For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_4193 | - | - | 100% (538) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_2995 | - | e-147 | 73.74% (358) | PUTATIVE AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_4415 | - | e-102 | 52.72% (368) | PUTATIVE AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3116 | fadD13 | 9e-25 | 25.87% (375) | chain-fatty-acid-CoA ligase |
| M. gilvum PYR-GCK | Mflv_2385 | - | 1e-160 | 78.96% (366) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv3089 | fadD13 | 9e-25 | 25.87% (375) | chain-fatty-acid-CoA ligase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 3e-23 | 26.42% (371) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 7e-26 | 28.35% (395) | putative long-chain-fatty-acid CoA ligase |
| M. marinum M | MMAR_0466 | - | 1e-144 | 71.58% (366) | long-chain-fatty-acid-CoA ligase |
| M. avium 104 | MAV_2574 | - | 1e-158 | 78.45% (362) | feruloyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_4883 | - | 1e-167 | 82.24% (366) | AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_1115 | - | 1e-143 | 71.31% (366) | long-chain-fatty-acid-CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_4263 | - | 1e-154 | 77.05% (366) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0466|M.marinum_M ---------------------------------------------MSVSL
MUL_1115|M.ulcerans_Agy99 ---------------------------------------------MSVSL
MAV_2574|M.avium_104 -------------------------------------------------M
Mflv_2385|M.gilvum_PYR-GCK ---------------------------------------------MSISL
Mvan_4263|M.vanbaalenii_PYR-1 ---------------------------------------------MSISL
MSMEG_4883|M.smegmatis_MC2_155 ---------------------------------------------MSISL
TH_4193|M.thermoresistible__bu ---------------------------------------------MSISL
Mb3116|M.bovis_AF2122/97 ---------------------------------------------MKNIG
Rv3089|M.tuberculosis_H37Rv ---------------------------------------------MKNIG
MAB_4559|M.abscessus_ATCC_1997 ---------------------------------------------MQFTQ
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
MMAR_0466|M.marinum_M LLEMAASASPDRIAVVSG---DLRLTTQQLSDLADGGAGAIAASDAQ---
MUL_1115|M.ulcerans_Agy99 LLEMAASASPDRIAVVSG---DLRLKTQQLSDLADGGAGAIAASDAQ---
MAV_2574|M.avium_104 LLEMAASGDPDRVAVVDG---DIRLTTVDLSELADGGAGVIAASGAS---
Mflv_2385|M.gilvum_PYR-GCK LLEMATDAGPDRTAVVSD---DTRLTTAELSALADGGAGVIAASGAR---
Mvan_4263|M.vanbaalenii_PYR-1 LLEMAQDAGPDRTAVVSD---DLRLTTAELSALADGGAGVIAASGAR---
MSMEG_4883|M.smegmatis_MC2_155 LLEMASSGDPDRTAVVSD---DTRLTAGELSTLADGAAGVIAGSGAA---
TH_4193|M.thermoresistible__bu LLEMAASSNPDRIAVVSD---QTRLTAAELSELADRAAGVIAGSGVR---
Mb3116|M.bovis_AF2122/97 WMLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTALGIAKGD
Rv3089|M.tuberculosis_H37Rv WMLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTALGIAKGD
MAB_4559|M.abscessus_ATCC_1997 WLHRALQQYPDRLITIDQ---GREHTVEQFADRVARLSAGLRANGVRPGD
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDE---EGTLTYKELDRAAHALANGLIAKGVRGGD
. * . :: . : : . .
MMAR_0466|M.marinum_M HVVYVGTGGAMLPLLIFASARAGLPFTSINYRLSADGIAALIRRLPRPLV
MUL_1115|M.ulcerans_Agy99 HVVYVGTGGAMLPLLIFASARAGLPFTSINYRLSADGIAALIRRLPRPLV
MAV_2574|M.avium_104 HVAYVGTGGVLLPLLLFSSARANTAFTPLNYRLSPEGLRELIDRLPSPLV
Mflv_2385|M.gilvum_PYR-GCK HVAYVGTGGALLPLLLFASARAAVPVTPLNYRLSAEGLRALLDRLPDPLV
Mvan_4263|M.vanbaalenii_PYR-1 HVAYVGAGGAMLPLLLFASARAAVPVTPLNYRLSADGLRALLDRLPDPLV
MSMEG_4883|M.smegmatis_MC2_155 HVAYVGTGGALLPLLLFASARAAIPFTPLNYRLSAEGLRELVDRLPTPLV
TH_4193|M.thermoresistible__bu HVAYVGTGGHLLPLLLFGSARANVPVTPLNYRLSAEGLRELIDRLPDPLV
Mb3116|M.bovis_AF2122/97 RVALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVV
Rv3089|M.tuberculosis_H37Rv RVALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVV
MAB_4559|M.abscessus_ATCC_1997 RVGMLSLNSDRYIEYLTAVPWLGAALNAVNIRWSLAEIGYSLRESGTRVL
MLBr_02546|M.leprae_Br4923 GIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVI
: : . . . :* . : : ::
MMAR_0466|M.marinum_M VVDERYRDTIA--ADQSLSSQQFLELAGRAEP-----------------V
MUL_1115|M.ulcerans_Agy99 VVDERYRETIA--ADQSLSSQQFLELAGRAEP-----------------V
MAV_2574|M.avium_104 VVDAEYRDIGAGFGQRVMTSDEFIEAARSTEP-----------------V
Mflv_2385|M.gilvum_PYR-GCK VVDDEYRDAVGDSYR-TMGSREFFEASRTAEP-----------------A
Mvan_4263|M.vanbaalenii_PYR-1 VVDDEYRDAVGDGYR-TIGSAEFLDAARTAEP-----------------A
MSMEG_4883|M.smegmatis_MC2_155 IADGEYAGMLAGAGRPVLTSEEFLSQARTADP-----------------A
TH_4193|M.thermoresistible__bu ITDPEYREVVGDAGEKVLTSDEFVTAARAGEP-----------------A
Mb3116|M.bovis_AF2122/97 IYGAPSAPVIDAIRAQADPPGTVTDWIGADS------LAERLRSAAADEP
Rv3089|M.tuberculosis_H37Rv IYGAPSAPVIDAIRAQADPPGTVTDWIGADS------LAERLRSAAADEP
MAB_4559|M.abscessus_ATCC_1997 LVDDTFKAAAAPLRAACACLETVIYCGAGPAPQ-DMIGYEDLLASHEPID
MLBr_02546|M.leprae_Br4923 IYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSSSA
: . .
MMAR_0466|M.marinum_M AEFPDPDSVAIVLFTSGTTSQPKAVELTHSNLTSYVTTTVEFGCAAPS-D
MUL_1115|M.ulcerans_Agy99 AEFPDPDSVAIVLFTSGTTSQPKAVELTHSNLTSYVTTTVEFGCAAPS-D
MAV_2574|M.avium_104 SVFADPDDVAVVLFTSGTTSRPKAVELTHNNLTSYVTGTVEFGSADPA-D
Mflv_2385|M.gilvum_PYR-GCK AEFADPDSVGVVLFTSGTTSKPKAVELTHTNLTSYIMGTVEFASAEPD-D
Mvan_4263|M.vanbaalenii_PYR-1 AEFADPDAVGVVLFTSGTTSKPKAVELSHANLTSYIMGTVEFASAEPD-D
MSMEG_4883|M.smegmatis_MC2_155 AEFADPDAVAVVLFTSGTTSRPKAVELTHNNLTSYITGTVEFGSAAPE-D
TH_4193|M.thermoresistible__bu AEFADPDDVAVVLFTSGTTSRPKAVELTHNNLTSYVTGTVEFDSAATE-D
Mb3116|M.bovis_AF2122/97 AVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWASTIDVRYR-D
Rv3089|M.tuberculosis_H37Rv AVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWASTIDVRYR-D
MAB_4559|M.abscessus_ATCC_1997 DTRTGGDSLLGVFYTGGTTGNPKGVMLSHNNVLASAMGSLSTGNFLTRGG
MLBr_02546|M.leprae_Br4923 PAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVPFRAH-E
. :: *.***. **.. . : .
MMAR_0466|M.marinum_M AALICVPPYHIAGVSAVLSNLYAGRKMVYLTNFDAHEWVRLTNAEQVTTA
MUL_1115|M.ulcerans_Agy99 AALICVPPYHIAGVSAVLSNLYAGRKMVYLNNFDAHEWVRLTNAEQVTTA
MAV_2574|M.avium_104 AALVCVPPYHIAGVGAALSNLYAGRAIVYLRRFDPHEWVRLVRDERVTTA
Mflv_2385|M.gilvum_PYR-GCK AALICVPPYHIAGVSAALSNLYAGRKMVYLRHFDAEKWVRLVADEGVTSA
Mvan_4263|M.vanbaalenii_PYR-1 AALICVPPYHIAGVSAALSNLYAGRKMVYLTQFDAGRWVDLVTGEGVTSA
MSMEG_4883|M.smegmatis_MC2_155 AALICVPPYHIAGVSAAMSNLYAGRKMVYLRNFDAHRWVELVRTEGVTSA
TH_4193|M.thermoresistible__bu AALICVPPYHIAGVGAAMSNLYAGRKMVYLRHFDARDWVRLVREEKVTTA
Mb3116|M.bovis_AF2122/97 RLLLPLPMFHVAALTTVIFSAMRGVTLISMPQFDATKVWSLIVEERVCIG
Rv3089|M.tuberculosis_H37Rv RLLLPLPMFHVAALTTVIFSAMRGVTLISMPQFDATKVWSLIVEERVCIG
MAB_4559|M.abscessus_ATCC_1997 RLLHSAPMFHMADFSAVLAGNLSGSTHVIVPSFSPQGVLDAIVAHDVQDM
MLBr_02546|M.leprae_Br4923 VTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVLEDIEKHQATAM
* * :* . * : *.. . .
MMAR_0466|M.marinum_M TVVPTMLDRIVAVLE--TGEHKLPSLRNLAYGGSKVGLPLVRRALELLPD
MUL_1115|M.ulcerans_Agy99 TVVPTMLDRIVAVLE--TGEHKLPSLRNLAYGCSKVGLPLVRRALELLPD
MAV_2574|M.avium_104 TVVPTMLSRIVAVLE--EQSAELPTLRNFAYGGSKVARPLVRRALDLLPQ
Mflv_2385|M.gilvum_PYR-GCK TVVPTMLDRIVTVLE--TTDTALPTLRTLAYGGSKVPLPLVRKALSLLPD
Mvan_4263|M.vanbaalenii_PYR-1 TVVPTMLDRIVSVLE--TRGTTLPTLRTLAYGGSKVPLPLVRKALSLLPA
MSMEG_4883|M.smegmatis_MC2_155 TVVPTMLDRIVTALE--TTRAELPTLRNLAYGGSKVALPLVRKALELMPN
TH_4193|M.thermoresistible__bu TVVPTMLDRIVTVLQ--TDGGDLPTLRNLAYGGSKVALPLVRTALELLPN
Mb3116|M.bovis_AF2122/97 GAVPAILNFMRQVPE--FAELDAPDFRYFITGGAPMPEALIK--IYAAKN
Rv3089|M.tuberculosis_H37Rv GAVPAILNFMRQVPE--FAELDAPDFRYFITGGAPMPEALIK--IYAAKN
MAB_4559|M.abscessus_ATCC_1997 LLVPTMIQMLVDHPG--AAQLDLSGIRSITYGASVISEAVLQRATRVFPN
MLBr_02546|M.leprae_Br4923 VVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRALEELGP
**.::. : . :* . . : : :
MMAR_0466|M.marinum_M VGFVNAYGLTETSSTIAVLTP--DDHRAAQSAAAAGLARRLGSVGRPVPG
MUL_1115|M.ulcerans_Agy99 VGFVNAYRLTETSSTIAVLTP--DDHRAAQSAAAAGLARRLGSVGRPVPG
MAV_2574|M.avium_104 VGFVNAYGLTETSSTIAVLTP--EDHRLAHEARDDAVARRLTSVGRPVPG
Mflv_2385|M.gilvum_PYR-GCK VGFVNAYGLTETSSTIAVLTP--DDHRAALAAADDAALRRLGSVGQPVPG
Mvan_4263|M.vanbaalenii_PYR-1 VGFVNAYGLTETSSTIAVLTP--DDHRAALAASDEAAIRRLGSVGQPVPG
MSMEG_4883|M.smegmatis_MC2_155 VGFVNAYGLTETSSTIAVLGP--DDHRAALASDDPGVTRRLGSVGQVVPG
TH_4193|M.thermoresistible__bu VGFVNAYGLTETSSTIAVLGP--EDHREALAATDPAVARRLGSVGRPVPG
Mb3116|M.bovis_AF2122/97 IEVVQGYALTESCGGGTLLLS--EDALR-----------KAGSAGRATMF
Rv3089|M.tuberculosis_H37Rv IEVVQGYALTESCGGGTLLLS--EDALR-----------KAGSAGRATMF
MAB_4559|M.abscessus_ATCC_1997 ARFTQAYGMTEVSPVATLLLP--DDHDDPA---------LLRSAGRAAPH
MLBr_02546|M.leprae_Br4923 VIYN-MYGSTEIAFATIAGPKDLQIN--------------SATVGPVVKG
* ** . : :.* .
MMAR_0466|M.marinum_M VELQIRGQDGRVLGPGETGELFVRGGQVSGRYTGIGSVLDG---HGWFGT
MUL_1115|M.ulcerans_Agy99 VELQIRGQDGRVLGPGETGELFVRGEQVSGRYTGIGSVLDG---HGWFGT
MAV_2574|M.avium_104 IEVQIRAEDGTVLGPGETGELFVRGPQVSGRYTEIGSVLDD---HGWFAT
Mflv_2385|M.gilvum_PYR-GCK IEVEVRAEDGTVLGPGETGELFVRGEQVSGKYTDIGSVLDE---NGWFPT
Mvan_4263|M.vanbaalenii_PYR-1 IEVEIRADDGTVLGAGETGELFVRGEQVSGKYTDIGSVLDE---QGWFPT
MSMEG_4883|M.smegmatis_MC2_155 IEVQIRGEDGTVLGPGETGELFVRGEQVSGRYTEIGSVLDE---DGWFPT
TH_4193|M.thermoresistible__bu VEVQIRAEDGTVLGPGETGELFVRGEQVSGRYAEIGSVLXXXSPTGCARL
Mb3116|M.bovis_AF2122/97 TDVAVRG-DDGVIREHGEGEVVIKSDILLKEYWNRPEATRDAFDNGWFRT
Rv3089|M.tuberculosis_H37Rv TDVAVRG-DDGVIREHGEGEVVIKSDILLKEYWNRPEATRDAFDNGWFRT
MAB_4559|M.abscessus_ATCC_1997 CEVRIVDPDDNEVPRGEIGEVIVKGDNVMLGYWELPEESAAAIRDGWMHT
MLBr_02546|M.leprae_Br4923 VKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGGG---GKQIIDGLLSS
.: : .. : *.:.: . * *
MMAR_0466|M.marinum_M KDIAMLD----------EDGYLFIGGRSDDTIIR--GGE--------NIA
MUL_1115|M.ulcerans_Agy99 KDIAMLD----------EDGYLFIGGRSDDTIIR--GGE--------NIA
MAV_2574|M.avium_104 RDVAMLD----------EDGYLFIGGRSDDTIIR--GGE--------NIA
Mflv_2385|M.gilvum_PYR-GCK KDVAYLD----------SEGYLFIGGRSDDTIIR--GGE--------NIA
Mvan_4263|M.vanbaalenii_PYR-1 KDVAFLD----------EEGYLFIGGRSDDTIIR--GGE--------NIA
MSMEG_4883|M.smegmatis_MC2_155 KDVAMLD----------QDGYLFIGGRSDDTIIR--GGE--------NIA
TH_4193|M.thermoresistible__bu GASESLSPVTGGLRTWIHDRYPAARLHSDLDHHRRPGGAGARRRHRRRCG
Mb3116|M.bovis_AF2122/97 GDIGEID----------DEGYLYIKDRLKDMIIS--GGE--------NVY
Rv3089|M.tuberculosis_H37Rv GDIGEID----------DEGYLYIKDRLKDMIIS--GGE--------NVY
MAB_4559|M.abscessus_ATCC_1997 GDAGRMD----------DRGYVYIVDRIKDMVVT--GGE--------NVY
MLBr_02546|M.leprae_Br4923 GDVGYFD----------EHDLLYISGRDDEMIVS--GGE--------NVF
:. : . ** .
MMAR_0466|M.marinum_M PAELEEVLIEHPQVRDVAVVGV-EDAQWGQEIVAVVVPVAGVDP---DPE
MUL_1115|M.ulcerans_Agy99 PAELEEVLIEHPQVRDVAVVGV-EDAQWGQEIVAVVVPVAGVDP---DPE
MAV_2574|M.avium_104 PSEVEDVLIEHPDVREVVVVGL-DDAEWGQAIVAVIVPESGTAP---APE
Mflv_2385|M.gilvum_PYR-GCK PAEIEDVLVEHPHVRDCAVVGA-DDPQWGQIIVAVVVPHQDTAP---DPE
Mvan_4263|M.vanbaalenii_PYR-1 PAEIEDVLVEHPHVRDCAVVGA-DDPEWGQIIVAVVVAQPGTEP---DVE
MSMEG_4883|M.smegmatis_MC2_155 PAEIEDVLVEHPDVRDVAVVGP-EDPQWGQIIVAVVVPADGAEP---DAD
TH_4193|M.thermoresistible__bu PSDRQRRCRCGGDRRGGASDRAGERARCGAGGRRGQGSRGGPGDRGGDHQ
Mb3116|M.bovis_AF2122/97 PAEIESVIIGVPGVSEVAVIGL-PDEKWGEIAAAIVVAD-QNEVS---EQ
Rv3089|M.tuberculosis_H37Rv PAEIESVIIGVPGVSEVAVIGL-PDEKWGEIAAAIVVAD-QNEVS---EQ
MAB_4559|M.abscessus_ATCC_1997 SAEVENALAKHPAVAACAVIGI-PDEQWGERVHAVVVKQAQSECC---DG
MLBr_02546|M.leprae_Br4923 PAEVEDLISGHPEVVEATAIGV-DDKEWGARLRAFVVKKQDATID---ED
.:: : . . *
MMAR_0466|M.marinum_M ELREFVRRSLRGSRTPDRVVFRHELPTTATGKILRREIIEELAGTKS---
MUL_1115|M.ulcerans_Agy99 ELREFVRRSLRGSRTPDRVVFRRELPTTATGKILRREIIEELAGTKS---
MAV_2574|M.avium_104 RLREFARSKLRGSRTPDRIVFRDELPTTPTGKVLRREILEDLKPAAAEH-
Mflv_2385|M.gilvum_PYR-GCK DLRAHVRSQLRGSRTPDRVVFRDELPTNATGKVLRRELVSELNQDRSPAQ
Mvan_4263|M.vanbaalenii_PYR-1 DLRSHVRSQLRGSRTPDRVVFRDELPTNATGKVLRRELVDELNQDPSPAQ
MSMEG_4883|M.smegmatis_MC2_155 VLREHVRKHLRGSRTPDRVVFRAELPTNATGKVLRRQLVDEL-------Q
TH_4193|M.thermoresistible__bu TGVVQRRHHRRRGCDADDGALHPAHPGGTRRDTDRRDLGPRPARRLRRRP
Mb3116|M.bovis_AF2122/97 QIVEYCGTRLARYKLPKKVIFAEAIPRNPTGKILKTVLREQYSATVPK--
Rv3089|M.tuberculosis_H37Rv QIVEYCGTRLARYKLPKKVIFAEAIPRNPTGKILKTVLREQYSATVPK--
MAB_4559|M.abscessus_ATCC_1997 DLQEHCREHIANYKVPRSFEFVDELPLSGAGKILKRVLRQKYWESRDAGV
MLBr_02546|M.leprae_Br4923 AIKAYVRDHLARYKVPREVIFLEELPRNPTGKVLKRELRDFEVH------
. : * . : :
MMAR_0466|M.marinum_M ----------
MUL_1115|M.ulcerans_Agy99 ----------
MAV_2574|M.avium_104 ----------
Mflv_2385|M.gilvum_PYR-GCK PAV-------
Mvan_4263|M.vanbaalenii_PYR-1 PAV-------
MSMEG_4883|M.smegmatis_MC2_155 PIS-------
TH_4193|M.thermoresistible__bu GRGLSRDRRD
Mb3116|M.bovis_AF2122/97 ----------
Rv3089|M.tuberculosis_H37Rv ----------
MAB_4559|M.abscessus_ATCC_1997 S---------
MLBr_02546|M.leprae_Br4923 ----------