For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_3448 | - | - | 100% (510) | putative AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_4415 | - | e-130 | 49.20% (500) | PUTATIVE AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_2995 | - | e-127 | 49.60% (496) | PUTATIVE AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0276 | fadD2 | 2e-53 | 31.18% (510) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_2385 | - | 1e-130 | 49.90% (507) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0270 | fadD2 | 2e-53 | 31.18% (510) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 9e-56 | 30.77% (520) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 3e-65 | 31.85% (518) | putative long-chain-fatty-acid CoA ligase |
| M. marinum M | MMAR_0466 | - | 1e-123 | 47.70% (499) | long-chain-fatty-acid-CoA ligase |
| M. avium 104 | MAV_1843 | - | 1e-135 | 51.00% (502) | AMP-dependent synthetase and ligase |
| M. smegmatis MC2 155 | MSMEG_4883 | - | 1e-130 | 50.50% (499) | AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_1115 | - | 1e-121 | 47.29% (499) | long-chain-fatty-acid-CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_4263 | - | 1e-135 | 51.80% (500) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0466|M.marinum_M --------------------------------------------------
MUL_1115|M.ulcerans_Agy99 --------------------------------------------------
MAV_1843|M.avium_104 --------------------------------------------------
Mflv_2385|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4263|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4883|M.smegmatis_MC2_155 --------------------------------------------------
TH_3448|M.thermoresistible__bu --------------------------------------------------
Mb0276|M.bovis_AF2122/97 MPNLTDLPGQAVSKLQKSIGQYVARGTAELHYLRKIIESGAIGLEPPLNY
Rv0270|M.tuberculosis_H37Rv MPNLTDLPGQAVSKLQKSIGQYVARGTAELHYLRKIIESGAIGLEPPLNY
MLBr_02546|M.leprae_Br4923 -----------MTKLR----HYLERGAAEVHYLRSIFESGALGFEPPLTY
MAB_4559|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0466|M.marinum_M ----------MSVSLLLEMAASASPDRIAVVSGDLRLTTQQLSDLADGGA
MUL_1115|M.ulcerans_Agy99 ----------MSVSLLLEMAASASPDRIAVVSGDLRLKTQQLSDLADGGA
MAV_1843|M.avium_104 -----MKAEALSISLLLEMAVSEDPDRVALVDGANRLTLGELSSLADGGA
Mflv_2385|M.gilvum_PYR-GCK ----------MSISLLLEMATDAGPDRTAVVSDDTRLTTAELSALADGGA
Mvan_4263|M.vanbaalenii_PYR-1 ----------MSISLLLEMAQDAGPDRTAVVSDDLRLTTAELSALADGGA
MSMEG_4883|M.smegmatis_MC2_155 ----------MSISLLLEMASSGDPDRTAVVSDDTRLTAGELSTLADGAA
TH_3448|M.thermoresistible__bu ----------MNLTMLLEMAAEAGPDRVAVGPRDGGITYRQLLDRARALA
Mb0276|M.bovis_AF2122/97 AALAADIRKWGEVGMLPSHNARRAPNRAAVIDEEGTLTFSELDEAAHAVA
Rv0270|M.tuberculosis_H37Rv AALAADIRKWGEVGMLPSHNARRAPNRAAVIDEEGTLTFSELDEAAHAVA
MLBr_02546|M.leprae_Br4923 AAMAVAMRKWGDLAMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALA
MAB_4559|M.abscessus_ATCC_1997 ----------MQFTQWLHRALQQYPDRLITIDQGREHTVEQFADRVARLS
.. *.* . :: . :
MMAR_0466|M.marinum_M GAIAA----SDAQHVVYVGTGGAMLPLLIFASARAGLPFTSINYRLSADG
MUL_1115|M.ulcerans_Agy99 GAIAA----SDAQHVVYVGTGGAMLPLLIFASARAGLPFTSINYRLSADG
MAV_1843|M.avium_104 GVIAA----SGAQHVAYVGSGVTMAPLLIFASARAGNAYTPINYRLSAGG
Mflv_2385|M.gilvum_PYR-GCK GVIAA----SGARHVAYVGTGGALLPLLLFASARAAVPVTPLNYRLSAEG
Mvan_4263|M.vanbaalenii_PYR-1 GVIAA----SGARHVAYVGAGGAMLPLLLFASARAAVPVTPLNYRLSADG
MSMEG_4883|M.smegmatis_MC2_155 GVIAG----SGAAHVAYVGTGGALLPLLLFASARAAIPFTPLNYRLSAEG
TH_3448|M.thermoresistible__bu GELIAPDQAAAPENVALLDLNSPAVPMLVFGTAAAGVPIAPLNYRLTDDQ
Mb0276|M.bovis_AF2122/97 NGLLAKG-VRAGDGVAILARNHRWFVIANYGAARVGARIILLNSEFSGPQ
Rv0270|M.tuberculosis_H37Rv NGLLAKG-VRAGDGVAILARNHRWFVIANYGAARVGARIILLNSEFSGPQ
MLBr_02546|M.leprae_Br4923 NGLIAKG-VRGGDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQ
MAB_4559|M.abscessus_ATCC_1997 AGLRANG-VRPGDRVGMLSLNSDRYIEYLTAVPWLGAALNAVNIRWSLAE
: . : : . . . . :* . :
MMAR_0466|M.marinum_M IAALIRRLPRPLVVVDERYRDTI--AADQSLSSQQ---------------
MUL_1115|M.ulcerans_Agy99 IAALIRRLPRPLVVVDERYRETI--AADQSLSSQQ---------------
MAV_1843|M.avium_104 IQELIVRLPDPLVIVDSRYRDMVGDVGKLVMDSDE---------------
Mflv_2385|M.gilvum_PYR-GCK LRALLDRLPDPLVVVDDEYRDAVGDSYR-TMGSRE---------------
Mvan_4263|M.vanbaalenii_PYR-1 LRALLDRLPDPLVVVDDEYRDAVGDGYR-TIGSAE---------------
MSMEG_4883|M.smegmatis_MC2_155 LRELVDRLPTPLVIADGEYAGMLAGAGRPVLTSEE---------------
TH_3448|M.thermoresistible__bu VNDAVRRLTPVMVVAGTDAAHRVPPGDGVVVRRTDD--------------
Mb0276|M.bovis_AF2122/97 IKEVSDREGAKVIIYDDEYTKAVSLAQPPLGKLRALGVNPDDDKPSGSSD
Rv0270|M.tuberculosis_H37Rv IKEVSDREGAKVIIYDDEYTKAVSLAQPPLGKLRALGVNPDDDKPSGSSD
MLBr_02546|M.leprae_Br4923 IKEVSEREGAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTD
MAB_4559|M.abscessus_ATCC_1997 IGYSLRESGTRVLLVDDTFKAAAAPLRAACACLETVIYCGAG--PAPQDM
: . ::: .
MMAR_0466|M.marinum_M --FLELAGRAEPVAEFPDP-DSVAIVLFTSGTTSQPKAVELTHSNLTSYV
MUL_1115|M.ulcerans_Agy99 --FLELAGRAEPVAEFPDP-DSVAIVLFTSGTTSQPKAVELTHSNLTSYV
MAV_1843|M.avium_104 --FLAAARAADPVAEFADP-EDVAIVLFTSGTTSKPKAVELTHGNLTSYI
Mflv_2385|M.gilvum_PYR-GCK --FFEASRTAEPAAEFADP-DSVGVVLFTSGTTSKPKAVELTHTNLTSYI
Mvan_4263|M.vanbaalenii_PYR-1 --FLDAARTAEPAAEFADP-DAVGVVLFTSGTTSKPKAVELSHANLTSYI
MSMEG_4883|M.smegmatis_MC2_155 --FLSQARTADPAAEFADP-DAVAVVLFTSGTTSRPKAVELTHNNLTSYI
TH_3448|M.thermoresistible__bu VVRSAAAGAAGAELPFVDP-DDPAVLLFTSGTTGAPKAAVLRHRHLTSYI
Mb0276|M.bovis_AF2122/97 ETLAELIAHSSTAPAPKAS-RRASIIILTSGTTGTPKGANRNTPPTLAPI
Rv0270|M.tuberculosis_H37Rv ETLAELIAHSSTAPAPKAS-RRASIIILTSGTTGTPKGANRNTPPTLAPI
MLBr_02546|M.leprae_Br4923 ETLAELIARSSSAPAPKVR-KRASIIILTSGTTGTPKGANRNTPASLAPL
MAB_4559|M.abscessus_ATCC_1997 IGYEDLLASHEPIDDTRTGGDSLLGVFYTGGTTGNPKGVMLSHNNVLASA
. :: *.***. **.. :
MMAR_0466|M.marinum_M TTTVEFGCAAP-SDAALICVPPYHIAGVSAVLSNLYAGRKMVYLTNFDAH
MUL_1115|M.ulcerans_Agy99 TTTVEFGCAAP-SDAALICVPPYHIAGVSAVLSNLYAGRKMVYLNNFDAH
MAV_1843|M.avium_104 TGTVEFGSAEP-EDAALICVPPYHIAGVNAAISNLYAGRKMVYLANFDAR
Mflv_2385|M.gilvum_PYR-GCK MGTVEFASAEP-DDAALICVPPYHIAGVSAALSNLYAGRKMVYLRHFDAE
Mvan_4263|M.vanbaalenii_PYR-1 MGTVEFASAEP-DDAALICVPPYHIAGVSAALSNLYAGRKMVYLTQFDAG
MSMEG_4883|M.smegmatis_MC2_155 TGTVEFGSAAP-EDAALICVPPYHIAGVSAAMSNLYAGRKMVYLRNFDAH
TH_3448|M.thermoresistible__bu VGTVEFFNADE-DEAILVSVPNYHIAGISSVLSSVYAGRRMVQLPAFSPE
Mb0276|M.bovis_AF2122/97 GGILSHVPFKA-GEVTLLPSPMFHALGYMHAALAMFLGSTLVLRRRFKPA
Rv0270|M.tuberculosis_H37Rv GGILSHVPFKA-GEVTLLPSPMFHALGYMHAALAMFLGSTLVLRRRFKPA
MLBr_02546|M.leprae_Br4923 GGILSKVPFRA-HEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPA
MAB_4559|M.abscessus_ATCC_1997 MGSLSTGNFLTRGGRLLHSAPMFHMADFSAVLAGNLSGSTHVIVPSFSPQ
:. * * :* . . * * *..
MMAR_0466|M.marinum_M EWVRLTNAEQVTTATVVPTMLDRIVAVLETGE--HKLPSLRNLAYGGSKV
MUL_1115|M.ulcerans_Agy99 EWVRLTNAEQVTTATVVPTMLDRIVAVLETGE--HKLPSLRNLAYGCSKV
MAV_1843|M.avium_104 EWVRLVAAERVTTATVVPTMLDRIVAALERDP--VELPSLRNLAYGGSKV
Mflv_2385|M.gilvum_PYR-GCK KWVRLVADEGVTSATVVPTMLDRIVTVLETTD--TALPTLRTLAYGGSKV
Mvan_4263|M.vanbaalenii_PYR-1 RWVDLVTGEGVTSATVVPTMLDRIVSVLETRG--TTLPTLRTLAYGGSKV
MSMEG_4883|M.smegmatis_MC2_155 RWVELVRTEGVTSATVVPTMLDRIVTALETTR--AELPTLRNLAYGGSKV
TH_3448|M.thermoresistible__bu GWVELAAAERITQAMVVPTMLGRILDVLEERG--TELPALRTLSYGGGRM
Mb0276|M.bovis_AF2122/97 LVLEDIEKHKATSMVVVPVMLSRILDQLEKTEPKPDLSSLKIVFVSGSQL
Rv0270|M.tuberculosis_H37Rv LVLEDIEKHKATSMVVVPVMLSRILDQLEKTEPKPDLSSLKIVFVSGSQL
MLBr_02546|M.leprae_Br4923 TVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQL
MAB_4559|M.abscessus_ATCC_1997 GVLDAIVAHDVQDMLLVPTMIQMLVDHPGAAQ--LDLSGIRSITYGASVI
: . :**.*: :: *. :: : . . :
MMAR_0466|M.marinum_M GLPLVRRALELLPDVGFVNAYGLTETSSTIAVLTPDDHRAAQSAAAAGLA
MUL_1115|M.ulcerans_Agy99 GLPLVRRALELLPDVGFVNAYRLTETSSTIAVLTPDDHRAAQSAAAAGLA
MAV_1843|M.avium_104 GLPLVRKALDLLPHVGFVNAYGLTETSSTIAVLTPDDHREAYGNPDEAVA
Mflv_2385|M.gilvum_PYR-GCK PLPLVRKALSLLPDVGFVNAYGLTETSSTIAVLTPDDHRAALAAADDAAL
Mvan_4263|M.vanbaalenii_PYR-1 PLPLVRKALSLLPAVGFVNAYGLTETSSTIAVLTPDDHRAALAASDEAAI
MSMEG_4883|M.smegmatis_MC2_155 ALPLVRKALELMPNVGFVNAYGLTETSSTIAVLGPDDHRAALASDDPGVT
TH_3448|M.thermoresistible__bu PVQTVERAMRLLPHVDFVNAYGLTETSSTIAVLGPEDHRAAFGSDDPAVR
Mb0276|M.bovis_AF2122/97 GAELATRALGDLGPVIYN-MYGSTEVAFATIAGPKD------------LQ
Rv0270|M.tuberculosis_H37Rv GAELATRALGDLGPVIYN-MYGSTEVAFATIAGPKD------------LQ
MLBr_02546|M.leprae_Br4923 GAELATRALEELGPVIYN-MYGSTEIAFATIAGPKD------------LQ
MAB_4559|M.abscessus_ATCC_1997 SEAVLQRATRVFPNARFTQAYGMTEVSPVATLLLPDDHDDP---------
:* : . : * ** : . :
MMAR_0466|M.marinum_M RRLGSVGRPVPGVELQIRGQDGRVLGPGETGELFVRGGQVSG---RYTGI
MUL_1115|M.ulcerans_Agy99 RRLGSVGRPVPGVELQIRGQDGRVLGPGETGELFVRGEQVSG---RYTGI
MAV_1843|M.avium_104 KRLGSVGRPVPGVEVQIRDESGRVLGPGEPGELYVRGEQVSG---KYTGI
Mflv_2385|M.gilvum_PYR-GCK RRLGSVGQPVPGIEVEVRAEDGTVLGPGETGELFVRGEQVSG---KYTDI
Mvan_4263|M.vanbaalenii_PYR-1 RRLGSVGQPVPGIEVEIRADDGTVLGAGETGELFVRGEQVSG---KYTDI
MSMEG_4883|M.smegmatis_MC2_155 RRLGSVGQVVPGIEVQIRGEDGTVLGPGETGELFVRGEQVSG---RYTEI
TH_3448|M.thermoresistible__bu ARLGSVGRPLPSVEVEIRDHTGAPVPPGQFGEVYVRGEQVAG---EYTSH
Mb0276|M.bovis_AF2122/97 FNPSTVGPVVKGVTVKILDENGNEVPQGAVGRIFVGNAFPFE---GYTGG
Rv0270|M.tuberculosis_H37Rv FNPSTVGPVVKGVTVKILDENGNEVPQGAVGRIFVGNAFPFE---GYTGG
MLBr_02546|M.leprae_Br4923 INSATVGPVVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFE---GYTGG
MAB_4559|M.abscessus_ATCC_1997 ALLRSAGRAAPHCEVRIVDPDDNEVPRGEIGEVIVKGDNVMLGYWELPEE
:.* :.: . : * *.: * . .
MMAR_0466|M.marinum_M GSVLDGHGWFGTKDIAMLDEDGYLFIGGRSDDTIIRGGENIAPAELEEVL
MUL_1115|M.ulcerans_Agy99 GSVLDGHGWFGTKDIAMLDEDGYLFIGGRSDDTIIRGGENIAPAELEEVL
MAV_1843|M.avium_104 GSVLDDEGWFPTRDIATLDEAGYLFITGRADDTIIRGGENIAPAELEDVL
Mflv_2385|M.gilvum_PYR-GCK GSVLDENGWFPTKDVAYLDSEGYLFIGGRSDDTIIRGGENIAPAEIEDVL
Mvan_4263|M.vanbaalenii_PYR-1 GSVLDEQGWFPTKDVAFLDEEGYLFIGGRSDDTIIRGGENIAPAEIEDVL
MSMEG_4883|M.smegmatis_MC2_155 GSVLDEDGWFPTKDVAMLDQDGYLFIGGRSDDTIIRGGENIAPAEIEDVL
TH_3448|M.thermoresistible__bu -SALDAEGWYPTRDRGRLDDAGYLFLDGRADDVIVRGGENISPGEIEDVL
Mb0276|M.bovis_AF2122/97 GGKQIIDGLLSSGDVGYFDERGLLYVSGRDDEMIVSGGENVFPAEVEDLI
Rv0270|M.tuberculosis_H37Rv GGKQIIDGLLSSGDVGYFDERGLLYVSGRDDEMIVSGGENVFPAEVEDLI
MLBr_02546|M.leprae_Br4923 GGKQIIDGLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLI
MAB_4559|M.abscessus_ATCC_1997 SAAAIRDGWMHTGDAGRMDDRGYVYIVDRIKDMVVTGGENVYSAEVENAL
. .* : * . :*. . ::: .* .: :: ****: ..*:*: :
MMAR_0466|M.marinum_M IEHPQVRDVAVVGVEDAQWGQEIVAVVVPVAGVDPDPEELREFVRRSLRG
MUL_1115|M.ulcerans_Agy99 IEHPQVRDVAVVGVEDAQWGQEIVAVVVPVAGVDPDPEELREFVRRSLRG
MAV_1843|M.avium_104 IEHPHVHEVAVVGVDDPQWGQAIVAVIVPVPGVTPDPDELRDYAHKYLRG
Mflv_2385|M.gilvum_PYR-GCK VEHPHVRDCAVVGADDPQWGQIIVAVVVPHQDTAPDPEDLRAHVRSQLRG
Mvan_4263|M.vanbaalenii_PYR-1 VEHPHVRDCAVVGADDPEWGQIIVAVVVAQPGTEPDVEDLRSHVRSQLRG
MSMEG_4883|M.smegmatis_MC2_155 VEHPDVRDVAVVGPEDPQWGQIIVAVVVPADGAEPDADVLREHVRKHLRG
TH_3448|M.thermoresistible__bu VEHPAVAEAAAVGVADREWGERVEAVVVAAPGAQVVESELQDWVRQRLRS
Mb0276|M.bovis_AF2122/97 SGHPDVVEAAAIGVDDKEFGARLRAFVVKKPGADLDEDTIKQYVRDHLAR
Rv0270|M.tuberculosis_H37Rv SGHPDVVEAAAIGVDDKEFGARLRAFVVKKPGADLDEDTIKQYVRDHLAR
MLBr_02546|M.leprae_Br4923 SGHPEVVEATAIGVDDKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLAR
MAB_4559|M.abscessus_ATCC_1997 AKHPAVAACAVIGIPDEQWGERVHAVVVKQAQSECCDGDLQEHCREHIAN
** * :.:* * ::* : *.:* :: : :
MMAR_0466|M.marinum_M SRTPDRVVFRHELPTTATGKILRREIIEELAGTKS------
MUL_1115|M.ulcerans_Agy99 SRTPDRVVFRRELPTTATGKILRREIIEELAGTKS------
MAV_1843|M.avium_104 SRTPDRVVFRDELPTNATGKLLRREIVDSLSATMAEK----
Mflv_2385|M.gilvum_PYR-GCK SRTPDRVVFRDELPTNATGKVLRRELVSELNQDRSPAQPAV
Mvan_4263|M.vanbaalenii_PYR-1 SRTPDRVVFRDELPTNATGKVLRRELVDELNQDPSPAQPAV
MSMEG_4883|M.smegmatis_MC2_155 SRTPDRVVFRAELPTNATGKVLRRQLVDEL-------QPIS
TH_3448|M.thermoresistible__bu TRVPARIHQWDELPYNETGKLLRRVLRDELNARTPTEQVAG
Mb0276|M.bovis_AF2122/97 YKVPREVIFLDELPRNPTGKVLKRELRKL------------
Rv0270|M.tuberculosis_H37Rv YKVPREVIFLDELPRNPTGKVLKRELRKL------------
MLBr_02546|M.leprae_Br4923 YKVPREVIFLEELPRNPTGKVLKRELRDFEVH---------
MAB_4559|M.abscessus_ATCC_1997 YKVPRSFEFVDELPLSGAGKILKRVLRQKYWESRDAGVS--
:.* . *** . :**:*:* : .