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TDVVTHTETAPTPAAKAAKPVHTRAVIIGTGFSGLGMAIALQKQGVGFVILEKADDIGGTWRDNSYPGCA CDIPSHLYSFSFEPKPDWKNPFSYQPEIWDYLKGVTEKYGLRRYIEFNSLVDRAHWDDDEHRWHVFTTDG REYVAQFLISGAGALHIPSLPDIEGRDEFAGPAFHSAEWDHTVDLTGKRVAVIGTGASAIQIVPEIVGQV AELQLYQRTPPWVVPRSNPEIPPAVRAAMENVPGLRALVRLAIYWGQEALAFGMTKRPNLLKVIEAYAKY NIRRSVKDKELRRKLTPHYRIGCKRILNSSTYYGAVADPKTELVTDHIARITPDGIVTADGTHRPVDVIV YATGFHVTDSYTYVQIKGLHGEDLVDRWNREGIGAHRGITVADVPNLFFLLGPNTGLGHNSVVFMIESQI RYVADAIATCDKLGAQALAPTRAAQDRFNDELQRRLGPSVWNSGGCSSWYLDEHGKNTVLWGGYTWEYWR ATRAVKPEEYQFYGIGSRAGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3915 | - | - | 100% (512) | flavin-containing monooxygenase FMO |
| M. avium 104 | MAV_1795 | - | e-107 | 42.68% (478) | flavin-binding monooxygenase |
| M. avium 104 | MAV_3378 | - | 8e-91 | 39.03% (497) | lipolytic enzyme |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3075c | - | 0.0 | 83.60% (500) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4287 | - | 0.0 | 68.38% (506) | putative monooxygenase |
| M. tuberculosis H37Rv | Rv3049c | - | 0.0 | 83.60% (500) | monooxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 4e-31 | 27.32% (399) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_3920c | - | 0.0 | 62.95% (502) | monooxygenase |
| M. marinum M | MMAR_1644 | - | 0.0 | 86.19% (514) | monooxygenase |
| M. smegmatis MC2 155 | MSMEG_2310 | - | 0.0 | 71.90% (484) | monooxygenase |
| M. thermoresistible (build 8) | TH_4080 | - | 0.0 | 73.31% (502) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1880 | - | 0.0 | 85.80% (514) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_2059 | - | 0.0 | 70.82% (490) | putative monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4287|M.gilvum_PYR-GCK -------MTVAESADT----TAPPQTPVRTRTLIIGSGFSGLGMAIELQR
Mvan_2059|M.vanbaalenii_PYR-1 -------MTVAEQADL----TSAGQTPVRTRALIIGSGFSGLGMGIELQR
MSMEG_2310|M.smegmatis_MC2_155 ---------------M----TAADQQPIRTRALVIGTGFSGLGMAIELQR
MMAR_1644|M.marinum_M MTDVVIPSTETTASGE----PQAPTPPVKTRAVIIGTGFSGLGMAIALQK
MUL_1880|M.ulcerans_Agy99 MTDVVIPSTETTASGE----PQAPTPPVKTRAVIIGTGFSGLGMAIALQK
MAV_3915|M.avium_104 MTDVVT-HTETAPTPA----AKAAKP-VHTRAVIIGTGFSGLGMAIALQK
Mb3075c|M.bovis_AF2122/97 ---MSIADTAAKPSTP----SPANQPPVRTRAVIIGTGFSGLGMAIALQK
Rv3049c|M.tuberculosis_H37Rv ---MSIADTAAKPSTP----SPANQPPVRTRAVIIGTGFSGLGMAIALQK
TH_4080|M.thermoresistible__bu ---MTVTEPSADITPA----NTPTQPPVRTRALIVGTGFSGLGMAIALQR
MAB_3920c|M.abscessus_ATCC_199 ---MTVTETSHEEQRPDTVGDGGSSEPIRIRALIVGTGFSGIGAGIALQK
MLBr_00065|M.leprae_Br4923 --------------------MVVMAETEYLDVVIVGAGISGVSAAWHLQD
.:::*:*:**:. . **
Mflv_4287|M.gilvum_PYR-GCK RG--VDFLILEKSDEIGGTWRDNTYPGCACDIPSHMYSFSFEPKADWSHM
Mvan_2059|M.vanbaalenii_PYR-1 RG--VDFLILEKADEIGGTWRDNTYPGCACDIPSHMYSFSFEPKPDWTHM
MSMEG_2310|M.smegmatis_MC2_155 RG--VDFLILEKADEIGGTWRDNTYPGCACDIPSHMYSFSFEPKADWKHM
MMAR_1644|M.marinum_M QG--VDFVILEKSDDVGGTWRDNSYPGCACDIPSHLYSFSFEPKPDWRNP
MUL_1880|M.ulcerans_Agy99 QG--VDFVILEKSDDVGGTWRDNSYPGCACDIPSHLYSFSFEPKPDWRNP
MAV_3915|M.avium_104 QG--VGFVILEKADDIGGTWRDNSYPGCACDIPSHLYSFSFEPKPDWKNP
Mb3075c|M.bovis_AF2122/97 QG--VDFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHL
Rv3049c|M.tuberculosis_H37Rv QG--VDFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHL
TH_4080|M.thermoresistible__bu RG--IDFLMLEKADDIGGTWRDNTYPGCACDIPSHLYSFSFEPKADWRHL
MAB_3920c|M.abscessus_ATCC_199 MG--VPFHILEKAGEMGGTWRDNTYPGAACDVPTHLYSFSFEPRSTWDRL
MLBr_00065|M.leprae_Br4923 RCPNKSYVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAI
: :*** :**** *** .* : .* *.* .
Mflv_4287|M.gilvum_PYR-GCK WSFQPEIQEYLLGVTAKYGLRRYIEFGAHVDRAHWDDAEMRWHVFTKDG-
Mvan_2059|M.vanbaalenii_PYR-1 WSFQPEIQDYLLGVTAKYGLRRYVEFGAHVDRALWDDDEMRWHVHTKDG-
MSMEG_2310|M.smegmatis_MC2_155 WSFQPEIQDYLLGVTAKYGLRRHIHFNSHVDRAHWDDEELRWHVFTKTG-
MMAR_1644|M.marinum_M FSYQPEIWDYLKGVTEKYGLRRYVEFNSLVDRAYWDDEECRWHVFTSDG-
MUL_1880|M.ulcerans_Agy99 FSYQPEIWDYLKGVTEKYGLRRYVEFNSLVDRAYWDDEECRWHVFTSDG-
MAV_3915|M.avium_104 FSYQPEIWDYLKGVTEKYGLRRYIEFNSLVDRAHWDDDEHRWHVFTTDG-
Mb3075c|M.bovis_AF2122/97 FSYWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFTADG-
Rv3049c|M.tuberculosis_H37Rv FSYWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFTADG-
TH_4080|M.thermoresistible__bu FSYQDEIQEYLQGVTAKYGLRRYIHFDSLVDRAHWDDTEHRWHVFTADG-
MAB_3920c|M.abscessus_ATCC_199 FSQQPEIFDYLKEVGAKYGLYRHVTFNTRVTRGYWDEDEYRWHVFTDGG-
MLBr_00065|M.leprae_Br4923 ADGKP-ILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNG
. * *: . :*: ::: :. * . *.. * ** * . .
Mflv_4287|M.gilvum_PYR-GCK --REFIAQFLVSGAGGLHIPL--IPEFEGYDDFLASGRAAFHSAQWDHSV
Mvan_2059|M.vanbaalenii_PYR-1 --REFIAQFLISGAGGLHIPL--IPEFDGYDEYLAAGRVAFHSAQWDHDV
MSMEG_2310|M.smegmatis_MC2_155 --QEYIAQFLVSGAGGLHIPQ--IPDIEGRESFAG---AAFHSAQWDHSV
MMAR_1644|M.marinum_M --REYVAQFLISGAGALHIPS--LPEIEGREEFAG---PAFHSAEWDHSV
MUL_1880|M.ulcerans_Agy99 --REYVAQFLISGAGALHIPS--SPEIEGREEFAG---PAFHSAEWDHSV
MAV_3915|M.avium_104 --REYVAQFLISGAGALHIPS--LPDIEGRDEFAG---PAFHSAEWDHTV
Mb3075c|M.bovis_AF2122/97 --REYVAQFLISGAGALHIPS--FPEIAGRDEFAG---PAFHSAQWDHSI
Rv3049c|M.tuberculosis_H37Rv --REYVAQFLISGAGALHIPS--FPEIAGRDEFAG---PAFHSAQWDHSI
TH_4080|M.thermoresistible__bu --REYIAQFLISCAGALHIPS--IPDFPGRDQFAG---PAFHSAQWDHSV
MAB_3920c|M.abscessus_ATCC_199 --QEYICQFLISGVGALHIPS--IPEIEGLDRFEG---PVFHSAQWNHDY
MLBr_00065|M.leprae_Br4923 TPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTG---PIIHPQHWPEDL
: ..**. * : * : * : : . :*. .* .
Mflv_4287|M.gilvum_PYR-GCK DIAGKKVAVIGTGASAIQIVPEIVED-VAELQLYQRTPAWVMPRPNNPIP
Mvan_2059|M.vanbaalenii_PYR-1 DITGKKVAVIGTGASAIQIVPEIVKD-VDELQLYQRTPAWVMPRPNNPIP
MSMEG_2310|M.smegmatis_MC2_155 DLRGKRVAVIGTGASAIQIVPEIVKD-VAELHLYQRTPAWVMPRVNNAFP
MMAR_1644|M.marinum_M DLTGKRVAIIGTGASAIQIVPEIVEQ-VGELQLYQRTPPWVVPRSNPEIP
MUL_1880|M.ulcerans_Agy99 DLTGKRVAIIGAGASAIQIVPEIVEQ-VGELQLYQRTPPWVVPRSNPEIP
MAV_3915|M.avium_104 DLTGKRVAVIGTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRSNPEIP
Mb3075c|M.bovis_AF2122/97 DLTGKRVAIVGTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRTNEELP
Rv3049c|M.tuberculosis_H37Rv DLTGKRVAIVGTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRTNEELP
TH_4080|M.thermoresistible__bu DLTGKRVAVIGTGASAIQIVPEIIDR-VAQLQLYQRTPAWVVPRTNDELP
MAB_3920c|M.abscessus_ATCC_199 DLTGKKVAVIGTGASAIQFVPEIVGK-VGELKLFQRTPPWVLPRTNVEFG
MLBr_00065|M.leprae_Br4923 DYAAKNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKI
* .*.:.::*:**:*: :** : . .: : **:*.:::.:
Mflv_4287|M.gilvum_PYR-GCK EGMQRAFATVPGTRAAMRAGIYWIHETVGFAMTKQPKLLKIGELLGKWNI
Mvan_2059|M.vanbaalenii_PYR-1 EGLQRVFTNVPGTRAAMRAGIYWLHEAVGFAMTKQPRLLKLGELAGKWNI
MSMEG_2310|M.smegmatis_MC2_155 QWLRNVFSYVPGTRALLRAAIYWIHEGVGFAMTKEPRLLKIGEWMGRYNI
MMAR_1644|M.marinum_M PALRRAMENVPGLRALARLGIYWAQEALAFGMTKRPNVLKVGEAYAKYNI
MUL_1880|M.ulcerans_Agy99 PALRRAMENVPGLRALARLGIYWAQEALAFGMTKRPNVLKVGEAYAKYNI
MAV_3915|M.avium_104 PAVRAAMENVPGLRALVRLAIYWGQEALAFGMTKRPNLLKVIEAYAKYNI
Mb3075c|M.bovis_AF2122/97 VSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYAKYNI
Rv3049c|M.tuberculosis_H37Rv VSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYAKYNI
TH_4080|M.thermoresistible__bu AWLRRALENIPGLRLALRGGIYALQEALAVGMTKYPGMLRIGHLLGKWNI
MAB_3920c|M.abscessus_ATCC_199 ALAKRAFAGVPGLRALFRSGMYFGAEAGAYAMNRRPALLKGIELLGRAYI
MLBr_00065|M.leprae_Br4923 AARLNRWLPDKYAYTAVRWKNILRQSALYGACQKWP--QRMRNILLGHVA
* . . : * : .
Mflv_4287|M.gilvum_PYR-GCK RRSVKDPVLRRKLTPDYRAGCKR--ILNSDTYYRGIADPRTEVITDRIAR
Mvan_2059|M.vanbaalenii_PYR-1 RRSIKDRELRRKLTPDYRAGCKR--ILNSDTYYRGIADPRTEVITDRIAR
MSMEG_2310|M.smegmatis_MC2_155 NRSIKDPELRRKLTPSYRAGCKR--ILNSDTYYRGIADPKTQVITEGIAR
MMAR_1644|M.marinum_M RRSVKDRELRRKLTPHYRIGCKR--ILNSSSYYPAVANPKTRLITDRIAR
MUL_1880|M.ulcerans_Agy99 RRSVKDRELRRKLTPHYRIGCKR--ILNSSSYYPAVANPKTRLITDRIAR
MAV_3915|M.avium_104 RRSVKDKELRRKLTPHYRIGCKR--ILNSSTYYGAVADPKTELVTDHIAR
Mb3075c|M.bovis_AF2122/97 RRSVKDRELRRKLTPRYRIGCKR--ILNSSTYYPAVADPKTELITDRIDR
Rv3049c|M.tuberculosis_H37Rv RRSVKDRELRRKLTPRYRIGCKR--ILNSSTYYPAVADPKTELITDRIDR
TH_4080|M.thermoresistible__bu NRSVKDPQLRAKLTPDYRLGCKR--ILNSSTYYPAVADPRTEVITESIDR
MAB_3920c|M.abscessus_ATCC_199 KSQISDPEVRRKVTPDYRAGCKR--LLGSATYYKAIENRKTELVTEAITR
MLBr_00065|M.leprae_Br4923 RRLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDR
. .. :: :. * *. :* :: . : .: . . ::*: * *
Mflv_4287|M.gilvum_PYR-GCK FTARGIVTADEHGRETEREADVVVFATGFHVTDSYTYVDIKGPGGEDLVD
Mvan_2059|M.vanbaalenii_PYR-1 FSPRGIVTTDEHGRETEREADVVVFATGFHVTDSYTYVDIKGPGGVDLVD
MSMEG_2310|M.smegmatis_MC2_155 MTPTGIVTNDG----VEHPVDIVVYATGFHVTDSYTYVDIKGAGGEDLVD
MMAR_1644|M.marinum_M ITRNGIVTADG----VEHQADVIVYATGFHVTDSYTYVQIKGQHGEDLVD
MUL_1880|M.ulcerans_Agy99 ITRNGIVTADG----VEHQADVIVYATGFHVTDSYTYVQIKGQHGEDLVD
MAV_3915|M.avium_104 ITPDGIVTADG----THRPVDVIVYATGFHVTDSYTYVQIKGLHGEDLVD
Mb3075c|M.bovis_AF2122/97 ITHDGIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDLVD
Rv3049c|M.tuberculosis_H37Rv ITHDGIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDLVD
TH_4080|M.thermoresistible__bu ITTDGIVTSDG----TERAVDVIVYATGFHVSDSYKYVQIKGLNGEDIVD
MAB_3920c|M.abscessus_ATCC_199 VTTDGVVTSDG----IERKVDAIIFGTGFHVTDSYKYLDLKGQGGEDLGE
MLBr_00065|M.leprae_Br4923 FTSTGIRLKSG----NELRADIIVTATGLNLQLFGGAVATVDGQPVDLAQ
.: *: . .* :: .**::: : . *: :
Mflv_4287|M.gilvum_PYR-GCK RWNREGISALRGITVAGMPNLFFLLGPNTALGHNSVVFMIESQIRYAAKA
Mvan_2059|M.vanbaalenii_PYR-1 RWNREGIAALRGITVADMPNLFFLLGPNTALGHNSVVFMIESQIRYAAKA
MSMEG_2310|M.smegmatis_MC2_155 RWNREGIQAHRGVAVAGMPNLFFLLGPNTALGHNSVVFMIEQQIRYVGQA
MMAR_1644|M.marinum_M RWNREGIGAHRGIAVADVPNLFFLLGPNTGLGHNSVVFMIESQIHYVADA
MUL_1880|M.ulcerans_Agy99 RWNREGIGAHRGIAVADVPNLFFLLGPNTGLGHNSVVFMIESQIHYVADA
MAV_3915|M.avium_104 RWNREGIGAHRGITVADVPNLFFLLGPNTGLGHNSVVFMIESQIRYVADA
Mb3075c|M.bovis_AF2122/97 RWNREGIGAHRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVADA
Rv3049c|M.tuberculosis_H37Rv RWNREGIGAHRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVADA
TH_4080|M.thermoresistible__bu RFNREGPMAHRGTAVADLPNAYLLLGPNTGLGHNSMVYMIESQINYVIEA
MAB_3920c|M.abscessus_ATCC_199 RWSSQGVTAHRGITIAGMPNLFFLLGPNTGLGHNSIVFMIESQIHYVTEA
MLBr_00065|M.leprae_Br4923 TMS------YKGMMLSGLPNMIYTVG----YTNASWTLKADLVSEFFCRL
. :* ::.:** :* : * . : .:
Mflv_4287|M.gilvum_PYR-GCK IAAVEKKGVQCLTPTREAQDAYNDELQDDLRGTVWSTGGCRSWYLDEHGV
Mvan_2059|M.vanbaalenii_PYR-1 IAAVDKAGAQALAPTRAAQDDYNDELQHDLGGTVWSTGGCRSWYLDEHGV
MSMEG_2310|M.smegmatis_MC2_155 IAAVDKAGAAALAPTRRAQDAFNAELQRDLSGTVFNTGGCKSWYLDEHGV
MMAR_1644|M.marinum_M IAKCDKRGAQALAPTRAAQDRFNEELQRRLAGSVWNSGGCSSWYLDEHGR
MUL_1880|M.ulcerans_Agy99 IAKCDKRGAQALAPTRAAQDRFNEELQRRLAGSVWNSGGCSSWYLDEHGR
MAV_3915|M.avium_104 IATCDKLGAQALAPTRAAQDRFNDELQRRLGPSVWNSGGCSSWYLDEHGK
Mb3075c|M.bovis_AF2122/97 IAKCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEHGK
Rv3049c|M.tuberculosis_H37Rv IAKCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEHGK
TH_4080|M.thermoresistible__bu IKAVDKAGAQALAPTREAQDRYNAELQARLGRSVWNTGGCRSWYLDEHGN
MAB_3920c|M.abscessus_ATCC_199 IKQVDAAYAQALVPTREAQDRFNAEVQRKLQGSVWNSGGCQSWYLDEHGK
MLBr_00065|M.leprae_Br4923 LNYMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDA----LPKQG-
: : :. ..* : . * : .. * ::*
Mflv_4287|M.gilvum_PYR-GCK NRTLWSGMTWQYWLATRRFKESEYTFG-----------------------
Mvan_2059|M.vanbaalenii_PYR-1 NRTLWSGMTWQYWLATRRFNKSEYTFR-----------------------
MSMEG_2310|M.smegmatis_MC2_155 NRTLWSGMTWQYWKALRRLDPSEFEFLDQRVLARS---------------
MMAR_1644|M.marinum_M NTVLWCGYTWQYWLATRSVKPEEYQFFKAG-----AKSSVNG--------
MUL_1880|M.ulcerans_Agy99 NTVLWCGYTWQYWLATRSVKPEEYQFFKAG-----AKSSVNG--------
MAV_3915|M.avium_104 NTVLWGGYTWEYWRATRAVKPEEYQFYGIG-----SRAGV----------
Mb3075c|M.bovis_AF2122/97 NTVLWCGYTWQYWLTTRSVNPAEYRFFGIGNGLSSDRATVAAAN------
Rv3049c|M.tuberculosis_H37Rv NTVLWCGYTWQYWLTTRSVNPAEYRFFGIGNGLSSDRATVAAAN------
TH_4080|M.thermoresistible__bu NRVLWGGFTWQYRLATRTLDPAEYRFWG----------------------
MAB_3920c|M.abscessus_ATCC_199 NRTLWSGFTFEYWSQTRKVDPSEYEFEGAVRPAVRRTIPRADGPRQKSPS
MLBr_00065|M.leprae_Br4923 SRTPWR-LNQNYLRDIRLIRRGKVADEGLLFAKKTTPVTV----------
. . * . :* * . :
Mflv_4287|M.gilvum_PYR-GCK ----
Mvan_2059|M.vanbaalenii_PYR-1 ----
MSMEG_2310|M.smegmatis_MC2_155 ----
MMAR_1644|M.marinum_M ----
MUL_1880|M.ulcerans_Agy99 ----
MAV_3915|M.avium_104 ----
Mb3075c|M.bovis_AF2122/97 ----
Rv3049c|M.tuberculosis_H37Rv ----
TH_4080|M.thermoresistible__bu ----
MAB_3920c|M.abscessus_ATCC_199 MAAQ
MLBr_00065|M.leprae_Br4923 ----