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LQTPPYVAVIGAGISGLTAGKMLKDYGIDYTTFESSDRIGGNWAFGNPNGHSSAYRSLHIDTSKDRLSFK DFPMPEHYPSFPHHAQIKAYLDDYADTFGLLDHIEFENGVVHAGRTDDGGWIIRDQGGADRHFDLLVVAN GHHWDPRLPEFPGSFDGESIHSHAYIDPATPLELTGKRILVVGIGNSAADITVELSSKALRNQVTLSTRS SAWIVPKYIAGRPGDTLFRTSPHLPLSWQRKAVQLIAPMLGTDPTMYGLPPADHKLFEAHPTQSVELPLR LGSGDVTPKPNVARLDGSTVHFVDGTHSDFDVIIYATGYNITFPFFDPDFVSAPDNAIRLYKRMFIPGIE NLVFMGFAQAVPTLFPFVESQSRLLAAYAVGRYALPPVDEMERTIDADQQLHAGHCTDRPRHTQQVDYFV YEHDLRTRELPAGLKRAQRAVAVAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4373 | - | - | 100% (446) | flavin-containing monooxygenase |
| M. gilvum PYR-GCK | Mflv_3867 | - | 4e-22 | 31.48% (324) | FAD dependent oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1123 | - | 3e-19 | 27.30% (403) | FAD dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0916 | - | 1e-21 | 32.56% (215) | monooxygenase |
| M. tuberculosis H37Rv | Rv0892 | - | 1e-21 | 32.56% (215) | monooxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 1e-06 | 21.92% (406) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2607 | - | 0.0 | 68.74% (435) | putative flavin-containing monooxygenase |
| M. marinum M | MMAR_1644 | - | 2e-20 | 24.59% (366) | monooxygenase |
| M. avium 104 | MAV_3915 | - | 6e-21 | 25.56% (356) | flavin-containing monooxygenase FMO |
| M. smegmatis MC2 155 | MSMEG_2202 | - | 0.0 | 82.99% (441) | dimethylaniline monooxygenase |
| M. thermoresistible (build 8) | TH_0016 | - | 0.0 | 86.14% (433) | dimethylaniline monooxygenase |
| M. ulcerans Agy99 | MUL_1880 | - | 5e-20 | 24.32% (366) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_1971 | - | 0.0 | 87.84% (444) | dimethylaniline monooxygenase (N-oxide-forming) |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0916|M.bovis_AF2122/97 MTGRCPT---------------------VAVVGAGMSGMCVAITLLSAGI
Rv0892|M.tuberculosis_H37Rv MTGRCPT---------------------VAVVGAGMSGMCVAITLLSAGI
MMAR_1644|M.marinum_M MT-DVVIPSTETTASGEPQAPTPPVKTRAVIIGTGFSGLGMAIALQKQGV
MUL_1880|M.ulcerans_Agy99 MT-DVVIPSTETTASGEPQAPTPPVKTRAVIIGTGFSGLGMAIALQKQGV
MAV_3915|M.avium_104 MT-DVVT-HTETAPTPAAKAAKP-VHTRAVIIGTGFSGLGMAIALQKQGV
Mflv_4373|M.gilvum_PYR-GCK MLQTPPY---------------------VAVIGAGISGLTAGKMLKDYGI
Mvan_1971|M.vanbaalenii_PYR-1 MDQTHPR---------------------VAVIGAGISGLTAGKMLKDYGV
MSMEG_2202|M.smegmatis_MC2_155 MTPALPR---------------------TAIIGAGISGLTAGKMLKDYRV
TH_0016|M.thermoresistible__bu VKRRYPR---------------------TAVIGAGISGLTAGKMLKDYGV
MAB_2607|M.abscessus_ATCC_1997 --MTGPS---------------------TAIIGAGISGLTSVKMLSDYGI
MLBr_00065|M.leprae_Br4923 MVVMAET-----------------EYLDVVIVGAGISGVSAAWHLQDRCP
..::*:*:**: * .
Mb0916|M.bovis_AF2122/97 T-DVCIYEKADDVGGTWRD-------NTYPGLTCDVPSRLYQYSFAKNPN
Rv0892|M.tuberculosis_H37Rv T-DVCIYEKADDVGGTWRD-------NTYPGLTCDVPSRLYQYSFAKNPN
MMAR_1644|M.marinum_M --DFVILEKSDDVGGTWRD-------NSYPGCACDIPSHLYSFSFEPKPD
MUL_1880|M.ulcerans_Agy99 --DFVILEKSDDVGGTWRD-------NSYPGCACDIPSHLYSFSFEPKPD
MAV_3915|M.avium_104 --GFVILEKADDIGGTWRD-------NSYPGCACDIPSHLYSFSFEPKPD
Mflv_4373|M.gilvum_PYR-GCK --DYTTFESSDRIGGNWAFGNPNGHSSAYRSLHIDTSKDRLSFKDFPMPE
Mvan_1971|M.vanbaalenii_PYR-1 --SYTTFETSDRIGGNWAFGNPNGHSSAYRSLHIDTSKDRLSFKDFPMPE
MSMEG_2202|M.smegmatis_MC2_155 --PYTTFETSDRIGGNWAFGNPNGHSSAYRSLHIDTSKHRLSFKDFPMPE
TH_0016|M.thermoresistible__bu --PYTTFELSDRIGGNWAFGNPNGHSSAYRSLHIDTSKHRLSFKDFPMPE
MAB_2607|M.abscessus_ATCC_1997 --PHTCFETSDRIGGNWAFGNPNGHSSAYRSLHIDTSRHQLSFRDFPMPD
MLBr_00065|M.leprae_Br4923 NKSYVILEKRAGMGGTWDL-------FRYPGIRSDSDMYTLGFRFRPWT-
* :**.* * . * : .
Mb0916|M.bovis_AF2122/97 WTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDDG--RWVLRT
Rv0892|M.tuberculosis_H37Rv WTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDDG--RWVLRT
MMAR_1644|M.marinum_M WRNPFSYQPEIWDYLKGVTEKYGLRRYVEFNSLVDRAYWDDEECRWHVFT
MUL_1880|M.ulcerans_Agy99 WRNPFSYQPEIWDYLKGVTEKYGLRRYVEFNSLVDRAYWDDEECRWHVFT
MAV_3915|M.avium_104 WKNPFSYQPEIWDYLKGVTEKYGLRRYIEFNSLVDRAHWDDDEHRWHVFT
Mflv_4373|M.gilvum_PYR-GCK HYPSFPHHAQIKAYLDDYADTFGLLDHIEFENGVVHAGRTDDG-GWIIRD
Mvan_1971|M.vanbaalenii_PYR-1 HYPSFPHHSQVKAYLDEYAEVFGLLEHIEFGNGVVHAAKDGSG-GWRILD
MSMEG_2202|M.smegmatis_MC2_155 HYPSFPHHTQIKEYLDAYADAFGLLDHIEFGNGVVHAERGAHG-GWVIED
TH_0016|M.thermoresistible__bu HYPAFPHHSEIKAYLDSYAEAFGLLDNIEFNNGVVHARLDDGG-GWLIED
MAB_2607|M.abscessus_ATCC_1997 SYPHFPHHTLIKQYLEDYARAFDLKRNIEFQNGIVHAEHRPGG-GWELLT
MLBr_00065|M.leprae_Br4923 KCQAIADGKPILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQV
:. : *: : ..: :.: : * * :
Mb0916|M.bovis_AF2122/97 DSGTES---TVDFLISATGVLHHPR--IPPIAGLDDFRGTVFHSARWDHT
Rv0892|M.tuberculosis_H37Rv DSGTES---TVDFLISATGVLHHPR--IPPIAGLDDFRGTVFHSARWDHT
MMAR_1644|M.marinum_M SDGREY---VAQFLISGAGALHIPS--LPEIEGREEFAGPAFHSAEWDHS
MUL_1880|M.ulcerans_Agy99 SDGREY---VAQFLISGAGALHIPS--SPEIEGREEFAGPAFHSAEWDHS
MAV_3915|M.avium_104 TDGREY---VAQFLISGAGALHIPS--LPDIEGRDEFAGPAFHSAEWDHT
Mflv_4373|M.gilvum_PYR-GCK QGGADR---HFDLLVVANGHHWDPR--LPEFPG--SFDGESIHSHAYIDP
Mvan_1971|M.vanbaalenii_PYR-1 QAGAQR---HFDLLVVANGHHWDPR--LPQFPG--SFAGESIHSHSYVDP
MSMEG_2202|M.smegmatis_MC2_155 QASARR---DFDLLVVANGHHWDPR--MPDFPG--EFTGEQIHSHHYIDP
TH_0016|M.thermoresistible__bu QSGATR---EFDLLVVGNGHHWDPR--YPDFPG--TFTGETIHSHHYIDP
MAB_2607|M.abscessus_ATCC_1997 QAGERR---LFDLLVVANGHHWDPR--YPDFPG--TFTGTALHSHHYIDP
MLBr_00065|M.leprae_Br4923 ENNGTPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPED
. .:*. * * : * * * :*. : .
Mb0916|M.bovis_AF2122/97 ---VPLLGRRIAVIGTGSTGVQLVCGLAGVAG--KVTMFQRTAQWVLPWP
Rv0892|M.tuberculosis_H37Rv ---VPLLGRRIAVIGTGSTGVQLVCGLAGVAG--KVTMFQRTAQWVLPWP
MMAR_1644|M.marinum_M ---VDLTGKRVAIIGTGASAIQIVPEIVEQVG--ELQLYQRTPPWVVPRS
MUL_1880|M.ulcerans_Agy99 ---VDLTGKRVAIIGAGASAIQIVPEIVEQVG--ELQLYQRTPPWVVPRS
MAV_3915|M.avium_104 ---VDLTGKRVAVIGTGASAIQIVPEIVGQVA--ELQLYQRTPPWVVPRS
Mflv_4373|M.gilvum_PYR-GCK ATPLELTGKRILVVGIGNSAADITVELSSKALRNQVTLSTRSSAWIVPKY
Mvan_1971|M.vanbaalenii_PYR-1 STPLDLSGKRILVVGIGNSAADITVELSSKALRNDVTLSTRSSAWIVPKY
MSMEG_2202|M.smegmatis_MC2_155 RTPLDLTGKRILVVGIGNSAADITVELSSRTLQNQVTLSTRSSAWIVPKY
TH_0016|M.thermoresistible__bu ATPLDLTGKRILVVGLGNSAADITVELSSRALRNKVTLSTRSSAWIVPKY
MAB_2607|M.abscessus_ATCC_1997 RTPLDLMDKRILVVGLGNSAADIAVELSSRATGNTVTLSTRSGAWIVPKY
MLBr_00065|M.leprae_Br4923 ---LDYAAKNIVVIGSGATAVTLVPALANSGAK-HVTMLQRSPTYIVSQP
: :.: ::* * :. :. : : : *: :::.
Mb0916|M.bovis_AF2122/97 NPRYSKLARVFHRAFPCLGSLAYKAYSLSFETFAVALSNPGLHRKLVGAV
Rv0892|M.tuberculosis_H37Rv NPRYSKLARVFHRAFPCLGSLAYKAYSLSFETFAVALSNPGLHRKLVGAV
MMAR_1644|M.marinum_M NPEIPPALRRAMENVPGLRALARLGIYWAQEALAFGMTKRPNVLKVGEAY
MUL_1880|M.ulcerans_Agy99 NPEIPPALRRAMENVPGLRALARLGIYWAQEALAFGMTKRPNVLKVGEAY
MAV_3915|M.avium_104 NPEIPPAVRAAMENVPGLRALVRLAIYWGQEALAFGMTKRPNLLKVIEAY
Mflv_4373|M.gilvum_PYR-GCK IAGRPGDT--------LFRTSPHLPLSWQRKAVQLIAPMLG---------
Mvan_1971|M.vanbaalenii_PYR-1 IAGRPGDT--------FWRTSPYLPLSWQRKAVQLVAPMLG---------
MSMEG_2202|M.smegmatis_MC2_155 LAGQPGDK--------FFRTTPYLPLSWQRKAVQMIAPMLG---------
TH_0016|M.thermoresistible__bu IAGQPGDK--------LWRTTPYLPLSWQRKAMQLVAPLLG---------
MAB_2607|M.abscessus_ATCC_1997 VAGQPADK--------YFRTSPHLPMSWQRKLFQMMQPLMS---------
MLBr_00065|M.leprae_Br4923 AKDKIAARLNRWLPDKYAYTAVRWKNILRQSALYGACQKWPQRMRN--IL
: . .
Mb0916|M.bovis_AF2122/97 CRASLRR-VRDPRLRRALTPDYEPMCKRLVMS--GGFYRAIQRDDVELVT
Rv0892|M.tuberculosis_H37Rv CRASLRR-VRDPRLRRALTPDYEPMCKRLVMS--GGFYRAIQRDDVELVT
MMAR_1644|M.marinum_M AKYNIRRSVKDRELRRKLTPHYRIGCKRILNS--SSYYPAVANPKTRLIT
MUL_1880|M.ulcerans_Agy99 AKYNIRRSVKDRELRRKLTPHYRIGCKRILNS--SSYYPAVANPKTRLIT
MAV_3915|M.avium_104 AKYNIRRSVKDKELRRKLTPHYRIGCKRILNS--STYYGAVADPKTELVT
Mflv_4373|M.gilvum_PYR-GCK ---------TDPTMYGLPPADHKLFEAHPTQS--VELPLRLGSGDVTPKP
Mvan_1971|M.vanbaalenii_PYR-1 ---------TDPTMYGLPPADHKLFEAHPTQS--VELPLRLGSGDVTPKP
MSMEG_2202|M.smegmatis_MC2_155 ---------TDPTAYGLPAPNHKLFEAHPTQS--VELPLRLGSGDVTPKP
TH_0016|M.thermoresistible__bu ---------TDPTMYGLPPANHKLFEAHPTQS--VELPLRLGSGDVIPKP
MAB_2607|M.abscessus_ATCC_1997 ---------GRPDQLGLPMPNHKFGEAHFTQS--VELPLRLGSGDIVPKP
MLBr_00065|M.leprae_Br4923 LGHVARRLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVT
..:. : : .
Mb0916|M.bovis_AF2122/97 AGIDHVEHRGIVTDDGVLHEVDVIVLATGFDSHAFFRPMQLTGRDGIRID
Rv0892|M.tuberculosis_H37Rv AGIDHVEHRGIVTDDGVLHEVDVIVLATGFDSHAFFRPMQLTGRDGIRID
MMAR_1644|M.marinum_M DRIARITRNGIVTADGVEHQADVIVYATGFHVTDSYTYVQIKGQHGEDLV
MUL_1880|M.ulcerans_Agy99 DRIARITRNGIVTADGVEHQADVIVYATGFHVTDSYTYVQIKGQHGEDLV
MAV_3915|M.avium_104 DHIARITPDGIVTADGTHRPVDVIVYATGFHVTDSYTYVQIKGLHGEDLV
Mflv_4373|M.gilvum_PYR-GCK N-VARLDGSTVHFVDGTHSDFDVIIYATGYNITFPFFDPDFVSAPDNAIR
Mvan_1971|M.vanbaalenii_PYR-1 N-VARLDGHTVHFVDGTSADFDVIIYATGYNITFPFFDPEFISAPDNSIR
MSMEG_2202|M.smegmatis_MC2_155 N-VARLSGDTVLFEDGTSDVFDVIIYATGYNITFPFFDRDFISAPDNQIR
TH_0016|M.thermoresistible__bu N-VSRLDGATVHFEDGTSDDFDAIIYATGYNITFPFFDPDFISAPDNHIR
MAB_2607|M.abscessus_ATCC_1997 D-ISRFDGHTVHFEDGTSTDVDVIIFATGYNITFPFFDPEFLSAPDNRID
MLBr_00065|M.leprae_Br4923 DAIDRFTSTGIRLKSGNELRADIIVTATGLNLQLFGGAVATVDGQPVDLA
: :. : .* * *: *** . . :
Mb0916|M.bovis_AF2122/97 DVWQ-DGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPLTAVAESQAEHIVQ
Rv0892|M.tuberculosis_H37Rv DVWQ-DGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPLTAVAESQAEHIVQ
MMAR_1644|M.marinum_M DRWNREGIGAHRGIAVADVPNLFFLLGPNTGLGHNSVVFMIESQIHYVAD
MUL_1880|M.ulcerans_Agy99 DRWNREGIGAHRGIAVADVPNLFFLLGPNTGLGHNSVVFMIESQIHYVAD
MAV_3915|M.avium_104 DRWNREGIGAHRGITVADVPNLFFLLGPNTGLGHNSVVFMIESQIRYVAD
Mflv_4373|M.gilvum_PYR-GCK ---------LYKRMFIPGIENLVFMG---FAQAVPTLFPFVESQSRLLAA
Mvan_1971|M.vanbaalenii_PYR-1 ---------LYKRMFKPGVDDLVFIG---FAQSVPTLFPFVECQSRLLAA
MSMEG_2202|M.smegmatis_MC2_155 ---------LYKRMFKPGIDDLVFIG---FAQAIPTLFPFVECQSRLLAA
TH_0016|M.thermoresistible__bu ---------LYKRMFKPGVENLVFIG---FAQAVPTLFPFVECQSRLMAA
MAB_2607|M.abscessus_ATCC_1997 ---------LYKRMFKPGLDDLIFVG---LAQAVPSLFPFVECQARLVGA
MLBr_00065|M.leprae_Br4923 QTMS------YKGMMLSGLPNMIYTVGYTNASWTLKADLVSEFFCRLLNY
:: : ... ::. . * . :
Mb0916|M.bovis_AF2122/97 WIKRWRHGEFDTMEPKSAATEAYNTVLRAAMPNTVWTTG-CDSWYLNKDG
Rv0892|M.tuberculosis_H37Rv WIKRWRHGEFDTMEPKSAATEAYNTVLRAAMPNTVWTTG-CDSWYLNKDG
MMAR_1644|M.marinum_M AIAKCDKRGAQALAPTRAAQDRFNEELQRRLAGSVWNSGGCSSWYLDEHG
MUL_1880|M.ulcerans_Agy99 AIAKCDKRGAQALAPTRAAQDRFNEELQRRLAGSVWNSGGCSSWYLDEHG
MAV_3915|M.avium_104 AIATCDKLGAQALAPTRAAQDRFNDELQRRLGPSVWNSGGCSSWYLDEHG
Mflv_4373|M.gilvum_PYR-GCK YAVGR-----YALPPVDEMERTIDADQQLHAG------------HCTDRP
Mvan_1971|M.vanbaalenii_PYR-1 YAVGR-----YALPSADEMERTIDADQQLHAG------------HCTDRP
MSMEG_2202|M.smegmatis_MC2_155 YAVGR-----YALPSTDEMERVIDADQRLHAG------------HCTDRP
TH_0016|M.thermoresistible__bu YAVGR-----YALPPVDEMERVIDADQQLHAG------------HCIDRP
MAB_2607|M.abscessus_ATCC_1997 YAAGK-----YRLPPVDEMRAVIEAEHRKYTG------------HMLDRP
MLBr_00065|M.leprae_Br4923 MNANDFDTVAVEYPGSDVEERPFMDFTPGYVLR-----------SLDALP
Mb0916|M.bovis_AF2122/97 -IPEVWPFAPAKHRAMLANLHPEEYDLRRYAAVRATSRPQSA-
Rv0892|M.tuberculosis_H37Rv -IPEVWPFAPAKHRAMLANLHPEEYDLRRYAAVRATSRPQSA-
MMAR_1644|M.marinum_M RNTVLWCGYTWQYWLATRSVKPEEYQFFKAGAKSSVNG-----
MUL_1880|M.ulcerans_Agy99 RNTVLWCGYTWQYWLATRSVKPEEYQFFKAGAKSSVNG-----
MAV_3915|M.avium_104 KNTVLWGGYTWEYWRATRAVKPEEYQFYGIGSRAGV-------
Mflv_4373|M.gilvum_PYR-GCK RHTQQVDYFVYEHDLRTRELPAGLKRAQRAVAVAR--------
Mvan_1971|M.vanbaalenii_PYR-1 RHTQQVDYFVYEHDLLKREIPAGRKRAQRVAAVAR--------
MSMEG_2202|M.smegmatis_MC2_155 RHTQQVDYFYYEHDIRAREMPAGAKRAERRAAGTRTAIVGSVA
TH_0016|M.thermoresistible__bu RHTQQVDYFYYEHDLRTRELPAGLKRAGHTAPRRTPVAL----
MAB_2607|M.abscessus_ATCC_1997 RHTQQLDYFLYEHDMRTKELPRGLARAGGVA------------
MLBr_00065|M.leprae_Br4923 KQGSRTPWRLNQNYLRDIRLIRRGKVADEGLLFAKKTTPVTV-
: :