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M. thermoresistible (build 8) TH_3892 (aldA_2)

annotation: aldehyde dehydrogenase NAD dependent AldA_2
coordinates: 470624 - 472069
length: 482

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3892aldA_2-100% (482)aldehyde dehydrogenase NAD dependent AldA_2
M. thermoresistible (build 8)TH_2814-e-15456.78% (479) PUTATIVE aldehyde dehydrogenase
M. thermoresistible (build 8)TH_3100-e-14555.19% (482) PUTATIVE aldehyde dehydrogenase (NAD) family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0791aldA1e-14753.11% (482) aldehyde dehydrogenase NAD dependant AldA
M. gilvum PYR-GCKMflv_1600-1e-15256.37% (479) aldehyde dehydrogenase
M. tuberculosis H37RvRv0768aldA1e-14753.11% (482) aldehyde dehydrogenase NAD dependent AldA
M. leprae Br4923MLBr_02573gabD13e-4429.49% (468) succinic semialdehyde dehydrogenase
M. abscessus ATCC 19977MAB_1218-1e-14252.49% (482) aldehyde dehydrogenase AldA
M. marinum MMMAR_4322aldA_20.082.74% (481) aldehyde dehydrogenase NAD dependent AldA_2
M. avium 104MAV_1275-0.081.50% (481) aldehyde dehydrogenase family protein
M. smegmatis MC2 155MSMEG_5859-1e-14954.07% (479) aldehyde dehydrogenase (NAD) family protein
M. ulcerans Agy99MUL_0477aldA1e-14453.53% (482) NAD-dependent aldehyde dehydrogenase, AldA
M. vanbaalenii PYR-1Mvan_5157-1e-15255.19% (482) aldehyde dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_4322|M.marinum_M               MADTTEAVEVRFESKMMIDGKLVDGQAGTFTNINPATEEPLGEVADASKT
MAV_1275|M.avium_104                ---------------MMIDGKLVDGQAGTFTNINPATEEPLGEVADASKE
TH_3892|M.thermoresistible__bu      ---------------MMIDGKLVEGSAGTFTTINPATEEPLGEVADASVA
Mflv_1600|M.gilvum_PYR-GCK          -----MAILADRDSKLLIDGKLVAGSAGTFPTVNPATEETLGVAADAGAD
Mvan_5157|M.vanbaalenii_PYR-1       -----MAILADRESRLLIDGKLVAGSSGTFTTVNPATEETLGVAADASAE
MSMEG_5859|M.smegmatis_MC2_155      -----MPLLADRQSQLLIDGKLVAGRKGVFDTVNPATEEVLGVAADATAE
MAB_1218|M.abscessus_ATCC_1997      -----MTVLSDGDSELFIDGKLLPGGAGRFPTVNPATEEVLGTAADADSD
Mb0791|M.bovis_AF2122/97            -----MALWGDGISALLIDGKLSDGRAGTFPTVNPATEEVLGVAADADAE
Rv0768|M.tuberculosis_H37Rv         -----MALWGDGISALLIDGKLSDGRAGTFPTVNPATEEVLGVAADADAE
MUL_0477|M.ulcerans_Agy99           -----MALLADGVSSLFIDGKRCEGAAGTFATVNPATEETLGVAADAVAG
MLBr_02573|M.leprae_Br4923          ---------------------------MSIATINPATGETVKTFTPTTQD
                                                                 : .:**** * :   : :   

MMAR_4322|M.marinum_M               DMHRAIDAARRAFDETDWSTNRALRKRCLEQLQEAIEAEREELREELILE
MAV_1275|M.avium_104                DMHRAIDAARRAFDETDWSTNRELRKRCLLQLHEAIESEKEELREELILE
TH_3892|M.thermoresistible__bu      DMHRAIDAARRAFDETDWSTNHAFRQRCLLQLQEALETEQEELREELILE
Mflv_1600|M.gilvum_PYR-GCK          DMDAAIGAARRAFDETGWSTDTALRVRCIRQLQNAMRAHVEELRELTIAE
Mvan_5157|M.vanbaalenii_PYR-1       DMSAAIGAARRSFDETDWATNTDLRVRCIRQLQQAMRDHVEELRELTIAE
MSMEG_5859|M.smegmatis_MC2_155      DMGDAIEAARRAFDDTDWSTDTELRVRCIRQLRDALREHVEELRDLTIAE
MAB_1218|M.abscessus_ATCC_1997      DMSDAIEAARRAFDDSGWSRDVALRVHCIRQLRDGMKTHIEELRELTIAE
Mb0791|M.bovis_AF2122/97            DMGRAIEAARRAFDSTDWSRNTELRVRCVRQLRDAMQQHVEELRELTISE
Rv0768|M.tuberculosis_H37Rv         DMGRAIEAARRAFDSTDWSRNTELRVRCVRQLRDAMQQHVEELRELTISE
MUL_0477|M.ulcerans_Agy99           DMDRAIEAARRAFDDTDWSRNTELRVRCVRQLRDAMREHIEELRALTISE
MLBr_02573|M.leprae_Br4923          EVEDAIARAYARFDN-YRHTTFTQRAKWANATADLLEAEANQSAALMTLE
                                    ::  **  *   **.         * :      : :. . ::       *

MMAR_4322|M.marinum_M               AGAPRAITFGPQLDAPLADALRYPVKLIDEYPWETDLGDVLVSITGQMTT
MAV_1275|M.avium_104                VGSPRAITFGPQLDAPLEDGLKYPARLIDEYAWETDLGDKVISLTGTLTT
TH_3892|M.thermoresistible__bu      VGCPRSITHGPQLDAPLSDALRYPAELIDEYSWETALGDAMVSVTGMNTT
Mflv_1600|M.gilvum_PYR-GCK          VGAPRMLTAAAQLEGPVDD-LSFCADTAESYRWSTDLG--IASPMGIKTR
Mvan_5157|M.vanbaalenii_PYR-1       VGAPRMLTSAAQLEGPVED-LSFCADTAESYAWTTDLG--IASPMGIKTH
MSMEG_5859|M.smegmatis_MC2_155      VGAPRMLTSGAQLEGPIDD-LAFSADTAENYPWRTDLG--HATPQGIPTD
MAB_1218|M.abscessus_ATCC_1997      VGAPRMLTAGAQLEGPVDD-LQFAADTAESFDWTSDLG--VASPMGIKTR
Mb0791|M.bovis_AF2122/97            VGAPRMLTASAQLEGPVGD-LSFAADTAESYPWKQDLG--EASPLGIATR
Rv0768|M.tuberculosis_H37Rv         VGAPRMLTASAQLEGPVGD-LSFAADTAESYPWKQDLG--EASPLGIATR
MUL_0477|M.ulcerans_Agy99           VGAPRMLTAAAQLEGPVND-LAFSADTAESYSWKQDLG--AAAPMGIPTR
MLBr_02573|M.leprae_Br4923          MG--KTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVGASKALAR
                                     *  : :  . :      . : : .   :                   : 

MMAR_4322|M.marinum_M               RKVWREPVGVVGAIVPWNFPFEVTINKLGQALGTGNTVVLKPAPDTPFNA
MAV_1275|M.avium_104                RKVWREPVGVVGAIVPWNFPFEVTLNKLGQALGTGNTVVLKPAPNTPFNA
TH_3892|M.thermoresistible__bu      RRVWREPAGVVGAIVPWNFPFEVSIQKIGQALGTGCTVVLKPAPDTPFNA
Mflv_1600|M.gilvum_PYR-GCK          RTVTREAIGVVGAITPWNFPHQINLAKVGPALAAGNTLVLKPAPDTPWAA
Mvan_5157|M.vanbaalenii_PYR-1       RTIAREAVGVVGAITPWNFPHQINLAKIGPALAAGNTLVLKPAPDTPWAA
MSMEG_5859|M.smegmatis_MC2_155      RVIAREAVGVVGAITPWNFPHQINLAKVGPALAAGNTLVLKPAPDTPWAA
MAB_1218|M.abscessus_ATCC_1997      RTLAREAVGVVGAVTPWNFPHQINLAKVGPALAAGNTLVLKPAPDTPWCA
Mb0791|M.bovis_AF2122/97            RTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCA
Rv0768|M.tuberculosis_H37Rv         RTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCA
MUL_0477|M.ulcerans_Agy99           RTVVREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCA
MLBr_02573|M.leprae_Br4923          ----YQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCA
                                         :. *** *: *****   .:   . ** :* . :** *.:.*  *

MMAR_4322|M.marinum_M               TRLGRLIAEKTDIPPGVVSVVTASDHLVGEELTLSPKVDLISFTGSTGVG
MAV_1275|M.avium_104                TRLGRLIAEKTDIPAGVVNVVTASDHFVGEELTLSPKVDLISFTGSTVVG
TH_3892|M.thermoresistible__bu      TRLGRLIAERTDIPPGVVNVVTASDHLIGEELTLSPKVDLISFTGSTAVG
Mflv_1600|M.gilvum_PYR-GCK          AVLGELITEHTDFPAGVINIVTSSDHGVGALLSKDPRVDMVSFTGSTNTG
Mvan_5157|M.vanbaalenii_PYR-1       AVLGELIAEHTDFPAGVINIVTSSDHGVGALLSKDPRVDMVSFTGSTNTG
MSMEG_5859|M.smegmatis_MC2_155      AVLGQIITEHTDFPPGVINIVTSSDHSVGALLSKDPRVDMVSFTGSTATG
MAB_1218|M.abscessus_ATCC_1997      AVLGRIIAEHTDFPPGVVNIVTSSDHRIGAQLSTDPRVDMVSFTGSTATG
Mb0791|M.bovis_AF2122/97            AALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTGSTATG
Rv0768|M.tuberculosis_H37Rv         AALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTGSTATG
MUL_0477|M.ulcerans_Agy99           AVLGELIADCTDIPPGVVNIVTSSEHGLGALLAKDPRVDMVSFTGSTATG
MLBr_02573|M.leprae_Br4923          LYLADVIARG-GFPEDCFQTLLISANGVEAILR-DPRVAAATLTGSEPAG
                                      *. :*.   .:* . .. :  * : :   *  .*:*   ::***  .*

MMAR_4322|M.marinum_M               KRIMEKGAATMKRLFLELGGKSATIVLED---AEFGLACAIG-IAPCMHA
MAV_1275|M.avium_104                QRIMEKGAATMKRLFLELGGKSATIVLED---ADFGMACAIG-IAPCMHA
TH_3892|M.thermoresistible__bu      KRIMAKGAATMKRLFLELGGKSATIVLED---ADFALGCMMG-IAPCMHA
Mflv_1600|M.gilvum_PYR-GCK          RAVMADGAATLTKVFLELGGKSAFLVLDD---ADLAGACSMAAFTASMHA
Mvan_5157|M.vanbaalenii_PYR-1       RAVMADGAATLKKVFLELGGKSAFLVIDD---ADLAGACSMAAFTASMHA
MSMEG_5859|M.smegmatis_MC2_155      RAVMTDAALTIKKVFLELGGKSAFLVLDD---ADLTGACSMAAFTVAMHA
MAB_1218|M.abscessus_ATCC_1997      RAVMTDAAATVKKVFLELGGKSAFIVLDDLDEAALGSACSVAAFTAAMHA
Mb0791|M.bovis_AF2122/97            RAVMADAAATIKKVFLELGGKSAFVVLDD---ADLAAASAVSAFSACMHA
Rv0768|M.tuberculosis_H37Rv         RAVMADAAATIKKVFLELGGKSAFVVLDD---ADLAAASAVSAFSACMHA
MUL_0477|M.ulcerans_Agy99           RSVMADGAATIKRMFLELGGKSAFIVLDD---ADLAAASSVSAFTASMHA
MLBr_02573|M.leprae_Br4923          QAVGAIAGNEIKPTVLELGGSDPFIVMPS---ADLDAAVATAVTGRVQNN
                                    : :   ..  :.  .*****... :*: .   * :  .   .      : 

MMAR_4322|M.marinum_M               GQGCANPTRMLLPRSRYDEGVAILKSIYDNVMPGDPQDPATLCGPVISDK
MAV_1275|M.avium_104                GQGCANPTRMLLPRSRYDEGVAILKGIYENVTCGDPQDPGTLCGPVISQV
TH_3892|M.thermoresistible__bu      GQGCANPTRLLLPRSRYDEGIEILRGIYEGVAPGDPQDPATLCGPVINEK
Mflv_1600|M.gilvum_PYR-GCK          GQGCAITTRLLVPRARYDEAVEAAAATMGGLKPGDPDKPGTICGPVISAR
Mvan_5157|M.vanbaalenii_PYR-1       GQGCAITTRLVVPRDRYDEAVEAAAATMGGLKAGDPTKPGTVCGPLISER
MSMEG_5859|M.smegmatis_MC2_155      GQGCAITTRLVVPRARYDEAVEIAAGTLGSIKPGDPTSKRTVCGPVISAR
MAB_1218|M.abscessus_ATCC_1997      GQGCAITTRLVVPRERYDDAVAAAAATMGSLKPGDPAKPGTICGPVISAR
Mb0791|M.bovis_AF2122/97            GQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISAR
Rv0768|M.tuberculosis_H37Rv         GQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISAR
MUL_0477|M.ulcerans_Agy99           GQGCAITTRLVVPRARYDEAVAIAAGTMSSIKPGDPDDARTVCGPLISQR
MLBr_02573|M.leprae_Br4923          GQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATES
                                    **.*  ..*::     *:: :    .    :  *** .  *  **: .  

MMAR_4322|M.marinum_M               QRKRVLGYLNKGVEEGATCLVGGPDAPTGFDRGFYVRPTLFVDVDNSMTI
MAV_1275|M.avium_104                QRDRVMGYIRKGVEEGATALVGGPDAPTGFDKGYYVRPTLFTDVDNSMTI
TH_3892|M.thermoresistible__bu      QRTRIRGYIRKGVEEGARLVVGGEDPPDGLDKGFFVRPTLFADVDNSMTI
Mflv_1600|M.gilvum_PYR-GCK          QRDRIQSYLDSAVAEGGRFACGG-GRPADRDTGFFIEPTVIAGLDNNAKV
Mvan_5157|M.vanbaalenii_PYR-1       QRERVQGYLDSAIAEGGRFACGG-GRPADRDTGFFIDPTVIAGLDNNAKV
MSMEG_5859|M.smegmatis_MC2_155      QRDRVQSYLDLAIKEGGRFACGG-GRPADMDKGFWIEPTVIAGLDNNARV
MAB_1218|M.abscessus_ATCC_1997      QRDRVQSYLDLAVAEGGSFACGG-GRPEGKDRGFFIEPTVVAGLTNAARV
Mb0791|M.bovis_AF2122/97            QRDRVQGYLDLAVAEGGRFACGG-ARPADREVGFYIEPTVIAGLTNDARV
Rv0768|M.tuberculosis_H37Rv         QRDRVQGYLDLAVAEGGRFACGG-ARPADREVGFYIEPTVIAGLTNDARV
MUL_0477|M.ulcerans_Agy99           QRDRVEGYLDLAIAEGGTFACGG-GRPAGRQVGYFIEPTVIAGLTTDARP
MLBr_02573|M.leprae_Br4923          GRAQVEQQVDAAAAAGAVIRCGG-KRPD--RPGWFYPPTVITDITKDMAL
                                     * ::   :  .   *.    **   *     *::  **:...: .    

MMAR_4322|M.marinum_M               AQEEIFGPVLSVIPFDTEEDAIRIANDSVYGLAGNVMSGSLEHSLAVARR
MAV_1275|M.avium_104                AQEEIFGPVLCVIPFDDEEDAIRIANDSRYGLAGNVMSGSLERSLSVARR
TH_3892|M.thermoresistible__bu      AQEEIFGPVLAVIPYDDEDDAVRIANDTAYGLAGNVMSSSIEHALAVARR
Mflv_1600|M.gilvum_PYR-GCK          AREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVFSPDLERANGVAAR
Mvan_5157|M.vanbaalenii_PYR-1       AREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVFSADPERAAGIAAR
MSMEG_5859|M.smegmatis_MC2_155      AREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVFSGDDARAQAVASR
MAB_1218|M.abscessus_ATCC_1997      AREEIFGPVLVVIAHDGDEDAVRIANDSPYGLSGTVFGDDDERSARVASR
Mb0791|M.bovis_AF2122/97            AREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASR
Rv0768|M.tuberculosis_H37Rv         AREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASR
MUL_0477|M.ulcerans_Agy99           AREEIFGPVLTVLAHDGDDDAVRIANDSPYGLSGTVYGGDPQRAADVAAR
MLBr_02573|M.leprae_Br4923          YTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDN
                                      :*:****  *      :**:.*** : :**....   .  .   .  .

MMAR_4322|M.marinum_M               LRAGFIGVNGGAPYGADTPFGGYKDSGVGRQNGVAGFDQYTQIKSLGYPA
MAV_1275|M.avium_104                IRAGFMGVNGGAPYGADTPFGGYKYSGVGRQNGVAGFDQYTEIKSVAYPA
TH_3892|M.thermoresistible__bu      LRAGFIGINGAAGYGADTPFGGYKDSGVGRQNGVAGFDQYTEIKSVAYPA
Mflv_1600|M.gilvum_PYR-GCK          LRVGTVNINGGVWYSADMPFGGYKQSGIGREMGLAGFEEYLEIKAIATAV
Mvan_5157|M.vanbaalenii_PYR-1       MRVGTVNVNGGVWYSADMPFGGYKQSGIGREMGLAGFEEYLEIKAIATAA
MSMEG_5859|M.smegmatis_MC2_155      MRVGTVNVNGGIWYSADAPFGGYKQSGVGREMGLAGFEEYTEIKLIATLA
MAB_1218|M.abscessus_ATCC_1997      LRVGTVNVNGGVWYSADAPFGGYKQSGNGREMGVAGFEEYLETKVIATAV
Mb0791|M.bovis_AF2122/97            LRVGTVNVNGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIATAA
Rv0768|M.tuberculosis_H37Rv         LRVGTVNVNGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIATAA
MUL_0477|M.ulcerans_Agy99           LRVGAVNVNGGVWYCADAPFGGYKQSGIGREMGLAGFEEYLETKLIATAA
MLBr_02573|M.leprae_Br4923          IVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA-
                                    : .* : :**     .: **** * ** **: .  *: :: : * :    

MMAR_4322|M.marinum_M               G
MAV_1275|M.avium_104                G
TH_3892|M.thermoresistible__bu      -
Mflv_1600|M.gilvum_PYR-GCK          N
Mvan_5157|M.vanbaalenii_PYR-1       N
MSMEG_5859|M.smegmatis_MC2_155      G
MAB_1218|M.abscessus_ATCC_1997      K
Mb0791|M.bovis_AF2122/97            N
Rv0768|M.tuberculosis_H37Rv         N
MUL_0477|M.ulcerans_Agy99           N
MLBr_02573|M.leprae_Br4923          -