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M. thermoresistible (build 8) TH_4006 (-)

annotation: conserved hypothetical protein; putative thiolase domain
coordinates: 228256 - 229407
length: 384

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4006--100% (384)conserved hypothetical protein; putative thiolase domain
M. thermoresistible (build 8)TH_3921-0.085.08% (382) PUTATIVE lipid-transfer protein
M. thermoresistible (build 8)TH_0532-e-13460.21% (377) putative thiolase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1653c-1e-5335.06% (405) lipid-transfer protein
M. gilvum PYR-GCKMflv_2519-1e-13561.94% (381) thiolase
M. tuberculosis H37RvRv1627c-1e-5335.06% (405) lipid-transfer protein
M. leprae Br4923MLBr_02158-4e-1236.44% (118) hypothetical protein MLBr_02158
M. abscessus ATCC 19977MAB_2619-3e-5335.15% (404) lipid-transfer protein
M. marinum MMMAR_2430-2e-5034.48% (406) nonspecific lipid-transfer protein
M. avium 104MAV_2573-0.086.39% (382) lipid-transfer protein
M. smegmatis MC2 155MSMEG_4778-1e-13360.53% (380) putative thiolase
M. ulcerans Agy99MUL_4955ltp1_11e-4833.17% (413) lipid-transfer protein Ltp1_1
M. vanbaalenii PYR-1Mvan_4139-1e-13260.32% (378) thiolase

CLUSTAL 2.0.9 multiple sequence alignment


Mb1653c|M.bovis_AF2122/97           --MRMS-APEPVYILGAGMHPWGKW-GNDFTEYGVVAARAALRDAGVDWR
Rv1627c|M.tuberculosis_H37Rv        --MRMS-APEPVYILGAGMHPWGKW-GNDFTEYGVVAARAALRDAGVDWR
MMAR_2430|M.marinum_M               ----MS-APEPLYILGAGMHPWGKW-GNDFTEYGVAAARAALREAGLEWR
MAB_2619|M.abscessus_ATCC_1997      ----MSRTPDPVYILGAGMHPWGKW-GRDFTEYGVAAARTALQDAELDWR
TH_4006|M.thermoresistible__bu      ------MSTPDIAIIGVGIHPFGRYADRSALEMGAVAIGRALKDAGVDWS
MAV_2573|M.avium_104                -----MSSTPDIAIIGVGLHPFGRYEDRSALEMGAVAISRALRDAGVAWS
Mflv_2519|M.gilvum_PYR-GCK          MTSS----ANDVAIIGVGLHPFGRF-DKTAMEMGAEAIQSALTDAGVDWK
Mvan_4139|M.vanbaalenii_PYR-1       MTNSSPNAAGEVAIIGVGLHPFGRF-DKTAMQMGAEAIQSALTDAGVEWK
MSMEG_4778|M.smegmatis_MC2_155      MTND-------VAIIGVGLHPFGRF-DKPAVQMGAEAIRLALKDAGVEWK
MLBr_02158|M.leprae_Br4923          --------------------------------------------------
MUL_4955|M.ulcerans_Agy99           -----MSASDEIWILGIRMTKFGKHPDLDTVDLAAQAAMSALDDAGVSMA
                                                                                      

Mb1653c|M.bovis_AF2122/97           HVQLVAGADTIRNGYPGFVAGATFAQKLGWTGVPVSSSYAACASGSQALQ
Rv1627c|M.tuberculosis_H37Rv        HVQLVAGADTIRNGYPGFVAGATFAQKLGWTGVPVSSSYAACASGSQALQ
MMAR_2430|M.marinum_M               QIQLVAGADTIRNGYPGFVAGATFAQKLGWNGVPVSSSYAACASGSQALQ
MAB_2619|M.abscessus_ATCC_1997      QIQFVAGADTIRNGYPGFIAGSTFAQKLGWNGVPISSTYAACASGSQALQ
TH_4006|M.thermoresistible__bu      DVGSLYAGSLEVA------NPEAITGLVGMTGIPARATLSGCATGNSLLT
MAV_2573|M.avium_104                DVGSLYAGSLEVA------NPEAVTGLAGMTGLPARATLSGCATGNSLLT
Mflv_2519|M.gilvum_PYR-GCK          DIQFGFGGSYEVS------NPDAVTRLVGLTGITFTNVFNACATAASAIQ
Mvan_4139|M.vanbaalenii_PYR-1       DIQFGFGGSYEVS------NPDAVTRLVGLTGITFTNVFNACATAASAIQ
MSMEG_4778|M.smegmatis_MC2_155      DIQFGFGGSYEVS------NPDSVTRLVGLTGITFTNVFNACATSASAIQ
MLBr_02158|M.leprae_Br4923          --------------------------------------------------
MUL_4955|M.ulcerans_Agy99           DIGVLAAGNLMAANAG---IGQQLQKQIGQTGIPVYNVANACATGATALR
                                                                                      

Mb1653c|M.bovis_AF2122/97           SARAQILAGFCDVALVIGADTTP-KGFFAPVGGERKGDPDWQRFHLIGAT
Rv1627c|M.tuberculosis_H37Rv        SARAQILAGFCDVALVIGADTTP-KGFFAPVGGERKGDPDWQRFHLIGAT
MMAR_2430|M.marinum_M               SARAQILAGFCDVALVVGADTTP-KGFFAPVGGERKNDPDWQRFHLIGAT
MAB_2619|M.abscessus_ATCC_1997      SARAQILAGFCDVALVIGADTTP-KGFFAPVGGERKADPDWQRFHLIGAT
TH_4006|M.thermoresistible__bu      LAARDVVAGVADIAVGVGLDKHP-RGAFGADPAVAGLPQWYGDQGMFLTT
MAV_2573|M.avium_104                LAARDVQLGEADIAVGVGLDKHP-RGAFGADPSVSGLPQWYGDQGMFLTT
Mflv_2519|M.gilvum_PYR-GCK          QTADTIRLGKYDIGIAIGLDKHP-RGAFTDDPAKLALPQWYANNGQFVTT
Mvan_4139|M.vanbaalenii_PYR-1       QTADTIRLGKYDIGIAIGLDKHP-RGAFTDDPAKLALPQWYAENGQFVTT
MSMEG_4778|M.smegmatis_MC2_155      QTADTIRLGKYDIGVAVGLDKHP-RGAFTDDPAKLALPQWYAQNGQFVTT
MLBr_02158|M.leprae_Br4923          --------------------------------------------------
MUL_4955|M.ulcerans_Agy99           TAIMAVKAGEVDYGMAVGVEKLSGAGLLGGGGKKKSDADVWTPAGRYGAV
                                                                                      

Mb1653c|M.bovis_AF2122/97           N-----------TVYFALLARRRMDLYG-ATVEDFAQVKVKNSRHGLDNP
Rv1627c|M.tuberculosis_H37Rv        N-----------TVYFALLARRRMDLYG-ATVEDFAQVKVKNSRHGLDNP
MMAR_2430|M.marinum_M               N-----------PVYFALLARRRMDLYG-ATLEDFAQVKVKNSRHGLQNP
MAB_2619|M.abscessus_ATCC_1997      N-----------PVYFALLARRRMDLFG-ATVEDFAQVKVKNSRHGLNNP
TH_4006|M.thermoresistible__bu      -------------HYFGTKIMRYMHDHG-ISEQTLARVAVKNLGNGARAP
MAV_2573|M.avium_104                -------------HYFGTKIMRYMHDHG-ITEETLARVAAKNFDNGALAP
Mflv_2519|M.gilvum_PYR-GCK          -------------KFFGMKANHYLHKHN-ISEETLARVANKNFRNGVINP
Mvan_4139|M.vanbaalenii_PYR-1       -------------KFFGMKANHYIHKHN-ISEETLARVANKNFRNGVLNP
MSMEG_4778|M.smegmatis_MC2_155      -------------KFFGMKANKYLHDHN-ISQDTLARVANKNFRNGALNP
MLBr_02158|M.leprae_Br4923          ----------------------------------MCSVASRFLR------
MUL_4955|M.ulcerans_Agy99           APVDGRIGTETMPGVFAQIGTEYGHKYGGTSFELFAKISEKNHAHSTLNP
                                                                      :. :  :         

Mb1653c|M.bovis_AF2122/97           NARYRKENSIDDVLASPVVSDPLRLLDICATSDGAAALIVASKSFTEKHL
Rv1627c|M.tuberculosis_H37Rv        NARYRKENSIDDVLASPVVSDPLRLLDICATSDGAAALIVASKSFTEKHL
MMAR_2430|M.marinum_M               NARYRKEVSVEDVLASQVVAEPLRLLDICATSDGAAALIVASAKFAREHL
MAB_2619|M.abscessus_ATCC_1997      NARFRKESSVADVLASPVVSDPLRLLDICATSDGAAALIVASADFAKKHL
TH_4006|M.thermoresistible__bu      HAWRRKPMSLETILESPVVNAPLRQFMYCNPNEGAAAVVVCRAEDAKKYT
MAV_2573|M.avium_104                HAWRRKPMSVDAILSSPVVNAPLRQYMYCNPNEGAAAVVVCRADKAKQYT
Mflv_2519|M.gilvum_PYR-GCK          NAFRRKEISVEEIMASPVLNYPLRQYMFCAPDEGAAAVIMCRADIAHKYT
Mvan_4139|M.vanbaalenii_PYR-1       NAFRRKEISVEEIMASPVLNYPLRQYMFCAPDEGAAAVIMCRGDIAHRFT
MSMEG_4778|M.smegmatis_MC2_155      NAFRRKEISVEEILASPTLNHPLTQYMFCAPDEGAAAVIMCRADIAHKFT
MLBr_02158|M.leprae_Br4923          -------------------TRSLTQCMFCALNKGAFAVIVCLGDIAHKFT
MUL_4955|M.ulcerans_Agy99           LAAYQKRFTLEQIMNDVMIAYPNTRPMCSANCDGAAAAIVCNGETLKSLS
                                                         .      .   .** * ::.  .  .   

Mb1653c|M.bovis_AF2122/97           GSVAGVPSVRAISTVTPKYPQHLPELPDIATDSTAAVPAPERVFKDQILD
Rv1627c|M.tuberculosis_H37Rv        GSVAGVPSVRAISTVTPKYPQHLPELPDIATDSTAAVPAPERVFKDQILD
MMAR_2430|M.marinum_M               GSLDGVPSVRAVSTVTPRYPQHLPELPDIATDSTAVVPAPERVFKDQILD
MAB_2619|M.abscessus_ATCC_1997      GSVDGVPSVRAVATITPKYPQHLPELPDIATDSTAVVPAPERVFKDQIVD
TH_4006|M.thermoresistible__bu      GTPIYLRASALRSRREGCYELLRTSIELPLVEGT-TAAAAK---------
MAV_2573|M.avium_104                DSPIYLRSTALRSRREGAYELLRTSIELPIVPGT-TAEAAR---------
Mflv_2519|M.gilvum_PYR-GCK          DKPVYVRASEIRTRTYGAYEVHATSAPLDEDPSP-TVFAAK---------
Mvan_4139|M.vanbaalenii_PYR-1       DKPVFVRASEIRTRTFGAYEVHATSAPLEEDPSP-TVFAAK---------
MSMEG_4778|M.smegmatis_MC2_155      DKPVYVRASEIRTRTFGAYEVHATSAPPESDAAP-TVYAAR---------
MLBr_02158|M.leprae_Br4923          DKTVHVHVTEIRTRRYGAYEVHATFAPLVEDASPKRCTIAK---------
MUL_4955|M.ulcerans_Agy99           ARQR--RRAVKVSASVLTTDPYEPGCQVLPNVNTLTRNAAK---------
                                                :          .         .     ..         

Mb1653c|M.bovis_AF2122/97           AAYAEAGIGPEDLSLAEVYDLSTAL-ELDWYEHLGLCPKGEAEALLRSGA
Rv1627c|M.tuberculosis_H37Rv        AAYAEAGIGPEDLSLAEVYDLSTAL-ELDWYEHLGLCPKGEAEALLRSGA
MMAR_2430|M.marinum_M               AAYTEAGIGPEDLSLAEVYDLSTAL-ELDWYEHLGLCPKGEAEALLRSGA
MAB_2619|M.abscessus_ATCC_1997      AAYAEAGIGPEDISLAEVYDLSTAL-ELDWYEHLGLCAKGEGEQLLRSGA
TH_4006|M.thermoresistible__bu      AAYEQAGIGPEDVDVAQLQDTDSGS-EIIHMAETGLCKDGEQEQMLADGE
MAV_2573|M.avium_104                AAYELAGIGPEDVDVAQLQDTDSGS-EIIHMAETGLCKDGEQEALLADGA
Mflv_2519|M.gilvum_PYR-GCK          AAYEAAGIGPEDVDIAQLQDTDAGA-EVIHMAETGLCADGEQEKLLADGA
Mvan_4139|M.vanbaalenii_PYR-1       AAYEAAGIGPEDVDIAQLQDTDAGA-EVIHMAETGLCADGEQEKLLADGA
MSMEG_4778|M.smegmatis_MC2_155      AAYEAAGIGPEDVDIAQLQDTDAGA-EVIHMAETGLCADGDQEKLIAEGA
MLBr_02158|M.leprae_Br4923          AVYRGRQASDLRTSTSPSCRTSVPAPEVIQMDETVLCADGEQEKLASW--
MUL_4955|M.ulcerans_Agy99           TAYEQAGVGPSDLDLVELHDCFATA-ELVHYDNLMLCEQGGAADFFESGA
                                    :.*     .    .            *:    .  ** .*    :     

Mb1653c|M.bovis_AF2122/97           TTLGGRVPVNPSGGLACFGEAIPAQAIAQVCELTWQLRGQATGRQVAD-A
Rv1627c|M.tuberculosis_H37Rv        TTLGGRVPVNPSGGLACFGEAIPAQAIAQVCELTWQLRGQATGRQVAD-A
MMAR_2430|M.marinum_M               TTIGGRVPVNPSGGLACFGEAIPAQAIAQVCELNWQLRGQATGRQVEN-A
MAB_2619|M.abscessus_ATCC_1997      TTVGGRVPVNASGGLACFGEAIPAQAIAQVCELTWQLRGQAGDRQVEG-A
TH_4006|M.thermoresistible__bu      TEIGGRIPINTDGGLLANGEPVGASGLRQVYELVHQLRGTAGERQVPNNP
MAV_2573|M.avium_104                TKIGGRLPINTDGGLLANGEPVGASGLRQVYELVQQLRGTAGDRQVPNDP
Mflv_2519|M.gilvum_PYR-GCK          TEIHGSIPVNTDGGLIANGEPIGASGLRQVHELVRQLRGEAGDRQVPGAP
Mvan_4139|M.vanbaalenii_PYR-1       TEIHGSIPVNTDGGLIANGEPIGASGLRQVHELVRQLRGQAGDRQVPGQP
MSMEG_4778|M.smegmatis_MC2_155      TEIDGSIPVNTDGGLIANGEPIGASGLRQMHELVRQLRGEAGDRQVPGNP
MLBr_02158|M.leprae_Br4923          --------------------------------------------------
MUL_4955|M.ulcerans_Agy99           PWRHGSTPVNVSGGLQSKGHPIAATGIANVWEICHQLRGEAGDRQIDN-A
                                                                                      

Mb1653c|M.bovis_AF2122/97           KVGVTANQGLFGHGSSVIVAR---
Rv1627c|M.tuberculosis_H37Rv        KVGVTANQGLFGHGSSVIVAR---
MMAR_2430|M.marinum_M               RVGVTANQGLFGHGSSVIVAR---
MAB_2619|M.abscessus_ATCC_1997      RVGITANQGLFGNGSSVIVAR---
TH_4006|M.thermoresistible__bu      KVGLAQVYGSPGTGAITILSR---
MAV_2573|M.avium_104                QVGLAQLYGAPGTAAVAILSK---
Mflv_2519|M.gilvum_PYR-GCK          RVGLAQVYGAPGTASATILSL---
Mvan_4139|M.vanbaalenii_PYR-1       RVGLAQVYGAPGTASATILSL---
MSMEG_4778|M.smegmatis_MC2_155      RVGLAQVYGAPGTASATILSL---
MLBr_02158|M.leprae_Br4923          ------------------------
MUL_4955|M.ulcerans_Agy99           KVGLAHVIGLGSACGVHILERSAA