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M. thermoresistible (build 8) TH_2148 (-)

annotation: alcohol dehydrogenase
coordinates: 4227450 - 4228448
length: 333

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2148--100% (333)alcohol dehydrogenase
M. thermoresistible (build 8)TH_3212-2e-1727.01% (311) PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein
M. thermoresistible (build 8)TH_3440-3e-1230.08% (246) PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3806-2e-1126.22% (286) putative oxidoreductase
M. gilvum PYR-GCKMflv_4458-1e-9958.84% (328) alcohol dehydrogenase
M. tuberculosis H37RvRv3777-1e-1126.22% (286) oxidoreductase
M. leprae Br4923MLBr_00118-2e-1225.85% (352) putative oxidireductase
M. abscessus ATCC 19977MAB_4603c-9e-1226.25% (259) oxidoreductase
M. marinum MMMAR_1499-1e-14876.51% (332) oxidoreductase
M. avium 104MAV_0308-9e-1528.69% (244) alcohol dehydrogenase, zinc-binding
M. smegmatis MC2 155MSMEG_2079-1e-15079.22% (332) alcohol dehydrogenase
M. ulcerans Agy99MUL_2438-1e-14675.60% (332) oxidoreductase
M. vanbaalenii PYR-1Mvan_1903-3e-9958.54% (328) alcohol dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


TH_2148|M.thermoresistible__bu      ---VESFPALVARRDNGQ-ITTAVETLTAADLPPGEVTIRVHYSSVNYKD
MSMEG_2079|M.smegmatis_MC2_155      ---MESFQALVARTDGDR-VEAGLETLEPSALPPGEVTIRVLYSSVNFKD
MMAR_1499|M.marinum_M               ---MDTFHALVAHQDGDR-ITASIRTLTPNDLPPGDVTIRVHFSSVNFKD
MUL_2438|M.ulcerans_Agy99           ---MDTFHALVAHQDGDR-ITASIRTLTPNYLSPGDVTIRVHFSSVNFKD
Mflv_4458|M.gilvum_PYR-GCK          ---MTQINAMVAHEDAEGGIVLRREILDESALPDGDVEIHVEFSSVNYKD
Mvan_1903|M.vanbaalenii_PYR-1       MADMTEINAMVAHQDAEGGIELRHEVVDESFLPEGDVDIHVEYSSVNYKD
Mb3806|M.bovis_AF2122/97            ------MTIMRAVVAESS-DRLVWQEVPDVSAGPGEVLIKVAASGVNRAD
Rv3777|M.tuberculosis_H37Rv         ------MTIMRAVVAESS-DRLVWQEVPDVSAGPGEVLIKVAASGVNRAD
MLBr_00118|M.leprae_Br4923          ---------MHAIVAESA-NQMVWREVPDVTAGPGEVLIEVAASGVNRAD
MAB_4603c|M.abscessus_ATCC_199      ------MKAIQAQSLSGP-EGLVYTDVETPGAGPNVVVVDVKAAGVCFPD
MAV_0308|M.avium_104                ------MRAVVCRSYGTP-EDLVLDEVPDPVPGPGQLLVRVRAAAVNFPD
                                             : .              :       . : : *  :.*   *

TH_2148|M.thermoresistible__bu      ALAVTPGGGVVREYPVAPGIDLTGEVVASESPEFAVGDLVLAHGYEIG-T
MSMEG_2079|M.smegmatis_MC2_155      ALALTPKGGVVREYPVVPGIDLTGEVVASESPEFAVGDLVLAHGYDIG-T
MMAR_1499|M.marinum_M               ALALTPGGGVVRKYPVVPGIDLTGEVVESQSPEFSVGDLVLAHGYEIG-T
MUL_2438|M.ulcerans_Agy99           GLALTPGGGVVRKYPVVPGIDLTGEVVESQSPEFSVGDLVLAHGYEIG-T
Mflv_4458|M.gilvum_PYR-GCK          ALAVTPKGGVARSYPLVPGIDVAGTVTSSSSPDFAVGDRVIAHGQDIG-T
Mvan_1903|M.vanbaalenii_PYR-1       ALAVTPKGGVARSYPLIPGIDVAGTVTSSRSPEFAVGDRVIAHGQDIG-T
Mb3806|M.bovis_AF2122/97            VLQAAGKYPPPPGVSDIIGLEVSGIVAAVG-----PGVTEWSAGQEVCAL
Rv3777|M.tuberculosis_H37Rv         VLQAAGKYPPPPGVSDIIGLEVSGIVAAVG-----PGVTEWSAGQEVCAL
MLBr_00118|M.leprae_Br4923          VLQVAGKYPHPPGASAIIGMEVAGVVAAVS-----SGVTEWSVGQEVCAL
MAB_4603c|M.abscessus_ATCC_199      YLMTKGEYQLKMEPPFVPGIETAGVVRSAP-----EGS-GIKPGDRVMAF
MAV_0308|M.avium_104                VLFIAGKYQVKIPPPFIPGNEIAGEVIAAG-----EGA-RFLPGQRVAGT
                                     *            .   * : :* *          *      *  :   

TH_2148|M.thermoresistible__bu      GRHGGYAEYTRLPADQVVALGSLTPREGAAIGTAGFTAAMSVEALTRWGI
MSMEG_2079|M.smegmatis_MC2_155      GHHGGYAEYARLPADQIVALGALTPREGAAIGTAGFTAAMSVEAITARGI
MMAR_1499|M.marinum_M               GRHGGYAEYVRLPADQVVALGTLSPREGAAIGTAGFTAAMSVQALINWGV
MUL_2438|M.ulcerans_Agy99           GRHGGYAEYVRLPADQVVALGTLSPREGAAIGTAGFTAAMSVQALINWGV
Mflv_4458|M.gilvum_PYR-GCK          GRHGGYAQTARYPADYLVKLANLSTADAAAIGTAGFTAAMSVLALRTHGV
Mvan_1903|M.vanbaalenii_PYR-1       GRHGGYAQTARYPADYLVKLSTLSTSAAAAIGTAGFTAAMSVNAVRAHGI
Mb3806|M.bovis_AF2122/97            LAGGGYAEYVAVPADQVLPIPPSVNLVDSAALPEVACTVWSNLVMTAH--
Rv3777|M.tuberculosis_H37Rv         LAGGGYAEYVAVPADQVLPIPPSVNLVDSAALPEVACTVWSNLVMTAH--
MLBr_00118|M.leprae_Br4923          LAGGGYAEYVAVPASQVMPIPKGVNVVDSAGIPEVACTVWSNLVMAAH--
MAB_4603c|M.abscessus_ATCC_199      NFIGGYAERVAVAPSNILPTPPQLDDAEAVALIANYHTMYFAYARRGQ--
MAV_0308|M.avium_104                TF-GAFAEQALLDADQAEPIPDDADFASAAAFGVTYRTAYHALRSTAG--
                                       *.:*: .   ..             :.       :            

TH_2148|M.thermoresistible__bu      TADAGPIVVTGASGGVGSVSVDLLAAAGFDVVASTGKPHAADLLTGLGAA
MSMEG_2079|M.smegmatis_MC2_155      TPDDGPVVVTGATGGVGSVGVDLLSALGYHVVASTGKADRADELRALGAA
MMAR_1499|M.marinum_M               APDAGPVVVTGASGGVGSISVDLLAAAGYQVVASTGKPQAAELLKSLGAA
MUL_2438|M.ulcerans_Agy99           APDAGPVVVTGASGGVGSISVDLLAAAGYQVVASTGKPQAAELLKSLGAA
Mflv_4458|M.gilvum_PYR-GCK          EPSDGPVLVTGATGGVGAVSVDLLAGLGYEVVASTGKSQAHDLLRDLGAA
Mvan_1903|M.vanbaalenii_PYR-1       SPSDGPVLVTGATGGVGSVSVDLLAGLGYEVVASTGKADAHDLLRDLGAA
Mb3806|M.bovis_AF2122/97            LRPGQLVLIHGGASGIGSHAIQVARALAARVAITAGSPEKLELCRDLGAQ
Rv3777|M.tuberculosis_H37Rv         LRPGQLVLIHGGASGIGSHAIQVVRALAARVAITAGSPEKLELCRDLGAQ
MLBr_00118|M.leprae_Br4923          LSAGQLLLLHGGTSGIGSHGIQVARALGAKVAVTAGSEEKLEFCRALGAQ
MAB_4603c|M.abscessus_ATCC_199      LRAGETVLVLGAAGGIGTAAIQIAKGMGAKVIAVVNRTAATEFVKSVGAD
MAV_0308|M.avium_104                VTAGDWVVVLGAAGGVGLAAVDLAVAMQARVLAAASSPEKLELCRRRGAE
                                          ::: *.:.*:*  .:::  .    *   ..     :     ** 

TH_2148|M.thermoresistible__bu      EVIGRLPADPHATPRPLNR-ARWAGAVDCVGGVTLADVLSTLQYGGAVAA
MSMEG_2079|M.smegmatis_MC2_155      EVIGRLPADPDAKPRPLAR-AQWAAAVDCVGGATLADVLSTLKYGGAVAA
MMAR_1499|M.marinum_M               EVIGRLPADPDAKPRPLAK-ARWAAAVDCVGGATLADVLSTVDYGGAVAA
MUL_2438|M.ulcerans_Agy99           EVIGRLPADPDAKPRPLAK-ARWAAAVDCVGGATLADVLSTVDYGGAVAA
Mflv_4458|M.gilvum_PYR-GCK          EVIDRVPG-PDEKVRALGK-AHWAGVVDCVGGKTLAYALSTLKYGGVAAI
Mvan_1903|M.vanbaalenii_PYR-1       EVIDRVPG-PDEKVRPLGK-AHWAAVVDCVGGATLAYALSTTKYGGVAAA
Mb3806|M.bovis_AF2122/97            ITINYRDEDFVARLKQETDGSGADIILDIMGASYLDRNIDALATDGQLIV
Rv3777|M.tuberculosis_H37Rv         ITINYRDEDFVARLKQETDGSGADIILDIMGASYLDRNIDALATDGQLIV
MLBr_00118|M.leprae_Br4923          ITINYRDEDFVARLQQQN--GGADVILDIMGAAYLDRNIDALAIDGQLIV
MAB_4603c|M.abscessus_ATCC_199      IVLPLE-EGWAKAVREATGGAGVDMVVDPIGGPAFDDAVRTLASEGRLLV
MAV_0308|M.avium_104                ATVDYDREDLKTRIRDLTG-DRARVVLDPVGGPYSEPALRGLARGGTFVT
                                     .:           :           :* :*.      :      *    

TH_2148|M.thermoresistible__bu      GGLTGGAALHTTVMPFILRGVGLLGIESVKMPIG--------PRRELWQR
MSMEG_2079|M.smegmatis_MC2_155      SGLTGGVALHTTVMPFILRGVALLGIDSVQMPIG--------PRRALWEK
MMAR_1499|M.marinum_M               SGLTGGAALHTTVMPFILRGIALLGMDSVLMPIG--------PRRRLWSL
MUL_2438|M.ulcerans_Agy99           SGLTGGAALHTTAMPFILRGIALLGMDSVLMPIG--------PRRRLWSL
Mflv_4458|M.gilvum_PYR-GCK          SGLAGSPELPTTVMPFILRGATLAGIDSVLLPIE--------SRREIWTQ
Mvan_1903|M.vanbaalenii_PYR-1       SGLAGSPDLPATVLPFILRGVTLAGIDSVLLPIA--------KRRDIWAQ
Mb3806|M.bovis_AF2122/97            IGMQGGVKAELNLGKLLTKRARVIGTTLRARPVSGPHGKAAIAQAVAASV
Rv3777|M.tuberculosis_H37Rv         IGMQGGVKAELNLGKLLTKRARVIGTTLRARPVSGPHGKAAIAQAVAASV
MLBr_00118|M.leprae_Br4923          IGLQGGVKGELNLGKVLSKRARIIGSTLRARPVNGPNSKSEIVAAVTASI
MAB_4603c|M.abscessus_ATCC_199      VGFAAGGIPTIKVNRLLLRNASLIGVAWGEFLRT----HADYLYETQAGL
MAV_0308|M.avium_104                LGYASGTIPAIPLNLVLLKDICVRGMEIRTFMTD----RPDDAVRDLTEL
                                     *  ..         .: :   : *                         

TH_2148|M.thermoresistible__bu      LGGPLKPGHLAEITHEVDVRDVMTVIDEVRAGRFTGRAVVRVAGGF----
MSMEG_2079|M.smegmatis_MC2_155      LGGPLKPRHLDDVTHEVDIKDVVGVIDEVRAGRYAGRAVVKVAGGF----
MMAR_1499|M.marinum_M               LGDSLRPRRLDDLTTDIDIKDVVGVLDQLRAGEFTGRAVVRVAGAF----
MUL_2438|M.ulcerans_Agy99           LGDSLRPRRLDDLTTDVDIKDVVGVLDQLRAGEFTGRAVVRVAGAF----
Mflv_4458|M.gilvum_PYR-GCK          IESGLAPRHLARITRDVPVRDVADVLGTIIGGGVTGRTRVVVHDGF----
Mvan_1903|M.vanbaalenii_PYR-1       IESELLPRHLARITRDVPVRQVADVLGAIIGGGVTGRTRVVVHDGF----
Mb3806|M.bovis_AF2122/97            WPMIAANRVRPVIGTRLPIQQAAQAHELMLSGKTFGKILLTV--------
Rv3777|M.tuberculosis_H37Rv         WPMIAANRVRPVIGTRLPIQQAAQAHELMLSGKTFGKILLTV--------
MLBr_00118|M.leprae_Br4923          WPMIADGSVRPIIGARMAVQQAADAHQLLLSGKVSGKIVLTVAGSGTETL
MAB_4603c|M.abscessus_ATCC_199      EKLVAEG-MRPPVSARIPLSEGRQALQDFADGKVYGKMVLVP--------
MAV_0308|M.avium_104                SQMFAAGTVRPYIGARFPLARTAAALRHVADRKVLGKVVIDVA-------
                                                :   . :     .   .      *:  :          

TH_2148|M.thermoresistible__bu      -----
MSMEG_2079|M.smegmatis_MC2_155      -----
MMAR_1499|M.marinum_M               -----
MUL_2438|M.ulcerans_Agy99           -----
Mflv_4458|M.gilvum_PYR-GCK          -----
Mvan_1903|M.vanbaalenii_PYR-1       -----
Mb3806|M.bovis_AF2122/97            -----
Rv3777|M.tuberculosis_H37Rv         -----
MLBr_00118|M.leprae_Br4923          LSRHH
MAB_4603c|M.abscessus_ATCC_199      -----
MAV_0308|M.avium_104                -----