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MRSVMGALSVALGVMTPATATADPSSNVPPAAIDRLMFSQREAERVMGAGLPNVQRQSATFALDTDRPDC GSVVLASVSSYDRSPYMAAHSQALWDHPGWFTLVDQSVAVFSTDQEARGFTRSEADRWRTCENQTINVSE QAVDGSVLQATVDIRDITQVDNVLAVSYGRNDSAYAFCQHVLLGERNVAIDIRTCSTVSKSDGERAFELM KIVGPRVWEA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0360 | - | - | 100% (220) | hypothetical protein MAB_0360 |
| M. abscessus ATCC 19977 | MAB_0361 | - | 6e-38 | 44.55% (211) | hypothetical protein MAB_0361 |
| M. abscessus ATCC 19977 | MAB_0358 | - | 9e-36 | 40.65% (214) | membrane protein PknM or lipoprotein LppH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1297c | pknH | 7e-08 | 22.91% (179) | transmembrane serine/threonine-protein kinase H |
| M. gilvum PYR-GCK | Mflv_2235 | - | 2e-08 | 24.36% (234) | putative lipoprotein LppH |
| M. tuberculosis H37Rv | Rv1266c | pknH | 2e-08 | 22.11% (199) | transmembrane serine/threonine-protein kinase H |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_2444 | - | 2e-09 | 22.89% (201) | transmembrane serine/threonine-protein kinase |
| M. avium 104 | MAV_1417 | - | 2e-05 | 23.15% (216) | serine/threonine-protein kinase PknE |
| M. smegmatis MC2 155 | MSMEG_4597 | lppH | 9e-10 | 26.94% (193) | putative lipoprotein lpph |
| M. thermoresistible (build 8) | TH_3555 | - | 3e-07 | 24.46% (233) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_3666 | lppR_1 | 2e-05 | 19.86% (146) | lipoprotein, LppR_1 |
| M. vanbaalenii PYR-1 | Mvan_3878 | - | 9e-09 | 26.07% (211) | hypothetical protein Mvan_3878 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1297c|M.bovis_AF2122/97 MSDAQ-DSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTA
Rv1266c|M.tuberculosis_H37Rv MSDAQ-DSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTA
MAV_1417|M.avium_104 MSDER-SSKVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLLNE
MMAR_2444|M.marinum_M MSDTVPTSRVGTQFGPYRLRRLLGRGGMGEVYEAHDTVKDRTVALKLMSQ
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4597|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3666|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 EFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGT
Rv1266c|M.tuberculosis_H37Rv EFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGT
MAV_1417|M.avium_104 SFSSDPVFRERMKREARTAGRLQEPHVVPVHDYGEIDGQMFLEMRLVEGT
MMAR_2444|M.marinum_M QFNSDSTFRRRMQREAHTAGRLQEPHIVPIHDFGEIDGQLFIDMRFIEGT
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4597|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3666|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 DLDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITR
Rv1266c|M.tuberculosis_H37Rv DLDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITR
MAV_1417|M.avium_104 DLDSVLKRFGPLPPPRAVAIITQIASALDAAHAAGVMHRDVKPQNILVTR
MMAR_2444|M.marinum_M DLGSVLKR-GALPAPRAVAIVSQVAEALDAAHRGGVVHRDIKPENILITG
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4597|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3666|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 DDFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIY
Rv1266c|M.tuberculosis_H37Rv DDFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIY
MAV_1417|M.avium_104 DDFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSDAEVTYRADIY
MMAR_2444|M.marinum_M NDFAYLVDFGIAAAATDQHLTKTGTAVGSWSYMAPERFGDDEVTYRSDIY
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4597|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3666|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ALACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAV
Rv1266c|M.tuberculosis_H37Rv ALACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAV
MAV_1417|M.avium_104 ALACVLFECLTGSAPYRADSAGVLVSAHVMDPIPAPSARRPGVPKAFDAV
MMAR_2444|M.marinum_M ALACVLYECLTGTPPYQTQNLSTLMGAHLMQPIPRPSRHRPDIPTAFDEV
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------MADNGL
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4597|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3666|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 VARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPG-
Rv1266c|M.tuberculosis_H37Rv VARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPAP
MAV_1417|M.avium_104 IARGMAKKPEDRYASAGDLALAAKEALSTPDQDRAATILRRSQEAALPAA
MMAR_2444|M.marinum_M IARGMAKDPALRYPTAGELARAARQALSAGDQERAATLIAGTHQLAAPP-
Mvan_3878|M.vanbaalenii_PYR-1 VNN--VGAVRCAYAAGAGLAASVLLCACVSTVEGAAVRHPGAATLDVPP-
Mflv_2235|M.gilvum_PYR-GCK ---------MRRAVAIAGIAIMVTGCASTSSAESAEPPTRTMIPR-----
TH_3555|M.thermoresistible__bu ----MTKLTRRILGGCAAAVVVLTGAACTHSVEGSAVYAPEVPRDDLPL-
MSMEG_4597|M.smegmatis_MC2_155 ----MIPVAPLRRRRPSPLTLAAIVATVVALALAAAAVVVSVSGIG----
MAB_0360|M.abscessus_ATCC_1997 ---------MRSVMGALSVALGVMTPATATADPSSN--------------
MUL_3666|M.ulcerans_Agy99 ----MTVGRAGWAGAVALLGIGLLGTGCTNTVAGVSTHAGQPGANALTP-
Mb1297c|M.bovis_AF2122/97 ----------TAAVTAQPPTMPTVTPPPIQAAP-----------------
Rv1266c|M.tuberculosis_H37Rv PKPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKPSYTPPAQPGPAGQRP
MAV_1417|M.avium_104 GQR------DAGASTVLAPPPAVNTRQPGSAAS-----------------
MMAR_2444|M.marinum_M -----------------SGPMPWAPPPWTSPAR-----------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4597|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3666|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 --TGQPSWAPNSGPMPASGPTPTPQYYQGG--GWGAPPS--GGPSPWAQT
Rv1266c|M.tuberculosis_H37Rv GPTGQPSWAPNSGPMPASGPTPTPQYYQGG--GWGAPPS--GGPSPWAQT
MAV_1417|M.avium_104 --QAGRGWTPESGPIPAAG-QPGPPYYQGGNANWAAAPAQFAGPPPWGRP
MMAR_2444|M.marinum_M --RTRTPWLLAVAVLVVVIVVVGTGIFLARK-EPASGPT--GGVSTTAGA
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4597|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3666|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 PRKTNPWPLVAGAAAVVLVLVLGAIGIWIANRPKPVQP-PQPVAEERLSA
Rv1266c|M.tuberculosis_H37Rv PRKTNPWPLVAGAAAVVLVLVLGAIGIWIAIRPKPVQP-PQPVAEERLSA
MAV_1417|M.avium_104 PPKRRVWPIVA-AVVAVLVVIAGGVGVWLVIRPKPEPPQAAPLTSDRLGA
MMAR_2444|M.marinum_M PS-----------------------GITATAGP--------TVAPTQLES
Mvan_3878|M.vanbaalenii_PYR-1 ------------------------------------------LDEAALDR
Mflv_2235|M.gilvum_PYR-GCK -----------------------------------------PLVEREIGE
TH_3555|M.thermoresistible__bu ------------------------------------------VKIAELRD
MSMEG_4597|M.smegmatis_MC2_155 -----------------------------------------NVPSAALKG
MAB_0360|M.abscessus_ATCC_1997 ------------------------------------------VPPAAIDR
MUL_3666|M.ulcerans_Agy99 ----------------------------------------EQVLPDGEEV
:
Mb1297c|M.bovis_AF2122/97 LLLNSSEVNAVMGSSSMQPGKPITSMDSS--PVTVSLPDCQGALYTSQDP
Rv1266c|M.tuberculosis_H37Rv LLLNSSEVNAVMGSSSMQPGKPITSMDSS--PVTVSLPDCQGALYTSQDP
MAV_1417|M.avium_104 LLLSASEVNAVMGSSTMEPGKPITATDSS--SVTVSVPDCQGALYTTQDP
MMAR_2444|M.marinum_M FLLSPEQINTIVGTTGIVIDHNATEMTDPGPENSLSTEQCLGALIGYQTR
Mvan_3878|M.vanbaalenii_PYR-1 VLLSVDELNSIMGSIRMKVSSELDEMTDH--TAEVSNPDCLGTVYAAEEP
Mflv_2235|M.gilvum_PYR-GCK VLLSPEEIAALMGVPAMTVIEAQTSLSDH--SDIMAPIECLAIDGAGELQ
TH_3555|M.thermoresistible__bu LIPTADEARTVVEAPNLIYLLAYTKPDSLP-PDMLSEPECASAVIPNDAS
MSMEG_4597|M.smegmatis_MC2_155 LLLTPQEVAKAHGAQAIEVISDDDSLDSN-----EPDSECLGLLNDRAER
MAB_0360|M.abscessus_ATCC_1997 LMFSQREAERVMGAGLPNVQRQSATFALD-----TDRPDCGSVVLAS-VS
MUL_3666|M.ulcerans_Agy99 KAAVGNDLPPHSPPMVGDIGVLPNGIRDN---SAAAPIECLGAIAPAMRI
: :* .
Mb1297c|M.bovis_AF2122/97 VYAGTGYTAINGLISSEPGDNYEHW-VNQAVVAFPTADKARAFVQTSADK
Rv1266c|M.tuberculosis_H37Rv VYAGTGYTAINGLISSEPGDNYEHW-VNQAVVAFPTADKARAFVQTSADK
MAV_1417|M.avium_104 VYAGSGYSAVNGLVSSEPGDNYDHW-VNQAVVLFPSADKAKSFLQTSLQK
MMAR_2444|M.marinum_M TYKSSGYTGMLAQLMQKPRSTPGYV-VVQGAVIFASADQAVGFVAAQADQ
Mvan_3878|M.vanbaalenii_PYR-1 AYAGTGWTAVRDQVAREPDGDNDHW-VEQTAVIYPAARNAQDFFDRSSVT
Mflv_2235|M.gilvum_PYR-GCK VYANSDYRASRDQSLND-GEGWKTY-VKQAVVLFPYLEKAGEFFDASVAQ
TH_3555|M.thermoresistible__bu AYRGSGYAAVYGRLADDLRSHR----ISTGVAAFAGAQEAHEWVTQQVDR
MSMEG_4597|M.smegmatis_MC2_155 AYRGSGWRAVHHQSLAD--QARHVM-FSQSLIAMSDIHGAARYVDEQHAL
MAB_0360|M.abscessus_ATCC_1997 SYDRSPYMAAHSQALWD-HPGWFTL-VDQSVAVFSTDQEARGFTRSEADR
MUL_3666|M.ulcerans_Agy99 SYEVAPVRAAALQDYWNYDSGVVASSATVAAIKLASSDDAQRLFASFTQQ
* : . . . *
Mb1297c|M.bovis_AF2122/97 WKNCAGKTVTV-----TNKAKTYRWTFADVKGSPPTITVIDTQ---EGAE
Rv1266c|M.tuberculosis_H37Rv WKNCAGKTVTV-----TNKAKTYRWTFADVKGSPPTITVIDTQ---EGAE
MAV_1417|M.avium_104 WKGCAGQTVTV-----TNKSKTYRWTFAQVQGAPPKITLMDTQ---EGAD
MMAR_2444|M.marinum_M WRSCAGKDVTQ-----VNNGKTSRWTFREVSGAPPKISLQRDL---ADSV
Mvan_3878|M.vanbaalenii_PYR-1 WQDCANATITT-----GDG--DYLWELDAAQVDDTVLTQRVTQ---DGAD
Mflv_2235|M.gilvum_PYR-GCK WPACREYTHTQ-----SGS----VWNPGEITSADRTLSTVAMQRD-AAAP
TH_3555|M.thermoresistible__bu WRDCTDRTLTI-----SLNGQELQWKTSGPTRAEGVHVLLRRQ----EGT
MSMEG_4597|M.smegmatis_MC2_155 WKVCSAQVLHRK----NEDGLVADYVVTMVKRSDGILAASYHR---DGGD
MAB_0360|M.abscessus_ATCC_1997 WRTCENQTINVSEQAVDGSVLQATVDIRDITQVDNVLAVSYGR---NDSA
MUL_3666|M.ulcerans_Agy99 WRQCEGRTVTMYT--HDRSDTELYSKVTEVRTDGPILSATIISWDNHHTP
* *
Mb1297c|M.bovis_AF2122/97 GWECQRAMSVANNVVVDVNACG---YQITNQAGQIAAKIVDKVNKE-
Rv1266c|M.tuberculosis_H37Rv GWECQRAMSVANNVVVDVNACG---YRITNQAGQIAAKIVDKVNKE-
MAV_1417|M.avium_104 GWECQRALSVANNVIVDINACG---YRITDQGDQIADKIVAKIDNE-
MMAR_2444|M.marinum_M -VVCQHVLSAVSNIVLDVNVCA---PNVTDQASEIADTMAAKVPT--
Mvan_3878|M.vanbaalenii_PYR-1 GWACQHALSVVSNLTVEAWACG---YSISDEAAEIAVAMIENAATK-
Mflv_2235|M.gilvum_PYR-GCK GWGCGRALVHRNNVIVDVNTCS---AAPGDSAVRIAHQIADKVDAQW
TH_3555|M.thermoresistible__bu DYACSRGVAARSNVAADVLVCGRNPEAVNPQAGKLANLMLSKIGD--
MSMEG_4597|M.smegmatis_MC2_155 GRTCVRGMAWRRNVVIDVTTCG--PGPTLWRLPGIIVPISARIQEA-
MAB_0360|M.abscessus_ATCC_1997 YAFCQHVLLGERNVAIDIRTCSTVSKSDGERAFELMKIVGPRVWEA-
MUL_3666|M.ulcerans_Agy99 QSPVERAVGVQGDVLADAKVALRPHSQPGTRAIELVKVMLRKVSSTN
: : :: : .. : : .