHLLGWVV
MSMEG_4707|M.smegmatis_MC2_155 RLRSVVLAAPVTPYMLNTADNPEGPLSKTQAAQMAAALTTNSDAFYR---
TH_2963|M.thermoresistible__bu LVRSLVLMNTSAGPEDPAKADRYRTMARIYRFTGIGPLRRAVLP------
Mvan_2912|M.vanbaalenii_PYR-1 YCERLVLISSGGLGPELGRSLRLLSTPGIELLLPVAAAPSVVAVGERVRS
:
MMAR_3505|M.marinum_M -GALAELFYGQAAEVPG---MRELFGRLQRSVSSPSMAKLWWQAFMATDV
MUL_4838|M.ulcerans_Agy99 -EQGFDVLRIMAPSVAHDDAFRHWWDLAGNRAASPSTARAFINAVQASDA
Mb2237c|M.bovis_AF2122/97 ALSSAAVRRNMVGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRR
Rv2214c|M.tuberculosis_H37Rv ALSSAAVRRNMVGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRR
MLBr_00862|M.leprae_Br4923 ALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRR
Mflv_3856|M.gilvum_PYR-GCK --WSRAMAPVIMGTPERPDLEGELADTFCRTD--PQRALAFARATFLSDN
MAV_4984|M.avium_104 ------ETLQLSESAIKDLANREFPYLAGSIRHTAGRELAQTRAYRLTER
MAB_0470c|M.abscessus_ATCC_199 RRAASGLPDDVLGDLIAEDLTVSAQQAADAEERFFLSGLASMRQHRRDLG
MSMEG_4707|M.smegmatis_MC2_155 -EMMTGVFSADGVLTISEDALQQVLDMCGQAS--KNAALACMAAFSNTDF
TH_2963|M.thermoresistible__bu ----LMFGPAFLADPDSEDVIDEWERRLRRYPRSSVRDAVLAVAN-RAGV
Mvan_2912|M.vanbaalenii_PYR-1 WLGARGLASPEVGETWNAYASLSDPQTRTAFLR-TLRSVVDAQGQAVSAL
MMAR_3505|M.marinum_M RAVLGSIRVPTLVLARPGDQLVPLESS-AALAAAIPNAQFRLLP---PGP
MUL_4838|M.ulcerans_Agy99 RDSLPHITAPTLILHRVGTKFVPVEHG-RYLAEHIAGSRLVELPG--SDS
Mb2237c|M.bovis_AF2122/97 GRAIPIVDVPVQLIVNSQDPYVRPYGY-DQTARWVPRLWRRDIKAGHFSP
Rv2214c|M.tuberculosis_H37Rv GRAIPIVDVPVQLIVNSQDPYVRPYGY-DQTARWVPRLWRRDIKAGHFSP
MLBr_00862|M.leprae_Br4923 GKGVPVVNVPVQLIVNTMDRYVRPYGY-DATARWVPRLWRRDIKAGHFSP
Mflv_3856|M.gilvum_PYR-GCK RTDLARVTVPTVVIECARDTLAPREVG-AYCHEQIAGSTLVTLDAS--GH
MAV_4984|M.avium_104 ---HANITTPVRMLLGTESPAYLRAAT-AVLAAKIPGATIVALHG--QGH
MAB_0470c|M.abscessus_ATCC_199 NIPVTVISGVKTTLLDRSIRAAFLAAH-RRSAQRLGARHVLAQKSGHLVV
MSMEG_4707|M.smegmatis_MC2_155 REDLPRVTVPALVIHGDADATTPLQNCGERTHAALPNSRLHVISGG--PH
TH_2963|M.thermoresistible__bu EDELAAIDVPTLVIGGAQDAATPPAHA-QALAAGIRGARLEIIDDC--GH
Mvan_2912|M.vanbaalenii_PYR-1 NRLHFTLGLPTLLIWGDQDRLIPPAHG-EAAHAALPGSRLVILPAV--GH
: : :
MMAR_3505|M.marinum_M HTPFDIIDDLAREVLDFFTGES----------------------------
MUL_4838|M.ulcerans_Agy99 LYWVGDTAALLDEVEEFITGVR----------------------------
Mb2237c|M.bovis_AF2122/97 MSHPQVMAAAVHDFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAG
Rv2214c|M.tuberculosis_H37Rv MSHPQVMAAAVHDFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAG
MLBr_00862|M.leprae_Br4923 MSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAG
Mflv_3856|M.gilvum_PYR-GCK CPHLSAPEDTAAAIADFALRL-----------------------------
MAV_4984|M.avium_104 QAIDYDPDQFARAVLEFD--------------------------------
MAB_0470c|M.abscessus_ATCC_199 FTEPQLVADEIRRIAERIAAAA----------------------------
MSMEG_4707|M.smegmatis_MC2_155 GIPVSHTEEFNRVLLDFLAEDLAAAR------------------------
TH_2963|M.thermoresistible__bu SSPLERPDVVTELLRGFLLEHT----------------------------
Mvan_2912|M.vanbaalenii_PYR-1 FPQVEAPLAVADTLDDFIANSSP---------------------------
.
MMAR_3505|M.marinum_M -----------GAPADERVLKTVLFTDIVSSTEKLSTMGDTAWRHQLNG-
MUL_4838|M.ulcerans_Agy99 -----------GGFVTERVLTAVMFTGIVGSTQRAATVGDLRWRDLLDN-
Mb2237c|M.bovis_AF2122/97 SGIGRETALAFAREGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVS
Rv2214c|M.tuberculosis_H37Rv SGIGRETALAFAREGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVS
MLBr_00862|M.leprae_Br4923 SGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVS
Mflv_3856|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4984|M.avium_104 -------------------SEEVDSGGVGAVTA-----------------
MAB_0470c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 --------------------------------------------------
TH_2963|M.thermoresistible__bu --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 ------------------WHGPPRHADHAEAD------------------
MMAR_3505|M.marinum_M ------------------HDSVVDNLLLRYGGTRAKHTGDGVFALFDA--
MUL_4838|M.ulcerans_Agy99 ------------------HDNLVRHEIQRFGGREVNTAGDGFVATFSS--
Mb2237c|M.bovis_AF2122/97 DAEAVEAFAERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNL
Rv2214c|M.tuberculosis_H37Rv DAEAVEAFAERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNL
MLBr_00862|M.leprae_Br4923 DAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNL
Mflv_3856|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4984|M.avium_104 --------------------------------------------------
MAB_0470c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 --------------------------------------------------
TH_2963|M.thermoresistible__bu --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3505|M.marinum_M --------------------------PTKAARCALQLVPALAALNIAIRA
MUL_4838|M.ulcerans_Agy99 --------------------------PSAAINCADAVVDAVAVLGIEVRV
Mb2237c|M.bovis_AF2122/97 GGVVNGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYM
Rv2214c|M.tuberculosis_H37Rv GGVVNGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYM
MLBr_00862|M.leprae_Br4923 GGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYM
Mflv_3856|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4984|M.avium_104 --------------------------------------------------
MAB_0470c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 --------------------------------------------------
TH_2963|M.thermoresistible__bu --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3505|M.marinum_M GIHTGECERRGQEWSGMAVHIGARIGVLADAGEVFASRTVRDLTAGSG--
MUL_4838|M.ulcerans_Agy99 GIHAGEVEVRGADVADLAVHIGARVCALAGSSEVLVSSTVRDIVTGSS--
Mb2237c|M.bovis_AF2122/97 FSDCLRAELDAAGVGLTTICPGVIDTNIVATTGFHAPGTDEEKIDGRRGQ
Rv2214c|M.tuberculosis_H37Rv FSDCLRAELDAAGVGLTTICPGVIDTNIVATTGFHAPGTDEEKIDGRRGQ
MLBr_00862|M.leprae_Br4923 FSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQ
Mflv_3856|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4984|M.avium_104 --------------------------------------------------
MAB_0470c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 --------------------------------------------------
TH_2963|M.thermoresistible__bu --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3505|M.marinum_M ----LTFESLGPQQLKG---------------LPEQIEIYRVSAA-----
MUL_4838|M.ulcerans_Agy99 ----HRFAERGEHELKG---------------VPGRWRLCALVREHLTGQ
Mb2237c|M.bovis_AF2122/97 IDKMFALRSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQAL
Rv2214c|M.tuberculosis_H37Rv IDKMFALRSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQAL
MLBr_00862|M.leprae_Br4923 LDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVL
Mflv_3856|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4984|M.avium_104 --------------------------------------------------
MAB_0470c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 --------------------------------------------------
TH_2963|M.thermoresistible__bu --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3505|M.marinum_M ---------
MUL_4838|M.ulcerans_Agy99 R--------
Mb2237c|M.bovis_AF2122/97 RSTARLRVI
Rv2214c|M.tuberculosis_H37Rv RSTARLRVI
MLBr_00862|M.leprae_Br4923 RSTARIRVI
Mflv_3856|M.gilvum_PYR-GCK ---------
MAV_4984|M.avium_104 ---------
MAB_0470c|M.abscessus_ATCC_199 ---------
MSMEG_4707|M.smegmatis_MC2_155 ---------
TH_2963|M.thermoresistible__bu ---------
Mvan_2912|M.vanbaalenii_PYR-1 ---------