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ADNGLVNNVGAVRCAYAAGAGLAASVLLCACVSTVEGAAVRHPGAATLDVPPLDEAALDRVLLSVDELNS IMGSIRMKVSSELDEMTDHTAEVSNPDCLGTVYAAEEPAYAGTGWTAVRDQVAREPDGDNDHWVEQTAVI YPAARNAQDFFDRSSVTWQDCANATITTGDGDYLWELDAAQVDDTVLTQRVTQDGADGWACQHALSVVSN LTVEAWACGYSISDEAAEIAVAMIENAATK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3878 | - | - | 100% (241) | hypothetical protein Mvan_3878 |
| M. vanbaalenii PYR-1 | Mvan_3880 | - | 2e-50 | 43.95% (223) | hypothetical protein Mvan_3880 |
| M. vanbaalenii PYR-1 | Mvan_4460 | - | 2e-21 | 31.96% (219) | putative lipoprotein LppH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1297c | pknH | 2e-36 | 36.56% (186) | transmembrane serine/threonine-protein kinase H |
| M. gilvum PYR-GCK | Mflv_2675 | - | 6e-79 | 64.45% (211) | hypothetical protein Mflv_2675 |
| M. tuberculosis H37Rv | Rv1266c | pknH | 3e-36 | 36.56% (186) | transmembrane serine/threonine-protein kinase H |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0360 | - | 8e-09 | 26.07% (211) | hypothetical protein MAB_0360 |
| M. marinum M | MMAR_4171 | - | 3e-35 | 32.56% (215) | transmembrane serine/threonine-protein kinase |
| M. avium 104 | MAV_1417 | - | 1e-36 | 40.00% (190) | serine/threonine-protein kinase PknE |
| M. smegmatis MC2 155 | MSMEG_4554 | - | 8e-47 | 42.22% (225) | serine/threonine-protein kinase PknH, putative |
| M. thermoresistible (build 8) | TH_3756 | - | 2e-21 | 31.63% (215) | PUTATIVE putative conserved lipoprotein LppH |
| M. ulcerans Agy99 | MUL_4150 | lppH | 2e-31 | 33.05% (236) | lipoprotein LppH |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAE
Rv1266c|M.tuberculosis_H37Rv MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAE
MMAR_4171|M.marinum_M MSDAQGSRVGSTFGPYRLTRLLGRGGMGEVYEAEHTVKEWTVAVKLMSET
MAV_1417|M.avium_104 MSDERSSKVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLLNES
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 FSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD
Rv1266c|M.tuberculosis_H37Rv FSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD
MMAR_4171|M.marinum_M FSKDPVFRERMKREARITGRLQEPHVVPIHDYGEIDGQMYLEMRLIEGTD
MAV_1417|M.avium_104 FSSDPVFRERMKREARTAGRLQEPHVVPVHDYGEIDGQMFLEMRLVEGTD
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 LDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRD
Rv1266c|M.tuberculosis_H37Rv LDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRD
MMAR_4171|M.marinum_M LDNLLKRFGPLTPPRAVAIITQVASALDAAHAAGVMHRDVKPQNILVTRE
MAV_1417|M.avium_104 LDSVLKRFGPLPPPRAVAIITQIASALDAAHAAGVMHRDVKPQNILVTRD
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
Rv1266c|M.tuberculosis_H37Rv DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
MMAR_4171|M.marinum_M DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
MAV_1417|M.avium_104 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSDAEVTYRADIYA
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 LACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVV
Rv1266c|M.tuberculosis_H37Rv LACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVV
MMAR_4171|M.marinum_M LACVLHECLTGSPPYRADSASMLVTAHMMDPIPQPSTVRAGIPKAFDTVI
MAV_1417|M.avium_104 LACVLFECLTGSAPYRADSAGVLVSAHVMDPIPAPSARRPGVPKAFDAVI
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPG--
Rv1266c|M.tuberculosis_H37Rv ARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPAPP
MMAR_4171|M.marinum_M ARGMAKQPGDRYASAGDLALAAHEALSNPDQDHAADILRRSQEATLPGPP
MAV_1417|M.avium_104 ARGMAKKPEDRYASAGDLALAAKEALSTPDQDRAATILRRSQEAALPAAG
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ---------TAAVTAQPPTMPTVTPPPIQAAP------------------
Rv1266c|M.tuberculosis_H37Rv KPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKPSYTPPAQPGPAG----
MMAR_4171|M.marinum_M DPAAPPTMPATAAAPPARPGPAATPPRPAPTPQQPPYYPAAAAPAAGSPP
MAV_1417|M.avium_104 QR-------DAGASTVLAPPPAVNTRQPGSAAS-----------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 -----------------------------------------------MAD
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ------------------------------TGQPSWAPNSGPMPASGPTP
Rv1266c|M.tuberculosis_H37Rv -------------------------QRPGPTGQPSWAPNSGPMPASGPTP
MMAR_4171|M.marinum_M SGPSAVAGPPRGVAPSGPAGPSGPIPRPPAAGQPGWQQASGPIPASQPTP
MAV_1417|M.avium_104 ------------------------------QAGRGWTPESGPIPAAG-QP
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0360|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 NGLVNNVGAVRCAYAAG-------------------------AGLAASVL
Mflv_2675|M.gilvum_PYR-GCK -------------------------------------------MTALMLP
MSMEG_4554|M.smegmatis_MC2_155 ---MTPGRRWTRLCTAG-------------------------AAAAVMCL
Mb1297c|M.bovis_AF2122/97 TPQYYQGGGWG-APPSG---GPSPWAQTP-----RKTNPWPLVAGAAAVV
Rv1266c|M.tuberculosis_H37Rv TPQYYQGGGWG-APPSG---GPSPWAQTP-----RKTNPWPLVAGAAAVV
MMAR_4171|M.marinum_M SPPYYQGAGWGGAPPPGQPAGPSTWNQGPQGPGPRGRNPWPIVA-AVAIV
MAV_1417|M.avium_104 GPPYYQGGNANWAAAPAQFAGPPPWGRPP-----PKRRVWPIVA-AVVAV
TH_3756|M.thermoresistible__bu ----------------------------------------------MGVL
MUL_4150|M.ulcerans_Agy99 ----MRQRVAALAALVG----------------------------GAGML
MAB_0360|M.abscessus_ATCC_1997 -----------------------------------------------MRS
Mvan_3878|M.vanbaalenii_PYR-1 LCACVSTVEGAAVRHPGAATLD-VPPLDEAALDRVLLSVDELNSIMGSIR
Mflv_2675|M.gilvum_PYR-GCK MTACVETVDGTALRGHGAGLTD-VAPLDESRLDSVLVGIDEINSIMGATG
MSMEG_4554|M.smegmatis_MC2_155 LSGCVTVVGGTATRDP-AAPPP-GAAVTEVDLDNLLLPVTELGDIVGSDD
Mb1297c|M.bovis_AF2122/97 LVLVLGAIGIWIANRP-KPVQP-PQPVAEERLSALLLNSSEVNAVMGSSS
Rv1266c|M.tuberculosis_H37Rv LVLVLGAIGIWIAIRP-KPVQP-PQPVAEERLSALLLNSSEVNAVMGSSS
MMAR_4171|M.marinum_M LVLIVGGIGVWMITQPPKPSPP-PKPIAEDRLSSLLLSPAEVNSVMGASN
MAV_1417|M.avium_104 LVVIAGGVGVWLVIRP-KPEPPQAAPLTSDRLGALLLSASEVNAVMGSST
TH_3756|M.thermoresistible__bu VAGCGSTGHAESTTAPSTTKTLIPRPLVERELPGLLLSPEQVNAAMGTTD
MUL_4150|M.ulcerans_Agy99 VTGCTNIVDGN-AVAADMSGPLNQTPIAVSALDDLLLDVSQIDSALGATS
MAB_0360|M.abscessus_ATCC_1997 VMGALSVALGVMTPATATADPS--SNVPPAAIDRLMFSQREAERVMGAG-
: : : ::. : :*:
Mvan_3878|M.vanbaalenii_PYR-1 MKVSSELDEMTDHTAEVSNPDCLGTVYAAEEPAYAGTGWTAVRD---QVA
Mflv_2675|M.gilvum_PYR-GCK MEVTGELDEMSDHSADVSDPDCLGAVYGAEAPVYEGTDWTAVRD---QVA
MSMEG_4554|M.smegmatis_MC2_155 LTVTVELDQFNDSSAAMDDPDCLAAAFGAQERVYAGTGWTAVRD---QIV
Mb1297c|M.bovis_AF2122/97 MQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAING---LIS
Rv1266c|M.tuberculosis_H37Rv MQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAING---LIS
MMAR_4171|M.marinum_M IQPGKPITSMDASPVTLSLPECQGALYTSQDPVYSGTGYTAISG---LVA
MAV_1417|M.avium_104 MEPGKPITATDSSSVTVSVPDCQGALYTTQDPVYAGSGYSAVNG---LVS
TH_3756|M.thermoresistible__bu MAIISSQTSLSDHSNTMAPPECLALDGAGEADVYADSGYRAAR----DHS
MUL_4150|M.ulcerans_Agy99 MKVWFNAKAMWDWSKNISDKNCLAVDGPAQDEVYAGTGWTAMRGQRMDDS
MAB_0360|M.abscessus_ATCC_1997 --LPNVQRQSATFALDTDRPDCGSVVLASVS-SYDRSPYMAAHS----QA
. :* . * : : *
Mvan_3878|M.vanbaalenii_PYR-1 REPDGDNDHWVEQTAVIYPAARNAQDFFDRSSVTWQDCAN-------ATI
Mflv_2675|M.gilvum_PYR-GCK REPGAGNDHWVEQAVVLYPEERNARDFLESSQAVWRDCAN-------NAL
MSMEG_4554|M.smegmatis_MC2_155 REPGSFSPHWIEQVVVLFTSDLHARDFFDQSRETWRGCVG-----TLTTY
Mb1297c|M.bovis_AF2122/97 SEPGDNYEHWVNQAVVAFPTADKARAFVQTSADKWKNCAG-----KTVTV
Rv1266c|M.tuberculosis_H37Rv SEPGDNYEHWVNQAVVAFPTADKARAFVQTSADKWKNCAG-----KTVTV
MMAR_4171|M.marinum_M SEPGDNNDHWVNQAVVSFPSAAKASSFVETMAGKWKNCAG-----KTVTV
MAV_1417|M.avium_104 SEPGDNYDHWVNQAVVLFPSADKAKSFLQTSLQKWKGCAG-----QTVTV
TH_3756|M.thermoresistible__bu LNNGDNFTHYAKQAVVLFPLAETARAFFEASAEQWPACHEY----RHT--
MUL_4150|M.ulcerans_Agy99 VDDSKRRKHYAIQAVVAFPSAHDASAFYNSSVRSWGNCSNR----RFTDV
MAB_0360|M.abscessus_ATCC_1997 LWDHPGWFTLVDQSVAVFSTDQEARGFTRSEADRWRTCENQTINVSEQAV
* .. :. * * * *
Mvan_3878|M.vanbaalenii_PYR-1 TTGDGDYLWELDAAQVDDTVLTQRVTQ--DGADGWACQHALSVVSNLTVE
Mflv_2675|M.gilvum_PYR-GCK GVG--DYLWELGAVEAADLMLTQVTTQ--EGADGWSCQHALSLVSNVTVE
MSMEG_4554|M.smegmatis_MC2_155 DIDQMPLEWVVGEVTAEESTISQLSVP--ETAVRGGCHHALSVAANLVAE
Mb1297c|M.bovis_AF2122/97 TNKAKTYRWTFADVKGSPPTITVIDTQ--EGAEGWECQRAMSVANNVVVD
Rv1266c|M.tuberculosis_H37Rv TNKAKTYRWTFADVKGSPPTITVIDTQ--EGAEGWECQRAMSVANNVVVD
MMAR_4171|M.marinum_M TNKSKTYRWTFAQVVGSPPRITMLETQ--EGAEGWECQRAMSVANNVIVD
MAV_1417|M.avium_104 TNKSKTYRWTFAQVQGAPPKITLMDTQ--EGADGWECQRALSVANNVIVD
TH_3756|M.thermoresistible__bu ---QSGTKWYVAELTRDGDILKAITVQRDAGHPGWGCGRALVLRNNIIGD
MUL_4150|M.ulcerans_Agy99 STDQPDTIWTVSDVVNDNGMLSTSQVQ-EAGD-GWTCQRALTVRNNVAID
MAB_0360|M.abscessus_ATCC_1997 DGSVLQATVDIRDITQVDNVLAVSYGR--NDSAYAFCQHVLLGERNVAID
. : * :.: *: :
Mvan_3878|M.vanbaalenii_PYR-1 AWACGYSISDE---AAEIAVAMIENAATK---
Mflv_2675|M.gilvum_PYR-GCK AWACGYDITDE---AARIADAMIRNAAG----
MSMEG_4554|M.smegmatis_MC2_155 AWACGEGVEDQ---ASEIVDQIVANIE-----
Mb1297c|M.bovis_AF2122/97 VNACGYQITNQ---AGQIAAKIVDKVNKE---
Rv1266c|M.tuberculosis_H37Rv VNACGYRITNQ---AGQIAAKIVDKVNKE---
MMAR_4171|M.marinum_M INSCGYHITDQ---GGALADKIVDKIHKETKY
MAV_1417|M.avium_104 INACGYRITDQ---GDQIADKIVAKIDNE---
TH_3756|M.thermoresistible__bu VNTCS-ADPGDS--AVRIAQQIGENVDAVW--
MUL_4150|M.ulcerans_Agy99 VVTCAYSQSGSV--AADVAQQIAAKAAKQ---
MAB_0360|M.abscessus_ATCC_1997 IRTCSTVSKSDGERAFELMKIVGPRVWEA---
:*. .. . : : .