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STEQLDAVIVGAGFGGMGAAIQLDRLGYQKIAILDREDDLGGTWHVNRYPGLTVDVPSTTYSYWFEPNPY WSRLYAPGTELKSYAVHVADKYDLRRYMRFNTTVEGARWDEESRRWSVSLVGGHTLTAQFLILATGYLCQ PRKPDIPGIEDFAGTVLHAQEWDDDYSLKGRRAAIIGTGSTGVQLIPKLADDVAELTVYQRTPIWVMPKL DFPFGRAAQRLFAKVPATQQFLRMSSDAFMDVMVTIAMWKFRQFRPVNTAAARIGALHRFLAIRDKGLRR KLTPDYDFGCKRPTLSNTYYRTFNKKHVHLETSGIERIEADGIVTRDGTKKVIDTLVLATGFDVWESNLP AIPVIGREGRDLGKWWRENKFQAYEGLTVPLFPNLLTQASPYAWVGMSWFDTVEYQMRHMKRLFGELQRR GADTFEVTEEANAEFLDRMETLLEDSVFRLGNCANSRSYWFNSSGEAPLFRPQSIRQAVKEQETFPLSDY AIA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3377 | - | - | 100% (494) | FAD dependent oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0184 | - | 0.0 | 63.49% (493) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3372 | - | 0.0 | 63.88% (490) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1428c | - | 1e-111 | 42.62% (488) | monoxygenase |
| M. tuberculosis H37Rv | Rv1393c | - | 1e-111 | 42.62% (488) | monoxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 1e-35 | 27.33% (439) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2477c | - | 0.0 | 63.41% (492) | monooxygenase |
| M. marinum M | MMAR_2207 | - | 1e-111 | 43.18% (484) | monoxygenase |
| M. avium 104 | MAV_2172 | - | 0.0 | 62.63% (495) | FAD dependent oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_0816 | - | 0.0 | 64.14% (488) | flavin-binding monooxygenase |
| M. thermoresistible (build 8) | TH_2450 | - | 8e-86 | 36.00% (500) | PUTATIVE putative FAD dependent oxidoreductase |
| M. ulcerans Agy99 | MUL_1793 | - | 1e-109 | 42.77% (484) | monoxygenase |
| M. vanbaalenii PYR-1 | Mvan_3109 | - | 0.0 | 86.03% (494) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1428c|M.bovis_AF2122/97 ------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSDYLVVEAGDGVGGT
Rv1393c|M.tuberculosis_H37Rv ------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSDYLVVEAGDGVGGT
MMAR_2207|M.marinum_M ----MSIEPDYQIVIVGAGFSGIGAAISLD-KAGFGDYLVIEAGDGVGGT
MUL_1793|M.ulcerans_Agy99 -------------MIVGAGFSGIGAAISLD-KAGFGDYLVIEAGDAVGGT
Mflv_3377|M.gilvum_PYR-GCK -----MSTEQLDAVIVGAGFGGMGAAIQLD-RLGYQKIAILDREDDLGGT
Mvan_3109|M.vanbaalenii_PYR-1 -----MSTEQLDAVIVGAGFGGMGAAIQLN-RLGYRNIAILDREDDLGGT
MAV_2172|M.avium_104 -----MVTDRFDAIIVGAGFGGIGAAIQLK-RLGFDNIVILDREDDLGGT
MSMEG_0816|M.smegmatis_MC2_155 -----MRPVVHDAVIVGAGFAGLGAAIQLK-KMSFDDFVILEREDDLGGT
MAB_2477c|M.abscessus_ATCC_199 ------MTTQFDAVIVGAGFGGMGAAIQLK-ELGLTNLAILDREDDLGGT
TH_2450|M.thermoresistible__bu MTVTGDVRPEYDVAIIGAGPGGIAAAHKLR-RRGITDIAILERGDDFGGT
MLBr_00065|M.leprae_Br4923 -MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILEKRAGMGGT
*:*** .*:.** * . . ::: .***
Mb1428c|M.bovis_AF2122/97 WHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHELKAYAEHCVDKYG
Rv1393c|M.tuberculosis_H37Rv WHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHELKAYAEHCVDKYG
MMAR_2207|M.marinum_M WFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGRELRAYAEHCADKYG
MUL_1793|M.ulcerans_Agy99 WFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGRELRAYAEHCADKYG
Mflv_3377|M.gilvum_PYR-GCK WHVNRYPGLTVDVPSTTYSYWFEPNPYWSRLYAPGTELKSYAVHVADKYD
Mvan_3109|M.vanbaalenii_PYR-1 WHVNRYPGLTVDVPSTTYSYWFEPNPYWSRLYAPGSELKTYAEHVADKYD
MAV_2172|M.avium_104 WHVNHYPGIAVDIPSTTYSYWFEPNPGWSRLFAPGGEVKQYAADVADKYD
MSMEG_0816|M.smegmatis_MC2_155 WYVNHYPGLAVDVPTTTYSYFFEPNPSWSRLFSTGREIKRYADDVADKYD
MAB_2477c|M.abscessus_ATCC_199 WHVNHYPGLAVDIPSATYSYSFEPNPYWSRLFAPGSELKQYASHVADKHD
TH_2450|M.thermoresistible__bu WRDNHYPGLAVDIPILWYQFSFNRNPRWSRVFAPGPEIHRYLTDTARSLG
MLBr_00065|M.leprae_Br4923 WDLFRYPGIRSDSDMYTLGFRFRP-WTKCQAIADGKPILEYIKSTAVMHG
* ***: * : *. .: : * : * . .
Mb1428c|M.bovis_AF2122/97 IRSRIRLNTKVLAAEFDDEHSLWRVQTDPGGE---ITARFLISACGILTV
Rv1393c|M.tuberculosis_H37Rv IRSRIRLNTKVLAAEFDDEHSLWRVQTDPGGE---ITARFLISACGILTV
MMAR_2207|M.marinum_M IRPRIRFNTKVLGAEFDDERSLWRLQTDPGGE---LTTRFIINASGVLTV
MUL_1793|M.ulcerans_Agy99 IRPRIRFNTKVLGAELDDERSLWRLQTDPGGD---LITRFIINASGVLTV
Mflv_3377|M.gilvum_PYR-GCK LRRYMRFNTTVEGARWDEESRRWSVSLVGGHT---LTAQFLILATGYLCQ
Mvan_3109|M.vanbaalenii_PYR-1 LRRYMRFNTTVEGARWDEENQQWVVSLAGGQT---LQSQFLVLATGYLCQ
MAV_2172|M.avium_104 VRRHMRFNTTVEGAQWDEDAEVWRVALAGGES---LTTRFLITATGFLSQ
MSMEG_0816|M.smegmatis_MC2_155 VRRHIRFGTTVTGARWDEDDNVWQVSLTDGEQ---LQARFLITATGFLSQ
MAB_2477c|M.abscessus_ATCC_199 LRKYMRFNTPVSGARWDEEHQHWVVATESGDT---VTGKYLLTATGYLSQ
TH_2450|M.thermoresistible__bu LYPLLRPHHDVVGQRWNAENAMWQLTVRDRPP---VTARFVISSVGGYVN
MLBr_00065|M.leprae_Br4923 IDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMISCSFLFLCSGYYNY
: :* * . . * : : ::. . *
Mb1428c|M.bovis_AF2122/97 PK--LPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGIIGTGASAVQVIPE
Rv1393c|M.tuberculosis_H37Rv PK--LPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGIIGTGASAVQVIPE
MMAR_2207|M.marinum_M PK--LPDIAGVDSFAGVTMHTARWDHSQELTGKRVGIIGTGASAVQVIPE
MUL_1793|M.ulcerans_Agy99 PK--LPDIAGVDSFAGVTMHTARWDHSQELTGKRVGIIGTGASAVQVIPE
Mflv_3377|M.gilvum_PYR-GCK PR--KPDIPGIEDFAGTVLHAQEWDDDYSLKGRRAAIIGTGSTGVQLIPK
Mvan_3109|M.vanbaalenii_PYR-1 PK--KPDIPGIDTFAGTVLHAQEWDDNYSLRGKKAAIIGTGSTGVQLIPK
MAV_2172|M.avium_104 PH--TPDIPGIGSFGGKVVHTTAWDHDYRYQGRRIAVIGTGASAVQVVPE
MSMEG_0816|M.smegmatis_MC2_155 PH--TPDIPGITEFDGKVIHTTDWDDGCSLYGRRAAVVGTGATAVQLIPE
MAB_2477c|M.abscessus_ATCC_199 PK--MPDIEGIESFAGKVIHTTKWDNSYRAAGHRIGLIGTGATAVQLIPE
TH_2450|M.thermoresistible__bu AR--ATDLEGLSDFTGKVLRPNCWDDGYDTRDKRVAVIGTGSSGAQIVSA
MLBr_00065|M.leprae_Br4923 EQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVVIGSGATAVTLVPA
: . : * * * ::. * . :. ::*:*::.. ::.
Mb1428c|M.bovis_AF2122/97 MAPI-VSHLTVFQRTPIWCFPKFDVPLPTAVR-WAMRIPGGKAVHRLLSQ
Rv1393c|M.tuberculosis_H37Rv MAPI-VSHLTVFQRTPIWCFPKFDVPLPTAVR-WAMRIPGGKAVHRLLSQ
MMAR_2207|M.marinum_M IAPI-VKHLTVFQRTPIWCFPKFDFPLPAALR-WAMRIPGGKALQRLLSQ
MUL_1793|M.ulcerans_Agy99 IAPI-VKHLTVFQRTPIWCFPKFDFPLPAALR-WAMRIPGGKALQRLLSQ
Mflv_3377|M.gilvum_PYR-GCK LADD-VAELTVYQRTPIWVMPKLDFPFGRAAQRLFAKVPATQQFLRMSSD
Mvan_3109|M.vanbaalenii_PYR-1 LAED-VADLTVYQRTPIWVMPKFDLSFGPRTQRIFAKFPATQRFVRLSSD
MAV_2172|M.avium_104 LAKE-AEELTVYQRTATHVLPKVDFEFDPAVRRLFARVPAAQRALRWVTD
MSMEG_0816|M.smegmatis_MC2_155 LAER-VAELTVYQRTPIWVVPKVDVRFPPAVRALFARVPLTQRVVRAITD
MAB_2477c|M.abscessus_ATCC_199 LAKD-AQHLTVYQRTPIWVVPKADAKVPGVVKKLFAKVPRTQKIARTVGS
TH_2450|M.thermoresistible__bu LSGR-VARLDVYQRTPNWILPRPDFALPRALQ-RVLELPGVAAVLHNIGR
MLBr_00065|M.leprae_Br4923 LANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPDKYAYTAVRWKNI
:: . : : **:. ..: :
Mb1428c|M.bovis_AF2122/97 AFVEATFPIAAHYFAVFP-----------LAKHMESAGRRYLRQQVHDPV
Rv1393c|M.tuberculosis_H37Rv AFVEATFPIAAHYFAVFP-----------LAKHMESAGRRYLRQQVHDPV
MMAR_2207|M.marinum_M AYVEATFPISAHYFTVFP-----------LARWSAVLGRRYLRQRVNDPV
MUL_1793|M.ulcerans_Agy99 AYVEATFPISAHYFTVFP-----------LARWSAVLGRRYLRQRVDDPV
Mflv_3377|M.gilvum_PYR-GCK AFMDVMVTIAMWKFRQFR----------PVNTAAARIGALHRFLAIRDKG
Mvan_3109|M.vanbaalenii_PYR-1 LFMDIMTTLAMWKFRQLR----------PINTAAAKIGTLHRFLAIRDKE
MAV_2172|M.avium_104 VLLEIIMIVGALHFKESRG---------RGNISASDLAKINRFRWIRDKE
MSMEG_0816|M.smegmatis_MC2_155 AIYAFMVDTAVLKHRYFR----------RLNIAAADLGRLHLAASIRDPD
MAB_2477c|M.abscessus_ATCC_199 AILEVIMVGGVLHFRQFR----------QANHGASLLAKAHLFAQVRDRE
TH_2450|M.thermoresistible__bu AVFDLFFVVPIVHLMAHVPDRVLVRLLRGYDSLARFAFRVLLRAVVHDPQ
MLBr_00065|M.leprae_Br4923 LRQSALYGACQKWPQRMR------------NILLGHVARRLPKGYDVQKH
:
Mb1428c|M.bovis_AF2122/97 VREQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVATTD
Rv1393c|M.tuberculosis_H37Rv VREQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVATTD
MMAR_2207|M.marinum_M VRDQLTPRYAVGCKRPGFHNGYLSTFNRDNVQLVTEPIEKITPTAVATDD
MUL_1793|M.ulcerans_Agy99 VRDQLTPRYAVDCKRPGFHNGYLSTFNRDNVQLVTEPIEKITPTSVATDD
Mflv_3377|M.gilvum_PYR-GCK LRRKLTPDYDFGCKRPTLSNTYYRTFNKKHVHLETSGIERIEADGIVTRD
Mvan_3109|M.vanbaalenii_PYR-1 LRRKLTPDYDFGCKRPTLSNVYYRTFTKPHVHLETAGIERIEPDGIVGKD
MAV_2172|M.avium_104 LRAKLTPDYDCGCKRPTFSNSFYRVLTQPNVHLETNPIERIEPDGIVTAD
MSMEG_0816|M.smegmatis_MC2_155 LRSKLTPDYDFGCKRPTFSNSYYRTFTKPHVHLQADGIDHVEPDGIVNAD
MAB_2477c|M.abscessus_ATCC_199 LRRKLTPDYDFGCKRPTFSNTYFRAFTKKNVSLETASIARIEADGIVTAD
TH_2450|M.thermoresistible__bu TRRRLMPAHGILAKRPIISGSYLPAFNDPRTHLITTPIERITAAGVRTTD
MLBr_00065|M.leprae_Br4923 FGPHYNPWEQRLCLVP--DGDLFRAIRKGTVDMVTDAIDRFTSTGIRLKS
: * . * . .: . : : * :. . .: .
Mb1428c|M.bovis_AF2122/97 GASHEIDVLVLATGFKVLDTDS-IPTYAVTGTGGASLSRFWDEHRLQAYE
Rv1393c|M.tuberculosis_H37Rv GASHEIDVLVLATGFKVLDTDS-IPTYAVTGTGGASLSRFWDEHRLQAYE
MMAR_2207|M.marinum_M GTDHEIDVLILATGFKVLDTDD-VLTYPVIGRAGRSLSQFWEEHRAQAYQ
MUL_1793|M.ulcerans_Agy99 GTDHEIDVLILATGFKVLDTDD-VLTYPVIGRAGRSLSQFWEEHRAQAYQ
Mflv_3377|M.gilvum_PYR-GCK GTKKVIDTLVLATGFDVWESN--LPAIPVIGREGRDLGKWWRENKFQAYE
Mvan_3109|M.vanbaalenii_PYR-1 GTKRVIDTLVLATGFDVWESN--LPAIEVIGREGRDLGKWWRENRFQAYE
MAV_2172|M.avium_104 GRKNVIDTLVLATGFDLWEAN--FPAIEVIGRKGRNLGKWWRETRFQAYQ
MSMEG_0816|M.smegmatis_MC2_155 GSKTVIDTLVLATGFDLWEAN--FPAIEVIGRQGRDLGKWWRETRFQAYQ
MAB_2477c|M.abscessus_ATCC_199 GRKTVIDTLVLATGFNLWEST--FPAFEVIGREDYNLGKFWRDNRFQAFE
TH_2450|M.thermoresistible__bu GVERPVDLIVTATGYELWTDPETYFPGTILGDAGFDLALDYRENGLRSYG
MLBr_00065|M.leprae_Br4923 GNELRADIIVTATGLNLQLFGG---AVATVDGQPVDLAQTMS------YK
* . * :: *** .: . . .*. :
Mb1428c|M.bovis_AF2122/97 GVSVPGYPNFFTVFGPYGYVGSSYFALIETQAHHIIRCLKRARRTGATRI
Rv1393c|M.tuberculosis_H37Rv GVSVPGYPNFFTVFGPYGYVGSSYFALIETQAHHIIRCLKRARRTGATRI
MMAR_2207|M.marinum_M GVSVPGYPNFFAVFGPYGYVGSSYFALIETQTHHILRCLKRARRDGATRV
MUL_1793|M.ulcerans_Agy99 GVSVPGYRNFFAVFGPYGYVGSSYFALIETQTHHILRCLKRARRDGATRV
Mflv_3377|M.gilvum_PYR-GCK GLTVPLFPNLLTQASPYAWVGMSWFDTVEYQMRHMKRLFGELQRRGADTF
Mvan_3109|M.vanbaalenii_PYR-1 GLTVPLFPNMVTQASPYAWVGMSWFDTVEYQMRHMNRLLGELQRKGARTF
MAV_2172|M.avium_104 GVSMPYFPNYLSLASPFAFSGLSFFHTIEYQMRHMDRLLGEVKRRGATTF
MSMEG_0816|M.smegmatis_MC2_155 GVSMPYFPNYLSLAGPYAFLGLNFFNTMEYQMRLMERLLGEVARRDARTF
MAB_2477c|M.abscessus_ATCC_199 GIAVPKFPNLLTLNGPYSYSGLSYFDTIESQMRHIKRLFAEMARTGTEVF
TH_2450|M.thermoresistible__bu GTAHPRLPNRWEIVGPLAFVGVGWTDFVETMAEHAVRIIDAARRRGADVV
MLBr_00065|M.leprae_Br4923 GMMLSGLPNMIYTVG---YTNASWTLKADLVSEFFCRLLNYMNANDFDTV
* . * . : . .: : . * : . .
Mb1428c|M.bovis_AF2122/97 EVTEEANARYFAEVMRRRHRQVFWQDSCRL---ANSYYFDKNGDVP-LRP
Rv1393c|M.tuberculosis_H37Rv EVTEEANARYFAEVMRRRHRQVFWQDSCRL---ANSYYFDKNGDVP-LRP
MMAR_2207|M.marinum_M EVTEEANARYFAEMMRRRYRQVFWQDSCRR---ANSYYFDKNGDVP-LRP
MUL_1793|M.ulcerans_Agy99 EVTEEANARYFAEMMRRRYRQVFWQDSCRR---ANSYYFDKNGDVP-LRP
Mflv_3377|M.gilvum_PYR-GCK EVTEEANAEFLDRMETLLEDSVFRLGNCAN---SRSYWFNSSGEAPLFRP
Mvan_3109|M.vanbaalenii_PYR-1 EVTEEANARFLERMLTLLDDSVFRLGDCTN---SRSYWFNSSGEAPLFRP
MAV_2172|M.avium_104 EVTEEANDRFMERMTKLLDNSVFYAGNCAT---SRSYYFSPSGEASLLRP
MSMEG_0816|M.smegmatis_MC2_155 EVTEEANRRYLDRMTDALGDSLFTLGNCAS---ARSYYFNPSGEATLLRP
MAB_2477c|M.abscessus_ATCC_199 EVTDEANTEFLDRMTRNLDNSVFYLGSCQT---SRSYYFNQHGEAALLRP
TH_2450|M.thermoresistible__bu TVTDEAFGRWDARMRKAGKAARLYYTRCNPG--VNTYYVNSQRDTVYHRP
MLBr_00065|M.leprae_Br4923 AVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLRDIRL
* . . : . .: : *
Mb1428c|M.bovis_AF2122/97 TTTVEAYWRSRRFDLGDYRISS---------------------
Rv1393c|M.tuberculosis_H37Rv TTTVEAYWRSRRFDLGDYRISS---------------------
MMAR_2207|M.marinum_M TTTVEAYWRGRHFDLDNYRFGR---------------------
MUL_1793|M.ulcerans_Agy99 TTTVEAYWRGRHFDLDDYRFGR---------------------
Mflv_3377|M.gilvum_PYR-GCK QSIRQAVKEQETFPLSDYAIA----------------------
Mvan_3109|M.vanbaalenii_PYR-1 TSIRQAVKEQEKFPLADYAIA----------------------
MAV_2172|M.avium_104 TSTLNSIREASSFPLSDYVIA----------------------
MSMEG_0816|M.smegmatis_MC2_155 MTTRRAVAEASRFPLSDYTFA----------------------
MAB_2477c|M.abscessus_ATCC_199 TSTASAYKEQESFPLEAYQLA----------------------
TH_2450|M.thermoresistible__bu QTITESLVFAHRPPLTDYRFERRPAAARSAVRALRHAEGNEAV
MLBr_00065|M.leprae_Br4923 IRRGKVADEGLLFAKKTTPVTV---------------------
.