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MAPSSIGPTRRWLMLAIGLLTTLCANVFINGVAFLIPTLHDERGLDLAGAALMSSLPSLGMVVTLIAWGY VVDRIGERAVLTAGSALTAAASFAAASMDTLLTTGIFLFLGGMAAASSNTASARLVVGWFDAERRGLVMG IRQTAQPLGVGVGALVIPRLAESHGLSAALLFPAVVCAVSAVLCLAAVIDPPRPARADAARTDLANPYRN SAMLWRIHLTSVLLVIPQVVVWTFTLVWMISEHGWSPESAGVLVMVAQIMGAAGRIGAGRWSDHYVRRSG DLLASRLRPIRIIAAAAAASMALLALTDLVNSPLSIALMMVASVITVSDNGLAFTLIAEYAGPFWSGRAL GTQNTSQLFAQGVAPPLFGGLIAVAGYPVAFAVCALLPVLAIPAVPLKVTVDR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4231 | - | - | 100% (403) | major facilitator transporter |
| M. gilvum PYR-GCK | Mflv_4405 | - | 9e-13 | 23.88% (402) | major facilitator transporter |
| M. gilvum PYR-GCK | Mflv_2530 | - | 2e-12 | 25.13% (374) | major facilitator transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3018 | - | 1e-123 | 54.41% (397) | integral membrane protein |
| M. tuberculosis H37Rv | Rv2994 | - | 1e-123 | 54.41% (397) | integral membrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3302 | - | 1e-142 | 62.94% (394) | major facilitator transporter |
| M. marinum M | MMAR_1717 | - | 1e-123 | 54.52% (398) | integral membrane transport protein |
| M. avium 104 | MAV_3846 | - | 1e-116 | 52.63% (399) | sugar transporter family protein |
| M. smegmatis MC2 155 | MSMEG_2380 | - | 1e-157 | 70.60% (398) | sugar transporter family protein |
| M. thermoresistible (build 8) | TH_2039 | - | 1e-158 | 69.44% (396) | PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_0911 | - | 5e-07 | 25.45% (224) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_2131 | - | 0.0 | 84.37% (403) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3018|M.bovis_AF2122/97 -----------------------------MSRDPTG-----VGARWAIMI
Rv2994|M.tuberculosis_H37Rv -----------------------------MSRDPTG-----VGARWAIMI
MMAR_1717|M.marinum_M -----------------------------MPDESSATQELSLSARWWIVI
MAV_3846|M.avium_104 MAGRRPQAPMTGNGTRPTPKYPGGMQAWGMQTDPVATPDVGAGTRWSIMV
Mflv_4231|M.gilvum_PYR-GCK ----------------------------------MAPSSIGPTRRWLMLA
Mvan_2131|M.vanbaalenii_PYR-1 --------------MSHIMRIWFSIVRRLCNHGAMPATAISSMRRWSMLA
MSMEG_2380|M.smegmatis_MC2_155 ------------------MELRFDILRSRDSMERMAAPVIGTLRRWSMLV
TH_2039|M.thermoresistible__bu ----------------------------------MPVSSISPARRWSMLV
MAB_3302|M.abscessus_ATCC_1997 ------------------------------MVTMVHVDEVGTARRWAMLA
MUL_0911|M.ulcerans_Agy99 ----------------------------------MRIQPVFRDHPILALA
:
Mb3018|M.bovis_AF2122/97 VSLGVTASSFLFINGVAFLIPRLENARGTPLSHAGLLASMPSWGLVVTMF
Rv2994|M.tuberculosis_H37Rv VSLGVTASSFLFINGVAFLIPRLENARGTPLSHAGLLASMPSWGLVVTMF
MMAR_1717|M.marinum_M VSLIVTASSFLFINGVAFLIPRLENARDTPLAEAGLLASMPSWGMVVTLV
MAV_3846|M.avium_104 VSLLATASSFLFINGVAFLIPSLQGARGIRLDEAGLLASMPSWGMVVTLV
Mflv_4231|M.gilvum_PYR-GCK IGLLTTLCANVFINGVAFLIPTLHDERGLDLAGAALMSSLPSLGMVVTLI
Mvan_2131|M.vanbaalenii_PYR-1 IGLLATLCANVFINGVAFLIPTLHDERGLDLAAAGLMSSLPSLGMVVTLI
MSMEG_2380|M.smegmatis_MC2_155 IALTSTMCANVFINGAAFLIPTLHAERGLDLARSGLLSSMPSFGMVTTLI
TH_2039|M.thermoresistible__bu IALAATLFSVVFINGVAFVIPTLHREHGLSLAQAGLLSALPSFGMVATLI
MAB_3302|M.abscessus_ATCC_1997 IALGSTAGANVFINGVAFLIPALHAERGLDLANAGLLSAMPSFGMVLTLI
MUL_0911|M.ulcerans_Agy99 VICLSVFVISVDATIVNVALPTLSRELGADTAQLQWIVDAYTLVMSGLLL
: . : . . . :* * . : : : :.
Mb3018|M.bovis_AF2122/97 AWGYLLDHVGERMVMAVGSALTAAAAYAAASV-HSLLWIGVFLFLGGMAA
Rv2994|M.tuberculosis_H37Rv AWGYLLDHVGERMVMAVGSALTAAAAYAAASV-HSLLWIGVFLFLGGMAA
MMAR_1717|M.marinum_M AWGYVLDHVGEQIVMTVGSALTAIAAYAAASV-DSLLLMGIYLFLGGMAA
MAV_3846|M.avium_104 AWGYVLDRVGERVVMTTGSALTALAAYAASSA-HSMVLIAVYLFLGGMAA
Mflv_4231|M.gilvum_PYR-GCK AWGYVVDRIGERAVLTAGSALTAAASFAAASM-DTLLTTGIFLFLGGMAA
Mvan_2131|M.vanbaalenii_PYR-1 AWGYVVDRVGERVVLTLGSALTAAAAFAAAAA-DTLLTTGVFLFLGGMAA
MSMEG_2380|M.smegmatis_MC2_155 AWGYVVDRFGERLVLGLGSALTAAAALAAASV-QSLFAVGLFLLLGGMAA
TH_2039|M.thermoresistible__bu AWGYLVDRIGERIVLTVGSALTAASAFAAAAV-DSLLLVGVFLLLGGMAA
MAB_3302|M.abscessus_ATCC_1997 AWGALIDKFGERIALVSGLALTAVAAFAAAES-PSLTVTGAFLLLGGAAA
MUL_0911|M.ulcerans_Agy99 SAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLVAARAAMGVGAA
: * : *: *.: : * * * :: *: : . :* **
Mb3018|M.bovis_AF2122/97 GGCNSAGGRLVSGWFPPQQRGLAMGIRQTAQPLGIASGALVIPELAE-RG
Rv2994|M.tuberculosis_H37Rv GGCNSAGGRLVSGWFPPQQRGLAMGIRQTAQPLGIASGALVIPELAE-RG
MMAR_1717|M.marinum_M ASCNSAGGRLVSGWFPPHQRGLAMGIRQTAQPLGIALGALVIPELAE-HS
MAV_3846|M.avium_104 ASCNTAGGRLVSAWFPPHQRGLAMGIRQTAQPLGIALGAMVIPELAE-HG
Mflv_4231|M.gilvum_PYR-GCK ASSNTASARLVVGWFDAERRGLVMGIRQTAQPLGVGVGALVIPRLAESHG
Mvan_2131|M.vanbaalenii_PYR-1 ASSNTASGRLVVGWFDAERRGLVMGIRQTAQPLGVGVGALVIPRLAQAEG
MSMEG_2380|M.smegmatis_MC2_155 ASSNSASGRLVVGWFPPEQRGLVMGIRQTATPLGVGLGALVIPRLAESHG
TH_2039|M.thermoresistible__bu ASSNTASARVVVGWFPPHQRGLVMGIRQTAQPLGVALGALVIPRLAQSHG
MAB_3302|M.abscessus_ATCC_1997 AACNSASGRVVVGWFPPHQRGTVMGIRQMAQPLGVAAGALVIPRIAEGHG
MUL_0911|M.ulcerans_Agy99 VIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPITGGWLLEHFS
:: . :. : . *. .:*: :*:. *.:. : : .
Mb3018|M.bovis_AF2122/97 VHAGLMF--PAVVCTLAAVASVLGIVDPPRKSRTKAS-------------
Rv2994|M.tuberculosis_H37Rv VHAGLMF--PAVVCTLAAVASVLGIVDPPRKSRTKAS-------------
MMAR_1717|M.marinum_M IHNALMF--PAAFCTIAAVASLVGVVDPPRKSRKVAS-------------
MAV_3846|M.avium_104 PQAGLRF--TALACVFGAVASVIGIVDPPRKPRASAS-------------
Mflv_4231|M.gilvum_PYR-GCK LSAALLF--PAVVCAVSAVLCLAAVIDPPRPARADAA-------------
Mvan_2131|M.vanbaalenii_PYR-1 VSAALLF--PAIVCAAAAVLCAIAVVDPPRPARAEAD-------------
MSMEG_2380|M.smegmatis_MC2_155 VSAALLF--PAVVCGIAAVVSAVFVLDPPRPPRAEAP-------------
TH_2039|M.thermoresistible__bu ISAALLF--PAAVCAVAAVICLIGVLDPPRPPRASAD-------------
MAB_3302|M.abscessus_ATCC_1997 VATALLF--PAIVCAVSSAVCLVGIIDPPRPPRSEAP-------------
MUL_0911|M.ulcerans_Agy99 WGSIFLVNVPIAVAAMAGAILFVPTSRDPAAPRVDVPGLMLSAVGITALV
: . . . ... * .* .
Mb3018|M.bovis_AF2122/97 ---------------------------------EQELASPYRGSSILWRI
Rv2994|M.tuberculosis_H37Rv ---------------------------------EQELASPYRGSSILWRI
MMAR_1717|M.marinum_M ---------------------------------KEELASPYRGSAVLWRI
MAV_3846|M.avium_104 ---------------------------------DQELASPYRGSLTLWRI
Mflv_4231|M.gilvum_PYR-GCK ---------------------------------RTDLANPYRNSAMLWRI
Mvan_2131|M.vanbaalenii_PYR-1 ---------------------------------DTDLANPYRGSPMLWRI
MSMEG_2380|M.smegmatis_MC2_155 ---------------------------------AEHLANPYRGSSVLWRI
TH_2039|M.thermoresistible__bu ---------------------------------GRHPQNPYRGSGLLWRI
MAB_3302|M.abscessus_ATCC_1997 ---------------------------------EEHLANPYRGSRVLWLI
MUL_0911|M.ulcerans_Agy99 YTIIEAPNWGWTSTRASGGFIAAAIVLVGFALWERRSSHPMLDVSVFANR
* . :
Mb3018|M.bovis_AF2122/97 HAASALLMMPQTVTVTFMLVWLINHHGWSVAQAGVLVTISQLLGALGRVA
Rv2994|M.tuberculosis_H37Rv HAASALLMMPQTVTVTFMLVWLINHHGWSVAQAGVLVTISQLLGALGRVA
MMAR_1717|M.marinum_M HASSALLMMPQTVTVTFMLVWLMNHHGWPVATAGILVTVSQLLGALGRIA
MAV_3846|M.avium_104 HAVAGLMMMPQTVTVTFMLVWLIRNLHWSVAAAGALVTLSQLLGALGRVA
Mflv_4231|M.gilvum_PYR-GCK HLTSVLLVIPQVVVWTFTLVWMISEHGWSPESAGVLVMVAQIMGAAGRIG
Mvan_2131|M.vanbaalenii_PYR-1 HLTSVLLVVPQVMVWTFTLVWLISEHRWSPESAGLLVMTAQILGAAGRIG
MSMEG_2380|M.smegmatis_MC2_155 HAVSVLLVVPQGVLWTFALVWLITDRGWSAASAGILVTVTQLLGAGGRIA
TH_2039|M.thermoresistible__bu HAVSVLLVVPQGVIWTFTLVWLMTERSWSAGSAGTMVMIAQVLGAGGRVA
MAB_3302|M.abscessus_ATCC_1997 HGVSVLLVVPQVVVWTFTLVWLVTDRGWSIGAASVMVTVAQLVGALGRVA
MUL_0911|M.ulcerans_Agy99 RFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQTGVRLLPVAFSIA
: . : :. . * ::::: . : ::: . :.
Mb3018|M.bovis_AF2122/97 VGRWS--------DHVGSRMRPVRLIAAAAAATLFLLAAVDNEGSRYDVL
Rv2994|M.tuberculosis_H37Rv VGRWS--------DHVGSRMRPVRLIAAAAAATLFLLAAVDNEGSRYDVL
MMAR_1717|M.marinum_M VGRWS--------DRVGSRMRPVRVIAIASAAALFLLALVDDEGSRYDVL
MAV_3846|M.avium_104 VGRWS--------DRLGSRMRPVRYIAAAAVLVLLLLAWADYLNSRWQAG
Mflv_4231|M.gilvum_PYR-GCK AGRWSDHYVRRSGDLLASRLRPIRIIAAAAAASMALLALTDLVNSPLSIA
Mvan_2131|M.vanbaalenii_PYR-1 AGRWSDTFVRRSGDVIASRLRPIRMIAAAAAAAMALLAVTDWLDSPVSIV
MSMEG_2380|M.smegmatis_MC2_155 AGKWS--------DVIGYRLRPIRTIALAAAVTMAALALTDWLSSPVSIA
TH_2039|M.thermoresistible__bu AGRWS--------DLVGSRLRPIRTIALAAAAAMALLALTDALDSPVSVA
MAB_3302|M.abscessus_ATCC_1997 AGMWS--------DRWGSRMRPIRAIAAAASATMALLAVTNQLDWSVSVV
MUL_0911|M.ulcerans_Agy99 LAAILG-------PRLVERVGTTAVVAAGLAVFAAALAWASTADATTPYT
. *: . :* . ** .. .
Mb3018|M.bovis_AF2122/97 LMIAISVIAVLDNGLEATAITEYAG----PYWSGRALGIQNTTQRLMAAA
Rv2994|M.tuberculosis_H37Rv LMIAISVIAVLDNGLEATAITEYAG----PYWSGRALGIQNTTQRLMAAA
MMAR_1717|M.marinum_M LMITITVIAVLDNGLQATAITEYAG----PYWSGRALGVQNTTQRLMAAA
MAV_3846|M.avium_104 LMVAISVIAVLDNGLEATAITEFAG----PYWSGRALGIQNTTQRMMAAA
Mflv_4231|M.gilvum_PYR-GCK LMMVASVITVSDNGLAFTLIAEYAG----PFWSGRALGTQNTSQLFAQGV
Mvan_2131|M.vanbaalenii_PYR-1 VMIAASVITVSDNGLAFTLIAEYAG----PFWSGRALGTQNTSQLFAQGV
MSMEG_2380|M.smegmatis_MC2_155 LMVAASVITVSDNGLAFTGIAEIAG----PFWSGRALGTQNTSQHLATAV
TH_2039|M.thermoresistible__bu FMVIAAVVTVSDNSLAFTAIAEIAG----PYWTGRALGTQNTSQLLTTAI
MAB_3302|M.abscessus_ATCC_1997 VMLVASVITVSDNGLAYTSIAEIAG----PFWSGRALGAQNTGQLLAAAV
MUL_0911|M.ulcerans_Agy99 QITLQMLLLGGGLGLTTAPATEAIMGSLPADRAGVGSAVNDTTRELGGTL
: :: . .* : :* . :* . . ::* : :
Mb3018|M.bovis_AF2122/97 GPPLFGSLITTAAYPTAWALCGVFPLAAVPLVPVRLLPPGLETRARRQSV
Rv2994|M.tuberculosis_H37Rv GPPLFGSLITTAAYPTAWALCGVFPLAAVPLVPVRLLPPGLETRARRQSV
MMAR_1717|M.marinum_M GPPIFGALITTAAYPLAWGLCGLFPLAAIPLVPTRLRPPGLEPRERPQSA
MAV_3846|M.avium_104 GPPLFGALISAAKYPPAWLLCALFPLAAMPLVPTRLLPPGLETRARRQSV
Mflv_4231|M.gilvum_PYR-GCK APPLFGGLIAVAGYPVAFAVCALLPVLAIPAVPLKVTVDR----------
Mvan_2131|M.vanbaalenii_PYR-1 APPLFGGLIAIAGYPVAFAVCALFPLLAIPSVPLTVKPDR----------
MSMEG_2380|M.smegmatis_MC2_155 SSPVFGGLIGVAGYPVAFAVCALLPALAIPLVPVEPARES----------
TH_2039|M.thermoresistible__bu TPPLFGGLIGVAGYPVAFALCAVLPLAAVPLVPADPATPQIRPSSPESPR
MAB_3302|M.abscessus_ATCC_1997 APPIFGAIAAAAGFSAAFAVCALFPLAAVGLVPVKLERPAP---------
MUL_0911|M.ulcerans_Agy99 GVAIAGSVFASVYSGQLGSASALATLPSDVRSAMKGSMAVAHKVIDQLPA
.: *.: . ..: . : .
Mb3018|M.bovis_AF2122/97 RRHRWWQAVRCHAWPNGPRRPGPPGQPRRVRQGGTAITPPT---------
Rv2994|M.tuberculosis_H37Rv RRHRWWQAVRCHAWPNGPRRPGPPGQPRRVRQGGTAITPPT---------
MMAR_1717|M.marinum_M RRLRRWQAVRSRELPSNPRPPDPPG-------------------------
MAV_3846|M.avium_104 RRLRWWRAVRSHALPDIVRRPGQPG-------------------------
Mflv_4231|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2131|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2380|M.smegmatis_MC2_155 --------------------------------------------------
TH_2039|M.thermoresistible__bu RVR-----------------------------------------------
MAB_3302|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_0911|M.ulcerans_Agy99 GPAAGVRDAVNHAFLDGLQVATLVCAGIALAAAIVVGWLLPARAGQPTPA
Mb3018|M.bovis_AF2122/97 ---------
Rv2994|M.tuberculosis_H37Rv ---------
MMAR_1717|M.marinum_M ---------
MAV_3846|M.avium_104 ---------
Mflv_4231|M.gilvum_PYR-GCK ---------
Mvan_2131|M.vanbaalenii_PYR-1 ---------
MSMEG_2380|M.smegmatis_MC2_155 ---------
TH_2039|M.thermoresistible__bu ---------
MAB_3302|M.abscessus_ATCC_1997 ---------
MUL_0911|M.ulcerans_Agy99 QTEPALAQV