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M. thermoresistible (build 8) TH_4502 (-)

annotation: methyltransferase
coordinates: 2436576 - 2437541
length: 322

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4502--100% (322)methyltransferase
M. thermoresistible (build 8)TH_2759-3e-8457.29% (295) PUTATIVE methyltransferase
M. thermoresistible (build 8)TH_2706-7e-6445.57% (316) PUTATIVE putative methyltransferase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0151-1e-11063.41% (317) hypothetical protein Mb0151
M. gilvum PYR-GCKMflv_0743-1e-11764.89% (319) putative methyltransferase
M. tuberculosis H37RvRv0146-1e-11063.41% (317) hypothetical protein Rv0146
M. leprae Br4923MLBr_02640-1e-10963.72% (317) hypothetical protein MLBr_02640
M. abscessus ATCC 19977MAB_4606c-9e-8755.48% (292) hypothetical protein MAB_4606c
M. marinum MMMAR_0357-1e-11164.06% (320) O-methyltransferase
M. avium 104MAV_5149-1e-11265.00% (320) methyltransferase, putative, family protein
M. smegmatis MC2 155MSMEG_0095-1e-12872.41% (319) methyltransferase
M. ulcerans Agy99MUL_4762-1e-11164.04% (317) O-methyltransferase
M. vanbaalenii PYR-1Mvan_0104-1e-11866.25% (317) putative methyltransferase

CLUSTAL 2.0.9 multiple sequence alignment


TH_4502|M.thermoresistible__bu      ---MSSLRTDDDTWDIATSVGSTAVMVAASRAAETEREDALIRDPYAKVL
MSMEG_0095|M.smegmatis_MC2_155      ---MSSLRTDDDTWDIATSVGSTAVMVAAARAGETERDDALIRDPYAKIL
Mflv_0743|M.gilvum_PYR-GCK          ---MSSLRTDDDTWDIASSVGATAVMVAAARAAETERHDALINDPYAKVL
Mvan_0104|M.vanbaalenii_PYR-1       ---MSSLRTDNDTWDIASSVGATAVMVAAARAAETERPEPLIDDPYAKIL
MMAR_0357|M.marinum_M               ---MSTMRTHDDTWDIRTSVGATAVMVAAARAVETSKPEPLIRDPYARML
MUL_4762|M.ulcerans_Agy99           ------MRTHDDTWDIRTSVGATAVMVAAARAVETSKPEPLIRDPYARML
Mb0151|M.bovis_AF2122/97            ------MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLL
Rv0146|M.tuberculosis_H37Rv         ------MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLL
MLBr_02640|M.leprae_Br4923          ------MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLL
MAV_5149|M.avium_104                ---MSSLRTHDDTWDIKSSVGTTAVMVAAARAVETEQPDPLIRDPYAKLL
MAB_4606c|M.abscessus_ATCC_199      MTGTTTARSDDDSWDIASSVGATAVMVAAARAAETRSASPLIQDPFAQLL
                                           *:.:*:*** :***:*******:** **   ..** **:*::*

TH_4502|M.thermoresistible__bu      VAGAGTG-VWELILDDDFTAKIEAADPETAAIFDHMGNYQAVRTHFFDTY
MSMEG_0095|M.smegmatis_MC2_155      VAGAGTG-VWETVLDSEFAAKIENLDPEAAAIFAHMGNYQAVRTHFFDAY
Mflv_0743|M.gilvum_PYR-GCK          VEGAGAG-AWRFIADEDLVAKASESDTEVGALFEHMKNYQAVRTHFFDAF
Mvan_0104|M.vanbaalenii_PYR-1       VAGAGNG-AWQYIADDGFVAKVTESDPEIGPLFEHMKNYQAVRTHFFDAF
MMAR_0357|M.marinum_M               VTNANAGVIWEAMLDQEMVAKVEAIDAETAATVEHMRSYQAVRTNFFDTY
MUL_4762|M.ulcerans_Agy99           VTNANAGVIWEAMLDQEMVAKVEAIDAETAATVEHMRSYQAVRTNFFDTY
Mb0151|M.bovis_AF2122/97            VTNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTY
Rv0146|M.tuberculosis_H37Rv         VTNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTY
MLBr_02640|M.leprae_Br4923          VTNTGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTY
MAV_5149|M.avium_104                VTNSGAGVLWEAMLDPDIAARVEALDEESAAHLHHMRGYQAVRTHFFDTY
MAB_4606c|M.abscessus_ATCC_199      VERAGSG-AWSVLASDGLRQQLAELDPDADRVMQYAVDYQAVRTRFFDGF
                                    *  :. *  *  : .  :  :    * :    . :  .******.*** :

TH_4502|M.thermoresistible__bu      FARAAEAGIRQVVILASGLDSRAYRLPWPDGTVVYEIDQPKVLEYKSATL
MSMEG_0095|M.smegmatis_MC2_155      YREAADAGIRQIVILASGLDSRAYRLDWPAGTTVYEIDQPKVLEYKSATL
Mflv_0743|M.gilvum_PYR-GCK          FSAAVDAGVRQIVILASGLDSRAFRLPWPAGTVVYEIDQPLVLDYKSSTL
Mvan_0104|M.vanbaalenii_PYR-1       FAAAVDAGIRQIVILASGLDSRAFRLPWPAGTTVFEIDQPLVLAYKSSTL
MMAR_0357|M.marinum_M               FADAVAAGIRQVVILASGLDSRAYRLDWPAGTTVYEIDQPQVLAYKSATL
MUL_4762|M.ulcerans_Agy99           FADAVAAGIRQVVILASGLDSRAYRLDWPAGTTVYEIDQPQVLAYKSATL
Mb0151|M.bovis_AF2122/97            FASAVAAGIRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSYKSTTL
Rv0146|M.tuberculosis_H37Rv         FASAVAAGIRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSYKSTTL
MLBr_02640|M.leprae_Br4923          FNNAVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTL
MAV_5149|M.avium_104                FADAVAAGIRQIVILASGLDSRAYRLDWPAGTTVYEIDQPQVLAYKSTTL
MAB_4606c|M.abscessus_ATCC_199      FERAAHAGITQVVILAAGLDSRAYRLDWPAGTTVYEIDQPLVLQYKRHTL
                                    :  *.  *: *.****:******:** ** ** *:***** ** **  **

TH_4502|M.thermoresistible__bu      AAHGVQPAADRREVAVDLRHDWPKALRAKGFDPQQRTAWLAEGLLMYLPA
MSMEG_0095|M.smegmatis_MC2_155      REHGIEPVAQRREVPVDLRFDWPTALHDAGFDASLPTAWLAEGLLMYLPA
Mflv_0743|M.gilvum_PYR-GCK          AAHGVAPTAERREVPIDLRQDWPAALVATGFDPARPTAWLAEGLLMYLPA
Mvan_0104|M.vanbaalenii_PYR-1       ASHGVQPTADRREVPIDLRQDWPTALTHAGFDADQPTAWLAEGLLMYLPA
MMAR_0357|M.marinum_M               AENGVTPAAERREVAIDLRQDWPSALRAAGFDPSARTAWLAEGLLMYLPA
MUL_4762|M.ulcerans_Agy99           AENGVTPAAERREVAIDLRQDWPSALRAAGFDPSARTAWLAEGLLMYLPA
Mb0151|M.bovis_AF2122/97            AENGVTPSAGRREVPADLRQDWPAALRDAGFDPTARTAWLAEGLLMYLPA
Rv0146|M.tuberculosis_H37Rv         AENGVTPSAGRREVPADLRQDWPAALRDAGFDPTARTAWLAEGLLMYLPA
MLBr_02640|M.leprae_Br4923          AEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPA
MAV_5149|M.avium_104                AENGVTPSADRREVAVDLRQDWPAALRAAGFDPTQRTAWLAEGLLMYLPA
MAB_4606c|M.abscessus_ATCC_199      DAHDVRSACLRREVPVDLRQDWPAALQREGFDVAEPTAWLAEGLLMYLPT
                                      :.: . . ****. *** *** **   ***    *************:

TH_4502|M.thermoresistible__bu      DAQDRLFENITALSAPGSRLAVETAAEEPVDR---REQMRARMERIASQF
MSMEG_0095|M.smegmatis_MC2_155      EAQDRLFELVTELSAPGSRIAVETAGVAATDR---REAMRERFKKFADQL
Mflv_0743|M.gilvum_PYR-GCK          DAQDRLFAQITELSAPGSQVAAESMGVHAPDR---RERMRERFASIASQI
Mvan_0104|M.vanbaalenii_PYR-1       DAQDRLFAQITELSAPGSRVAAESMGIHAQDR---RERMRERFASITAQF
MMAR_0357|M.marinum_M               EAQDRLFTQIGELSCAGSRIAAETAGNHADER---REQMRERFRKVAQTL
MUL_4762|M.ulcerans_Agy99           EAQDRLFTQIGELSCAGSRIAAETAGNHADER---REQMRERFRKVAQTL
Mb0151|M.bovis_AF2122/97            EAQDRLFTQVGAVSVAGSRIAAETAPVHGEER---RAEMRARFKKVADVL
Rv0146|M.tuberculosis_H37Rv         EAQDRLFTQVGAVSVAGSRIAAETAPVHGEER---RAEMRARFKKVADVL
MLBr_02640|M.leprae_Br4923          TAQDGLFTEIGGLSAVGSRIAVETSPLHGDEW---REQMQLRFRRVSDAL
MAV_5149|M.avium_104                EAQDRLFTLIGELSPAGSRVAAETAPNHADER---RQQMRERFKKVADEI
MAB_4606c|M.abscessus_ATCC_199      EAQDRLFELIVDQSAPGSRIAVEAVGPDNDKRQEFRSKMRAHFDRARKLA
                                     *** **  :   *  **::*.*:      .    *  *: ::       

TH_4502|M.thermoresistible__bu      GLEKA-LDVAQLMYDDPDRADVPEWLTGHGWRTEWVSAPDEMRRLDR--F
MSMEG_0095|M.smegmatis_MC2_155      NLSSA-LDIQELVYDDPDRADVAEWLDAHGWRARGVHALDEMRRLDR--L
Mflv_0743|M.gilvum_PYR-GCK          DIEP--MDITELTYEDPDRAEVAEWLAAHGWTAQAVPSQDAMRRLDR--Y
Mvan_0104|M.vanbaalenii_PYR-1       DVEP--MDITELTYEDPDRADVAQWLTAHGWRAEAVPSQDEMRRLHR--L
MMAR_0357|M.marinum_M               GLEQT-IDVHELIYHDPDRALLGQWLNEHGWRANAQNACDEMHRVGR--W
MUL_4762|M.ulcerans_Agy99           GLEQT-IDVHELIYHDPDRAPLGQWLNEHGWRANAQNACDEMHRVGR--W
Mb0151|M.bovis_AF2122/97            GIEQT-IDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMRRVGR--W
Rv0146|M.tuberculosis_H37Rv         GIEQT-IDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMRRVGR--W
MLBr_02640|M.leprae_Br4923          GFEQA-VDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGR--W
MAV_5149|M.avium_104                GFEQT-VDVGELMYRDDHRADVTEWLNAHGWRATAEHSTAAMRRLGR--W
MAB_4606c|M.abscessus_ATCC_199      GMDGESLDVGSLMYHDENRTDVPQWLAGRGWTVRAIPAEVEMAEAGRPGY
                                    ...   :*: .* * * .*: : :**  :** .    :   * .  *   

TH_4502|M.thermoresistible__bu      VAAAMPPGDDADAADLDDTAFSKFVTAERPS
MSMEG_0095|M.smegmatis_MC2_155      VELPDDP---------DRAAFSTFVTAQRL-
Mflv_0743|M.gilvum_PYR-GCK          VEVADSD----------GQSFSTFTTGTKL-
Mvan_0104|M.vanbaalenii_PYR-1       VEIADGD----------DQSFSTFTTAVKR-
MMAR_0357|M.marinum_M               VEGVPMAD--------DKQAYSEFVTAERL-
MUL_4762|M.ulcerans_Agy99           VEGVPMAD--------DKQAYSDFVTAERL-
Mb0151|M.bovis_AF2122/97            VEGVPMAD--------DPTAFAEFVTAERL-
Rv0146|M.tuberculosis_H37Rv         VEGVPMAD--------DPTAFAEFVTAERL-
MLBr_02640|M.leprae_Br4923          GDGVPMAD--------DKDAFAEFVTAHRL-
MAV_5149|M.avium_104                IENVPLAD--------DKDAFSDFVVAERR-
MAB_4606c|M.abscessus_ATCC_199      IEEDLRGN--------------TLIEAELKG
                                                           :  .