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ELRHIRYLLAVADHANFTRAAESLHISQPTLSQQIKQLERTLGVILLDRSGRAVRLTDAGEAYAQHARLA LRDLDAGERAVHDMHDLSRGHLRIAMTPTFTAYFIGPLVHRFHSAHPGITLTVRETTQDRIEADLLADRL DLGIAFAGPHPAGIDHCALFTETLRLVVGTGHRLAMRHRSLPVAQLSREALGLLSPDFATRQDIDAYFAG LGVAPHIAVEANSISALLEFVKRGSLATVLPDAIAHEHSDLHLVPLSPPLPIRTVELLRRSSAYHSAAAR AFTEMVHAGARGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0055c | - | - | 100% (294) | DNA-binding transcriptional regulator CynR |
| M. abscessus ATCC 19977 | MAB_2238 | - | 1e-36 | 35.86% (290) | LysR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3208c | - | 9e-29 | 33.20% (259) | LysR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 3e-18 | 30.40% (273) | oxidative stress response regulatory protein OXYS |
| M. gilvum PYR-GCK | Mflv_3565 | - | 3e-40 | 37.88% (293) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 3e-18 | 30.40% (273) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02041 | oxyR | 2e-22 | 28.67% (286) | putative LysR-family transcriptional regulator |
| M. marinum M | MMAR_2756 | oxyR | 1e-21 | 28.62% (283) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_1538 | - | 4e-30 | 28.27% (283) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_3840 | - | 9e-40 | 37.63% (287) | LysR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_3504 | - | 8e-16 | 24.36% (275) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 1e-22 | 28.98% (283) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_3362 | - | 2e-37 | 37.69% (268) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3565|M.gilvum_PYR-GCK ---------------MELRQLEYFVAIVEEGGFTRAASRERVAQPAVSAQ
Mvan_3362|M.vanbaalenii_PYR-1 ---------------MELRQLEYLVAVVEERSFTKAAQRERVAQPAVSAQ
MSMEG_3840|M.smegmatis_MC2_155 ---------------MELRQLEYFVAVAEEANFTRAAQRIHVAQPAVSAS
MAB_0055c|M.abscessus_ATCC_199 ---------------MELRHIRYLLAVADHANFTRAAESLHISQPTLSQQ
MMAR_2756|M.marinum_M MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MUL_2998|M.ulcerans_Agy99 -----MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MLBr_02041|M.leprae_Br4923 --------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQA
Mb0121|M.bovis_AF2122/97 ---------------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSA
Rv0117|M.tuberculosis_H37Rv ---------------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSA
MAV_1538|M.avium_104 ---------------MAVGDYEWFITLAELQHVTAAAEQLHVAQPTLTRM
TH_3504|M.thermoresistible__bu ----------VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSA
. ::::.: . ** : * :::
Mflv_3565|M.gilvum_PYR-GCK IRRLERSVGQPLLTRTSREVRLTRAGEALLPHARAALAAVRDGRAAVDDV
Mvan_3362|M.vanbaalenii_PYR-1 IRRLERQVGQPLLTRSHRGVRVTPAGAALLPHARAALAAVRDAQAAVDDV
MSMEG_3840|M.smegmatis_MC2_155 IRQLERELGQPLFDRSRREVRLTAAGEAVLPHAHAALRSVAAARTAVAEV
MAB_0055c|M.abscessus_ATCC_199 IKQLERTLGVILLDRSGRAVRLTDAGEAYAQHARLALRDLDAGERAVHDM
MMAR_2756|M.marinum_M LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MUL_2998|M.ulcerans_Agy99 LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MLBr_02041|M.leprae_Br4923 LAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGE
Mb0121|M.bovis_AF2122/97 IAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAV
Rv0117|M.tuberculosis_H37Rv IAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAV
MAV_1538|M.avium_104 LARLEQRLGVALFDRHGRRLSLNTYGRIFYEHARRAQLELDSARRAIADL
TH_3504|M.thermoresistible__bu VRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQT
: ** :. *. * :. * .:
Mflv_3565|M.gilvum_PYR-GCK AGLLRGSVAIG-TVTLHPMNVAHLIAEFHADHPDVEITLGTATSD-VLIA
Mvan_3362|M.vanbaalenii_PYR-1 ANLVRGAVAIG-TVTLHPVDVARLMADFHAEHPGVEITLGTDTSD-VLLA
MSMEG_3840|M.smegmatis_MC2_155 SGLVRGSVVVG-TVTAHDFDMAGLLAEFHGAHQLVDITLGTDESD-ALID
MAB_0055c|M.abscessus_ATCC_199 HDLSRGHLRIAMTPTFTAYFIGPLVHRFHSAHPGITLTVRETTQD-RIEA
MMAR_2756|M.marinum_M ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVIEDQTE-RLLT
MUL_2998|M.ulcerans_Agy99 ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVIEDQTE-RLLT
MLBr_02041|M.leprae_Br4923 SDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLPTLTLRVVEDQTE-HLLT
Mb0121|M.bovis_AF2122/97 RSGITGTLRLG-TVPTASTTASLVLSAFCSAHPLAKVQVCSRLAATELYR
Rv0117|M.tuberculosis_H37Rv RSGITGTLRLG-TVPTASTTASLVLSAFCSAHPLAKVQVCSRLAATELYR
MAV_1538|M.avium_104 ADPAVGEIRLAYLSSFGSTVVPRLIARFKESSPRVTFTLEEGAAE-SIAD
TH_3504|M.thermoresistible__bu EAAAQAHYVIGHTPALSGAEAYALIEPAVTAYPSTSFTLRQLYPD-ALTD
. .. . :: . : :
Mflv_3565|M.gilvum_PYR-GCK ELGDGRLDLAIVSIAVDEDLPGLEVAVITDEAVEAAVADGHPLAHR-RSL
Mvan_3362|M.vanbaalenii_PYR-1 KLEDGRLDAAIVSIGADEDPAGLEYEVITDEALEAAVTAQHRLARR-KSL
MSMEG_3840|M.smegmatis_MC2_155 GLLAGRLDAAIISVGSG-LPEGLAAEVVTDQRIVAAVGDGHPWRRR-RRI
MAB_0055c|M.abscessus_ATCC_199 DLLADRLDLGIAFAGPH--PAGIDHCALFTETLRLVVGTGHRLAMRHRSL
MMAR_2756|M.marinum_M ALREGSLDTALIALPAD--YGGLTEIPIYEEDFVLALPPGHPMADR-HGV
MUL_2998|M.ulcerans_Agy99 ALREGSLDTALIALPAD--YGGLTEIPIYEEDFVLALPPGHPMADR-HGV
MLBr_02041|M.leprae_Br4923 ALREGALDAAMIALPVE--TAGIAEIPIYDEDFVLALPPGHPLSGK-RRV
Mb0121|M.bovis_AF2122/97 RLREFELDAVIVHPETQ-DSDDVDLVPLYEEQYVLLSPADMLPPGT-STL
Rv0117|M.tuberculosis_H37Rv RLREFELDAVIVHPETQ-DSDDVDLVPLYEEQYVLLSPADMLPPGT-STL
MAV_1538|M.avium_104 RVRSGGVDIGVVSPRPV--ERTLAWRSLFRQRLGVAVPDGHRFARG-AAV
TH_3504|M.thermoresistible__bu AVFDGTVQLGLRRGVVP--TPELATAVIGYHRVRVAFVDSHPLAAR-ESV
: :: : : : . :
Mflv_3565|M.gilvum_PYR-GCK SLEQLSRHPLISLPAG--TGLRTRLDTACAAAGLRPRIA-FEATSPAELA
Mvan_3362|M.vanbaalenii_PYR-1 SLKQLCEYPVISLPAG--TGLRSRLDDACAAAGLRPRIA-FEATSPLELA
MSMEG_3840|M.smegmatis_MC2_155 ALTDLAGVPLITLPRG--TGIRRQLDRACRAAGVDVRVA-FEATTPGALA
MAB_0055c|M.abscessus_ATCC_199 PVAQLSREALGLLSPD--FATRQDIDAYFAGLGVAPHIA-VEANSISALL
MMAR_2756|M.marinum_M PVAALSELPLLLLDEG--HCLRDQALDVCQNAGVRAELADTRAASLATAV
MUL_2998|M.ulcerans_Agy99 PVAALSELPLLLLDEG--HCLRDQALDVCQNAGVRAEHADTRADSLATAV
MLBr_02041|M.leprae_Br4923 PTTALAQLPLLLLDEG--HCLRDQTLDICRKSGVQAELANTRAASLATAV
Mb0121|M.bovis_AF2122/97 VWRDAAQLPLALLTAD--MRDRQVIDAAFADHAVS-AIPQVETDSVASLF
Rv0117|M.tuberculosis_H37Rv VWRDAAQLPLALLTAD--MRDRQVIDAAFADHAVS-AIPQVETDSVASLF
MAV_1538|M.avium_104 SMVDLADEPFVTMHPG--FGMRRLLDELCAAAQFRPRVA-LQAPNLTTAA
TH_3504|M.thermoresistible__bu DITELAREQVALWAPPGTSYYSDFLMGACRRAGFEPDYVVSRVQGAATVA
. . . ..
Mflv_3565|M.gilvum_PYR-GCK ELARHGLGVAILPQ----SMARGGSG---LHALRLAPELRGRLVWAWRAD
Mvan_3362|M.vanbaalenii_PYR-1 DLARHGLGVAILPR----SMARGSAG---LHPLRLSPELRGRLVWAWRTD
MSMEG_3840|M.smegmatis_MC2_155 DLAERGLGAAVLPE----SVARARAA---LHPLPITPELRGRLVFAWRAT
MAB_0055c|M.abscessus_ATCC_199 EFVKRGSLATVLPD----AIAHEHSD---LHLVPLSPPLPIRTVELLRRS
MMAR_2756|M.marinum_M QCVNGGLGVTLIPQ----SAVSVEAARSRVGLAHFAAPTPGRRIGLVYRA
MUL_2998|M.ulcerans_Agy99 QCVNGGLGVTLIPQ----SAVSVEAARSRVGLTHFAAPTPGRRIGLVYRA
MLBr_02041|M.leprae_Br4923 QCVTGGLGVTLLPQ----SAAPVESVRSKLGLAQFAAPCPGRRIGLAFRS
Mb0121|M.bovis_AF2122/97 AQVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNA
Rv0117|M.tuberculosis_H37Rv AQVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNA
MAV_1538|M.avium_104 SLVAAGLGISLVPID-------GSSYPSGVSVKPLADADAYRDVGMIWDS
TH_3504|M.thermoresistible__bu APLTTG-GIAFVTA------AAGPTMNGRVQVVDLTPPLLVPVQALWQR-
* :.:. . : :
Mflv_3565|M.gilvum_PYR-GCK GAN--PAARVLGERARAMAVSPGSGAPAVVPGA--
Mvan_3362|M.vanbaalenii_PYR-1 ISG--PAARLLNARARAMIAATG--TPAVIPGA--
MSMEG_3840|M.smegmatis_MC2_155 GPMS-PAARALVTMARRRLGLGD---PDRVGGHE-
MAB_0055c|M.abscessus_ATCC_199 SAYHSAAARAFTEMVHAGARGR-------------
MMAR_2756|M.marinum_M SSGRDEAYRQLAAIMGESISNEQQVRLVN------
MUL_2998|M.ulcerans_Agy99 SSGRDEAYRQLAAIMGESISNEQQVRLVN------
MLBr_02041|M.leprae_Br4923 ASGRSASYRQIAKIIGELISTEHHVRLVA------
Mb0121|M.bovis_AF2122/97 LGPGSPVARALITCAQALALNEFFDTQLRGITRRR
Rv0117|M.tuberculosis_H37Rv LGPGSPVARALITCAQALALNEFFDTQLRGITRRR
MAV_1538|M.avium_104 GRPLPRSARDFIAGAAAVGHGGW------------
TH_3504|M.thermoresistible__bu --------HTLSAIRDRILEGLG------------
: :