For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_2544 | - | - | 100% (574) | acyl-CoA ligase |
| M. thermoresistible (build 8) | TH_2068 | fadD3 | 3e-70 | 34.53% (556) | PROBABLE FATTY-ACID-CoA LIGASE FADD3 (FATTY-ACID-CoA |
| M. thermoresistible (build 8) | TH_2591 | - | 3e-63 | 30.99% (568) | PUTATIVE feruloyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 3e-70 | 32.48% (548) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_4867 | - | 2e-74 | 33.78% (521) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 3e-70 | 32.48% (548) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 2e-50 | 29.78% (534) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 1e-73 | 35.16% (529) | AMP-binding domain protein |
| M. marinum M | MMAR_3852 | fadD35 | 2e-71 | 33.40% (518) | fatty-acid-CoA ligase FadD35 |
| M. avium 104 | MAV_5076 | - | 0.0 | 70.34% (563) | acyl-CoA ligase |
| M. smegmatis MC2 155 | MSMEG_5649 | - | 4e-69 | 31.39% (548) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 2e-68 | 33.03% (551) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_1563 | - | 3e-74 | 33.09% (550) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
TH_2544|M.thermoresistible__bu --------MRTHDDIHRRRATLAARFPVWRPTTLGGWLDDCARRYAER--
MAV_5076|M.avium_104 -----------MSDIAARRQALRDRFPVWRPRTLADWLDDCARTYGSR--
Mflv_4867|M.gilvum_PYR-GCK ---------------MTGSYDAGPTDVAILEETIGANFARIARTHPGRDA
Mvan_1563|M.vanbaalenii_PYR-1 ---------------MSQSYDAGPTDTAILEETIGANFERIAATYPDHEA
MSMEG_5649|M.smegmatis_MC2_155 ----------------MKSYDAGPTGAPVLEETIGANFERIAATYPEHEA
MAB_4377c|M.abscessus_ATCC_199 ----------------MKAYDAGATLSPIIEETIGENFERIARAHPDVGA
Mb2533c|M.bovis_AF2122/97 ------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREA
Rv2505c|M.tuberculosis_H37Rv ------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREA
MMAR_3852|M.marinum_M ------MATTAAADQNQLSYDRGPIAPALLEMTIGANLAATASQCESRDA
MUL_4126|M.ulcerans_Agy99 --------------------------MTSDPRTVPTALDRLVRRLPNHDA
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
:
TH_2544|M.thermoresistible__bu PFVITD------------DITLSYRDVAERSRGLAAGLSALGVRRGDRVG
MAV_5076|M.avium_104 PFVLCD------------HGALSYRQVAEESRRLAAGLRELGIGAGDRVG
Mflv_4867|M.gilvum_PYR-GCK LVDVAG------------GRRWTYAELDAEIDTVARGLMAIGVERGDRVG
Mvan_1563|M.vanbaalenii_PYR-1 LVDVTG------------GRRWTYAELDREIDTVAKGLMSLGTESGDRVG
MSMEG_5649|M.smegmatis_MC2_155 LVEVAT------------GRRWTYAELNDEIDATARGLMALGVDKGDRVG
MAB_4377c|M.abscessus_ATCC_199 LVDVSG------------DRRWTYRELDAEINRVARGLMSLGVAAGDRVG
Mb2533c|M.bovis_AF2122/97 LVDMVA------------RRRFNYSELLTDVHRLATGLVRAGIGPGDRVG
Rv2505c|M.tuberculosis_H37Rv LVDMVA------------RRRFNYSELLTDVHRLATGLVRAGIGPGDRVG
MMAR_3852|M.marinum_M LVDVRS------------GRRWSYAQLLTDVRQLATGLVRAGIGRGDRVG
MUL_4126|M.ulcerans_Agy99 LVTD--------------ERSFTVSELNDEVYRAAAALIELGVKPAARVG
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
. :: * .* * . :.
TH_2544|M.thermoresistible__bu LLMANYPEFVTLKFAIARLGAIAVPFNYLYRSDELRFVLADSGCRVLITM
MAV_5076|M.avium_104 MLLANSLEFVTVKFAIARLGAIAVPFNYLYRRDELAFVLGDSGCRVLVTM
Mflv_4867|M.gilvum_PYR-GCK IWAPNCPEWVIVQYATAKIGAILVNINPAYRTHELRYVLEQSGVATLISA
Mvan_1563|M.vanbaalenii_PYR-1 IWAPNCPEWTIVQYATAKIGAILVNINPAYRTHELSYVLEQSGVSTLISA
MSMEG_5649|M.smegmatis_MC2_155 IWAPNCAEWIMTQFAAAKVGAILVNINPAYRTHEVAYVLRQSGVRTLVSA
MAB_4377c|M.abscessus_ATCC_199 IWAPNCAEWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVRTLICA
Mb2533c|M.bovis_AF2122/97 IWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAV
Rv2505c|M.tuberculosis_H37Rv IWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAV
MMAR_3852|M.marinum_M IWAPNRWEWVLVQYATAEIGAVLVTINPAYQARELEYALRQSGVAMVIAA
MUL_4126|M.ulcerans_Agy99 IWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAM
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
: * : . .:** : :* : : :.
TH_2544|M.thermoresistible__bu TRFGQQDYQRMLDEIVPGWDRDPFPSRPGSAAGTVGELRHVVLRGTDGEP
MAV_5076|M.avium_104 TGFGSLDYQRMLDDIAPGWDTAGFAAR-HPAADELPSLRHVVLAEAE-QP
Mflv_4867|M.gilvum_PYR-GCK TQFKTSDYVAMVDEVRP----------------DVPALQRVLFIGTA---
Mvan_1563|M.vanbaalenii_PYR-1 TRFKTSDYVAMVDEVRP----------------DVPALQRVLFIGTD---
MSMEG_5649|M.smegmatis_MC2_155 SSFKTSDYASMIAEVRP----------------ECPDLLDVVFLDND---
MAB_4377c|M.abscessus_ATCC_199 KAFKSSDYVAMASQVMP----------------DAPGLRDVVFIGTS---
Mb2533c|M.bovis_AF2122/97 ASFKDADYAAMLAEVGP----------------RCPDLADVILLESD---
Rv2505c|M.tuberculosis_H37Rv ASFKDADYAAMLAEVGP----------------RCPDLADVILLESD---
MMAR_3852|M.marinum_M SGFKGSDYAAILAEVAP----------------GCPELHDVAFLDGD---
MUL_4126|M.ulcerans_Agy99 GHFLGSDRVAGLDRKAL----------------PALRHIVRIPIEEP---
MLBr_02546|M.leprae_Br4923 D-----EYTKVVSKAEP----------------ALGKLRALGVNPDE---
:
TH_2544|M.thermoresistible__bu PRPGRMTVTELEATGDPAALAAAAGDIDPQAAADLLYTSGTTGFPKGVVT
MAV_5076|M.avium_104 ARQGLPLVANLGAT--AARLDVPPECVDPLGPADLLYTSGTTGSPKGVLL
Mflv_4867|M.gilvum_PYR-GCK ---DWDTLRAAGSGVDDADLRRRSGALSNRDPINIQYTSGTTGFPKGATL
Mvan_1563|M.vanbaalenii_PYR-1 ---DWDRLRSRADVIDDALLRERSASLSHHDPVNIQYTSGTTGFPKGATL
MSMEG_5649|M.smegmatis_MC2_155 ---DWDRLR--ANQVDDAAFHERMATLANTDPINIQYTSGTTGFPKGATL
MAB_4377c|M.abscessus_ATCC_199 ---DWTELVAGAERVTETALRARMSQLSNTDPINIQYTSGTTGYPKGATL
Mb2533c|M.bovis_AF2122/97 ---RWDALAG--AEPDLPALQQTAARLDGSDPVNIQYTSGTTAYPKGVTL
Rv2505c|M.tuberculosis_H37Rv ---RWDALAG--AEPDLPALQQTAARLDGSDPVNIQYTSGTTAYPKGVTL
MMAR_3852|M.marinum_M ---GWAKLAG--SGADLVALQEIATTLSADDPINIQYTSGTTGFPKGVTL
MUL_4126|M.ulcerans_Agy99 ---DGTWDEFIETGTDTGAVTARAAAVSPDDVSDILFTSGTTGRSKGVLC
MLBr_02546|M.leprae_Br4923 --EEPPGSTDETLAELIARSSSAPAPKVRKRASIIILTSGTTGTPKGANR
: *****. .**.
TH_2544|M.thermoresistible__bu SHDAVLRTAYASALTRAFEDGRRILFSLPCYHMFGYIEGLLSVMFAG-GA
MAV_5076|M.avium_104 THDSVLRTAYASALTRAYADGRRIVYALPCYHMFGYIEGLLSAMFVG-GA
Mflv_4867|M.gilvum_PYR-GCK SHRNILNNGFFVTEQIRLQPGDRLCIPVPFYHCFGMVMGNLGCTTHGATI
Mvan_1563|M.vanbaalenii_PYR-1 SHRNILNNGFFVTEQIRLGPGDRLCIPVPFYHCFGMVMGNLGCTTHGATM
MSMEG_5649|M.smegmatis_MC2_155 SHRNILNNGFFVTELIALGPDDRLCIVPPFYHCFGMVMGTLGAVSHGTTI
MAB_4377c|M.abscessus_ATCC_199 SHRNVLNNGFFVAESIQLQAGDRLCIPVPFYHCFGMVMGNLGCTTHGATI
Mb2533c|M.bovis_AF2122/97 SHRNILNNGYLVGELLGYTAQDRICIPVPFYHCFGMVMGNLAATSHGAAM
Rv2505c|M.tuberculosis_H37Rv SHRNILNNGYLVGELLGYTAQDRICIPVPFYHCFGMVMGNLAATSHGAAM
MMAR_3852|M.marinum_M SHRNILNNGYLVGELLEYTAEDRICIPVPFYHCFGMVMGNLAATSHGACM
MUL_4126|M.ulcerans_Agy99 AHRQSLSASASWAANGKITADDRHLCINPFFHNFGYKAGILACLQTG-AT
MLBr_02546|M.leprae_Br4923 NTPASLAPLGGILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGS--T
* * :* :* . *. .
TH_2544|M.thermoresistible__bu IIPQPTFSPEGYFAGIARHRATDVLCVPTMAVAMAESAH--REDHDLDSL
MAV_5076|M.avium_104 AIMQQKFTAEGYFRAIDAHRATDMLCVPTMAVAMVESPA--RARYDLSSL
Mflv_4867|M.gilvum_PYR-GCK VIPAPAFDPGLTLRAIETERCTAVYGVPTMFIAMQNHPD--FAERDLSTL
Mvan_1563|M.vanbaalenii_PYR-1 VIPAPGFDPGQTLKTIETERCTAVYGVPTMFIAMQNHAD--FAERDLSSL
MSMEG_5649|M.smegmatis_MC2_155 VIPAPGFDPGITLSAVESEKCTGLYGVPTMFIAMLGHPD--FANFDLSSL
MAB_4377c|M.abscessus_ATCC_199 VMPAPGFDPGRTLEAIERERCVGVYGVPTMFIAMLADPG--FAHRDLSTL
Mb2533c|M.bovis_AF2122/97 VIPAPGFDPAATLRAVQDERCTSLYGVPTMFIAELGLPD--FTDYELGSL
Rv2505c|M.tuberculosis_H37Rv VIPAPGFDPAATLRAVQDERCTSLYGVPTMFIAELGLPD--FTDYELGSL
MMAR_3852|M.marinum_M VIPAPGFDPAATLRAVQAERCTSLYGVPTMFIAELGLAD--FATYDLSSL
MUL_4126|M.ulcerans_Agy99 LFPHLTFDPLRTLQAIERHRITVLPGPPTIYQTLLDHPA--RDDYDLSSL
MLBr_02546|M.leprae_Br4923 LVLRRRFKPATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSL
. * . : : .: . : *.: :*.:*
TH_2544|M.thermoresistible__bu RAMLCGSAPAPAWLWRQIERDFGVSEIVTGYGMTECGGAMTLTLPEDPLE
MAV_5076|M.avium_104 TAILCGSAPAPVWLWQRIAKDFGVSEIVTGYGMTECGGCMSLTLPEDPLA
Mflv_4867|M.gilvum_PYR-GCK RTGIMAGAVCPVEVMKRCVEEMHLTEMSIAYGMTETSPVSCQTLIDDDLE
Mvan_1563|M.vanbaalenii_PYR-1 RTGIMAGAVCPVEVMKRCVEEMNMSEISIAYGMTETSPVSCQTLIDDDLE
MSMEG_5649|M.smegmatis_MC2_155 RTGIMAGSVCPIEVMKRVVADMHMAEVAICYGMTETSPVSCQTLIDDDLD
MAB_4377c|M.abscessus_ATCC_199 RTGIMAGSVCPVEVMKRCIDEMHMAGVAIAYGMTETSPVSCQTLFDDDLD
Mb2533c|M.bovis_AF2122/97 RTGIMAGAACPVEVMRKVISRMHMPGVSICYGMTETSPVSTQTRADDSVD
Rv2505c|M.tuberculosis_H37Rv RTGIMAGAACPVEVMRKVISRMHMPGVSICYGMTETSPVSTQTRADDSVD
MMAR_3852|M.marinum_M RTGIMAGSTCPVEVMRKVIDQMHMAGISICYGMTETSPVATQTRSNDSLQ
MUL_4126|M.ulcerans_Agy99 RFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRADDDAL
MLBr_02546|M.leprae_Br4923 RVVFVSGSQLGAELATRALEELGP-VIYNMYGSTEIAFATIAG--PKDLQ
. ..: : : : : ** ** .
TH_2544|M.thermoresistible__bu LTSETVGRPKLAGAAGVDETGALTVYRTVDPGSGRELDAGATGELVSRGP
MAV_5076|M.avium_104 LASSTVGRPKLAGAAGVAGVDALVIYRVVDPDSGEELPPGTPGELLSTGP
Mflv_4867|M.gilvum_PYR-GCK RRTSTIGR-----------VHPHVEIKIVDPETGEIVERGTPGEFCTRGY
Mvan_1563|M.vanbaalenii_PYR-1 RRTSSIGR-----------VHPHVEIKIVDPDTGHVVERGTPGEFCTRGY
MSMEG_5649|M.smegmatis_MC2_155 RRTATIGR-----------AHPHVEIKIIDPDTGETVERGQPGEFCTRGY
MAB_4377c|M.abscessus_ATCC_199 RRTATVGR-----------AHPHIEIKIVDPNSGETVQRGQSGELCTRGY
Mb2533c|M.bovis_AF2122/97 RRVGTVGR-----------VGPHLEIKVVDPATGETVPRGVVGEFCTRGY
Rv2505c|M.tuberculosis_H37Rv RRVGTVGR-----------VGPHLEIKVVDPATGETVPRGVVGEFCTRGY
MMAR_3852|M.marinum_M RRVTTVGR-----------VGPHLEIKVVDPATGRIVPRGTAGEFCTRGY
MUL_4126|M.ulcerans_Agy99 TVATTCGR-----------PFADFELRIG-PDTGEVLLRGP---------
MLBr_02546|M.leprae_Br4923 INSATVGP-----------VVKGVKVKILDDSGKE-VPRGQVGRIFVGNA
: * : . : *
TH_2544|M.thermoresistible__bu TTMLGYWNRPAETAEALR-GGWLHSGDLGRIRDDGYLEITGRSKELYKSG
MAV_5076|M.avium_104 TAMIGYWNRPAETADALR-DGWLHSGDLGLVRADGYLELTGRRKELYKSG
Mflv_4867|M.gilvum_PYR-GCK SVMLGYWREDEKTAQAIDADGWMHTGDLAVMRPDGYCNIVGRIKDVVIRG
Mvan_1563|M.vanbaalenii_PYR-1 SVMLGYWRDEEKTAQAVDADGWMHTGDLAVMRPDGYCNIVGRIKDVVIRG
MSMEG_5649|M.smegmatis_MC2_155 SVMLGYWNDDEKTREAVDADGWMHTGDLAVMREDGYCTIVGRIKDMVIRG
MAB_4377c|M.abscessus_ATCC_199 SVMLGYWNDEAHTREVLDTDGWMHTGDLAVMRDDGYCTIIGRLKDMVIRG
Mb2533c|M.bovis_AF2122/97 SVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGRIKDLVVRG
Rv2505c|M.tuberculosis_H37Rv SVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGRIKDLVVRG
MMAR_3852|M.marinum_M SVMSGYWKAPERTAEVIDPEGWMHTGDLALMDECGYVQITGRIKDIVVRG
MUL_4126|M.ulcerans_Agy99 NVMLGYLDDPRATAAAIDADGWLHTGDIGVLDEAGNLRITDRLKDMYICG
MLBr_02546|M.leprae_Br4923 FPFEGYTGG----GGKQIIDGLLSSGDVGYFDEHDLLYISGRDDEMIVSG
: ** * : :**:. . . : .* .:: *
TH_2544|M.thermoresistible__bu GELVMPKEIEDLLAGYDDISQVFAVGLTDERWGEIGCVVVVPAHG-ARIT
MAV_5076|M.avium_104 GELVMPKEIEDLLAGHGDISQVFAVGLSDDRWGEIGCVVVVRAPG-ATIT
Mflv_4867|M.gilvum_PYR-GCK GENIYPREIEEFLYTHPDVEDAHVIGVPDDRYGEEVCAWIRMRPGRTALD
Mvan_1563|M.vanbaalenii_PYR-1 GENIYPREVEEFLYTHPDIEDAQVVGVPDARYGEEICAWIRMRPGRRALD
MSMEG_5649|M.smegmatis_MC2_155 GENIYPREIEEFLYTHPDIDDAQVIGVPDERYGEEICAWIRMKPGRPPLD
MAB_4377c|M.abscessus_ATCC_199 GENIYPREIEEFLLTHPDIEDVHVVGVPDEKYGEELCAWVRMRPDRVVID
Mb2533c|M.bovis_AF2122/97 GENISPREIEELLHTHPDIVDGHVIGVPDAKYGEELMAVVKLRNDAPELT
Rv2505c|M.tuberculosis_H37Rv GENISPREIEELLHTHPDIVDGHVIGVPDAKYGEELMAVVKLRNDAPELT
MMAR_3852|M.marinum_M GENISPREIEEFLHSHPDIVDAHVVGVPDERMGEELMAVVKLRAGAPELT
MUL_4126|M.ulcerans_Agy99 GFNVYPAEVEQVLARLDGVADVAVIGIPDHRLGEVGRAFIVARPG-FNLD
MLBr_02546|M.leprae_Br4923 GENVFPAEVEDLISGHPEVVEATAIGVDDKEWGARLRAFVVKKQD-ATID
* : * *:*:.: : : .:*: * . * . : . :
TH_2544|M.thermoresistible__bu EQEVLDRCRARLARFKVPKRVEFLQAAELPTTPTGKVQKFRLVERFTRRG
MAV_5076|M.avium_104 EDDVLALCRDKLARFKVPKRVVFYRSEDLPTTPTGKVQKFRLAEQLRSAD
Mflv_4867|M.gilvum_PYR-GCK AAAVREFATDKLAHYKIPRYVHVVD--EFPMTVTGKIRKVEMREVSARLL
Mvan_1563|M.vanbaalenii_PYR-1 AAAVREFAAGKLAHYKIPRYVHVVD--EFPMTVTGKIRKVEMREVSAGLF
MSMEG_5649|M.smegmatis_MC2_155 ADKVREFASGKLAHYKIPRYVHVVD--EFPMTVTGKIRKVQMREETVALL
MAB_4377c|M.abscessus_ATCC_199 AVAIRAFASGRLAHYKIPRYVHVVE--SFPMTVTGKVRKIEMRQQTIQIF
Mb2533c|M.bovis_AF2122/97 IERLREYCMGRIARFKIPRYLWIVD--EFPMTVTGKVRKVEMRQQALEYL
Rv2505c|M.tuberculosis_H37Rv IERLREYCMGRIARFKIPRYLWIVD--EFPMTVTGKVRKVEMRQQALEYL
MMAR_3852|M.marinum_M TGLLREYCAGQIAKFKIPRYLRLVD--EFPMTVTGKVRKVEMRQQAIEYL
MUL_4126|M.ulcerans_Agy99 EKSVIDYTREHLANFKAPRSVRFVD--TLPRNAGGKVVKPQLRELA----
MLBr_02546|M.leprae_Br4923 EDAIKAYVRDHLARYKVPREVIFLE--ELPRNPTGKVLKRELRDFEVH--
: ::*.:* *: : . :* . **: * .: :
TH_2544|M.thermoresistible__bu -------------
MAV_5076|M.avium_104 AVTGAERLPAGTS
Mflv_4867|M.gilvum_PYR-GCK GL-----------
Mvan_1563|M.vanbaalenii_PYR-1 AD-----------
MSMEG_5649|M.smegmatis_MC2_155 GLEA---------
MAB_4377c|M.abscessus_ATCC_199 GLPEPGRTDEQ--
Mb2533c|M.bovis_AF2122/97 RGQQ---------
Rv2505c|M.tuberculosis_H37Rv RGQQ---------
MMAR_3852|M.marinum_M RGQH---------
MUL_4126|M.ulcerans_Agy99 -------------
MLBr_02546|M.leprae_Br4923 -------------