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TAPHKVAFPARCAVNICYDKHLCSQVFPAGIPVEGFFEGMVELFDADLKRKGFDGVALPAGSYELHKING VRLDINKSLDELGVQDGDTLVLVPRVAGESFEPQYESLSTGLAAMGKWLGRDGGDRMFAPVTSLTAAHTA MAIIAMAVGVVLALTLRTRTITDSPVPAAMAGGIGVLLVIGALVVWWGWRERRDLFSGFGWLAVVLLAVA AACAPPGALGAAHALIGLVVVVLGAITIGVATRKRWQTAVVTAVVTVCGILAAVAAVRMFRPVSMQVLAI CVLVGLLVLIRMTPTVALWVARVRPPHFGSITGRDLFARRAGMPVDTVAPVSEADADDEDNELTDITARG TAIAASARLVNAVQVGMCVGVSLVLPAAVWGVLTPRQPWAWLALLVAGLTVGLFITQGRGFAAKYQAVAL VCGASAAVCAGVLKYALDTPKGVQTGLLWPAIFVAAFAALGLAVALVVPATRFRPIIRLTVEWLEVLAMI ALLPAAAALGGLFAWLRH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3887c | - | - | 100% (509) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. tuberculosis H37Rv | Rv1795 | - | 9e-32 | 23.66% (486) | hypothetical protein Rv1795 |
| M. tuberculosis H37Rv | Rv3448 | - | 7e-16 | 23.46% (486) | integral membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3917c | - | 1e-159 | 99.65% (288) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_0321 | - | 5e-11 | 23.05% (486) | hypothetical protein Mflv_0321 |
| M. leprae Br4923 | MLBr_01539 | - | 2e-38 | 27.42% (496) | hypothetical protein MLBr_01539 |
| M. abscessus ATCC 19977 | MAB_3757 | - | 1e-18 | 23.15% (514) | hypothetical protein MAB_3757 |
| M. marinum M | MMAR_2677 | - | 7e-34 | 25.86% (522) | hypothetical protein MMAR_2677 |
| M. avium 104 | MAV_0157 | snm | 0.0 | 84.24% (476) | secretion protein Snm4 |
| M. smegmatis MC2 155 | MSMEG_0623 | snm | 3e-12 | 25.00% (460) | secretion protein Snm4 |
| M. thermoresistible (build 8) | TH_2236 | - | 6e-15 | 23.19% (526) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_3080 | - | 8e-34 | 25.86% (522) | hypothetical protein MUL_3080 |
| M. vanbaalenii PYR-1 | Mvan_0420 | - | 6e-14 | 24.13% (460) | hypothetical protein Mvan_0420 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0321|M.gilvum_PYR-GCK ---MPQSALSDTN-TAMPIVRVAVLTATAGDEDG-DRAGRLTEIALPAQL
Mvan_0420|M.vanbaalenii_PYR-1 ---MPPLDTNTLAGVVMPIVRVAVLTAAVGDEAAADRTGRITEIALPADL
MSMEG_0623|M.smegmatis_MC2_155 ---MSEN-------TVMPIVRVAVLAAG-------DDGGRLTEMALPSEL
Rv3887c|M.tuberculosis_H37Rv ---------MTAPHKVAFPARCAVNICY---------DKHLCSQVFPAGI
Mb3917c|M.bovis_AF2122/97 --------------------------------------------------
MAV_0157|M.avium_104 --------------------------------------------------
MMAR_2677|M.marinum_M MTAVADAPQAELEGVSSPRAVVVGIMAG---------EGVQIGVLLDANA
MUL_3080|M.ulcerans_Agy99 MTAVADAPQAELEGVSSPRAVVVGIMAG---------EGVQIGVLLDANA
MLBr_01539|M.leprae_Br4923 MTAVADAPRTDIEGTSSPRVVVVGIVAG---------EGAQISVLLDANA
MAB_3757|M.abscessus_ATCC_1997 --MTHAQSGAEQRSAVLELCRVSIQAER-----------TQVDLALPTSV
TH_2236|M.thermoresistible__bu --LTATASASAPGAAATASGTGATPARPATTRVTILTGRRMTDLVLPAAA
Mflv_0321|M.gilvum_PYR-GCK PLREIIPAVQRIVAPSDDAPG---TDPVS--------LAPIGGAPYSLDA
Mvan_0420|M.vanbaalenii_PYR-1 PLREIVPAVQRIVAPSDDSAGG--AEQLS--------LAPIGGAPFSLDA
MSMEG_0623|M.smegmatis_MC2_155 PLREILPAVQRIVQPARENDGA--ADPAAAPNPVRLSLAPIGGAPFSLDA
Rv3887c|M.tuberculosis_H37Rv PVEGFFEGMVELFDADLKRKG---FDGVALP-AGSYELHKINGVRLDINK
Mb3917c|M.bovis_AF2122/97 --------------------------------------------------
MAV_0157|M.avium_104 -MEGFFEGMVELFDADLKRKG---FDGIALP-AGSYELHKINGVRLDINK
MMAR_2677|M.marinum_M PVSVMTDPLLKVVNSRLRELG---ESTLEAAGRGRWALCLIDGSPLRATQ
MUL_3080|M.ulcerans_Agy99 PVSVMTDPLLKVVNSRLRELG---ESTLEAAGRGRWALCLIDGSPLRATQ
MLBr_01539|M.leprae_Br4923 PVSVMTDPLLKVINSRLCELG---EGTLEPTGRGRWALCLIDGTPLWPTQ
MAB_3757|M.abscessus_ATCC_1997 PLALLVGSIVDIINQHVGVPEL--TSPED-AVETHWRLSRPGQPPLQMSS
TH_2236|M.thermoresistible__bu PIESYIDETVSVLAELLEDTPSDVLAGFDFKAQGVWAFARPGAPPLKSDE
Mflv_0321|M.gilvum_PYR-GCK TLTTVGVVDGDLLALQPIPAGPPAPRIVEDIADAAMIFS--------AAR
Mvan_0420|M.vanbaalenii_PYR-1 TLNTVGVVDGDLLALQPVPAGPPAPRIVEDIADAAMIFS--------ASR
MSMEG_0623|M.smegmatis_MC2_155 TLDTVGVVDGDLLALQAVPSGPPAPRIVEDIADAAVIFS--------EAR
Rv3887c|M.tuberculosis_H37Rv SLDELGVQDGDTLVLVPRVAGESFEPQYESLSTGLAAMGKWLGRDGGDRM
Mb3917c|M.bovis_AF2122/97 --------------------------------------------------
MAV_0157|M.avium_104 SLDELGVQDGDTLVLVPRVDGESFEPQYESLSSGLAAMGKWLGREGGDRM
MMAR_2677|M.marinum_M SLTEQDVYDGDRLWIRFIPDTEHRSQVIEHISTAVASN--------LSKR
MUL_3080|M.ulcerans_Agy99 SLTEQDVYDGDRLWIRFIPDTEHRSQVIEHISTAVASN--------LSKR
MLBr_01539|M.leprae_Br4923 SLTEQDVYDGDRLWIRFIADTERRSQVIEHISTAVSAN--------LSKR
MAB_3757|M.abscessus_ATCC_1997 TLGELEVRDGDLLILTRSDVAAPDP-LFDDVFLAVSTFR--------TVS
TH_2236|M.thermoresistible__bu SLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLD---------ES
Mflv_0321|M.gilvum_PYR-GCK EKPWGTPQIQRGATVAVVGLMLVATALAVAHRVVTDSIIGVFAVSAVAIA
Mvan_0420|M.vanbaalenii_PYR-1 EKPWGVANIRSGATAAVIGLTVVATALAVAHRVFTDSLIGLFAVSAVAIG
MSMEG_0623|M.smegmatis_MC2_155 RRQWGPTHIARGAALALIGLILVGTGLSVAHRVITGDLLGQFIVSGIALA
Rv3887c|M.tuberculosis_H37Rv FAPVTSLTAAHTAMAIIAMAVGVVLALTLRTRTITDSPVPAAMAGGIGVL
Mb3917c|M.bovis_AF2122/97 --------------------------------------------------
MAV_0157|M.avium_104 FAPVTPLTAAHTAVAVIAMAVAVVVGLCLRARTFTDGPIPAAVAGGIGAL
MMAR_2677|M.marinum_M FASIDPVVAVQVGAGMVGTGVILASGVLGWWRWHHNTWLTTIFASVIAVL
MUL_3080|M.ulcerans_Agy99 FASIDPVVAVQVGAGMVGTGVILASGVLGWWRWHHNTWLTTIFASVIAVL
MLBr_01539|M.leprae_Br4923 FAAIDSIVAVQVGALMVATGVLASSVLLVWWRWHHGFWLSVIYATVIALL
MAB_3757|M.abscessus_ATCC_1997 AHPWSRNAARILGASVCGLSALLGATALLRAGATNPGLLLPIIAVAIALV
TH_2236|M.thermoresistible__bu PEFDRSALNRYIAVAIPIVSLIVTIVGLLSWANSGQSWWWALGLGLLGLG
Mflv_0321|M.gilvum_PYR-GCK AVLGALVART-----GSPRVATALAAAALPSVGAAFTLAVPGDFGAS-AV
Mvan_0420|M.vanbaalenii_PYR-1 AVLGALLARA-----SSPRLATALAAAALPSVAAAFTLAVPGDFGAS-NI
MSMEG_0623|M.smegmatis_MC2_155 TVIAALAVRN-----RSAVLATSLAVTALVPVAAAFALGVPGDFGAP-NV
Rv3887c|M.tuberculosis_H37Rv LVIGALVVWWGWRERRDLFSG--FGWLAVVLLAVAAACAPPGALGAA-HA
Mb3917c|M.bovis_AF2122/97 --------------------------------------------MAA-HA
MAV_0157|M.avium_104 LLIATLVVRSGWRERRDLFSG--FAWLAVVALAVAGACAPPGVLGAA-HA
MMAR_2677|M.marinum_M VLMVAMMLLMRATTDADRRVADIMLVSGLAPLTVAAASAPPGSVGSP-QA
MUL_3080|M.ulcerans_Agy99 VLMVAMMLLMRATTDADRRVADIMLVSGLAPLTVAAASAPPGSVGSP-QA
MLBr_01539|M.leprae_Br4923 ILVMSTLVLMRATTREDRRAGDIMLLSGIAPVTAAAAAAPPGPLGSP-HA
MAB_3757|M.abscessus_ATCC_1997 AMTAAVFANR---VYDDSLASVMLSHCAVGFSAVAGALFVPGKYGAP-HA
TH_2236|M.thermoresistible__bu VLGGSMLAKSR---YDNIDMTESLLVGSMPLLAGAAALAVPLPRGVTSLG
.
Mflv_0321|M.gilvum_PYR-GCK LLGAAGIAAWSIISITVG--ERAIAVFTAVAAAALGVAVAAAAATVWSLS
Mvan_0420|M.vanbaalenii_PYR-1 VLGAAGVAAWSVISITVG--ERAIALFTAAAASALGVLLVSAVASVWTLT
MSMEG_0623|M.smegmatis_MC2_155 LLAAAGVAAWSLISMAGSPDDRGIAVFTATAVTGVGVLLVAGAASLWVIS
Rv3887c|M.tuberculosis_H37Rv LIGLVVVVLGAITIGVATRKRWQTAVVTAVVTVCGILAAVAAVRMFRPVS
Mb3917c|M.bovis_AF2122/97 LIGLVVVVLGAITIGVATRKRWQTAVVTAVVTVCGILAAVAAVRMFRPVS
MAV_0157|M.avium_104 LIGVVVVILGAIAIGVTARNRWQTAVVTAVVTVCGVLAAVAAVRMFRPAS
MMAR_2677|M.marinum_M VLGFGVLSIAAALALRFTGR--RLAIYTAIVTICGLTTLASLSRMVAATS
MUL_3080|M.ulcerans_Agy99 ALGFGVLSIAAALALRFTGR--RLAIYTAIVTICGLTTLASLSRMVAATS
MLBr_01539|M.leprae_Br4923 VMGFGVFAIAAMLALRFTGR--QLSIYTAMITISVVVAIASLARMVAMTS
MAB_3757|M.abscessus_ATCC_1997 MLALMVAMVVSILAMRATG--TGTTSLVAVASASFLGFAAALGYVLFEPP
TH_2236|M.thermoresistible__bu APQLAAVGAVILLITLASRGGPRRRAELASFIAVTALAVTAAAVAYGYGW
* .:
Mflv_0321|M.gilvum_PYR-GCK LLDIGCVLILIALLITVQAAQLSAMCARLPVPVIP----------APGDP
Mvan_0420|M.vanbaalenii_PYR-1 PVHVGCILILAGLVVTVQAAQLSAMCARLPVPVIP----------APGDP
MSMEG_0623|M.smegmatis_MC2_155 SDVIGCALVLLGLIVTVQAAQLSAMWARFPLPVIP----------APGDP
Rv3887c|M.tuberculosis_H37Rv MQVLAICVLVGLLVLIRMTPTVALWVARVRPPHFGSITGRDLFARRAGMP
Mb3917c|M.bovis_AF2122/97 MQVLAICVLVGLLVLIRMTPTVALWVARVRPPHFGSITGRDLFARRAGMP
MAV_0157|M.avium_104 VQVLAICVLVGLLVLVRMTPLIALWVARVRPPHFGSITGRDLFARREGMP
MMAR_2677|M.marinum_M AVTLFATMLLICVVMYHASPALSRRLSGIRLPVFPSATSRWVFEARPDLP
MUL_3080|M.ulcerans_Agy99 AVTLFATMLLICVVMYHASPALSRRLSGIRLPVFPSATSRWVFEARPDLP
MLBr_01539|M.leprae_Br4923 AVTLLSCVMLACVLLYHCAPALSRRLAGIRLPVFPSATSRWVFEARPDLP
MAB_3757|M.abscessus_ATCC_1997 IYSLGAVLGSVGICAVALSPRVAMVLARLPLPPVPTQGAPSR-PEHSTAP
TH_2236|M.thermoresistible__bu EYWVPVGAIAFGLIVVTNAAKLTVAVARIALPPIPAPGETVTNDDLLDPV
: : :. :: : . * .
Mflv_0321|M.gilvum_PYR-GCK APSALPRRVLEDLPRRIRAGDAYQTG-----------FIAAGVLLAVTGS
Mvan_0420|M.vanbaalenii_PYR-1 TPSAPPLRVLEDLPRRIRASDAHQTG-----------FIAAGVLLGVAGS
MSMEG_0623|M.smegmatis_MC2_155 TPAARPLSVLADLPRRVRVSQAHQTG-----------VIAAGVLLGVAGS
Rv3887c|M.tuberculosis_H37Rv VDTVAPVSEADADDEDNELTDITARGTAIAASARLVNAVQVGMCVGVSLV
Mb3917c|M.bovis_AF2122/97 VDTVAPVSEADADDEDNELTGITARGTAIAASARLVNAVQVGMCVGVSLV
MAV_0157|M.avium_104 VDTVAPVSEDESEEQDNELTDITARGAAIAASARLVNAVQVGLCVGVSIV
MMAR_2677|M.marinum_M TTVAVAAGGPPVLEGPASVRDVVLQ-------AERARSFLSGLLVGLGVL
MUL_3080|M.ulcerans_Agy99 TTVAVAAGGPPVLEGPASVRDVVLQ-------AERARSFLSGLLVGLGVL
MLBr_01539|M.leprae_Br4923 NTVVRSDGGPPVLEGPASVRDVLLQ-------SERARSYLSGLLLGLGVL
MAB_3757|M.abscessus_ATCC_1997 IEAIEGLDGLDTEGDDVEDATALPPLPDLREKALRAHAVLTGLVCGTSAV
TH_2236|M.thermoresistible__bu ITPDGSDEETSTWQAIIASVPESAQR--LQERSTLAKQLLIGFLTAGAVV
*. .
Mflv_0321|M.gilvum_PYR-GCK VLV---------VWPAVSGDGGVPVWSWYLVAATALAAALRARVWDSSAC
Mvan_0420|M.vanbaalenii_PYR-1 VFA---------VWPGVGGDGSASPWAWLLVGATALGAVLRARVWDSASC
MSMEG_0623|M.smegmatis_MC2_155 VAL---------VSSAN-----ASPWAWYIVVAAAAGAALRARVWDSAAC
Rv3887c|M.tuberculosis_H37Rv LPA---------AVWGVLTPRQPWAWLALLVAGLTVGLFITQGRGFAAKY
Mb3917c|M.bovis_AF2122/97 LPA---------AVWGVLTPRQPWAWLALLVAGLTVGLFITQGRGFAAKY
MAV_0157|M.avium_104 LPA---------AVWGVLTPGRPWAWLALVVAGLVVGIFITQGRGFAAKY
MMAR_2677|M.marinum_M MVV---------SLTSLCNPHTSERWLPLMLAGFTSGFLMLRGRSYVDRW
MUL_3080|M.ulcerans_Agy99 MVV---------SLTSLCNPHTSERWLPLMLAGFTSGFLMLRGRSYVDRW
MLBr_01539|M.leprae_Br4923 LVV---------SLTALSNPHVGQRWLPLLLAGFTSGFLLLRGRSYVDRW
MAB_3757|M.abscessus_ATCC_1997 TAVGAMLAALTFSGAGGHHPTGAHRLSGVVLAGLIALAMMLRARSHADLA
TH_2236|M.thermoresistible__bu LSAG----------AIAVVVQGHFFVHSLIVAGLVTMICAFRSRLYAERW
:: .
Mflv_0321|M.gilvum_PYR-GCK KAWLLGHGYLVTTVLLVLSAAHEKYSAAWWALGVLAVLVAAWAVAALNPR
Mvan_0420|M.vanbaalenii_PYR-1 KAWLLAQPFLMSAVLLGIFAVTGRYDAAWWTLGAFAVLAAAWVVAALNPR
MSMEG_0623|M.smegmatis_MC2_155 KAWLLGHSYLLAVALLVAFVIGDRYQAALWALAALAVLVLVWIVAALNPK
Rv3887c|M.tuberculosis_H37Rv QAVALVCGASAAVCAGVLKYALDTPKGVQTGLLWPAIFVAAFAALGLAVA
Mb3917c|M.bovis_AF2122/97 QAVALVCGASAAVCAGVLKYALDTPKGVQTGLLWPAIFVAAFAALGLAVA
MAV_0157|M.avium_104 QAVALVCGASAAVCAGVVKYALAAPHDAMTGLLWPVVAVTTFAAFGLAAA
MMAR_2677|M.marinum_M QSITLAVTAVIVVAAVSVRYALVLSS--PLSVSIVASLLVLLPAAGMTAA
MUL_3080|M.ulcerans_Agy99 QSITLAVTAVIVVAAVSVRYALVLSS--PLSVSIVASLLVLLPAAGMTAA
MLBr_01539|M.leprae_Br4923 QAITLAATAVLIVAAVVVRYALVLSS--PLAVSIGAAILVLLPAAGLIAA
MAB_3757|M.abscessus_ATCC_1997 QTVAINLGGIAIPAAAFAFVAVAYPT----AAVFTTVLAAIAAGSAIALG
TH_2236|M.thermoresistible__bu CAWALLAACTAIPTGVMVKLCMWYPER---AAVVLGIYVAAVLVAVIAVG
: : :
Mflv_0321|M.gilvum_PYR-GCK IAQPDT-YSLPMRRVVGFVATALDASVIPVMAYLVGLFTLVLNGF--
Mvan_0420|M.vanbaalenii_PYR-1 IAEPQT-YSLPMRRLLGFVAAAVDASVIPVMAYLVGLFAWALNGV--
MSMEG_0623|M.smegmatis_MC2_155 IASPDT-YSLPMRRMVGFLATGLDASLIPVMALLVGLFSLVLDR---
Rv3887c|M.tuberculosis_H37Rv LVVPATRFRPIIRLTVEWLEVLAMIALLPAAAALGGLFAWLRH----
Mb3917c|M.bovis_AF2122/97 LVVPATRFRPIIRLTVEWLEVLAMIALLPAAAALGGLFAWLRH----
MAV_0157|M.avium_104 LLVPAMRFRPFIRLTVEWVEVLAFIVLLPAAAALGGLFTWIRH----
MMAR_2677|M.marinum_M AVVPNTIYSPLFRKFVEWTEYLCLMPIFPLAFWLMNVYAAIRYR---
MUL_3080|M.ulcerans_Agy99 AVVPNTIYSPLFRKFVEWTEYLCLMPIFPLAFWLMNVYAAIRYR---
MLBr_01539|M.leprae_Br4923 AVVPNTIYSPLFRKLVEWIEYLCLVPIFPLALWLMDVYTAIRYR---
MAB_3757|M.abscessus_ATCC_1997 FLVSARKYSPVARRTVEIIEYIALSLIVPIAVWVCGVYSAVRGLNLP
TH_2236|M.thermoresistible__bu ATHGVRRMSPVTKRILELVDGAAIAATIPMLLWIGSVFDILRNIRF-
: : .* : .::