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M. thermoresistible (build 8) TH_2450 (-)

annotation: putative FAD dependent oxidoreductase
coordinates: 3156647 - 3158248
length: 534

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2450--100% (534)putative FAD dependent oxidoreductase
M. thermoresistible (build 8)TH_4080-3e-6435.73% (445) PUTATIVE conserved hypothetical protein
M. thermoresistible (build 8)TH_3452-3e-5831.01% (503) PUTATIVE lipolytic enzyme

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1428c-7e-8335.13% (501) monoxygenase
M. gilvum PYR-GCKMflv_3377-1e-8536.00% (500) FAD dependent oxidoreductase
M. tuberculosis H37RvRv1393c-7e-8335.13% (501) monoxygenase
M. leprae Br4923MLBr_00065-4e-2727.39% (449) putative monooxygenase
M. abscessus ATCC 19977MAB_0099-1e-13747.86% (514) monooxygenase
M. marinum MMMAR_2207-2e-8234.90% (510) monoxygenase
M. avium 104MAV_3378-1e-8135.26% (502) lipolytic enzyme
M. smegmatis MC2 155MSMEG_0816-1e-8234.46% (502) flavin-binding monooxygenase
M. ulcerans Agy99MUL_1793-3e-7834.86% (502) monoxygenase
M. vanbaalenii PYR-1Mvan_0721-1e-8233.99% (506) FAD-dependent pyridine nucleotide-disulphide oxidoreductase

CLUSTAL 2.0.9 multiple sequence alignment


TH_2450|M.thermoresistible__bu      MTVTGDVRPEYDVAIIGAGPGGIAAAHKLR-RRGITDIAILERGDDFGGT
MAB_0099|M.abscessus_ATCC_1997      ---MSDI--DFRVAIIGAGPGGIAAAYYLR-RQGINDFVILERADDFGGT
Mb1428c|M.bovis_AF2122/97           ------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSDYLVVEAGDGVGGT
Rv1393c|M.tuberculosis_H37Rv        ------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSDYLVVEAGDGVGGT
MAV_3378|M.avium_104                --MSSPAVPDHHTLIIGAGFSGIGAAIKLD-KAGLPDYRVIEAGDGVGGT
MMAR_2207|M.marinum_M               ----MSIEPDYQIVIVGAGFSGIGAAISLD-KAGFGDYLVIEAGDGVGGT
MUL_1793|M.ulcerans_Agy99           -------------MIVGAGFSGIGAAISLD-KAGFGDYLVIEAGDAVGGT
MSMEG_0816|M.smegmatis_MC2_155      -----MRPVVHDAVIVGAGFAGLGAAIQLK-KMSFDDFVILEREDDLGGT
Mvan_0721|M.vanbaalenii_PYR-1       -----MISEHFDAVIVGAGFAGIGAAIQFK-RMGIENFVILEREDDLGGT
Mflv_3377|M.gilvum_PYR-GCK          -----MSTEQLDAVIVGAGFGGMGAAIQLD-RLGYQKIAILDREDDLGGT
MLBr_00065|M.leprae_Br4923          -MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILEKRAGMGGT
                                                  *:*** .*:.**  :  :    .  :::    .***

TH_2450|M.thermoresistible__bu      WRDNHYPGLAVDIPILWYQFSFNRNPRWSRVFAPGPEIHRYLTDTARSLG
MAB_0099|M.abscessus_ATCC_1997      WRDNTYPGLAVDIPVVFYQLSFARTGRWNKLFADGADIQRYHLSVVAQLG
Mb1428c|M.bovis_AF2122/97           WHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHELKAYAEHCVDKYG
Rv1393c|M.tuberculosis_H37Rv        WHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHELKAYAEHCVDKYG
MAV_3378|M.avium_104                WHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGRELKAYAEHCADKYG
MMAR_2207|M.marinum_M               WFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGRELRAYAEHCADKYG
MUL_1793|M.ulcerans_Agy99           WFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGRELRAYAEHCADKYG
MSMEG_0816|M.smegmatis_MC2_155      WYVNHYPGLAVDVPTTTYSYFFEPNPSWSRLFSTGREIKRYADDVADKYD
Mvan_0721|M.vanbaalenii_PYR-1       WYVNHYPGLAVDVPTTTYSYFFEPNPNWSRLFSTGAEIKQYADDVADKYD
Mflv_3377|M.gilvum_PYR-GCK          WHVNRYPGLTVDVPSTTYSYWFEPNPYWSRLYAPGTELKSYAVHVADKYD
MLBr_00065|M.leprae_Br4923          WDLFRYPGIRSDSDMYTLGFRFRP-WTKCQAIADGKPILEYIKSTAVMHG
                                    *    ***:  *         *       :  : *  :  *    .   .

TH_2450|M.thermoresistible__bu      LYPLLRPHHDVVGQRWNAENAMWQLTVRDRPP---VTARFVISSVGG-YV
MAB_0099|M.abscessus_ATCC_1997      LREHFQGGSEVIAERWDDDGDYWELTITGKPV---VRARYVISAVGG-YI
Mb1428c|M.bovis_AF2122/97           IRSRIRLNTKVLAAEFDDEHSLWRVQTDPGGE---ITARFLISACG--IL
Rv1393c|M.tuberculosis_H37Rv        IRSRIRLNTKVLAAEFDDEHSLWRVQTDPGGE---ITARFLISACG--IL
MAV_3378|M.avium_104                IRSRIRFNTKVLAAEFDDEQRLWRVQTDPGGE---VTARFLISACG--VL
MMAR_2207|M.marinum_M               IRPRIRFNTKVLGAEFDDERSLWRLQTDPGGE---LTTRFIINASG--VL
MUL_1793|M.ulcerans_Agy99           IRPRIRFNTKVLGAELDDERSLWRLQTDPGGD---LITRFIINASG--VL
MSMEG_0816|M.smegmatis_MC2_155      VRRHIRFGTTVTGARWDEDDNVWQVSLTDGEQ---LQARFLITATG--FL
Mvan_0721|M.vanbaalenii_PYR-1       VRRHIRFGVTVGGARWDDDAQLWRVNLADGET---VDARYLVTATG--FL
Mflv_3377|M.gilvum_PYR-GCK          LRRYMRFNTTVEGARWDEESRRWSVSLVGGHT---LTAQFLILATG--YL
MLBr_00065|M.leprae_Br4923          IDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMISCSFLFLCSGYYNY
                                    :   ::    * .   .     * :          :   ::. . *    

TH_2450|M.thermoresistible__bu      NAR-ATDLEGLSDFTGKVLRPNCWDDGYDTRDKRVAVIGTGSSGAQIVSA
MAB_0099|M.abscessus_ATCC_1997      DTKPGPDIPGINDFRGKVMRPNEWDHSYDYTGKRVAVIGTGSSGIQIAPA
Mb1428c|M.bovis_AF2122/97           TVPKLPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGIIGTGASAVQVIPE
Rv1393c|M.tuberculosis_H37Rv        TVPKLPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGIIGTGASAVQVIPE
MAV_3378|M.avium_104                TVPNLPDIDGVDSFAGITMHTARWDHGQDLRGKRVAVIGTGASAVQVIPE
MMAR_2207|M.marinum_M               TVPKLPDIAGVDSFAGVTMHTARWDHSQELTGKRVGIIGTGASAVQVIPE
MUL_1793|M.ulcerans_Agy99           TVPKLPDIAGVDSFAGVTMHTARWDHSQELTGKRVGIIGTGASAVQVIPE
MSMEG_0816|M.smegmatis_MC2_155      SQPHTPDIPGITEFDGKVIHTTDWDDGCSLYGRRAAVVGTGATAVQLIPE
Mvan_0721|M.vanbaalenii_PYR-1       SQPHMPDIPGIAEFDGRVIHTTAWDDSYDPTGEKIGIIGTGATAVQLIPE
Mflv_3377|M.gilvum_PYR-GCK          CQPRKPDIPGIEDFAGTVLHAQEWDDDYSLKGRRAAIIGTGSTGVQLIPK
MLBr_00065|M.leprae_Br4923          EQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVVIGSGATAVTLVPA
                                         . : *  .* *  ::.  * .  .   ..  ::*:*::.  : . 

TH_2450|M.thermoresistible__bu      LSGR-VARLDVYQRTPNWILPRPDFALPRALQRVLELPGVAAVLHNIGRA
MAB_0099|M.abscessus_ATCC_1997      VART-AASVTTFQRTPAWIIPKPNPALSPRAQRILSAP-LMLTLINASIA
Mb1428c|M.bovis_AF2122/97           MAPI-VSHLTVFQRTPIWCFPKFDVPLPTAVR-WAMRIPGGKAVHRLLSQ
Rv1393c|M.tuberculosis_H37Rv        MAPI-VSHLTVFQRTPIWCFPKFDVPLPTAVR-WAMRIPGGKAVHRLLSQ
MAV_3378|M.avium_104                IAPI-VSSLTVFQRTPIWCFPKLDVPLPAPAR-WAMRFPGGKALQRLLSQ
MMAR_2207|M.marinum_M               IAPI-VKHLTVFQRTPIWCFPKFDFPLPAALR-WAMRIPGGKALQRLLSQ
MUL_1793|M.ulcerans_Agy99           IAPI-VKHLTVFQRTPIWCFPKFDFPLPAALR-WAMRIPGGKALQRLLSQ
MSMEG_0816|M.smegmatis_MC2_155      LAER-VAELTVYQRTPIWVVPKVDVRFPPAVRALFARVPLTQRVVRAITD
Mvan_0721|M.vanbaalenii_PYR-1       LAEK-AADLTVYQRTPIWVVPKIDFRFSERAKQLFARIPLTQRLIRVITD
Mflv_3377|M.gilvum_PYR-GCK          LADD-VAELTVYQRTPIWVMPKLDFPFGRAAQRLFAKVPATQQFLRMSSD
MLBr_00065|M.leprae_Br4923          LANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPDKYAYTAVRWKNI
                                    ::   .  :   **:* : ..:                       .    

TH_2450|M.thermoresistible__bu      VFDLFFVVPIVHLMAHVPDRVLVRLLRGYDSLARFAFRVLLRAVVHDPQT
MAB_0099|M.abscessus_ATCC_1997      VSMDIVEFVLFHLLPLLPESVLRVLIPRYDNMARRWYRRLLRSTVQDPEL
Mb1428c|M.bovis_AF2122/97           AFVEATFPIAAHYFAVFP----------LAKHMESAGRRYLRQQVHDPVV
Rv1393c|M.tuberculosis_H37Rv        AFVEATFPIAAHYFAVFP----------LAKHMESAGRRYLRQQVHDPVV
MAV_3378|M.avium_104                AYVELTFPISAHYFTVIP----------LAKRMAALGRAYLRRQVRDPAV
MMAR_2207|M.marinum_M               AYVEATFPISAHYFTVFP----------LARWSAVLGRRYLRQRVNDPVV
MUL_1793|M.ulcerans_Agy99           AYVEATFPISAHYFTVFP----------LARWSAVLGRRYLRQRVDDPVV
MSMEG_0816|M.smegmatis_MC2_155      AIYAFMVDTAVLKHRYFR---------RLNIAAADLGRLHLAASIRDPDL
Mvan_0721|M.vanbaalenii_PYR-1       TIYELMVWVAVLHNRQTRG--------RFNIAAGDLAKMHRFATIRDKEL
Mflv_3377|M.gilvum_PYR-GCK          AFMDVMVTIAMWKFRQFR---------PVNTAAARIGALHRFLAIRDKGL
MLBr_00065|M.leprae_Br4923          LRQSALYGACQKWPQRMR-----------NILLGHVARRLPKGYDVQKHF
                                                                                  :   

TH_2450|M.thermoresistible__bu      RRRLMPAHGILAKRPIISGSYLPAFNDPRTHLITTPIERITAAGVRTTDG
MAB_0099|M.abscessus_ATCC_1997      RKALMPSYGILARRTILSSDFLQAVDAGEVQLVIEPIARVTEDGIDTADG
Mb1428c|M.bovis_AF2122/97           REQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVATTDG
Rv1393c|M.tuberculosis_H37Rv        REQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVATTDG
MAV_3378|M.avium_104                REQLTPRYAVGCKRPGFHNGYLATFNRDNVRLVTEPIDKITPDAVATTDG
MMAR_2207|M.marinum_M               RDQLTPRYAVGCKRPGFHNGYLSTFNRDNVQLVTEPIEKITPTAVATDDG
MUL_1793|M.ulcerans_Agy99           RDQLTPRYAVDCKRPGFHNGYLSTFNRDNVQLVTEPIEKITPTSVATDDG
MSMEG_0816|M.smegmatis_MC2_155      RSKLTPDYDFGCKRPTFSNSYYRTFTKPHVHLQADGIDHVEPDGIVNADG
Mvan_0721|M.vanbaalenii_PYR-1       RAKLTPDYDFGCKRPTFSNSYYRTFTKPHVHLQDSGIARIESDGIVGNDG
Mflv_3377|M.gilvum_PYR-GCK          RRKLTPDYDFGCKRPTLSNTYYRTFNKKHVHLETSGIERIEADGIVTRDG
MLBr_00065|M.leprae_Br4923          GPHYNPWEQRLCLVP--DGDLFRAIRKGTVDMVTDAIDRFTSTGIRLKSG
                                         *     .  .   .    :.    . :    * :.   .:   .*

TH_2450|M.thermoresistible__bu      VERPVDLIVTATGYELWTDPETYFPGTILGDAGFDLALDYRENGLRSYGG
MAB_0099|M.abscessus_ATCC_1997      AHHAVDLLVLATGYEIYTDPEHYKPGAVRGRNGFDLGTYYCDNDMRTYGG
Mb1428c|M.bovis_AF2122/97           ASHEIDVLVLATGFKVL-DTDSIPTYAVTGTGGASLSRFWDEHRLQAYEG
Rv1393c|M.tuberculosis_H37Rv        ASHEIDVLVLATGFKVL-DTDSIPTYAVTGTGGASLSRFWDEHRLQAYEG
MAV_3378|M.avium_104                ETHEIDVLILATGFKVM-DPDSVPTFAVTGSGGRSLSRFWDEHRLQAYEG
MMAR_2207|M.marinum_M               TDHEIDVLILATGFKVL-DTDDVLTYPVIGRAGRSLSQFWEEHRAQAYQG
MUL_1793|M.ulcerans_Agy99           TDHEIDVLILATGFKVL-DTDDVLTYPVIGRAGRSLSQFWEEHRAQAYQG
MSMEG_0816|M.smegmatis_MC2_155      SKTVIDTLVLATGFDLW-EAN-FPAIEVIGRQGRDLGKWWRETRFQAYQG
Mvan_0721|M.vanbaalenii_PYR-1       TKTPIDTLVLATGFDLW-EAN-FPAIEVIGRDGRNLGKWWRETRFQAYQG
Mflv_3377|M.gilvum_PYR-GCK          TKKVIDTLVLATGFDVW-ESN-LPAIPVIGREGRDLGKWWRENKFQAYEG
MLBr_00065|M.leprae_Br4923          NELRADIIVTATGLNLQ-----LFGGAVATVDGQPVDLAQT----MSYKG
                                         * :: *** .:           :    *  :          :* *

TH_2450|M.thermoresistible__bu      TAHPRLPNRWEIVGPLAFVGVGWTDFVETMAEHAVRIIDAARRRGADVVT
MAB_0099|M.abscessus_ATCC_1997      SALPGLPNRWMLVGPEGNQGQGWHAMVEANARHAARIIGASSRCHREVAE
Mb1428c|M.bovis_AF2122/97           VSVPGYPNFFTVFGPYGYVGSSYFALIETQAHHIIRCLKRARRTGATRIE
Rv1393c|M.tuberculosis_H37Rv        VSVPGYPNFFTVFGPYGYVGSSYFALIETQAHHIIRCLKRARRTGATRIE
MAV_3378|M.avium_104                VTVPGFPNLFTVFGPYGYVGSSYFALIEAQTHHIVRCLKRAQRLGATRVE
MMAR_2207|M.marinum_M               VSVPGYPNFFAVFGPYGYVGSSYFALIETQTHHILRCLKRARRDGATRVE
MUL_1793|M.ulcerans_Agy99           VSVPGYRNFFAVFGPYGYVGSSYFALIETQTHHILRCLKRARRDGATRVE
MSMEG_0816|M.smegmatis_MC2_155      VSMPYFPNYLSLAGPYAFLGLNFFNTMEYQMRLMERLLGEVARRDARTFE
Mvan_0721|M.vanbaalenii_PYR-1       VSMPHFPNFLSLASPFAFLGLNFFNTVEYQMRHMDRLFGELRRRGATTFE
Mflv_3377|M.gilvum_PYR-GCK          LTVPLFPNLLTQASPYAWVGMSWFDTVEYQMRHMKRLFGELQRRGADTFE
MLBr_00065|M.leprae_Br4923          MMLSGLPNMIYTVG---YTNASWTLKADLVSEFFCRLLNYMNANDFDTVA
                                       .   *     .     . .:    :   .   * :            

TH_2450|M.thermoresistible__bu      VTDEAFGRWDARMRKAGKAARLYYTRCNPGVNTYYVNSQRDTVYHRPQTI
MAB_0099|M.abscessus_ATCC_1997      VSRRAFDRWVRKMAHQSKAIRLYATDCQPPLSTYFVNSKGETRYYRPQTV
Mb1428c|M.bovis_AF2122/97           VTEEANARYFAEVMRRRHRQVFWQDSCRL-ANSYYFDKNGD-VPLRPTTT
Rv1393c|M.tuberculosis_H37Rv        VTEEANARYFAEVMRRRHRQVFWQDSCRL-ANSYYFDKNGD-VPLRPTTT
MAV_3378|M.avium_104                VSEEANDRYFAEMMRRRHRQIFWQDSCRL-ANSYYFDKNGD-VPLRPGTT
MMAR_2207|M.marinum_M               VTEEANARYFAEMMRRRYRQVFWQDSCRR-ANSYYFDKNGD-VPLRPTTT
MUL_1793|M.ulcerans_Agy99           VTEEANARYFAEMMRRRYRQVFWQDSCRR-ANSYYFDKNGD-VPLRPTTT
MSMEG_0816|M.smegmatis_MC2_155      VTEEANRRYLDRMTDALGDSLFTLGNCAS-ARSYYFNPSGEATLLRPMTT
Mvan_0721|M.vanbaalenii_PYR-1       ITEEANARYLARMTALLGDSLFTNGSCAT-ARSYYFNPSGEPTLLRPTST
Mflv_3377|M.gilvum_PYR-GCK          VTEEANAEFLDRMETLLEDSVFRLGNCAN-SRSYWFNSSGEAPLFRPQSI
MLBr_00065|M.leprae_Br4923          VEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLRDIRLI
                                    :   .       .        :    .     :       :         

TH_2450|M.thermoresistible__bu      TESLVFAHRPPLTDYRFERRPAAARSAVRALRHAEGNEAV
MAB_0099|M.abscessus_ATCC_1997      SEMNWFSKHSPISDYSL--RPVSMETKVRYDQSA------
Mb1428c|M.bovis_AF2122/97           VEAYWRSRRFDLGDYRISS---------------------
Rv1393c|M.tuberculosis_H37Rv        VEAYWRSRRFDLGDYRISS---------------------
MAV_3378|M.avium_104                PEVYWRSRRFDLDDYRFTG---------------------
MMAR_2207|M.marinum_M               VEAYWRGRHFDLDNYRFGR---------------------
MUL_1793|M.ulcerans_Agy99           VEAYWRGRHFDLDDYRFGR---------------------
MSMEG_0816|M.smegmatis_MC2_155      RRAVAEASRFPLSDYTFA----------------------
Mvan_0721|M.vanbaalenii_PYR-1       RAAIREATDFPIDDYRIV----------------------
Mflv_3377|M.gilvum_PYR-GCK          RQAVKEQETFPLSDYAIA----------------------
MLBr_00065|M.leprae_Br4923          RRGKVADEGLLFAKKTTPVTV-------------------
                                               : .