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MTPALPRTAIIGAGISGLTAGKMLKDYRVPYTTFETSDRIGGNWAFGNPNGHSSAYRSLHIDTSKHRLSF KDFPMPEHYPSFPHHTQIKEYLDAYADAFGLLDHIEFGNGVVHAERGAHGGWVIEDQASARRDFDLLVVA NGHHWDPRMPDFPGEFTGEQIHSHHYIDPRTPLDLTGKRILVVGIGNSAADITVELSSRTLQNQVTLSTR SSAWIVPKYLAGQPGDKFFRTTPYLPLSWQRKAVQMIAPMLGTDPTAYGLPAPNHKLFEAHPTQSVELPL RLGSGDVTPKPNVARLSGDTVLFEDGTSDVFDVIIYATGYNITFPFFDRDFISAPDNQIRLYKRMFKPGI DDLVFIGFAQAIPTLFPFVECQSRLLAAYAVGRYALPSTDEMERVIDADQRLHAGHCTDRPRHTQQVDYF YYEHDIRAREMPAGAKRAERRAAGTRTAIVGSVA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2202 | - | - | 100% (454) | dimethylaniline monooxygenase |
| M. smegmatis MC2 155 | MSMEG_0816 | - | 3e-18 | 30.18% (222) | flavin-binding monooxygenase |
| M. smegmatis MC2 155 | MSMEG_2884 | - | 5e-18 | 30.60% (232) | cyclohexanone monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3075c | - | 9e-20 | 27.30% (370) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4373 | - | 0.0 | 82.99% (441) | flavin-containing monooxygenase |
| M. tuberculosis H37Rv | Rv3049c | - | 9e-20 | 27.30% (370) | monooxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 2e-09 | 22.69% (401) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2607 | - | 0.0 | 71.59% (433) | putative flavin-containing monooxygenase |
| M. marinum M | MMAR_1644 | - | 4e-20 | 24.52% (363) | monooxygenase |
| M. avium 104 | MAV_3915 | - | 1e-22 | 26.92% (364) | flavin-containing monooxygenase FMO |
| M. thermoresistible (build 8) | TH_0016 | - | 0.0 | 85.13% (437) | dimethylaniline monooxygenase |
| M. ulcerans Agy99 | MUL_1880 | - | 5e-20 | 24.52% (363) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_1971 | - | 0.0 | 83.90% (441) | dimethylaniline monooxygenase (N-oxide-forming) |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3075c|M.bovis_AF2122/97 ---MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGLGMAIALQK--QG
Rv3049c|M.tuberculosis_H37Rv ---MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGLGMAIALQK--QG
MMAR_1644|M.marinum_M MTDVVIPSTETTASGEPQAPTPPVKTRAVIIGTGFSGLGMAIALQK--QG
MUL_1880|M.ulcerans_Agy99 MTDVVIPSTETTASGEPQAPTPPVKTRAVIIGTGFSGLGMAIALQK--QG
MAV_3915|M.avium_104 MTDVVT-HTETAPTPAAKAAKP-VHTRAVIIGTGFSGLGMAIALQK--QG
Mflv_4373|M.gilvum_PYR-GCK --------------------MLQTPPYVAVIGAGISGLTAGKMLKD--YG
Mvan_1971|M.vanbaalenii_PYR-1 --------------------MDQTHPRVAVIGAGISGLTAGKMLKD--YG
TH_0016|M.thermoresistible__bu --------------------VKRRYPRTAVIGAGISGLTAGKMLKD--YG
MSMEG_2202|M.smegmatis_MC2_155 --------------------MTPALPRTAIIGAGISGLTAGKMLKD--YR
MAB_2607|M.abscessus_ATCC_1997 ----------------------MTGPSTAIIGAGISGLTSVKMLSD--YG
MLBr_00065|M.leprae_Br4923 ----------------MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPN
..::*:*:**: *..
Mb3075c|M.bovis_AF2122/97 VDFVILEKADDVGGTWRD-------NTYPGCACDIPSHLYSFSFEPKADW
Rv3049c|M.tuberculosis_H37Rv VDFVILEKADDVGGTWRD-------NTYPGCACDIPSHLYSFSFEPKADW
MMAR_1644|M.marinum_M VDFVILEKSDDVGGTWRD-------NSYPGCACDIPSHLYSFSFEPKPDW
MUL_1880|M.ulcerans_Agy99 VDFVILEKSDDVGGTWRD-------NSYPGCACDIPSHLYSFSFEPKPDW
MAV_3915|M.avium_104 VGFVILEKADDIGGTWRD-------NSYPGCACDIPSHLYSFSFEPKPDW
Mflv_4373|M.gilvum_PYR-GCK IDYTTFESSDRIGGNWAFGNPNGHSSAYRSLHIDTSKDRLSFKDFPMPEH
Mvan_1971|M.vanbaalenii_PYR-1 VSYTTFETSDRIGGNWAFGNPNGHSSAYRSLHIDTSKDRLSFKDFPMPEH
TH_0016|M.thermoresistible__bu VPYTTFELSDRIGGNWAFGNPNGHSSAYRSLHIDTSKHRLSFKDFPMPEH
MSMEG_2202|M.smegmatis_MC2_155 VPYTTFETSDRIGGNWAFGNPNGHSSAYRSLHIDTSKHRLSFKDFPMPEH
MAB_2607|M.abscessus_ATCC_1997 IPHTCFETSDRIGGNWAFGNPNGHSSAYRSLHIDTSRHQLSFRDFPMPDS
MLBr_00065|M.leprae_Br4923 KSYVILEKRAGMGGTWDLFR-------YPGIRSDSDMYTLGFRFRPWT-K
.. :* :**.* * . * .* * .
Mb3075c|M.bovis_AF2122/97 KHLFSYWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFTA
Rv3049c|M.tuberculosis_H37Rv KHLFSYWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFTA
MMAR_1644|M.marinum_M RNPFSYQPEIWDYLKGVTEKYGLRRYVEFNSLVDRAYWDDEECRWHVFTS
MUL_1880|M.ulcerans_Agy99 RNPFSYQPEIWDYLKGVTEKYGLRRYVEFNSLVDRAYWDDEECRWHVFTS
MAV_3915|M.avium_104 KNPFSYQPEIWDYLKGVTEKYGLRRYIEFNSLVDRAHWDDDEHRWHVFTT
Mflv_4373|M.gilvum_PYR-GCK YPSFPHHAQIKAYLDDYADTFGLLDHIEFENGVVHAGRTDD-GGWIIRDQ
Mvan_1971|M.vanbaalenii_PYR-1 YPSFPHHSQVKAYLDEYAEVFGLLEHIEFGNGVVHAAKDGS-GGWRILDQ
TH_0016|M.thermoresistible__bu YPAFPHHSEIKAYLDSYAEAFGLLDNIEFNNGVVHARLDDG-GGWLIEDQ
MSMEG_2202|M.smegmatis_MC2_155 YPSFPHHTQIKEYLDAYADAFGLLDHIEFGNGVVHAERGAH-GGWVIEDQ
MAB_2607|M.abscessus_ATCC_1997 YPHFPHHTLIKQYLEDYARAFDLKRNIEFQNGIVHAEHRPG-GGWELLTQ
MLBr_00065|M.leprae_Br4923 CQAIADGKPILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVE
:. : *:. : ..: :.: : . * :
Mb3075c|M.bovis_AF2122/97 DG---REYVAQFLISGAGALHIPS--FPEIAGRDEFAGPAFHSAQWDHS-
Rv3049c|M.tuberculosis_H37Rv DG---REYVAQFLISGAGALHIPS--FPEIAGRDEFAGPAFHSAQWDHS-
MMAR_1644|M.marinum_M DG---REYVAQFLISGAGALHIPS--LPEIEGREEFAGPAFHSAEWDHS-
MUL_1880|M.ulcerans_Agy99 DG---REYVAQFLISGAGALHIPS--SPEIEGREEFAGPAFHSAEWDHS-
MAV_3915|M.avium_104 DG---REYVAQFLISGAGALHIPS--LPDIEGRDEFAGPAFHSAEWDHT-
Mflv_4373|M.gilvum_PYR-GCK GG---ADRHFDLLVVANGHHWDPR--LPEFPG--SFDGESIHSHAYIDPA
Mvan_1971|M.vanbaalenii_PYR-1 AG---AQRHFDLLVVANGHHWDPR--LPQFPG--SFAGESIHSHSYVDPS
TH_0016|M.thermoresistible__bu SG---ATREFDLLVVGNGHHWDPR--YPDFPG--TFTGETIHSHHYIDPA
MSMEG_2202|M.smegmatis_MC2_155 AS---ARRDFDLLVVANGHHWDPR--MPDFPG--EFTGEQIHSHHYIDPR
MAB_2607|M.abscessus_ATCC_1997 AG---ERRLFDLLVVANGHHWDPR--YPDFPG--TFTGTALHSHHYIDPR
MLBr_00065|M.leprae_Br4923 NNGTPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPED-
. .:*. * * : * * * :*. : .
Mb3075c|M.bovis_AF2122/97 --IDLTGKRVAIVGTGASAIQIVPEIVGQVA--ELQLYQRTPPWVVPRTN
Rv3049c|M.tuberculosis_H37Rv --IDLTGKRVAIVGTGASAIQIVPEIVGQVA--ELQLYQRTPPWVVPRTN
MMAR_1644|M.marinum_M --VDLTGKRVAIIGTGASAIQIVPEIVEQVG--ELQLYQRTPPWVVPRSN
MUL_1880|M.ulcerans_Agy99 --VDLTGKRVAIIGAGASAIQIVPEIVEQVG--ELQLYQRTPPWVVPRSN
MAV_3915|M.avium_104 --VDLTGKRVAVIGTGASAIQIVPEIVGQVA--ELQLYQRTPPWVVPRSN
Mflv_4373|M.gilvum_PYR-GCK TPLELTGKRILVVGIGNSAADITVELSSKALRNQVTLSTRSSAWIVPKYI
Mvan_1971|M.vanbaalenii_PYR-1 TPLDLSGKRILVVGIGNSAADITVELSSKALRNDVTLSTRSSAWIVPKYI
TH_0016|M.thermoresistible__bu TPLDLTGKRILVVGLGNSAADITVELSSRALRNKVTLSTRSSAWIVPKYI
MSMEG_2202|M.smegmatis_MC2_155 TPLDLTGKRILVVGIGNSAADITVELSSRTLQNQVTLSTRSSAWIVPKYL
MAB_2607|M.abscessus_ATCC_1997 TPLDLMDKRILVVGLGNSAADIAVELSSRATGNTVTLSTRSGAWIVPKYV
MLBr_00065|M.leprae_Br4923 --LDYAAKNIVVIGSGATAVTLVPALANSGAK-HVTMLQRSPTYIVSQPA
:: *.: ::* * :* :. : : : *: .::*.:
Mb3075c|M.bovis_AF2122/97 EELPVSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYA
Rv3049c|M.tuberculosis_H37Rv EELPVSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYA
MMAR_1644|M.marinum_M PEIPPALRRAMENVPGLRALARLGIYWAQEALAFGMTKRPNVLKVGEAYA
MUL_1880|M.ulcerans_Agy99 PEIPPALRRAMENVPGLRALARLGIYWAQEALAFGMTKRPNVLKVGEAYA
MAV_3915|M.avium_104 PEIPPAVRAAMENVPGLRALVRLAIYWGQEALAFGMTKRPNLLKVIEAYA
Mflv_4373|M.gilvum_PYR-GCK AGRPGDT--------LFRTSPHLPLSWQRKAVQL---IAPMLGTDPTMYG
Mvan_1971|M.vanbaalenii_PYR-1 AGRPGDT--------FWRTSPYLPLSWQRKAVQL---VAPMLGTDPTMYG
TH_0016|M.thermoresistible__bu AGQPGDK--------LWRTTPYLPLSWQRKAMQL---VAPLLGTDPTMYG
MSMEG_2202|M.smegmatis_MC2_155 AGQPGDK--------FFRTTPYLPLSWQRKAVQM---IAPMLGTDPTAYG
MAB_2607|M.abscessus_ATCC_1997 AGQPADK--------YFRTSPHLPMSWQRKLFQM---MQPLMSGRPDQLG
MLBr_00065|M.leprae_Br4923 KDKIAARLNRWLPDKYAYTAVRWKNILRQSALYGACQKWPQRMRNILLGH
: :. . *
Mb3075c|M.bovis_AF2122/97 KYNIRRSVKDRELRRKLTPRYRIGCKRILNSSTYYPAVADPKTELITDRI
Rv3049c|M.tuberculosis_H37Rv KYNIRRSVKDRELRRKLTPRYRIGCKRILNSSTYYPAVADPKTELITDRI
MMAR_1644|M.marinum_M KYNIRRSVKDRELRRKLTPHYRIGCKRILNSSSYYPAVANPKTRLITDRI
MUL_1880|M.ulcerans_Agy99 KYNIRRSVKDRELRRKLTPHYRIGCKRILNSSSYYPAVANPKTRLITDRI
MAV_3915|M.avium_104 KYNIRRSVKDKELRRKLTPHYRIGCKRILNSSTYYGAVADPKTELVTDHI
Mflv_4373|M.gilvum_PYR-GCK LPPADHKLFEAHPTQSVELPLRLGSGDVTPKP----------------NV
Mvan_1971|M.vanbaalenii_PYR-1 LPPADHKLFEAHPTQSVELPLRLGSGDVTPKP----------------NV
TH_0016|M.thermoresistible__bu LPPANHKLFEAHPTQSVELPLRLGSGDVIPKP----------------NV
MSMEG_2202|M.smegmatis_MC2_155 LPAPNHKLFEAHPTQSVELPLRLGSGDVTPKP----------------NV
MAB_2607|M.abscessus_ATCC_1997 LPMPNHKFGEAHFTQSVELPLRLGSGDIVPKP----------------DI
MLBr_00065|M.leprae_Br4923 VARRLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAI
. : . : . :
Mb3075c|M.bovis_AF2122/97 DRITHDGIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDL
Rv3049c|M.tuberculosis_H37Rv DRITHDGIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDL
MMAR_1644|M.marinum_M ARITRNGIVTADG----VEHQADVIVYATGFHVTDSYTYVQIKGQHGEDL
MUL_1880|M.ulcerans_Agy99 ARITRNGIVTADG----VEHQADVIVYATGFHVTDSYTYVQIKGQHGEDL
MAV_3915|M.avium_104 ARITPDGIVTADG----THRPVDVIVYATGFHVTDSYTYVQIKGLHGEDL
Mflv_4373|M.gilvum_PYR-GCK ARLDGSTVHFVDG----THSDFDVIIYATGYNITFPFFDPDFVSAP----
Mvan_1971|M.vanbaalenii_PYR-1 ARLDGHTVHFVDG----TSADFDVIIYATGYNITFPFFDPEFISAP----
TH_0016|M.thermoresistible__bu SRLDGATVHFEDG----TSDDFDAIIYATGYNITFPFFDPDFISAP----
MSMEG_2202|M.smegmatis_MC2_155 ARLSGDTVLFEDG----TSDVFDVIIYATGYNITFPFFDRDFISAP----
MAB_2607|M.abscessus_ATCC_1997 SRFDGHTVHFEDG----TSTDVDVIIFATGYNITFPFFDPEFLSAP----
MLBr_00065|M.leprae_Br4923 DRFTSTGIRLKSG----NELRADIIVTATGLNLQLFGGAVATVDGQ----
*: : .* * *: *** :: .
Mb3075c|M.bovis_AF2122/97 VDRWNREGIGAHRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVA
Rv3049c|M.tuberculosis_H37Rv VDRWNREGIGAHRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVA
MMAR_1644|M.marinum_M VDRWNREGIGAHRGIAVADVPNLFFLLGPNTGLGHNSVVFMIESQIHYVA
MUL_1880|M.ulcerans_Agy99 VDRWNREGIGAHRGIAVADVPNLFFLLGPNTGLGHNSVVFMIESQIHYVA
MAV_3915|M.avium_104 VDRWNREGIGAHRGITVADVPNLFFLLGPNTGLGHNSVVFMIESQIRYVA
Mflv_4373|M.gilvum_PYR-GCK -----DNAIRLYKRMFIPGIENLVFMG---FAQAVPTLFPFVESQSR---
Mvan_1971|M.vanbaalenii_PYR-1 -----DNSIRLYKRMFKPGVDDLVFIG---FAQSVPTLFPFVECQSR---
TH_0016|M.thermoresistible__bu -----DNHIRLYKRMFKPGVENLVFIG---FAQAVPTLFPFVECQSR---
MSMEG_2202|M.smegmatis_MC2_155 -----DNQIRLYKRMFKPGIDDLVFIG---FAQAIPTLFPFVECQSR---
MAB_2607|M.abscessus_ATCC_1997 -----DNRIDLYKRMFKPGLDDLIFVG---LAQAVPSLFPFVECQAR---
MLBr_00065|M.leprae_Br4923 --PVDLAQTMSYKGMMLSGLPNMIYTVGYTNASWTLKADLVSEFFCRLLN
:: : ..: ::.: . . . * :
Mb3075c|M.bovis_AF2122/97 DAIAKCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEH
Rv3049c|M.tuberculosis_H37Rv DAIAKCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEH
MMAR_1644|M.marinum_M DAIAKCDKRGAQALAPTRAAQDRFNEELQRRLAGSVWNSGGCSSWYLDEH
MUL_1880|M.ulcerans_Agy99 DAIAKCDKRGAQALAPTRAAQDRFNEELQRRLAGSVWNSGGCSSWYLDEH
MAV_3915|M.avium_104 DAIATCDKLGAQALAPTRAAQDRFNDELQRRLGPSVWNSGGCSSWYLDEH
Mflv_4373|M.gilvum_PYR-GCK --LLAAYAVGRYALPPVDEMERTIDADQQLHAG------------HCTDR
Mvan_1971|M.vanbaalenii_PYR-1 --LLAAYAVGRYALPSADEMERTIDADQQLHAG------------HCTDR
TH_0016|M.thermoresistible__bu --LMAAYAVGRYALPPVDEMERVIDADQQLHAG------------HCIDR
MSMEG_2202|M.smegmatis_MC2_155 --LLAAYAVGRYALPSTDEMERVIDADQRLHAG------------HCTDR
MAB_2607|M.abscessus_ATCC_1997 --LVGAYAAGKYRLPPVDEMRAVIEAEHRKYTG------------HMLDR
MLBr_00065|M.leprae_Br4923 YMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLR-----------SLDAL
. . :
Mb3075c|M.bovis_AF2122/97 GKNTVLWCGYTWQYWLTTRSVNP-----AEYRFF---GIGNGLSSDRATV
Rv3049c|M.tuberculosis_H37Rv GKNTVLWCGYTWQYWLTTRSVNP-----AEYRFF---GIGNGLSSDRATV
MMAR_1644|M.marinum_M GRNTVLWCGYTWQYWLATRSVKP-----EEYQFF---KAG-----AKSSV
MUL_1880|M.ulcerans_Agy99 GRNTVLWCGYTWQYWLATRSVKP-----EEYQFF---KAG-----AKSSV
MAV_3915|M.avium_104 GKNTVLWGGYTWEYWRATRAVKP-----EEYQFY---GIG-----SRAGV
Mflv_4373|M.gilvum_PYR-GCK PRHTQQVDYFVYEHDLRTRELPA-----GLKRA-----------QRAVAV
Mvan_1971|M.vanbaalenii_PYR-1 PRHTQQVDYFVYEHDLLKREIPA-----GRKRA-----------QRVAAV
TH_0016|M.thermoresistible__bu PRHTQQVDYFYYEHDLRTRELPA-----GLKRAGH-------TAPRRTPV
MSMEG_2202|M.smegmatis_MC2_155 PRHTQQVDYFYYEHDIRAREMPA-----GAKRAERRA-----AGTRTAIV
MAB_2607|M.abscessus_ATCC_1997 PRHTQQLDYFLYEHDMRTKELPR-----GLARAG--------------GV
MLBr_00065|M.leprae_Br4923 PKQGSRTPWRLNQNYLRDIRLIRRGKVADEG---------LLFAKKTTPV
:: : : *
Mb3075c|M.bovis_AF2122/97 AAAN
Rv3049c|M.tuberculosis_H37Rv AAAN
MMAR_1644|M.marinum_M NG--
MUL_1880|M.ulcerans_Agy99 NG--
MAV_3915|M.avium_104 ----
Mflv_4373|M.gilvum_PYR-GCK AR--
Mvan_1971|M.vanbaalenii_PYR-1 AR--
TH_0016|M.thermoresistible__bu AL--
MSMEG_2202|M.smegmatis_MC2_155 GSVA
MAB_2607|M.abscessus_ATCC_1997 A---
MLBr_00065|M.leprae_Br4923 TV--