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M. thermoresistible (build 8) TH_4033 (-)

annotation: amidohydrolase 2
coordinates: 1458085 - 1458975
length: 297

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4033--100% (297)amidohydrolase 2
M. thermoresistible (build 8)TH_1218-7e-1730.30% (198) amidohydrolase family protein
M. thermoresistible (build 8)TH_1451-4e-0726.90% (145) amidohydrolase family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2325c-1e-2031.75% (252) antibiotic-resistance protein
M. gilvum PYR-GCKMflv_4348-3e-2031.47% (197) amidohydrolase 2
M. tuberculosis H37RvRv2303c-1e-2031.75% (252) antibiotic-resistance protein
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4667-5e-0927.41% (197) putative amidohydrolase
M. marinum MMMAR_4998-1e-2034.62% (182) hypothetical protein MMAR_4998
M. avium 104MAV_0646-3e-2235.64% (188) amidohydrolase family protein
M. smegmatis MC2 155MSMEG_2232-3e-1931.41% (191) amidohydrolase family protein
M. ulcerans Agy99MUL_4957-4e-1626.87% (201) hypothetical protein MUL_4957
M. vanbaalenii PYR-1Mvan_4952-1e-14782.15% (297) amidohydrolase 2

CLUSTAL 2.0.9 multiple sequence alignment


Mb2325c|M.bovis_AF2122/97           ---MTAPEPRVPVIDMWAPFVPSAEVIDDLREGFPVELLSYFEVFTKTTI
Rv2303c|M.tuberculosis_H37Rv        ---MTAPEPRVPVIDMWAPFVPSAEVIDDLREGFPVELLSYFEVFTKTTI
TH_4033|M.thermoresistible__bu      VYEYGVDFDAVTAIDMHAHIEIDCHGHQAYDDELVAATTAYFKMDAGPP-
Mvan_4952|M.vanbaalenii_PYR-1       MYEYGIDFDAVAAIDIHTHVEVDSHGHRAYDDVLVEATGKYFKMPQGSKG
Mflv_4348|M.gilvum_PYR-GCK          ----MSD----RVIDCLVNVHFGETANQP--EFMLKVRDDYFKGPQSLYD
MSMEG_2232|M.smegmatis_MC2_155      ----MTESPAGRAIDCLANVHFGETQNQP--AFMTKVRDDYFKGPKSMYD
MMAR_4998|M.marinum_M               ---------------MTIDAWMQHPTQRFLRSDMLASLRRWTDS--SIPE
MAV_0646|M.avium_104                ---------------MTIDVWMQHPTVRFLRSDMLASLRRWTGG--SIPD
MUL_4957|M.ulcerans_Agy99           ----MAGPVGLPVIDTMIGFPHEGSAQYDFIRKQTKDRESKENFEFPVEY
MAB_4667|M.abscessus_ATCC_1997      --MSESAFDPAPVRQIWQELGIPGIVDVHTHFMPKSVMDKVWAYFDSAGP
                                                                                      

Mb2325c|M.bovis_AF2122/97           SAEQFGAYAESLRRTDDQILDSLDDAGITRSLITGFDERSTCGVTFVHNA
Rv2303c|M.tuberculosis_H37Rv        SAEQFGAYAESLRRTDDQILDSLDDAGITRSLITGFDERSTCGVTFVHNA
TH_4033|M.thermoresistible__bu      --ADVDA-----------VADYYRRANIAAVVFT--IDAQSGMGHPPNSI
Mvan_4952|M.vanbaalenii_PYR-1       VVAGVDA-----------VAEQYRQHNTAAVVFT--IDARHGMRHAPNSI
Mflv_4348|M.gilvum_PYR-GCK          Q-VELPA-----------LLDEMAEHGVEKAILM--DNLVKPSVTARKFA
MSMEG_2232|M.smegmatis_MC2_155      P-IDLGA-----------LLEEMDANGVERAILM--DNLTKPSVTARKFV
MMAR_4998|M.marinum_M               AQIPIEA-----------TIASMDAADVEFGLLS--AWRGPNGQDLVSND
MAV_0646|M.avium_104                TDIPIEA-----------TLASMDAAGVGYGLLS--AWRGPNGQDLVSND
MUL_4957|M.ulcerans_Agy99           MFKDVPK-------------GLPTDDPVSLVLQQMDRFNIEKAMIGVRED
MAB_4667|M.abscessus_ATCC_1997      LVGRPWP------------ITYRADESQRVTTLRDFGVLRFTSLVYPHKP
                                                                                      

Mb2325c|M.bovis_AF2122/97           SVAAVAARYPDRFLP-FAGADILAGDSAVDEFERWVVEHGFRGLSLRPFM
Rv2303c|M.tuberculosis_H37Rv        SVAAVAARYPDRFLP-FAGADILAGDSAVDEFERWVVEHGFRGLSLRPFM
TH_4033|M.thermoresistible__bu      EDLVAGAARNNDVLIPFGSVDPWQGRHAVRRVREQVRDHGVKGFKFHPSF
Mvan_4952|M.vanbaalenii_PYR-1       EDLVAGAARNNDVLIPFGSVDPWQGRHAVHRVHELVRDHGVKGFKFHPSM
Mflv_4348|M.gilvum_PYR-GCK          E------ERPDKFALAIGGVNLLRPMPSLRELSSVVADLPVAYAAVGPSF
MSMEG_2232|M.smegmatis_MC2_155      E------AHPERFALAMGGVNLLRPIPSLRELAAAVRDLPVAYAVVGPSF
MMAR_4998|M.marinum_M               EVAGWVDLHPQRFAG-LAAVDLDRPMVAVRELRSRIASG-FVGLRVVPWL
MAV_0646|M.avium_104                EVAQWVAAHPNRFAG-LAAVDLDRPMEAVRELRCRIADGGFVGLRVVPWL
MUL_4957|M.ulcerans_Agy99           SAQLALKTFPDRFIPSGAIADPNDVMGSVAAIRREYEQFGIRATSVFPAG
MAB_4667|M.abscessus_ATCC_1997      QMAAWLNQWAAQFAAQTPDCIHTATFFPEPGAADYVREAIDAGVGVFKVH
                                    .           .              .         .       .    

Mb2325c|M.bovis_AF2122/97           IG---RPASDPAYFPCYAKCVELGVPVSIHTSADWTRTRLSD-------L
Rv2303c|M.tuberculosis_H37Rv        IG---RPASDPAYFPCYAKCVELGVPVSIHTSADWTRTRLSD-------L
TH_4033|M.thermoresistible__bu      QA---FEPNDRVFYPIYEAIAEAGVPALFHTGQTGLGSGLPGGHGIKLRY
Mvan_4952|M.vanbaalenii_PYR-1       QA---FEPNDRAYYPIYHAIAEAGVPALFHTGQTGMGAGLPGGHGIKLRY
Mflv_4348|M.gilvum_PYR-GCK          WGDGMYPPSDAVYYPLYTKCAELGLPLCINTGLP--GPPIPG------EV
MSMEG_2232|M.smegmatis_MC2_155      WGDGQYPPSDAVYYPLYTKCAELDLPLCVNTGLP--GPPIPG------EV
MMAR_4998|M.marinum_M               WE---APPTDRRYYPLFAECVESGVPFCTQVGHT--GPLRPSE-----TG
MAV_0646|M.avium_104                WN---APPTDRRYYPLFAACVEAGVPFCTQVGHT--GPLRPSE-----TG
MUL_4957|M.ulcerans_Agy99           TFP-QVPIDDPKMYPIYATCVELGIPIFVCAGIP--GPRLPFR------L
MAB_4667|M.abscessus_ATCC_1997      VQVGAFSPTDPLLVPVWGLIEDAGVPVVIHCGSG----PAPG------EF
                                             *    * :    : .:*     .        .         

Mb2325c|M.bovis_AF2122/97           GHPRHIDDVACRFPELTILMSHGGYPWVLQACLIAWKHPNVYLEL----A
Rv2303c|M.tuberculosis_H37Rv        GHPRHIDDVACRFPELTILMSHGGYPWVLQACLIAWKHPNVYLEL----A
TH_4033|M.thermoresistible__bu      SDPMLLDDVAADFPELTIVMAHPAVPWVDAQIAVAAHKANVYVDL----S
Mvan_4952|M.vanbaalenii_PYR-1       SDPMLLDDVAADFPELTIVMAHPAVPWVDAQISIATHKANVYIDL----S
Mflv_4348|M.gilvum_PYR-GCK          QNPIHLDRVCVRFPELKLCMIHGADPWWDVAIRLLIKYANLRIMT----S
MSMEG_2232|M.smegmatis_MC2_155      QNPIHLDRVCVRFPELRLCMIHGADPWWDIAIRMLIKYKNLRLMT----S
MMAR_4998|M.marinum_M               RPIPYIDQVALDFPELVIVCGHVGYPWTEEMVAVARKHENVYIDT----S
MAV_0646|M.avium_104                RPIPYIDQVALDFPELVIVCGHVGYPWTEEMVAVARKHENVYIDT----S
MUL_4957|M.ulcerans_Agy99           QEVSRIDIVMFDFPDLVFVTRHGCEPWEELAVKLMLKWPNLYYST----S
MAB_4667|M.abscessus_ATCC_1997      TGPDPVTALLKQFPHLRLIVAHMGMPEYSEFLDLCEQHDEVRLDTTMAFT
                                         :  :   **.* :   *   *       :  :  ::        :

Mb2325c|M.bovis_AF2122/97           AHRPKYFASPGAGWEPLMRFGQT-TIRNKIVYGTGGFLINRPYLQLCDEM
Rv2303c|M.tuberculosis_H37Rv        AHRPKYFASPGAGWEPLMRFGQT-TIRNKIVYGTGGFLINRPYLQLCDEM
TH_4033|M.thermoresistible__bu      GWSPKYFP------PQLVRAIGR-QLRTKVLFGTDFPYIK--LDRWRRDF
Mvan_4952|M.vanbaalenii_PYR-1       GWSPKYFP------AQLVHAMGR-QLRTKVLFGTDFPYIQ--IDRWRRDF
Mflv_4348|M.gilvum_PYR-GCK          AWSPKRLP------DSLLHYMRT-RGKNKVIFASDWPVLR--QSRVVPEA
MSMEG_2232|M.smegmatis_MC2_155      AWSPKRLP------ESLLHYMRT-RGPDKIIFASDFPVLR--MNRVVPEA
MMAR_4998|M.marinum_M               AYTIKRLP------HELIRFMKTGTGRRKVMFGTNFPMIA--HAHALAGL
MAV_0646|M.avium_104                AYTIERLP------DELVRFIKTGTGQRKVLFGTNYPMIT--AEHALAGL
MUL_4957|M.ulcerans_Agy99           AFAPKYYP------NAIIDYANS-RGADKVLYAGYFPMGLS-LERIFSEL
MAB_4667|M.abscessus_ATCC_1997      AFSNEKAP------FPESDYPRLVEMGHKIYFGSDFPNIPYGYAEAITAL
                                    .   :  .                    *: :.           .     

Mb2325c|M.bovis_AF2122/97           RALP-VPREVLEDWLWRN-ATRVLRLDT-----
Rv2303c|M.tuberculosis_H37Rv        RALP-VPREVLEDWLWRN-ATRVLRLDT-----
TH_4033|M.thermoresistible__bu      DTLD-IDPAVLP-LVYKENALRVLGIGSGA---
Mvan_4952|M.vanbaalenii_PYR-1       DTLD-IDPAVVP-LIYKQNALRVLGVASHRP--
Mflv_4348|M.gilvum_PYR-GCK          LALD-LPPDVLDNYLYNNANDFFFG-TDEQEI-
MSMEG_2232|M.smegmatis_MC2_155      RALD-LPPDVLDNYLYHNAAEFFFGGRQPQEF-
MMAR_4998|M.marinum_M               DELG-LEDEARRDFLHGN-AERVFGLAQRPPR-
MAV_0646|M.avium_104                DGLG-LSDEARRDFLHGN-AERVFRLEAAT---
MUL_4957|M.ulcerans_Agy99           PKVG-LKDEVWPKFLYGN-AARILGLTG-----
MAB_4667|M.abscessus_ATCC_1997      RRMPGIDDAWMRDVLYHN-GARLFGVDTSASGR
                                      :  :        :  :    .: