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TNPWNDPNMLDDGAIGRGDPSVRHHFRDSVSDTMRITDLAAPRKIPPGTGWRKFVYSVSFHKINPGESPR ERHYRNLQGRIRRHIRRQYVITVVSGKGGVGVTTMAACIGGVFRECRPENVIAIDAVPSFGTLADRIDES PPGDYAAIINDTDVQGYADIREHLGQNTVGLDVLAGNRTSDQPRPLVPAMFSAVLSRLRRTHTVIVIDTS PDLEHDVMKAVLQSTDTLVFVSGITADRSRPVLRAVDYLRAQGYHELVSRSTVILNHTDSITDKDALAYL TERFTKVGAIVEAMPFDPHLAKGGIIDTVHELNKKSRLRLFEITAGLADKYVPDAERAAQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3888c | - | - | 100% (341) | PROBABLE CONSERVED MEMBRANE PROTEIN |
| M. tuberculosis H37Rv | Rv3860 | - | 3e-45 | 35.21% (284) | hypothetical protein Rv3860 |
| M. tuberculosis H37Rv | Rv0530 | - | 7e-43 | 32.78% (302) | hypothetical protein Rv0530 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3890 | - | 2e-45 | 35.21% (284) | hypothetical protein Mb3890 |
| M. gilvum PYR-GCK | Mflv_0776 | - | 4e-51 | 36.33% (311) | hypothetical protein Mflv_0776 |
| M. leprae Br4923 | MLBr_00048 | - | 1e-38 | 33.01% (312) | hypothetical protein MLBr_00048 |
| M. abscessus ATCC 19977 | MAB_0630 | - | 3e-42 | 34.74% (285) | hypothetical protein MAB_0630 |
| M. marinum M | MMAR_0876 | - | 4e-45 | 32.36% (343) | hypothetical protein MMAR_0876 |
| M. avium 104 | MAV_0156 | - | 1e-164 | 90.82% (305) | hypothetical protein MAV_0156 |
| M. smegmatis MC2 155 | MSMEG_0053 | - | 1e-53 | 37.17% (304) | hypothetical protein MSMEG_0053 |
| M. thermoresistible (build 8) | TH_0884 | - | 8e-42 | 31.46% (302) | conserved hypothetical protein |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0069 | - | 2e-54 | 38.87% (301) | hypothetical protein Mvan_0069 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0876|M.marinum_M --------------------------------------------------
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_0630|M.abscessus_ATCC_1997 MADTNDNAPDSPPPSGPWREPIADGLGGGDTKGSPFRRSKNSNQEFVPPS
MLBr_00048|M.leprae_Br4923 ---------------------------MAADYDKLFRLDDGAYASPDQAA
Rv3888c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0156|M.avium_104 --------------------------------------------------
Mflv_0776|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0069|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0053|M.smegmatis_MC2_155 --------------------------------------------------
Mb3890|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0876|M.marinum_M --------------------------------------------------
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_0630|M.abscessus_ATCC_1997 ADYFPQPTLKPPPPLPKAPKLSRRQRNHQRPMNPIWEPDPLSAYGMPQQQ
MLBr_00048|M.leprae_Br4923 EQLFDDAPLYPPPIIPTCTTTPNGEVASP----------------MPDWS
Rv3888c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0156|M.avium_104 --------------------------------------------------
Mflv_0776|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0069|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0053|M.smegmatis_MC2_155 --------------------------------------------------
Mb3890|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0876|M.marinum_M --------------------------------------------------
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_0630|M.abscessus_ATCC_1997 NQAPPAPPQGYGAPVQQPPQNYQPPPQNYYAPPQNYYGPPTDQPATPVAP
MLBr_00048|M.leprae_Br4923 EQLPPNPPAASKSPLPPMPIGSSVQPPPASSESPRAPMPVSAPPRSPAAS
Rv3888c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0156|M.avium_104 --------------------------------------------------
Mflv_0776|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0069|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0053|M.smegmatis_MC2_155 --------------------------------------------------
Mb3890|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0876|M.marinum_M ---------------------------------MDVSDHPSAGVGASNAY
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_0630|M.abscessus_ATCC_1997 AEPAAPAVPPPAPATQLPAWPASAVVPEQPAPEAPAPARPAEQSPAPEGL
MLBr_00048|M.leprae_Br4923 LMPIS----EPPQWPPAEAPEHQFAKAEPPSVPIPINEPSPAKPATPMPM
Rv3888c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0156|M.avium_104 --------------------------------------------------
Mflv_0776|M.gilvum_PYR-GCK -------------------------MTDRE-----------------EPQ
Mvan_0069|M.vanbaalenii_PYR-1 ------------------------MVNDRD-----------------DPA
MSMEG_0053|M.smegmatis_MC2_155 -------------------------MADPDDTLRRELGWTGPEEDDFEPD
Mb3890|M.bovis_AF2122/97 -------------------------MYERD--------------------
MMAR_0876|M.marinum_M QGEGGKDHPTIQLPPVPHQPPQLGEPPVAGGSDAPTRAFAGFRTERRSAA
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_0630|M.abscessus_ATCC_1997 DEAAQEQTPVEVPPPAPPAPVAPDPAPQVRADDASAMIPEGLTPWGGRAP
MLBr_00048|M.leprae_Br4923 TPIDGSQRTPVTSPEPSLAEFEAQPPATPKPSLLPRPMSSPPEAPRPSAN
Rv3888c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0156|M.avium_104 --------------------------------------------------
Mflv_0776|M.gilvum_PYR-GCK ---------------------------------------RHDQERPGGMF
Mvan_0069|M.vanbaalenii_PYR-1 T---------------------------------DQAAVTPEPPRPREMF
MSMEG_0053|M.smegmatis_MC2_155 TGPTRPTLRPEPPSIPGRPPVSPTPPNPVNPDAEDRVPADPDAERARTTF
Mb3890|M.bovis_AF2122/97 -----------------------------------------EFLRDRIRP
MMAR_0876|M.marinum_M RAEGAEAPDVAQWESGPDTGPVAGLP-----RVDPTAYGAYYNGPPEP--
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_0630|M.abscessus_ATCC_1997 QMPSAPTSPAPSWAPPPAGPPLAPAPPAAFSRADWSAPAAPPRAPYVPGQ
MLBr_00048|M.leprae_Br4923 QHSRHARRGHHHRDETQQANPASATEPMIAPRARTAELRQAPHAAAEPAP
Rv3888c|M.tuberculosis_H37Rv ------------------------------------------MTNPWNDP
MAV_0156|M.avium_104 --------------------------------------------------
Mflv_0776|M.gilvum_PYR-GCK RQPTQ--PPQDWT------PPTRPVPAPP------PGY-PPR--PPWPDR
Mvan_0069|M.vanbaalenii_PYR-1 RQPTRPLPPQPRR------PDGWEQQQPP------PGW-APQ--APPSAP
MSMEG_0053|M.smegmatis_MC2_155 REPTQPSPPQQPSQPPPPPPPSALHPRPDPWEQRVPGWNAPQYGPPPGNQ
Mb3890|M.bovis_AF2122/97 HQPGTPRGYSPRP------PSGDRCPAPP------PGRHAAA-ATPPGPP
MMAR_0876|M.marinum_M -------PAEPQYRPESVPQTPY----PELSTSMLLR-PVKSPPT-EGWR
TH_0884|M.thermoresistible__bu ---------------------------VDLSTTALLG-QRRPAPS-RGWR
MAB_0630|M.abscessus_ATCC_1997 TPFTAARPEAPVYRPVPQPQQPSRPQGPSHDQLGLIR-SVKPLPK-SGWR
MLBr_00048|M.leprae_Br4923 TQHLTRPDGLVSHRTALHDSTATSAIGVQTGRSTGAKKPSKVVAK-RGWR
Rv3888c|M.tuberculosis_H37Rv NMLDDG---AIGRGDPSVRHHFRDSVSDTMRITDLAAPR-KIPPG-TGWR
MAV_0156|M.avium_104 -----------------------------MRITDLAAPR-KIPPG-SGWR
Mflv_0776|M.gilvum_PYR-GCK PYP--------QADHP-VPPQP-STYTERIRPADLVPSR-KPVPG-HGWR
Mvan_0069|M.vanbaalenii_PYR-1 PYPPRP-----QADAPWTAPQP-TSYAEWIRPADLVPHR-KVVPG-SGWR
MSMEG_0053|M.smegmatis_MC2_155 PWPQAGGFGGGPGQPPHVPPGPPQSYADRIRASDLVPPK-RQPPS-GGWR
Mb3890|M.bovis_AF2122/97 RLPSAP---LRPLPDPAWPRQPEAPPPSTWADPALAPIRSRTRPGERGWR
: . ***
MMAR_0876|M.marinum_M RLVYVLSGQLINLGESPRATRYNNLVAQINRPMRGCYRIALVSLKGGVGK
TH_0884|M.thermoresistible__bu RWLYRATFRTVNLGESPKVARHNELLNRVRHPLQDCYRIAVLSLKGGVGK
MAB_0630|M.abscessus_ATCC_1997 KAVHRLSGGAINPGESSEESHRSELIDRINLPVRGDYRIAVLSLKGGVGK
MLBr_00048|M.leprae_Br4923 HWVHTVTR--INLGLSPDERYELDLRTRVRRPPRGSYQIGILGLKGGAGK
Rv3888c|M.tuberculosis_H37Rv KFVYSVSFHKINPGESPRERHYRNLQGRIRRHIRRQYVITVVSGKGGVGV
MAV_0156|M.avium_104 KFIYTISFHKINPGESPRERHYRDLQNRIRRHIRRQYVITVVSGKGGVGV
Mflv_0776|M.gilvum_PYR-GCK LALLKATFGLVNVGPSPDERRAAALETAIRAPLRGHFKVGVMG-KGGVGK
Mvan_0069|M.vanbaalenii_PYR-1 LALYKASFGLINLGPSPEDKRVAELEATIRTPLRGRFKIGVMG-KGGVGK
MSMEG_0053|M.smegmatis_MC2_155 LLVYRATFGLVNPGPSAEELRQAELEAKIRGVLRGHYKIGVMG-KGGVGK
Mb3890|M.bovis_AF2122/97 RMVRLVTFGLVGLGRSGMQRQEAQFEATIRTVLHGNHKVAVLG-KGGVGK
: : :. * * : :. : . : ::. ***.*
MMAR_0876|M.marinum_M TTITATLGSTFASVRGDR-VVAVDANPDRGTLSQKVPLETPATVRHLIRD
TH_0884|M.thermoresistible__bu TTITATLGSTFGSARGDR-VVAVDANPDRGTLSQKVPLQTRATVRDLLRD
MAB_0630|M.abscessus_ATCC_1997 TTTTFSLGATFASLRGDR-VIAVDANPDFGTLAQRGPDETRSTARDLLRD
MLBr_00048|M.leprae_Br4923 TTVTVTLGSMFARVRNDR-ILVVDADTSCGNLADRAGRFSEANIADLLAD
Rv3888c|M.tuberculosis_H37Rv TTMAACIGGVFRECRPEN-VIAIDAVPSFGTLADRIDESPPGDYAAIIND
MAV_0156|M.avium_104 TTLVACIGGVFRECRPQN-VIAIDAVPGFGTLADRIDESPPGDYTAIIND
Mflv_0776|M.gilvum_PYR-GCK TTVSACIGSLFAELRHEDRVVAVDADTAFGKLGSRVDPRARRSFWELTAD
Mvan_0069|M.vanbaalenii_PYR-1 TTVSASIGSVLAEIRQDDRVVAVDADTAFGKLGSRVDPRAQGSFWELAAD
MSMEG_0053|M.smegmatis_MC2_155 TTVSATIGSIFAHLRQDDRVVAIDADTSFGKLGSRVDPRAHGSYWELTSD
Mb3890|M.bovis_AF2122/97 TSVAACVGSILAELRQQDRIVGIDADTAFGRLSSRIDPRAAGSFWELTTD
*: :*. : * : :: :** . * *..: . : *
MMAR_0876|M.marinum_M AEGIERYSDVRGYTSQAKNGFEVLASDTDPAASEAFSADDYTRTLDILER
TH_0884|M.thermoresistible__bu ADRIQTYSDMRAYTSQSPSRLEVLASESDPAVSEAFSSDDYTRTLRVLER
MAB_0630|M.abscessus_ATCC_1997 PD-IHRYSDVRRHTSQSASRLEVLASERDPAASELFSEADYLAVMRILQR
MLBr_00048|M.leprae_Br4923 KD-VKSYNDIRTHTSVNAVNLEVLPAAEYSTAQHALSGEDWNFAAATVSK
Rv3888c|M.tuberculosis_H37Rv TD-VQGYADIREHLGQNTVGLDVLAGNRTSDQPRPLVPAMFSAVLSRLRR
MAV_0156|M.avium_104 TD-VQGYADIREHLGQNAVGLDVLAGNRTSDQPRPLVPAMFSGVLSRLRR
Mflv_0776|M.gilvum_PYR-GCK QY-LETFADIRNHLGSNAAGLFVLAGEASPARRRVLDAAIYREAMARLDR
Mvan_0069|M.vanbaalenii_PYR-1 RH-LEAFADIRNHLGCNAAGLFVLAGEATPARRRVLDPAIYREATTRLDR
MSMEG_0053|M.smegmatis_MC2_155 KN-LETFADVRSRVGNNSAGLFVLAGESTPARRRVLDAAIYREAVTRLDK
Mb3890|M.bovis_AF2122/97 TN-LRSFTDITARLGRNSAGLYVLAGQPASGPRRALDPAIYREAALRLDH
:. : *: . : **.. . . : : . : :
MMAR_0876|M.marinum_M FYGLVLTDCGTGLLHSAMSAILAKSDILIVVSSGSIDGARSASATLDWLE
TH_0884|M.thermoresistible__bu FYSLVLTDCGTGLIHSAMSAVLANADVLIVISSGSVDGARSAAATLDWLD
MAB_0630|M.abscessus_ATCC_1997 FYNIILTDCGTGLMHSAMAGVLGEANAIVLVTSPAIDGARSALATLDWLD
MLBr_00048|M.leprae_Br4923 YYNVMLADCGVGLFDPVTRGVLSTASGVVIVTSTSVDAARQAAIALDWLR
Rv3888c|M.tuberculosis_H37Rv THTVIVIDTSPDLEHDVMKAVLQSTDTLVFVSGITADRSRPVLRAVDYLR
MAV_0156|M.avium_104 THTVMIVDTSPDLEHEVMKPVLENTDTLVFVSGITADRSRPVLRAVDYLR
Mflv_0776|M.gilvum_PYR-GCK HFTITVVDCSSTMDSPVTEEVLRDLDALVVVSSPWVDGAAAAGQTLDWLA
Mvan_0069|M.vanbaalenii_PYR-1 HFTISVIDCSSTMDSPVTQEVLRDLDALVVVSSPWVDGAAAAGQTLDWLA
MSMEG_0053|M.smegmatis_MC2_155 HFSISVVDCSSTMDSPVTQEVLRDLDALIVVSSPWVDGAATAGQTLDWLS
Mb3890|M.bovis_AF2122/97 HFAISVIDCGSSMEAAVTQEVLRDVDALIVVSSPWADGASAAANTIEWLS
. : : * . : . :* . ::.::. * : . ::::*
MMAR_0876|M.marinum_M AHGYEELVRNSIAVINAVRPRSSKVDMQKVIDHFARRCR--AVRLVPFDP
TH_0884|M.thermoresistible__bu AHGHQDMVRNSIAVINAVRPRSGKVDLQKVVDHFSRRCR--AVKMVPFDP
MAB_0630|M.abscessus_ATCC_1997 HHGYSHLVRQSVVAISSSRPGASSIDLEQLSRHFLTRAR--AVHIIPFDN
MLBr_00048|M.leprae_Br4923 HNGYQDLLSRACVVINHVMPKEPNIASKDLVQQFEQQIQPGRVVVLPWDK
Rv3888c|M.tuberculosis_H37Rv AQGYHELVSRSTVILNHTDSITDKDALAYLTERFTKVGA--IVEAMPFDP
MAV_0156|M.avium_104 SQGYHELVSRSTVIVNHTDQITDKDALAYLTERFTKVGA--TVEALPFDP
Mflv_0776|M.gilvum_PYR-GCK ARGMTTLLQHTVVVLNDSDGHADKRTRKVLAQQFSGHGQ--LVVEVPFDG
Mvan_0069|M.vanbaalenii_PYR-1 ARGLTDLLQRTVVVLNDSDGHADKRTRGILAQQFSGHGQ--LVIEVPFDG
MSMEG_0053|M.smegmatis_MC2_155 ANGMTRLLQRTVVVLNDSDGHADKRTRSILLNQFAGQGQ--AVVEIPFDG
Mb3890|M.bovis_AF2122/97 DYGLTGLLRRSIVVLNDSDGHADKRTKSLLAQEFIDHGQ--PVVEVPFDP
* :: .: . :. . : .* * :*:*
MMAR_0876|M.marinum_M HLEEGAEIV-LDRMKRETREALAELAAVVAEGFGPDQRRSSPSFG-
TH_0884|M.thermoresistible__bu HLEEGAEID-LDQLKPQTRQALLELAAVVADGFPGAQQLQSPPF--
MAB_0630|M.abscessus_ATCC_1997 HLSEGSEIS-LDLMGKKTRMAFMELAGSVADGFYEGGNTRQTSWG-
MLBr_00048|M.leprae_Br4923 HIAAGTEIR-LDRLDPLYRRRILELAAALSDDFERAGRH-------
Rv3888c|M.tuberculosis_H37Rv HLAKGGIIDTVHELNKKSRLRLFEITAGLADKYVPDAERAAQ----
MAV_0156|M.avium_104 HLAKGGIIDTVHELKKKTRLRLFEITAGLADKYIPDAERAVP----
Mflv_0776|M.gilvum_PYR-GCK HLRPGGVIDGTAQMSRPARRKLVEVCAALAAFYPTQDDRSRERR--
Mvan_0069|M.vanbaalenii_PYR-1 HLRPGGVIDGTGEMSPSARRKFIEVVAALAAFFPASVTRSG-----
MSMEG_0053|M.smegmatis_MC2_155 HLRPGGVVD-IQEMSPKVRRKFLEVAAALADHFPTSDDHTRERS--
Mb3890|M.bovis_AF2122/97 HLRPGGVIDMSHEMAPTTRLKILQVAATVTAYFASRPADAHGSPPR
*: * : : * : :: . :: :