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M. thermoresistible (build 8) TH_0434 ()

annotation: CONSERVED HYPOTHETICAL PROTEIN
coordinates: 951916 - 952707
length: 264

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0434-100% (264)CONSERVED HYPOTHETICAL PROTEIN
M. thermoresistible (build 8)TH_2570-3e-1634.09% (176) PUTATIVE alpha/beta hydrolase fold
M. thermoresistible (build 8)TH_2707-3e-1233.78% (148) PUTATIVE putative alpha/beta hydrolase fold

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2330c-7e-9868.36% (256) hypothetical protein Mb2330c
M. gilvum PYR-GCKMflv_3465-2e-1337.70% (122) peptidase S15
M. tuberculosis H37RvRv2307c-1e-9868.75% (256) hypothetical protein Rv2307c
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_2608-8e-1133.08% (130) putative hydrolase, alpha/beta fold
M. marinum MMMAR_3680-6e-1136.22% (127) hypothetical protein MMAR_3680
M. avium 104-----
M. smegmatis MC2 155MSMEG_2203-4e-1234.38% (128) alpha/beta hydrolase
M. ulcerans Agy99MUL_1035-2e-0934.11% (129) hypothetical protein MUL_1035
M. vanbaalenii PYR-1Mvan_2419-6e-1029.12% (182) alpha/beta hydrolase fold

CLUSTAL 2.0.9 multiple sequence alignment


MUL_1035|M.ulcerans_Agy99           ---------------------------MTQRQDVRFPC------------
Mvan_2419|M.vanbaalenii_PYR-1       ---------------------------MT-RQEVQIPA------------
MAB_2608|M.abscessus_ATCC_1997      ----------------------------MNRQSIRFNS------------
MSMEG_2203|M.smegmatis_MC2_155      ----------------------------MTYTEFTFHS------------
MMAR_3680|M.marinum_M               ---------------------------MVSTLGTAFES------------
Mflv_3465|M.gilvum_PYR-GCK          ------------------------MTAGWTTSAVSFPC------------
Mb2330c|M.bovis_AF2122/97           MSLKRCRALPVVAIVALVASGVITFIWSQQRRLIYFPSAGPVPSASSVLP
Rv2307c|M.tuberculosis_H37Rv        MSLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAGPVPSASSVLP
TH_0434|M.thermoresistible__bu      -----------------VATGVLGLLWSQQRRLIYFPSPGPVPSATTVSV
                                                                       : .            

MUL_1035|M.ulcerans_Agy99           ----------GEALISAWLYRPAGADPARPVPMLVMAHGLGAVRTMRLDA
Mvan_2419|M.vanbaalenii_PYR-1       ----------DGGQIAAYVYRPQVTGGG--TACIVMAHGFTGTRDDGLPD
MAB_2608|M.abscessus_ATCC_1997      ----------HGIDCEAWLYRAQTVEDT--APIVVMAHGVGGTKDSGLEP
MSMEG_2203|M.smegmatis_MC2_155      ----------GGQRCSAWHFPAGSGGSG--NPVVVMAHGFGGTKDSGLQP
MMAR_3680|M.marinum_M               ----------RGTRCAAWFTRP-AGPGP--YPLVVLAHGLGANHTMALAR
Mflv_3465|M.gilvum_PYR-GCK          ----------DGEQIAGVLYRPEGGAPP--FPCVVFAHGFSGTMDWILPD
Mb2330c|M.bovis_AF2122/97           AGRDVVVETQDGMRLGGWYFPHTSGGSG---PAVLVCNGNAGDRSM-RAE
Rv2307c|M.tuberculosis_H37Rv        AGRDVVVETQDGMRLGGWYFPHTSGGSG---PAVLVCNGNAGDRSM-RAE
TH_0434|M.thermoresistible__bu      DARDVVLRTADGLELGAWYFPAPGGRPS---PAVLVSNGNGGDRSG-RVA
                                                    .              . ::..:*  .        

MUL_1035|M.ulcerans_Agy99           YAQRFSAAGYACLVFDYRNFGDSEGQPRQLLDIRMQLQDWAAAVAYARTC
Mvan_2419|M.vanbaalenii_PYR-1       YAEAFCAAGHTVVLFDYRHFGASTGEPRQLLDIAEQRRDYHTVIAWARHL
MAB_2608|M.abscessus_ATCC_1997      FAVRLAEAGMHALAFDYRGFGASDGFPRQHVSFTHQIGDYHAAVNMARRL
MSMEG_2203|M.smegmatis_MC2_155      FAERFSAAGLDAVAFDYRGFGASEGEPRQSISVERQLADYDAAIRAAQAM
MMAR_3680|M.marinum_M               YERHFAAAGIATLAFDYRNLGASDGTPRQRLSLRRHRQDIAAALEFARSL
Mflv_3465|M.gilvum_PYR-GCK          FAAVFCAAGLAVLTFDYRGFGSSEGTPRQIVNSARQLEDIRAALDVVRNR
Mb2330c|M.bovis_AF2122/97           LAVALHGLGLSVLLFDYRGYGGNPGRPSE----QGLAADARAAQEWLSGQ
Rv2307c|M.tuberculosis_H37Rv        LAVALHGLGLSVLLFDYRGYGGNPGRPSE----QGLAADARAAQEWLSGQ
TH_0434|M.thermoresistible__bu      LAVSLRRLGMAVLLFDYRGYGGNPGRPSE----EGLALDIRAAHDWLREQ
                                        :   *   : ****  * . * * :         *  :.       

MUL_1035|M.ulcerans_Agy99           DGVDQARIGLWGTSFGGGHVIATAARLPGIAAVVAQCPFTDGIASVL---
Mvan_2419|M.vanbaalenii_PYR-1       DGVDPNRIVVWGSSFSGGHVLAVAAEDPRIAAVIAQAPFTDALATLR---
MAB_2608|M.abscessus_ATCC_1997      PGVDPTRIVLWGVSLAGGHVMAVAGARNDVAAVIALTPLVDGIAAARSAM
MSMEG_2203|M.smegmatis_MC2_155      PGVDPRKVVLWGSSFSGSHVLRAAARNTDVAAVIAMTPLTSGLAASRAAV
MMAR_3680|M.marinum_M               PDVDASRVALWGTSLGAMHVLLIAARRRDLCAVVVQCPIVDGPATLR---
Mflv_3465|M.gilvum_PYR-GCK          ADVDPGRIGLWGTSLGGSHVLQIAAEDPRVAAVVANVPALDMYTGLRGRH
Mb2330c|M.bovis_AF2122/97           SDVDPARIAYFGESLGAAVAVGLAVQRP-PAALVLRSPFTS---------
Rv2307c|M.tuberculosis_H37Rv        SDVDPARIAYFGESLGAAVAVGLAVQRP-PAALVLRSPFTS---------
TH_0434|M.thermoresistible__bu      PDVDPARMVYFGESLGAAVALELAVERP-PAALVLRSPFTS---------
                                     .**  ::  :* *:..  .:  *      .*::   *  .         

MUL_1035|M.ulcerans_Agy99           ---------AIAPTTAIRVTARSMRDLIGSRLGRPPVMIPTAGKPGEVAL
Mvan_2419|M.vanbaalenii_PYR-1       ---------EIPPGNIPLLLIAAVRDQVGAWRGRPPHTVAAVGSPGTVAA
MAB_2608|M.abscessus_ATCC_1997      --------TEHSAGTLLRSAVTGLRSR----LGRQQRTIPIVGRAGELAA
MSMEG_2203|M.smegmatis_MC2_155      --------TQRDVATALRWTLKGVKSRVAAAVGGAPTMMPLTAKPGEPGA
MMAR_3680|M.marinum_M               ---------RLGLAATLRAGPAIVEDALRCAAGLRRRYIPIVGPPGSLAA
Mflv_3465|M.gilvum_PYR-GCK          RSPDYRPGPAQIVVAVARLLSAAVVDEVRGRLGRSPRYLPVYGRLGR-AF
Mb2330c|M.bovis_AF2122/97           --------------------------------------------LAEVGA
Rv2307c|M.tuberculosis_H37Rv        --------------------------------------------LAEVGA
TH_0434|M.thermoresistible__bu      --------------------------------------------LADVAR
                                                                                 .  . 

MUL_1035|M.ulcerans_Agy99           MTAPDAYPGYLGLMPQGTQVPNEVAARIGIKVLGYRPGRSARKIACPILF
Mvan_2419|M.vanbaalenii_PYR-1       LTSPDAKPGFEAIIGPNSLWRNEFAARLMFTFAFNRPGRKAAKLRMPVLL
MAB_2608|M.abscessus_ATCC_1997      LTSDGYYEAHLAIAGP--AWRNEIDATVGTQLVSYRPTRCASRIGCPILV
MSMEG_2203|M.smegmatis_MC2_155      LALDGAYESYLSIAGP--TWRNEVDAGVGMELARVRTAAAAKALKCPVLV
MMAR_3680|M.marinum_M               VTAAGALQGWRSTVEPGGSFDNRIAASNLLGIGVTSTKRAARQISAPLLV
Mflv_3465|M.gilvum_PYR-GCK          FADPALAQRFRAVEAQAPSWRNAVAPRFLLHAPRYRDG-TIERVRCPVLV
Mb2330c|M.bovis_AF2122/97           VHYP-------------------WLPLRRLLLDHYPSIERIASVHAPVLV
Rv2307c|M.tuberculosis_H37Rv        VHYP-------------------WLPLRRLLLDHYPSIERIASVHAPVLV
TH_0434|M.thermoresistible__bu      VHYP-------------------WLPARWLLLDRYPSIDRIGSLRAPLLI
                                    .                        .                 :  *:*.

MUL_1035|M.ulcerans_Agy99           CVCETDSVAPAGPTLRYAARAPRGEVSGEVIRYPEGHFAIYLGDAFE-HV
Mvan_2419|M.vanbaalenii_PYR-1       CVCDDDVVTPPGPSVEAAHRAPRG----ELCRYPYGHFDIYHDP----KV
MAB_2608|M.abscessus_ATCC_1997      QIADFDRAAPP-HAAAKAAFKARA----EVRHYPCDHFGVYHGQECHELV
MSMEG_2203|M.smegmatis_MC2_155      QIADFDRFVPA-DSVAKTAVQARA----QVHHYACDHFDVWPGHDWFDTA
MMAR_3680|M.marinum_M               CVSRRETLMDPRHAEVVAGRAPRG----IARHYDGDHFEIYH-RPLVDSL
Mflv_3465|M.gilvum_PYR-GCK          TLARDDAEVST-PFVERKVRRGRD---VEIRKYPAGHFDMYHGAVR-DEV
Mb2330c|M.bovis_AF2122/97           IAGGSDDIVPATLSEWLVAAAAEPKRYVVVPGVGHNDPELLDGR----VM
Rv2307c|M.tuberculosis_H37Rv        IAGGSDDIVPATLSERLVAAAAEPKRYVVVPGVGHNDPELLDGR----VM
TH_0434|M.thermoresistible__bu      VAGDRDDIVPESQSRRLFDAAPEPKRYVLVPDAGHNDLTLLAGR----QM
                                         :                .            ..  :          

MUL_1035|M.ulcerans_Agy99           VADQLGFLDKHLKPAGQP-------
Mvan_2419|M.vanbaalenii_PYR-1       KADQLEFLARVVGDRTA--------
MAB_2608|M.abscessus_ATCC_1997      IGHQISFLSRHLSIEAVSHTEALHG
MSMEG_2203|M.smegmatis_MC2_155      VTDQIAFLRRTLSLR----------
MMAR_3680|M.marinum_M               LADQTAFLREHLHVEDT--------
Mflv_3465|M.gilvum_PYR-GCK          ARDQREFLIRHLQPDRAARKDR---
Mb2330c|M.bovis_AF2122/97           LDAIRRFLTETAVLGQ---------
Rv2307c|M.tuberculosis_H37Rv        LDAIRRFLTETAVLGQ---------
TH_0434|M.thermoresistible__bu      IGAIEEFLAPILHTA----------
                                          **