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MPTSDPGLRRVTVHAGAQAVDLTLPAAVPVATLIPSIVDILGDRGASPATAARYQLSALGAPALPNATTL AQCGIRDGAVLVLHKSSAQPPTPRCDDVAEAVAAALDTTARPQCQRTTRLSGALAASCITAGGGLMLVRN ALGTNVTRYSDATAGVVAAAGLAALLFAVIACRTYRDPIAGLTLSVIATIFGAVAGLLAVPGVPGVHSVL VAAMAAAATSVLAMRITGCGGITLTAVACCAVVVAAATLVGAITAAPVPAIGSLATLASFGLLEVSARMA VLLAGLSPRLPPALNPDDADALPTTDRLTTRANRADAWLTSLLAAFAASATIGAIGTAVATHGIHRSSMG GIALAAVTGALLLLRARSADTRRSLVFAICGITTVATAFTVAADRALEHGPWIAALTAMLAAVAMFLGFV APALSLSPVTYRTIELLECLALIAMVPLTAWLCGAYSAVRHLDLTWT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3448 | - | - | 100% (467) | PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN |
| M. tuberculosis H37Rv | Rv0290 | - | 1e-27 | 27.23% (481) | transmembrane protein |
| M. tuberculosis H37Rv | Rv3877 | - | 3e-25 | 27.22% (507) | transmembrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3478 | - | 0.0 | 99.79% (467) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_4960 | - | 1e-34 | 30.56% (468) | hypothetical protein Mflv_4960 |
| M. leprae Br4923 | MLBr_02529 | - | 6e-21 | 26.03% (484) | hypothetical protein MLBr_02529 |
| M. abscessus ATCC 19977 | MAB_3757 | - | 6e-58 | 34.06% (502) | hypothetical protein MAB_3757 |
| M. marinum M | MMAR_1101 | - | 1e-115 | 51.61% (467) | hypothetical protein MMAR_1101 |
| M. avium 104 | MAV_4391 | - | 9e-99 | 48.07% (466) | hypothetical protein MAV_4391 |
| M. smegmatis MC2 155 | MSMEG_1535 | - | 2e-39 | 30.75% (465) | hypothetical protein MSMEG_1535 |
| M. thermoresistible (build 8) | TH_3996 | - | 4e-49 | 32.03% (462) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_0859 | - | 1e-113 | 50.96% (467) | hypothetical protein MUL_0859 |
| M. vanbaalenii PYR-1 | Mvan_1446 | - | 1e-40 | 32.19% (466) | hypothetical protein Mvan_1446 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4960|M.gilvum_PYR-GCK -----------------------MPDTLCRLTVHVVG--------ADESA
Mvan_1446|M.vanbaalenii_PYR-1 MPFHPQPGKVLQRRPPGPSYVDFVPDTLRRVAVHALG--------PREAA
MSMEG_1535|M.smegmatis_MC2_155 ----------------------MMPESLYRVSIHCA-------AADHAG-
TH_3996|M.thermoresistible__bu -----------------------VSDSVRRVSVQIDTLVDMLIGTDRGGT
Rv3448|M.tuberculosis_H37Rv --------------------MPTSDPGLRRVTVHAGA------------Q
Mb3478|M.bovis_AF2122/97 --------------------MPTSDPGLRRVTVHAGA------------Q
MMAR_1101|M.marinum_M -------------------MLSGSEPGLCRVAVHSGT------------A
MUL_0859|M.ulcerans_Agy99 -------------------MLSGSEPGLCRVAVHSGT------------A
MAV_4391|M.avium_104 ------------------MALAVSTTGLCRVSVHWET------------Q
MAB_3757|M.abscessus_ATCC_1997 -----------MTHAQSGAEQRSAVLELCRVSIQAER------------T
MLBr_02529|M.leprae_Br4923 ------MVYVFAEEFCEGPVTSGAVMPIVRVAILADS------------R
: *:::
Mflv_4960|M.gilvum_PYR-GCK AVDLVLPAACPLGELMPSLVDTIFGDT----------AGQEHWQLTRVTG
Mvan_1446|M.vanbaalenii_PYR-1 AADLVLPAEQPLAELVPSIVDTVFGGP----------VGPRQWQLATPAG
MSMEG_1535|M.smegmatis_MC2_155 AADLVLPAAMTVSQLLPSIVAAVGAPG----------DLPRRWYLAPPGG
TH_3996|M.thermoresistible__bu VIDVTLPSGVEVAELIPAIVDLAVGADG------VDAESPTAWKLARVGG
Rv3448|M.tuberculosis_H37Rv AVDLTLPAAVPVATLIPSIVDILGD-------RGASPATAARYQLSALGA
Mb3478|M.bovis_AF2122/97 AVDLTLPAAVPVATLIPSIVDILGD-------RGASPATAARYQLSALGA
MMAR_1101|M.marinum_M VVDLSLPAALPVAELIPAIVESLGG-------RDIG-AAPTRYQLCPLGA
MUL_0859|M.ulcerans_Agy99 VVDLSLPAALPFAELIPAIVESLGG-------RDIG-AAPTRYQLCPLGA
MAV_4391|M.avium_104 AVDVSLPAEIAVAELIPSLVDMLGA-------GDGG---AGRYRLSAPGA
MAB_3757|M.abscessus_ATCC_1997 QVDLALPTSVPLALLVGSIVDIINQHVGVPELTSPEDAVETHWRLSRPGQ
MLBr_02529|M.leprae_Br4923 LIEMALPTELPLREILPAVKRLVVPAASDND-SPLAANASLHLSLAPIGG
:: **: . :: :: *
Mflv_4960|M.gilvum_PYR-GCK PPLNPALSLRDNDIGDGDMVMLTASRVPSPRI-SPTEACTVVALAGGNRE
Mvan_1446|M.vanbaalenii_PYR-1 VPLDSSMSLRDNVVEDGDVIVLTTARVPPPRL-LPTDPCAVVADAAEKGT
MSMEG_1535|M.smegmatis_MC2_155 APLDESMTLAQNEVHDGAVLVLTARLPVAPRS-YGLIHALTAAAPTPTPP
TH_3996|M.thermoresistible__bu TVLDASRTLTENGIREGELLMLTG---AASAP-VTRAEAPPGLEPAAGRW
Rv3448|M.tuberculosis_H37Rv PALPNATTLAQCGIRDGAVLVLHKSSAQPPTP-RCDDVAEAVAAALDTTA
Mb3478|M.bovis_AF2122/97 PALPNATTLAQCGIRDGAVLVLHKSSAQPPTP-RCDDVAEAVAAALDTTA
MMAR_1101|M.marinum_M GALPPSQSLAQSGIRDGTVLSLSRCSAEPAPG-PHDDDAEAVLATLRGST
MUL_0859|M.ulcerans_Agy99 GALPPSKSLAQRGIRDGTVLSLSRCSAEPAPG-PHDDDAEAVLATLRGST
MAV_4391|M.avium_104 AALDPSTTLAHNHIGDGAILVLSRIDVPLPAP-RYRDIADTVSAALDATA
MAB_3757|M.abscessus_ATCC_1997 PPLQMSSTLGELEVRDGDLLILTRSDVAAPDP-LFDDVFLAVSTFRTVSA
MLBr_02529|M.leprae_Br4923 APFSLDASLDTVGVVDGDLLALQPVPVGPAAPGIVEDIADAAMIFSTARL
: :* : :* :: * .
Mflv_4960|M.gilvum_PYR-GCK SGHGATPWC-IAGIIVAAVTLVR------------SGMVTPGGWHLWCAA
Mvan_1446|M.vanbaalenii_PYR-1 PGRGVNRAAGAAGIVACAVALVW------------SGTAAPTHWHLWCAA
MSMEG_1535|M.smegmatis_MC2_155 PASRMFAGLWTCAVGMAAVLCAG------------IGTGGPTRVIVAAVV
TH_3996|M.thermoresistible__bu HGARTALALWCPIAGTAAVVWTG------------LMRDDIGRTVPAAML
Rv3448|M.tuberculosis_H37Rv RPQCQRTTRLSGALAASCITAGGGLMLVRNALGTNVTRYSDATAGVVAAA
Mb3478|M.bovis_AF2122/97 RPQCQRTTRLSGALAASCITAGGGLMLVRNALGTNVTRYSDATAGVVAAA
MMAR_1101|M.marinum_M RPPSRRAKELTGALTAGGVGGVGAVLLVRDALG-NTDRHGAATAVVAITS
MUL_0859|M.ulcerans_Agy99 RPPSRRAKELTGALTAGGVGGVGAVLLVRDALG-NTDRHGAATAVVAITS
MAV_4391|M.avium_104 RP-DVAVRRVAGAAAAASFVAAGGLQLVRNTFSASVVPDSGGTVAVLVST
MAB_3757|M.abscessus_ATCC_1997 HPWSRNAARILGASVCGLSALLGATALLR----AGATNPGLLLPIIAVAI
MLBr_02529|M.leprae_Br4923 QSWGPTHIRRGALAATTAVTFAATG------LGVTYRAVTGALTGLLVVI
Mflv_4960|M.gilvum_PYR-GCK ALSGIAGTMSVALGRADRRVSTVLNTAAVVFAAATGVLAVPAAAWPAATL
Mvan_1446|M.vanbaalenii_PYR-1 ALSGSAAVGAVAAARAEPELTALLSTAAVVFATAAGLLAVRSAPWPATVL
MSMEG_1535|M.smegmatis_MC2_155 AVAVTAVAFASRRLALTAAAATSVQSLAVASVAILGFVAVPSDSGPGNVF
TH_3996|M.thermoresistible__bu TVGAVAAVLPYR-HRRDPLTATASALIVVMLAAVLGLLVVPDGPGPPNLM
Rv3448|M.tuberculosis_H37Rv GLAALLFAVIACRTYRDPIAGLTLSVIATIFGAVAGLLAVPGVPGVHSVL
Mb3478|M.bovis_AF2122/97 GLAALLFAVIACRTYRDPIAGLTLSVIATIFGAVAGLLAVPGVPGVHSVL
MMAR_1101|M.marinum_M GVLALLVAGMARRTGREPTAVFTLNVIATTFVAVGALLAVPGRLGVPNLM
MUL_0859|M.ulcerans_Agy99 RVLALLVAGMTRRTGREPTAVFTLNVIATTFVAVGALLAVPGRLGVPNLM
MAV_4391|M.avium_104 TLLTLGAAAVAHRGYRDPGAALALGAIATVFAGLAGFVAVPGAPSLSHVL
MAB_3757|M.abscessus_ATCC_1997 ALVAMTAAVFANRVYDDSLASVMLSHCAVGFSAVAGALFVPGKYGAPHAM
MLBr_02529|M.leprae_Br4923 VIAVLIALGGLVLRSRAARTGLVLSIAALVPIGAVFALAVPGIFGPAQVL
: . : * :
Mflv_4960|M.gilvum_PYR-GCK LAAASALAMSTLLARMCPG-AADLPAFCAVAGAVTAAAALSH----LAAP
Mvan_1446|M.vanbaalenii_PYR-1 LASSAGFCMSVLLLRLVAD-RALLTAFTAAGGAATAAAGLAN----LAAS
MSMEG_1535|M.smegmatis_MC2_155 LAATAAASLGVVLLRLTDGSVETMHAVVAFAVIAGIGAAVAT----LFPL
TH_3996|M.thermoresistible__bu LAAAAAAAAAMVMARLTGVDIVGLTAVATGAAAVAISLIPAV----LWPV
Rv3448|M.tuberculosis_H37Rv VAAMAAAATSVLAMRITGCGGITLTAVACCAVVVAAATLVGA----ITAA
Mb3478|M.bovis_AF2122/97 VAAMAAAATSVLAMRITGCGGITLTAVACCAVVVAAATLVGA----ITAA
MMAR_1101|M.marinum_M LAAMGASVAAALAIRLTGCGGVTFTAVMCCAIVIAAAALCGV----ITGA
MUL_0859|M.ulcerans_Agy99 LAAMGASVAAALAIRLTGCGGVTFTAVMCCAIVIAAAALCGV----ITGA
MAV_4391|M.avium_104 LAAAAAGLAAVSAIGLSGCG-AGLLALACWCLILATAALAGV----LSGA
MAB_3757|M.abscessus_ATCC_1997 LALMVAMVVSILAMRATGTGTTSLVAVASASFLGFAAALGYV----LFEP
MLBr_02529|M.leprae_Br4923 LASAGVTAWSLIALIVPGPERVRIVAFFTATVVIGVAVMLEAGAALLWQL
:* . : *. . :
Mflv_4960|M.gilvum_PYR-GCK RLTTAGAVLVVLSLAGLAISPRITIALARLSPSRPAVDDE----------
Mvan_1446|M.vanbaalenii_PYR-1 -PVTAGAALAALSTAALSVAPKLAVVTAGPEP------------------
MSMEG_1535|M.smegmatis_MC2_155 DIQAFGACLGALGIAALSLSPRMSIILAGLTPG-EASPAG----------
TH_3996|M.thermoresistible__bu PTVVIGVLTASLSMAVLAVAPRLSIALAGLTPAPDGGPDAP---------
Rv3448|M.tuberculosis_H37Rv PVPAIGSLATLASFGLLEVSARMAVLLAGLSPRLPPALNP----------
Mb3478|M.bovis_AF2122/97 PVPAIGSLDTLASFGLLEVSARMAVLLAGLSPRLPPALNP----------
MMAR_1101|M.marinum_M ALYVVGSLTTLAALVALEVSARVSMVVAGLSPKLPAAPGS----------
MUL_0859|M.ulcerans_Agy99 ALYVVGSLTTLAALVALEVSARVSMVVAGLSPKLPAAPGS----------
MAV_4391|M.avium_104 PLPAVASAAGLVSLCLLGMAARASLALAGLSPRPATAPAG----------
MAB_3757|M.abscessus_ATCC_1997 PIYSLGAVLGSVGICAVALSPRVAMVLARLPLPPVPTQGAPSRPEHSTAP
MLBr_02529|M.leprae_Br4923 TPLTIGCGLILAALLVTVEAAQLSALWARFPLPVIPAPGDP---------
. . :.: : *
Mflv_4960|M.gilvum_PYR-GCK -------------------------------EAAAAHTLLTALVAGWSSS
Mvan_1446|M.vanbaalenii_PYR-1 ---------------------------------AAAHSTLTGLVAGWSAT
MSMEG_1535|M.smegmatis_MC2_155 ---------------------------DVDVVAARGHRILCGLVAGASAA
TH_3996|M.thermoresistible__bu --------------------GSLFDDAPAAPRLVRGNAILTGILTGAAVT
Rv3448|M.tuberculosis_H37Rv -----------------DDADALPTTDRLTTRANRADAWLTSLLAAFAAS
Mb3478|M.bovis_AF2122/97 -----------------DDADALPTTDRLTTRANRADAWLTSLLAAFAAS
MMAR_1101|M.marinum_M -----------------EEAPELAAPDLLATRAVRADRWLNGLHGGFSSA
MUL_0859|M.ulcerans_Agy99 -----------------EEAPELAAPDLLATRAIRADRWLNGLHGGFSSA
MAV_4391|M.avium_104 -----------------GPE---PGEAWVSARARRADRWLTGLLAGLSSS
MAB_3757|M.abscessus_ATCC_1997 IEAIEGLDGLDTEGDDVEDATALPPLPDLREKALRAHAVLTGLVCGTSAV
MLBr_02529|M.leprae_Br4923 ----------------TPSAPSFQVLEDLPRRVRISSAHQSGFIAAATLL
. .: . :
Mflv_4960|M.gilvum_PYR-GCK AALGAVVVAAATI-----------VSGASAGLCAGLCVAAGVVLILRRNS
Mvan_1446|M.vanbaalenii_PYR-1 AAAGGVTVAAVAG-----------PAESSTILAALFAADLGGLLVLRTRS
MSMEG_1535|M.smegmatis_MC2_155 AALGAVLVAAD-------------GCGSVTFAAIAFDAAIGLALLSRGRS
TH_3996|M.thermoresistible__bu AVIGTTLIALGGVLVGQAAREPGSGPGGPWWTGPLFTALLAAALVLRARS
Rv3448|M.tuberculosis_H37Rv ATIGAIGTAVATHGIHRSS-----------MGGIALAAVTGALLLLRARS
Mb3478|M.bovis_AF2122/97 ATIGAIGTAVATHGIHRSS-----------MGGIALAAVTGALLLLRARS
MMAR_1101|M.marinum_M AALGAV---VAVLGSQR---------------AIGLTAVTGAVLLLRARA
MUL_0859|M.ulcerans_Agy99 AALGAV---VAVFGSQR---------------AIGLTAVTGAVLLLRARA
MAV_4391|M.avium_104 ATVGAA--VTVLAGAPR-------------LCCLAFGTGTGALLLLRSRG
MAB_3757|M.abscessus_ATCC_1997 TAVGAMLAALTFSGAGGHHP-----TGAHRLSGVVLAGLIALAMMLRARS
MLBr_02529|M.leprae_Br4923 SMLGSVAIALRPEAVSS--------------VGWYLVAATAVAATLRARV
: * : . * .
Mflv_4960|M.gilvum_PYR-GCK HADGVRRLWLGTSGFIACAAAVPAVADA----APAQAFWLSVAVAGGC--
Mvan_1446|M.vanbaalenii_PYR-1 HVVVHRRIALGAAGSVSLLAAFTVTVVA----APVHAPWLCACAAVLC--
MSMEG_1535|M.smegmatis_MC2_155 HASGRCRTVLGVTGFCALTAMFVLVVAW----SPPYGNWVGAAAVAVG--
TH_3996|M.thermoresistible__bu HADALRRGVLVGCGVGCATMAFTAVVIE----HPGQASAWGALAVAIG--
Rv3448|M.tuberculosis_H37Rv -ADTRRSLVFAICGITTVATAFTVAADR----ALEHGPWIAALTAMLAAV
Mb3478|M.bovis_AF2122/97 -ADTRRSLVFAICGITTVATAFTVAADR----ALEHGPWIAALTAMLAAV
MMAR_1101|M.marinum_M QVDGRSRLMFLIAGYVAGTAAFAVAAPG----LAQHGPWIAILTAALTAL
MUL_0859|M.ulcerans_Agy99 QVDGRSRLMFLIAGYVAGTAAFAVAAPG----LAQHGPWIAILTAALTAL
MAV_4391|M.avium_104 -GDGTRALVFAAGGIVTTATTFGVAAWS----APLPGPWVAATTATLVAA
MAB_3757|M.abscessus_ATCC_1997 HADLAQTVAINLGGIAIPAAAFAFVAVA----YPTAAVFTTVLAAIAAGS
MLBr_02529|M.leprae_Br4923 WDSVACKAWLLAQPYLVASVLLGLYTATGRYVAASAALLVLVVVVLAWAV
: . . . ..
Mflv_4960|M.gilvum_PYR-GCK VAGALRAGRPEPSNPALRHGIQVLEYVALAAVIPLAFWVSGVYGLVRDAS
Mvan_1446|M.vanbaalenii_PYR-1 VLAVRGAGSPASPNPLAHRMIQVTEYAALVALVPLAFWVSGIYGLVRQLS
MSMEG_1535|M.smegmatis_MC2_155 LAAMCSLGPASLTNAGILRIADAAEYVALAAVAPLACWLAGIFDAVRGFG
TH_3996|M.thermoresistible__bu LVAAGGR-PSAPVSPLIRRAADVAECVVLAALAPLACWVAGVYGLVRGLA
Rv3448|M.tuberculosis_H37Rv AMFLGFVAPALSLSPVTYRTIELLECLALIAMVPLTAWLCGAYSAVRHLD
Mb3478|M.bovis_AF2122/97 AMFLGFVAPALSLSPVTYRTIELLECLALIAMVPLTAWLCGAYSAVRHLD
MMAR_1101|M.marinum_M ALHLGFIAPTRPPSPIACRLIDALEFSASASLLPLACWTCGVFSAVGGLG
MUL_0859|M.ulcerans_Agy99 ALHLGFIAPTRPPSPIACRLIDALEFSASASLLPLACWTCGVFSAVGGLG
MAV_4391|M.avium_104 ALYLGCAP--RTCSPVLSRAADLLEWLALAALVPLTCWIAGLYGTVRGLT
MAB_3757|M.abscessus_ATCC_1997 AIALGFLVSARKYSPVARRTVEIIEYIALSLIVPIAVWVCGVYSAVRGLN
MLBr_02529|M.leprae_Br4923 VALNPRIASSDSYSLPLRRLLGMVASGLDASLIPAMAYLVSLFSWVLNR-
. : : * : . :. *
Mflv_4960|M.gilvum_PYR-GCK LL--
Mvan_1446|M.vanbaalenii_PYR-1 LA--
MSMEG_1535|M.smegmatis_MC2_155 M---
TH_3996|M.thermoresistible__bu LW--
Rv3448|M.tuberculosis_H37Rv LTWT
Mb3478|M.bovis_AF2122/97 LTWT
MMAR_1101|M.marinum_M LTWT
MUL_0859|M.ulcerans_Agy99 LTWT
MAV_4391|M.avium_104 LG--
MAB_3757|M.abscessus_ATCC_1997 LP--
MLBr_02529|M.leprae_Br4923 ----