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YEYGIDFDAVAAIDIHTHVEVDSHGHRAYDDVLVEATGKYFKMPQGSKGVVAGVDAVAEQYRQHNTAAVV FTIDARHGMRHAPNSIEDLVAGAARNNDVLIPFGSVDPWQGRHAVHRVHELVRDHGVKGFKFHPSMQAFE PNDRAYYPIYHAIAEAGVPALFHTGQTGMGAGLPGGHGIKLRYSDPMLLDDVAADFPELTIVMAHPAVPW VDAQISIATHKANVYIDLSGWSPKYFPAQLVHAMGRQLRTKVLFGTDFPYIQIDRWRRDFDTLDIDPAVV PLIYKQNALRVLGVASHRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4952 | - | - | 100% (300) | amidohydrolase 2 |
| M. vanbaalenii PYR-1 | Mvan_1996 | - | 1e-19 | 27.20% (261) | amidohydrolase 2 |
| M. vanbaalenii PYR-1 | Mvan_0424 | - | 1e-08 | 23.78% (185) | amidohydrolase 2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2325c | - | 8e-22 | 34.10% (217) | antibiotic-resistance protein |
| M. gilvum PYR-GCK | Mflv_4348 | - | 2e-20 | 27.59% (261) | amidohydrolase 2 |
| M. tuberculosis H37Rv | Rv2303c | - | 8e-22 | 34.10% (217) | antibiotic-resistance protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4667 | - | 6e-08 | 26.57% (143) | putative amidohydrolase |
| M. marinum M | MMAR_4998 | - | 7e-21 | 34.86% (175) | hypothetical protein MMAR_4998 |
| M. avium 104 | MAV_0646 | - | 4e-20 | 33.51% (188) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_2232 | - | 4e-19 | 32.77% (177) | amidohydrolase family protein |
| M. thermoresistible (build 8) | TH_4033 | - | 1e-147 | 82.15% (297) | PUTATIVE amidohydrolase 2 |
| M. ulcerans Agy99 | MUL_3876 | - | 1e-16 | 34.23% (149) | metal-dependent hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2325c|M.bovis_AF2122/97 ---MTAPEPRVPVIDMWAPFVPS---AEVIDDLREGFPVELLSYFEVFTK
Rv2303c|M.tuberculosis_H37Rv ---MTAPEPRVPVIDMWAPFVPS---AEVIDDLREGFPVELLSYFEVFTK
Mvan_4952|M.vanbaalenii_PYR-1 MYEYGIDFDAVAAIDIHTHVEVD---SHGHRAYDDVLVEATGKYFKMPQG
TH_4033|M.thermoresistible__bu VYEYGVDFDAVTAIDMHAHIEID---CHGHQAYDDELVAATTAYFKMDAG
Mflv_4348|M.gilvum_PYR-GCK ----MSD----RVIDCLVNVHFG---ETANQP--EFMLKVRDDYFKGPQS
MSMEG_2232|M.smegmatis_MC2_155 ----MTESPAGRAIDCLANVHFG---ETQNQP--AFMTKVRDDYFKGPKS
MUL_3876|M.ulcerans_Agy99 ----MTD----RAIDCLVNVHFG---EAEAQP--NWMLKVRDDYFKGPDS
MMAR_4998|M.marinum_M ---------------MTIDAWMQ---HPTQRFLRSDMLASLRRWTDS--S
MAV_0646|M.avium_104 ---------------MTIDVWMQ---HPTVRFLRSDMLASLRRWTGG--S
MAB_4667|M.abscessus_ATCC_1997 --MSESAFDPAPVRQIWQELGIPGIVDVHTHFMPKSVMDKVWAYFDSAGP
. :
Mb2325c|M.bovis_AF2122/97 TTISAEQFGAYAESLRRTDDQILDSLDDAGITRSLITGFDERSTCGVTFV
Rv2303c|M.tuberculosis_H37Rv TTISAEQFGAYAESLRRTDDQILDSLDDAGITRSLITGFDERSTCGVTFV
Mvan_4952|M.vanbaalenii_PYR-1 SKGVVAGVDAVAEQYR-----------QHNTAAVVFT-IDARHGMRHAPN
TH_4033|M.thermoresistible__bu PP---ADVDAVADYYR-----------RANIAAVVFT-IDAQSGMGHPPN
Mflv_4348|M.gilvum_PYR-GCK LYDQ-VELPALLDEMA-----------EHGVEKAILM-DNLVK----PSV
MSMEG_2232|M.smegmatis_MC2_155 MYDP-IDLGALLEEMD-----------ANGVERAILM-DNLTK----PSV
MUL_3876|M.ulcerans_Agy99 MFAP-VDLAQLLDEMD-----------EQGVQRAILM-DSLAS----PSL
MMAR_4998|M.marinum_M IPEAQIPIEATIASMD-----------AADVEFGLLS-AWRGPN-GQDLV
MAV_0646|M.avium_104 IPDTDIPIEATLASMD-----------AAGVGYGLLS-AWRGPN-GQDLV
MAB_4667|M.abscessus_ATCC_1997 LVGRPWPITYRADESQ-----------RVTTLRDFGVLRFTSLVYPHKPQ
. .
Mb2325c|M.bovis_AF2122/97 HNASVAAVAARYPDRFLPFAGADILAGDSAVDEFERWVVEHGFRGLSLRP
Rv2303c|M.tuberculosis_H37Rv HNASVAAVAARYPDRFLPFAGADILAGDSAVDEFERWVVEHGFRGLSLRP
Mvan_4952|M.vanbaalenii_PYR-1 SIEDLVAGAARNNDVLIPFGSVDPWQGRHAVHRVHELVRDHGVKGFKFHP
TH_4033|M.thermoresistible__bu SIEDLVAGAARNNDVLIPFGSVDPWQGRHAVRRVREQVRDHGVKGFKFHP
Mflv_4348|M.gilvum_PYR-GCK TARKFAE--ERPDKFALAIGGVNLLRPMPSLRELSSVVADLPVAYAAVGP
MSMEG_2232|M.smegmatis_MC2_155 TARKFVE--AHPERFALAMGGVNLLRPIPSLRELAAAVRDLPVAYAVVGP
MUL_3876|M.ulcerans_Agy99 TACKFVQ--AKPDRFALAMGGINLLRPVRPLRELTAIVGELPVAYAAVGP
MMAR_4998|M.marinum_M SNDEVAGWVDLHPQRFAGLAAVDLDRPMVAVRELRSRIASG-FVGLRVVP
MAV_0646|M.avium_104 SNDEVAQWVAAHPNRFAGLAAVDLDRPMEAVRELRCRIADGGFVGLRVVP
MAB_4667|M.abscessus_ATCC_1997 MAAWLNQWAAQFAAQTPDCIHTATFFPEPGAADYVREAIDAGVGVFKVHV
. . . .
Mb2325c|M.bovis_AF2122/97 FMIG---RPASDPAYFPCYAKCVELGVPVSIHTSADWTRTRLSD------
Rv2303c|M.tuberculosis_H37Rv FMIG---RPASDPAYFPCYAKCVELGVPVSIHTSADWTRTRLSD------
Mvan_4952|M.vanbaalenii_PYR-1 SMQA---FEPNDRAYYPIYHAIAEAGVPALFHTGQTGMGAGLPGGHGIKL
TH_4033|M.thermoresistible__bu SFQA---FEPNDRVFYPIYEAIAEAGVPALFHTGQTGLGSGLPGGHGIKL
Mflv_4348|M.gilvum_PYR-GCK SFWGDGMYPPSDAVYYPLYTKCAELGLPLCINTGLP--GPPIPG------
MSMEG_2232|M.smegmatis_MC2_155 SFWGDGQYPPSDAVYYPLYTKCAELDLPLCVNTGLP--GPPIPG------
MUL_3876|M.ulcerans_Agy99 SFWGEGQYPPSDAVYYPLYVKCAELELALCINTGIP--GPPIPG------
MMAR_4998|M.marinum_M WLWE---APPTDRRYYPLFAECVESGVPFCTQVGHT--GPLRPSE-----
MAV_0646|M.avium_104 WLWN---APPTDRRYYPLFAACVEAGVPFCTQVGHT--GPLRPSE-----
MAB_4667|M.abscessus_ATCC_1997 QVGA---FSPTDPLLVPVWGLIEDAGVPVVIHCGSG----PAPG------
. ..* * : : :. : . ..
Mb2325c|M.bovis_AF2122/97 -LGHPRHIDDVACRFPELTILMSHGGYPWVLQACLIAWKHPNVYLEL---
Rv2303c|M.tuberculosis_H37Rv -LGHPRHIDDVACRFPELTILMSHGGYPWVLQACLIAWKHPNVYLEL---
Mvan_4952|M.vanbaalenii_PYR-1 RYSDPMLLDDVAADFPELTIVMAHPAVPWVDAQISIATHKANVYIDL---
TH_4033|M.thermoresistible__bu RYSDPMLLDDVAADFPELTIVMAHPAVPWVDAQIAVAAHKANVYVDL---
Mflv_4348|M.gilvum_PYR-GCK EVQNPIHLDRVCVRFPELKLCMIHGADPWWDVAIRLLIKYANLRIMT---
MSMEG_2232|M.smegmatis_MC2_155 EVQNPIHLDRVCVRFPELRLCMIHGADPWWDIAIRMLIKYKNLRLMT---
MUL_3876|M.ulcerans_Agy99 EVQHPMHLDRVCVRFPELRLCMIHGADPWWDVAIRLLLKYSNSRLMT---
MMAR_4998|M.marinum_M TGRPIPYIDQVALDFPELVIVCGHVGYPWTEEMVAVARKHENVYIDT---
MAV_0646|M.avium_104 TGRPIPYIDQVALDFPELVIVCGHVGYPWTEEMVAVARKHENVYIDT---
MAB_4667|M.abscessus_ATCC_1997 EFTGPDPVTALLKQFPHLRLIVAHMGMPEYSEFLDLCEQHDEVRLDTTMA
: : **.* : * . * : : : :
Mb2325c|M.bovis_AF2122/97 -AAHRPKYFASPGAGWEPLMRFGQT-TIRNKIVYGTGGFLINRPYLQLCD
Rv2303c|M.tuberculosis_H37Rv -AAHRPKYFASPGAGWEPLMRFGQT-TIRNKIVYGTGGFLINRPYLQLCD
Mvan_4952|M.vanbaalenii_PYR-1 -SGWSPKYFP------AQLVHAMGR-QLRTKVLFGTDFPYIQ--IDRWRR
TH_4033|M.thermoresistible__bu -SGWSPKYFP------PQLVRAIGR-QLRTKVLFGTDFPYIK--LDRWRR
Mflv_4348|M.gilvum_PYR-GCK -SAWSPKRLP------DSLLHYMRT-RGKNKVIFASDWPVLR--QSRVVP
MSMEG_2232|M.smegmatis_MC2_155 -SAWSPKRLP------ESLLHYMRT-RGPDKIIFASDFPVLR--MNRVVP
MUL_3876|M.ulcerans_Agy99 -SAWTPKRLP------ESLLHYMRT-RGKNKVIFASDWPVLR--MRRVVP
MMAR_4998|M.marinum_M -SAYTIKRLP------HELIRFMKTGTGRRKVMFGTNFPMIA--HAHALA
MAV_0646|M.avium_104 -SAYTIERLP------DELVRFIKTGTGQRKVLFGTNYPMIT--AEHALA
MAB_4667|M.abscessus_ATCC_1997 FTAFSNEKAP------FPESDYPRLVEMGHKIYFGSDFPNIPYGYAEAIT
:. : . *: :.:. : .
Mb2325c|M.bovis_AF2122/97 EMRALP-VPREVLEDWLWRNATRVLRLDT-----
Rv2303c|M.tuberculosis_H37Rv EMRALP-VPREVLEDWLWRNATRVLRLDT-----
Mvan_4952|M.vanbaalenii_PYR-1 DFDTLD-IDPAVVP-LIYKQNALRVLGVASHRP-
TH_4033|M.thermoresistible__bu DFDTLD-IDPAVLP-LVYKENALRVLGIGSGA--
Mflv_4348|M.gilvum_PYR-GCK EALALD-LPPDVLDNYLYNNANDFFFG-TDEQEI
MSMEG_2232|M.smegmatis_MC2_155 EARALD-LPPDVLDNYLYHNAAEFFFGGRQPQEF
MUL_3876|M.ulcerans_Agy99 EARALD-LPADVLANYLYNNAQEFFFGEESGR--
MMAR_4998|M.marinum_M GLDELG-LEDEARRDFLHGNAERVFGLAQRPPR-
MAV_0646|M.avium_104 GLDGLG-LSDEARRDFLHGNAERVFRLEAAT---
MAB_4667|M.abscessus_ATCC_1997 ALRRMPGIDDAWMRDVLYHNGARLFGVDTSASGR
: : : : .