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M. thermoresistible (build 8) TH_0016 (-)

annotation: dimethylaniline monooxygenase
coordinates: 53918 - 55270
length: 451

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0016--100% (451)dimethylaniline monooxygenase
M. thermoresistible (build 8)TH_0014-e-17165.61% (442) dimethylaniline monooxygenase
M. thermoresistible (build 8)TH_4273-6e-2428.87% (336) PUTATIVE FAD dependent oxidoreductase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0916-3e-2131.80% (217) monooxygenase
M. gilvum PYR-GCKMflv_4373-0.086.14% (433) flavin-containing monooxygenase
M. tuberculosis H37RvRv0892-3e-2131.80% (217) monooxygenase
M. leprae Br4923MLBr_00065-1e-1023.23% (409) putative monooxygenase
M. abscessus ATCC 19977MAB_2607-0.072.54% (437) putative flavin-containing monooxygenase
M. marinum MMMAR_3138-4e-2123.54% (412) monooxygenase
M. avium 104MAV_3915-1e-2226.59% (361) flavin-containing monooxygenase FMO
M. smegmatis MC2 155MSMEG_2202-0.085.13% (437) dimethylaniline monooxygenase
M. ulcerans Agy99MUL_1880-6e-2125.07% (359) monooxygenase
M. vanbaalenii PYR-1Mvan_1971-0.084.39% (442) dimethylaniline monooxygenase (N-oxide-forming)

CLUSTAL 2.0.9 multiple sequence alignment


Mb0916|M.bovis_AF2122/97            ------------MTGRCPT-------------VAVVGAGMSGMCVAITLL
Rv0892|M.tuberculosis_H37Rv         ------------MTGRCPT-------------VAVVGAGMSGMCVAITLL
MAV_3915|M.avium_104                -----MTDVVT-HTETAPTPAAKAAKP-VHTRAVIIGTGFSGLGMAIALQ
MUL_1880|M.ulcerans_Agy99           -----MTDVVIPSTETTASGEPQAPTPPVKTRAVIIGTGFSGLGMAIALQ
MMAR_3138|M.marinum_M               MGSESGQ----------------------HYEIVIVGAGFSGIGTAISLL
Mflv_4373|M.gilvum_PYR-GCK          -------------------------MLQTPPYVAVIGAGISGLTAGKMLK
Mvan_1971|M.vanbaalenii_PYR-1       -------------------------MDQTHPRVAVIGAGISGLTAGKMLK
MSMEG_2202|M.smegmatis_MC2_155      -------------------------MTPALPRTAIIGAGISGLTAGKMLK
TH_0016|M.thermoresistible__bu      -------------------------VKRRYPRTAVIGAGISGLTAGKMLK
MAB_2607|M.abscessus_ATCC_1997      ---------------------------MTGPSTAIIGAGISGLTSVKMLS
MLBr_00065|M.leprae_Br4923          ---------------------MVVMAETEYLDVVIVGAGISGVSAAWHLQ
                                                                     .::*:*:**:     * 

Mb0916|M.bovis_AF2122/97            SAGIT-DVCIYEKADDVGGTWRD-------NTYPGLTCDVPSRLYQYSFA
Rv0892|M.tuberculosis_H37Rv         SAGIT-DVCIYEKADDVGGTWRD-------NTYPGLTCDVPSRLYQYSFA
MAV_3915|M.avium_104                KQGV--GFVILEKADDIGGTWRD-------NSYPGCACDIPSHLYSFSFE
MUL_1880|M.ulcerans_Agy99           KQGV--DFVILEKSDDVGGTWRD-------NSYPGCACDIPSHLYSFSFE
MMAR_3138|M.marinum_M               KAGFA-DFLIVDDADGVGGTWHW-------NTYPGIAVDIPSYSYQFSYE
Mflv_4373|M.gilvum_PYR-GCK          DYGI--DYTTFESSDRIGGNWAFGNPNGHSSAYRSLHIDTSKDRLSFKDF
Mvan_1971|M.vanbaalenii_PYR-1       DYGV--SYTTFETSDRIGGNWAFGNPNGHSSAYRSLHIDTSKDRLSFKDF
MSMEG_2202|M.smegmatis_MC2_155      DYRV--PYTTFETSDRIGGNWAFGNPNGHSSAYRSLHIDTSKHRLSFKDF
TH_0016|M.thermoresistible__bu      DYGV--PYTTFELSDRIGGNWAFGNPNGHSSAYRSLHIDTSKHRLSFKDF
MAB_2607|M.abscessus_ATCC_1997      DYGI--PHTCFETSDRIGGNWAFGNPNGHSSAYRSLHIDTSRHQLSFRDF
MLBr_00065|M.leprae_Br4923          DRCPNKSYVILEKRAGMGGTWDL-------FRYPGIRSDSDMYTLGFRFR
                                    .          :    :**.*           * .   *       :   

Mb0916|M.bovis_AF2122/97            KNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDDG--RW
Rv0892|M.tuberculosis_H37Rv         KNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDDG--RW
MAV_3915|M.avium_104                PKPDWKNPFSYQPEIWDYLKGVTEKYGLRRYIEFNSLVDRAHWDDDEHRW
MUL_1880|M.ulcerans_Agy99           PKPDWRNPFSYQPEIWDYLKGVTEKYGLRRYVEFNSLVDRAYWDDEECRW
MMAR_3138|M.marinum_M               MRTSWSRTYAHGDELKAYAERCVEKYGLQNYIRFNTTVDEACFDEGAALW
Mflv_4373|M.gilvum_PYR-GCK          PMPEHYPSFPHHAQIKAYLDDYADTFGLLDHIEFENGVVHAGRTDDG-GW
Mvan_1971|M.vanbaalenii_PYR-1       PMPEHYPSFPHHSQVKAYLDEYAEVFGLLEHIEFGNGVVHAAKDGSG-GW
MSMEG_2202|M.smegmatis_MC2_155      PMPEHYPSFPHHTQIKEYLDAYADAFGLLDHIEFGNGVVHAERGAHG-GW
TH_0016|M.thermoresistible__bu      PMPEHYPAFPHHSEIKAYLDSYAEAFGLLDNIEFNNGVVHARLDDGG-GW
MAB_2607|M.abscessus_ATCC_1997      PMPDSYPHFPHHTLIKQYLEDYARAFDLKRNIEFQNGIVHAEHRPGG-GW
MLBr_00065|M.leprae_Br4923          PWT-KCQAIADGKPILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRW
                                      .      .    :  *    .  ..:   :.:   :  *        *

Mb0916|M.bovis_AF2122/97            VLRTDSG---TESTVDFLISATGVLHHPR--IPPIAGLDDFRGTVFHSAR
Rv0892|M.tuberculosis_H37Rv         VLRTDSG---TESTVDFLISATGVLHHPR--IPPIAGLDDFRGTVFHSAR
MAV_3915|M.avium_104                HVFTTDG---REYVAQFLISGAGALHIPS--LPDIEGRDEFAGPAFHSAE
MUL_1880|M.ulcerans_Agy99           HVFTSDG---REYVAQFLISGAGALHIPS--SPEIEGREEFAGPAFHSAE
MMAR_3138|M.marinum_M               RLSCSSG---QNLTARFVINCSGVLSRPK--WPDIPGVRDFAGVTLHTAR
Mflv_4373|M.gilvum_PYR-GCK          IIRDQGG---ADRHFDLLVVANGHHWDPR--LPEFPG--SFDGESIHSHA
Mvan_1971|M.vanbaalenii_PYR-1       RILDQAG---AQRHFDLLVVANGHHWDPR--LPQFPG--SFAGESIHSHS
MSMEG_2202|M.smegmatis_MC2_155      VIEDQAS---ARRDFDLLVVANGHHWDPR--MPDFPG--EFTGEQIHSHH
TH_0016|M.thermoresistible__bu      LIEDQSG---ATREFDLLVVGNGHHWDPR--YPDFPG--TFTGETIHSHH
MAB_2607|M.abscessus_ATCC_1997      ELLTQAG---ERRLFDLLVVANGHHWDPR--YPDFPG--TFTGTALHSHH
MLBr_00065|M.leprae_Br4923          TVQVENNGTPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQH
                                     :    .         ::.   *         * : *   * *  :*.  

Mb0916|M.bovis_AF2122/97            WDH---TVPLLGRRIAVIGTGSTGVQLVCGLAGVAG--KVTMFQRTAQWV
Rv0892|M.tuberculosis_H37Rv         WDH---TVPLLGRRIAVIGTGSTGVQLVCGLAGVAG--KVTMFQRTAQWV
MAV_3915|M.avium_104                WDH---TVDLTGKRVAVIGTGASAIQIVPEIVGQVA--ELQLYQRTPPWV
MUL_1880|M.ulcerans_Agy99           WDH---SVDLTGKRVAIIGAGASAIQIVPEIVEQVG--ELQLYQRTPPWV
MMAR_3138|M.marinum_M               WDH---TKDLTGKRVAVIGTGASAVQLIPEVAKIAS--SLTVFQRTPIYC
Mflv_4373|M.gilvum_PYR-GCK          YIDPATPLELTGKRILVVGIGNSAADITVELSSKALRNQVTLSTRSSAWI
Mvan_1971|M.vanbaalenii_PYR-1       YVDPSTPLDLSGKRILVVGIGNSAADITVELSSKALRNDVTLSTRSSAWI
MSMEG_2202|M.smegmatis_MC2_155      YIDPRTPLDLTGKRILVVGIGNSAADITVELSSRTLQNQVTLSTRSSAWI
TH_0016|M.thermoresistible__bu      YIDPATPLDLTGKRILVVGLGNSAADITVELSSRALRNKVTLSTRSSAWI
MAB_2607|M.abscessus_ATCC_1997      YIDPRTPLDLMDKRILVVGLGNSAADIAVELSSRATGNTVTLSTRSGAWI
MLBr_00065|M.leprae_Br4923          WPE---DLDYAAKNIVVIGSGATAVTLVPALANSGAK-HVTMLQRSPTYI
                                    : .         :.: ::* * :.  :   :        : :  *:  : 

Mb0916|M.bovis_AF2122/97            LPWPNPRYSKLARVFHRAFPCLGSLAYKAYSLSFET---FAVALSNPGLH
Rv0892|M.tuberculosis_H37Rv         LPWPNPRYSKLARVFHRAFPCLGSLAYKAYSLSFET---FAVALSNPGLH
MAV_3915|M.avium_104                VPRSNPEIPPAVRAAMENVPGLRALVRLAIYWGQEA---LAFGMTKRPNL
MUL_1880|M.ulcerans_Agy99           VPRSNPEIPPALRRAMENVPGLRALARLGIYWAQEA---LAFGMTKRPNV
MMAR_3138|M.marinum_M               LPKPDFSIPSWAATVMRLVPGAQLMTRTASQAFVEFTFPIAAHFHSLIPV
Mflv_4373|M.gilvum_PYR-GCK          VPKYIAGRP--GDTLFRTSPHLPLSWQRKAVQLIAP--------------
Mvan_1971|M.vanbaalenii_PYR-1       VPKYIAGRP--GDTFWRTSPYLPLSWQRKAVQLVAP--------------
MSMEG_2202|M.smegmatis_MC2_155      VPKYLAGQP--GDKFFRTTPYLPLSWQRKAVQMIAP--------------
TH_0016|M.thermoresistible__bu      VPKYIAGQP--GDKLWRTTPYLPLSWQRKAMQLVAP--------------
MAB_2607|M.abscessus_ATCC_1997      VPKYVAGQP--ADKYFRTSPHLPMSWQRKLFQMMQP--------------
MLBr_00065|M.leprae_Br4923          VSQP--AKDKIAARLNRWLPDKYAYTAVRWKNILRQS---ALYGACQKWP
                                    :.              .  *                              

Mb0916|M.bovis_AF2122/97            RKLVGAVCRASLRR-VRDPRLRRALTPDYEPMCKRLVMS--GGFYRAIQR
Rv0892|M.tuberculosis_H37Rv         RKLVGAVCRASLRR-VRDPRLRRALTPDYEPMCKRLVMS--GGFYRAIQR
MAV_3915|M.avium_104                LKVIEAYAKYNIRRSVKDKELRRKLTPHYRIGCKRILNS--STYYGAVAD
MUL_1880|M.ulcerans_Agy99           LKVGEAYAKYNIRRSVKDRELRRKLTPHYRIGCKRILNS--SSYYPAVAN
MMAR_3138|M.marinum_M               SDLMEEAAKRYMRRAVDDPVTRDQLIPRYSLGCKRPSFH--NSYLATYNR
Mflv_4373|M.gilvum_PYR-GCK          -------------MLGTDPTMYGLPPADHKLFEAHPTQS--VELPLRLGS
Mvan_1971|M.vanbaalenii_PYR-1       -------------MLGTDPTMYGLPPADHKLFEAHPTQS--VELPLRLGS
MSMEG_2202|M.smegmatis_MC2_155      -------------MLGTDPTAYGLPAPNHKLFEAHPTQS--VELPLRLGS
TH_0016|M.thermoresistible__bu      -------------LLGTDPTMYGLPPANHKLFEAHPTQS--VELPLRLGS
MAB_2607|M.abscessus_ATCC_1997      -------------LMSGRPDQLGLPMPNHKFGEAHFTQS--VELPLRLGS
MLBr_00065|M.leprae_Br4923          QRMRNILLGHVARRLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRK
                                                              . :     :               

Mb0916|M.bovis_AF2122/97            DDVELVTAGIDHVEHRGIVTDDGVLHEVDVIVLATGFDSHAF--FRPMQL
Rv0892|M.tuberculosis_H37Rv         DDVELVTAGIDHVEHRGIVTDDGVLHEVDVIVLATGFDSHAF--FRPMQL
MAV_3915|M.avium_104                PKTELVTDHIARITPDGIVTADGTHRPVDVIVYATGFHVTDS--YTYVQI
MUL_1880|M.ulcerans_Agy99           PKTRLITDRIARITRNGIVTADGVEHQADVIVYATGFHVTDS--YTYVQI
MMAR_3138|M.marinum_M               RNVSLETSGITHVDHASVHTEDGKSYPIDVMVLATGFKVMESGNMPTYVL
Mflv_4373|M.gilvum_PYR-GCK          GDVTPKPN-VARLDGSTVHFVDGTHSDFDVIIYATGYNITFP-FFDPDFV
Mvan_1971|M.vanbaalenii_PYR-1       GDVTPKPN-VARLDGHTVHFVDGTSADFDVIIYATGYNITFP-FFDPEFI
MSMEG_2202|M.smegmatis_MC2_155      GDVTPKPN-VARLSGDTVLFEDGTSDVFDVIIYATGYNITFP-FFDRDFI
TH_0016|M.thermoresistible__bu      GDVIPKPN-VSRLDGATVHFEDGTSDDFDAIIYATGYNITFP-FFDPDFI
MAB_2607|M.abscessus_ATCC_1997      GDIVPKPD-ISRFDGHTVHFEDGTSTDVDVIIFATGYNITFP-FFDPEFL
MLBr_00065|M.leprae_Br4923          GTVDMVTDAIDRFTSTGIRLKSGNELRADIIVTATGLNLQLFG-GAVATV
                                          .  : :.    :   .*     * :: *** .           :

Mb0916|M.bovis_AF2122/97            TGRDGIRIDDVWQ-DGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPLTAVA
Rv0892|M.tuberculosis_H37Rv         TGRDGIRIDDVWQ-DGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPLTAVA
MAV_3915|M.avium_104                KGLHGEDLVDRWNREGIGAHRGITVADVPNLFFLLGPNTGLGHNSVVFMI
MUL_1880|M.ulcerans_Agy99           KGQHGEDLVDRWNREGIGAHRGIAVADVPNLFFLLGPNTGLGHNSVVFMI
MMAR_3138|M.marinum_M               KGRGGVEQSAWWDEHRLQAFEGVSVPGFPNHFNIFGPYG-YNGSSYFTLI
Mflv_4373|M.gilvum_PYR-GCK          SAPD----------NAIRLYKRMFIPGIENLVFMG---FAQAVPTLFPFV
Mvan_1971|M.vanbaalenii_PYR-1       SAPD----------NSIRLYKRMFKPGVDDLVFIG---FAQSVPTLFPFV
MSMEG_2202|M.smegmatis_MC2_155      SAPD----------NQIRLYKRMFKPGIDDLVFIG---FAQAIPTLFPFV
TH_0016|M.thermoresistible__bu      SAPD----------NHIRLYKRMFKPGVENLVFIG---FAQAVPTLFPFV
MAB_2607|M.abscessus_ATCC_1997      SAPD----------NRIDLYKRMFKPGLDDLIFVG---LAQAVPSLFPFV
MLBr_00065|M.leprae_Br4923          DGQP-------VDLAQTMSYKGMMLSGLPNMIYTVGYTNASWTLKADLVS
                                     .                 .. :  ... : .                . 

Mb0916|M.bovis_AF2122/97            ESQAEHIVQWIK-RWRHGEFDTMEPKSAAT--EAYN-TVLRAAMPNTVWT
Rv0892|M.tuberculosis_H37Rv         ESQAEHIVQWIK-RWRHGEFDTMEPKSAAT--EAYN-TVLRAAMPNTVWT
MAV_3915|M.avium_104                ESQIRYVADAIA-TCDKLGAQALAPTRAAQ--DRFN-DELQRRLGPSVWN
MUL_1880|M.ulcerans_Agy99           ESQIHYVADAIA-KCDKRGAQALAPTRAAQ--DRFN-EELQRRLAGSVWN
MMAR_3138|M.marinum_M               EAQSRHIVRCLR-RARTLKADYVEVRQQAN--DRYFGDMVSRRHRQVFWQ
Mflv_4373|M.gilvum_PYR-GCK          ESQSRLLAAYAVGRYALPPVDEMERTIDAD--QQLHAGHCTDRPR-----
Mvan_1971|M.vanbaalenii_PYR-1       ECQSRLLAAYAVGRYALPSADEMERTIDAD--QQLHAGHCTDRPR-----
MSMEG_2202|M.smegmatis_MC2_155      ECQSRLLAAYAVGRYALPSTDEMERVIDAD--QRLHAGHCTDRPR-----
TH_0016|M.thermoresistible__bu      ECQSRLMAAYAVGRYALPPVDEMERVIDAD--QQLHAGHCIDRPR-----
MAB_2607|M.abscessus_ATCC_1997      ECQARLVGAYAAGKYRLPPVDEMRAVIEAE--HRKYTGHMLDRPR-----
MLBr_00065|M.leprae_Br4923          EFFCRLLNYMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQ
                                    *   . :             :                             

Mb0916|M.bovis_AF2122/97            TG---CDSWYLNKDG-IPEVWPFAPAKHRAMLANLHPEEYDLRRYAAVRA
Rv0892|M.tuberculosis_H37Rv         TG---CDSWYLNKDG-IPEVWPFAPAKHRAMLANLHPEEYDLRRYAAVRA
MAV_3915|M.avium_104                SGG--CSSWYLDEHGKNTVLWGGYTWEYWRATRAVKPEEYQFYGIGSRAG
MUL_1880|M.ulcerans_Agy99           SGG--CSSWYLDEHGRNTVLWCGYTWQYWLATRSVKPEEYQFFKAGAKSS
MMAR_3138|M.marinum_M               PSCSNANSYYFDKHG-DVPLRPSTTLETYWRSRTFRLSDYRFERRAESVG
Mflv_4373|M.gilvum_PYR-GCK          ----------------HTQQVDYFVYEHDLRTRELPAGLKRAQRAVAVAR
Mvan_1971|M.vanbaalenii_PYR-1       ----------------HTQQVDYFVYEHDLLKREIPAGRKRAQRVAAVAR
MSMEG_2202|M.smegmatis_MC2_155      ----------------HTQQVDYFYYEHDIRAREMPAGAKRAERRAAGTR
TH_0016|M.thermoresistible__bu      ----------------HTQQVDYFYYEHDLRTRELPAGLKRAGHTAPRRT
MAB_2607|M.abscessus_ATCC_1997      ----------------HTQQLDYFLYEHDMRTKELPRGLARAGGVA----
MLBr_00065|M.leprae_Br4923          GSR------------TPWRLNQNYLRDIRLIRRGKVADEGLLFAKKTTPV
                                                              .                       

Mb0916|M.bovis_AF2122/97            TSRPQSA-
Rv0892|M.tuberculosis_H37Rv         TSRPQSA-
MAV_3915|M.avium_104                V-------
MUL_1880|M.ulcerans_Agy99           VNG-----
MMAR_3138|M.marinum_M               AR------
Mflv_4373|M.gilvum_PYR-GCK          --------
Mvan_1971|M.vanbaalenii_PYR-1       --------
MSMEG_2202|M.smegmatis_MC2_155      TAIVGSVA
TH_0016|M.thermoresistible__bu      PVAL----
MAB_2607|M.abscessus_ATCC_1997      --------
MLBr_00065|M.leprae_Br4923          TV------