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VEGFFEGMVELFDADLKRKGFDGIALPAGSYELHKINGVRLDINKSLDELGVQDGDTLVLVPRVDGESFE PQYESLSSGLAAMGKWLGREGGDRMFAPVTPLTAAHTAVAVIAMAVAVVVGLCLRARTFTDGPIPAAVAG GIGALLLIATLVVRSGWRERRDLFSGFAWLAVVALAVAGACAPPGVLGAAHALIGVVVVILGAIAIGVTA RNRWQTAVVTAVVTVCGVLAAVAAVRMFRPASVQVLAICVLVGLLVLVRMTPLIALWVARVRPPHFGSIT GRDLFARREGMPVDTVAPVSEDESEEQDNELTDITARGAAIAASARLVNAVQVGLCVGVSIVLPAAVWGV LTPGRPWAWLALVVAGLVVGIFITQGRGFAAKYQAVALVCGASAAVCAGVVKYALAAPHDAMTGLLWPVV AVTTFAAFGLAAALLVPAMRFRPFIRLTVEWVEVLAFIVLLPAAAALGGLFTWIRH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0157 | snm | - | 100% (476) | secretion protein Snm4 |
| M. avium 104 | MAV_2919 | snm | 1e-39 | 26.46% (480) | secretion protein Snm4 |
| M. avium 104 | MAV_4863 | - | 1e-10 | 25.87% (433) | hypothetical protein MAV_4863 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3917c | - | 1e-136 | 82.64% (288) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_0321 | - | 1e-11 | 23.89% (452) | hypothetical protein Mflv_0321 |
| M. tuberculosis H37Rv | Rv3887c | - | 0.0 | 84.24% (476) | transmembrane protein |
| M. leprae Br4923 | MLBr_01539 | - | 1e-36 | 27.63% (456) | hypothetical protein MLBr_01539 |
| M. abscessus ATCC 19977 | MAB_3757 | - | 4e-18 | 24.32% (444) | hypothetical protein MAB_3757 |
| M. marinum M | MMAR_2677 | - | 5e-34 | 26.26% (457) | hypothetical protein MMAR_2677 |
| M. smegmatis MC2 155 | MSMEG_0623 | snm | 8e-15 | 24.62% (463) | secretion protein Snm4 |
| M. thermoresistible (build 8) | TH_3948 | - | 3e-16 | 25.23% (436) | PUTATIVE secretion protein Snm4 |
| M. ulcerans Agy99 | MUL_3080 | - | 5e-34 | 26.26% (457) | hypothetical protein MUL_3080 |
| M. vanbaalenii PYR-1 | Mvan_0420 | - | 8e-15 | 25.55% (458) | hypothetical protein Mvan_0420 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0623|M.smegmatis_MC2_155 ----------MSENTVMPIVRVAVLAAG-------DDGGRLTEMALPSEL
TH_3948|M.thermoresistible__bu ----------MSDNTVMPIVRVAVLAAG-------DDGGRLTEMALPAEL
Mflv_0321|M.gilvum_PYR-GCK ---MPQSALSDTN-TAMPIVRVAVLTATAGDEDG-DRAGRLTEIALPAQL
Mvan_0420|M.vanbaalenii_PYR-1 ---MPPLDTNTLAGVVMPIVRVAVLTAAVGDEAAADRTGRITEIALPADL
Mb3917c|M.bovis_AF2122/97 --------------------------------------------------
Rv3887c|M.tuberculosis_H37Rv ---------MTAPHKVAFPARCAVNICYDK-----HLCSQVFPAGIPVEG
MAV_0157|M.avium_104 -----------------------------------------------MEG
MMAR_2677|M.marinum_M MTAVADAPQAELEGVSSPRAVVVGIMAGEG-----VQIGVLLDANAPVSV
MUL_3080|M.ulcerans_Agy99 MTAVADAPQAELEGVSSPRAVVVGIMAGEG-----VQIGVLLDANAPVSV
MLBr_01539|M.leprae_Br4923 MTAVADAPRTDIEGTSSPRVVVVGIVAGEG-----AQISVLLDANAPVSV
MAB_3757|M.abscessus_ATCC_1997 --MTHAQSGAEQRSAVLELCRVSIQAER-------TQVDLALPTSVPLAL
MSMEG_0623|M.smegmatis_MC2_155 PLREILPAVQRIVQPARENDGAADPAAAPNPVRLSLAPIGGAPFSLDATL
TH_3948|M.thermoresistible__bu PLREILPAVQQMAAPTEDG------ADVPDAVRLSLAPIGGAPFSLDATL
Mflv_0321|M.gilvum_PYR-GCK PLREIIPAVQRIVAPSDDA--------PG-TDPVSLAPIGGAPYSLDATL
Mvan_0420|M.vanbaalenii_PYR-1 PLREIVPAVQRIVAPSDDS--------AGGAEQLSLAPIGGAPFSLDATL
Mb3917c|M.bovis_AF2122/97 --------------------------------------------------
Rv3887c|M.tuberculosis_H37Rv FFEGMVELFDADLKRKGFDG-----VALP-AGSYELHKINGVRLDINKSL
MAV_0157|M.avium_104 FFEGMVELFDADLKRKGFDG-----IALP-AGSYELHKINGVRLDINKSL
MMAR_2677|M.marinum_M MTDPLLKVVNSRLRELGEST-----LEAAGRGRWALCLIDGSPLRATQSL
MUL_3080|M.ulcerans_Agy99 MTDPLLKVVNSRLRELGEST-----LEAAGRGRWALCLIDGSPLRATQSL
MLBr_01539|M.leprae_Br4923 MTDPLLKVINSRLCELGEGT-----LEPTGRGRWALCLIDGTPLWPTQSL
MAB_3757|M.abscessus_ATCC_1997 LVGSIVDIINQHVGVPELTS-----PEDAVETHWRLSRPGQPPLQMSSTL
MSMEG_0623|M.smegmatis_MC2_155 DTVGVVDGDLLALQAVPSGPPAPRIVEDIADAAVIFS--------EARRR
TH_3948|M.thermoresistible__bu QTVGVVDGDLLALQPIPSGPPAPRIVEDIADAAVIFS--------AARTR
Mflv_0321|M.gilvum_PYR-GCK TTVGVVDGDLLALQPIPAGPPAPRIVEDIADAAMIFS--------AAREK
Mvan_0420|M.vanbaalenii_PYR-1 NTVGVVDGDLLALQPVPAGPPAPRIVEDIADAAMIFS--------ASREK
Mb3917c|M.bovis_AF2122/97 --------------------------------------------------
Rv3887c|M.tuberculosis_H37Rv DELGVQDGDTLVLVPRVAGESFEPQYESLSTGLAAMGKWLGRDGGDRMFA
MAV_0157|M.avium_104 DELGVQDGDTLVLVPRVDGESFEPQYESLSSGLAAMGKWLGREGGDRMFA
MMAR_2677|M.marinum_M TEQDVYDGDRLWIRFIPDTEHRSQVIEHISTAVASN--------LSKRFA
MUL_3080|M.ulcerans_Agy99 TEQDVYDGDRLWIRFIPDTEHRSQVIEHISTAVASN--------LSKRFA
MLBr_01539|M.leprae_Br4923 TEQDVYDGDRLWIRFIADTERRSQVIEHISTAVSAN--------LSKRFA
MAB_3757|M.abscessus_ATCC_1997 GELEVRDGDLLILTRSDVAAPDP-LFDDVFLAVSTFR--------TVSAH
MSMEG_0623|M.smegmatis_MC2_155 QWGPTHIARGAALALIGLILVGTGLSVAHRVITGDLLGQFIVSGIALATV
TH_3948|M.thermoresistible__bu PWSPAHIARAAAVALIGLILAASALSVAHRILTGDVLGLFVVSGVAVATV
Mflv_0321|M.gilvum_PYR-GCK PWGTPQIQRGATVAVVGLMLVATALAVAHRVVTDSIIGVFAVSAVAIAAV
Mvan_0420|M.vanbaalenii_PYR-1 PWGVANIRSGATAAVIGLTVVATALAVAHRVFTDSLIGLFAVSAVAIGAV
Mb3917c|M.bovis_AF2122/97 --------------------------------------------------
Rv3887c|M.tuberculosis_H37Rv PVTSLTAAHTAMAIIAMAVGVVLALTLRTRTITDSPVPAAMAGGIGVLLV
MAV_0157|M.avium_104 PVTPLTAAHTAVAVIAMAVAVVVGLCLRARTFTDGPIPAAVAGGIGALLL
MMAR_2677|M.marinum_M SIDPVVAVQVGAGMVGTGVILASGVLGWWRWHHNTWLTTIFASVIAVLVL
MUL_3080|M.ulcerans_Agy99 SIDPVVAVQVGAGMVGTGVILASGVLGWWRWHHNTWLTTIFASVIAVLVL
MLBr_01539|M.leprae_Br4923 AIDSIVAVQVGALMVATGVLASSVLLVWWRWHHGFWLSVIYATVIALLIL
MAB_3757|M.abscessus_ATCC_1997 PWSRNAARILGASVCGLSALLGATALLRAGATNPGLLLPIIAVAIALVAM
MSMEG_0623|M.smegmatis_MC2_155 IAALAVRN-----RSAVLATSLAVTALVPVAAAFALGVPGDFGAPNVLLA
TH_3948|M.thermoresistible__bu LAALLARP-----RSIPLAAALSVAALVPVGAAFALAVPGDFGAPHLLLA
Mflv_0321|M.gilvum_PYR-GCK LGALVART-----GSPRVATALAAAALPSVGAAFTLAVPGDFGASAVLLG
Mvan_0420|M.vanbaalenii_PYR-1 LGALLARA-----SSPRLATALAAAALPSVAAAFTLAVPGDFGASNIVLG
Mb3917c|M.bovis_AF2122/97 ------------------------------------------MAAHALIG
Rv3887c|M.tuberculosis_H37Rv IGALVVWWGWRERRDLFSG--FGWLAVVLLAVAAACAPPGALGAAHALIG
MAV_0157|M.avium_104 IATLVVRSGWRERRDLFSG--FAWLAVVALAVAGACAPPGVLGAAHALIG
MMAR_2677|M.marinum_M MVAMMLLMRATTDADRRVADIMLVSGLAPLTVAAASAPPGSVGSPQAVLG
MUL_3080|M.ulcerans_Agy99 MVAMMLLMRATTDADRRVADIMLVSGLAPLTVAAASAPPGSVGSPQAALG
MLBr_01539|M.leprae_Br4923 VMSTLVLMRATTREDRRAGDIMLLSGIAPVTAAAAAAPPGPLGSPHAVMG
MAB_3757|M.abscessus_ATCC_1997 TAAVFANR---VYDDSLASVMLSHCAVGFSAVAGALFVPGKYGAPHAMLA
:. :.
MSMEG_0623|M.smegmatis_MC2_155 AAGVAAWSLISMAGSPDDRGIAVFTATAVTGVGVLLVAGAASLWVISSDV
TH_3948|M.thermoresistible__bu AAGVTAWSIISIT--VAERSVAVFTTASVLGVATMAAAAAATLWEPSWVV
Mflv_0321|M.gilvum_PYR-GCK AAGIAAWSIISIT--VGERAIAVFTAVAAAALGVAVAAAAATVWSLSLLD
Mvan_0420|M.vanbaalenii_PYR-1 AAGVAAWSVISIT--VGERAIALFTAAAASALGVLLVSAVASVWTLTPVH
Mb3917c|M.bovis_AF2122/97 LVVVVLGAITIGVATRKRWQTAVVTAVVTVCGILAAVAAVRMFRPVSMQV
Rv3887c|M.tuberculosis_H37Rv LVVVVLGAITIGVATRKRWQTAVVTAVVTVCGILAAVAAVRMFRPVSMQV
MAV_0157|M.avium_104 VVVVILGAIAIGVTARNRWQTAVVTAVVTVCGVLAAVAAVRMFRPASVQV
MMAR_2677|M.marinum_M FGVLSIAAALALRFTGR--RLAIYTAIVTICGLTTLASLSRMVAATSAVT
MUL_3080|M.ulcerans_Agy99 FGVLSIAAALALRFTGR--RLAIYTAIVTICGLTTLASLSRMVAATSAVT
MLBr_01539|M.leprae_Br4923 FGVFAIAAMLALRFTGR--QLSIYTAMITISVVVAIASLARMVAMTSAVT
MAB_3757|M.abscessus_ATCC_1997 LMVAMVVSILAMRATGT--GTTSLVAVASASFLGFAAALGYVLFEPPIYS
: : .: .: . .
MSMEG_0623|M.smegmatis_MC2_155 IGCALVLLGLIVTVQAAQLSAMWARFPLPVIP----------APGDPTPA
TH_3948|M.thermoresistible__bu LGCGLIVLGLLVTVQAAQLSAMFARFPLPVIP----------APGDPTPS
Mflv_0321|M.gilvum_PYR-GCK IGCVLILIALLITVQAAQLSAMCARLPVPVIP----------APGDPAPS
Mvan_0420|M.vanbaalenii_PYR-1 VGCILILAGLVVTVQAAQLSAMCARLPVPVIP----------APGDPTPS
Mb3917c|M.bovis_AF2122/97 LAICVLVGLLVLIRMTPTVALWVARVRPPHFGSITGRDLFARRAGMPVDT
Rv3887c|M.tuberculosis_H37Rv LAICVLVGLLVLIRMTPTVALWVARVRPPHFGSITGRDLFARRAGMPVDT
MAV_0157|M.avium_104 LAICVLVGLLVLVRMTPLIALWVARVRPPHFGSITGRDLFARREGMPVDT
MMAR_2677|M.marinum_M LFATMLLICVVMYHASPALSRRLSGIRLPVFPSATSRWVFEARPDLPTTV
MUL_3080|M.ulcerans_Agy99 LFATMLLICVVMYHASPALSRRLSGIRLPVFPSATSRWVFEARPDLPTTV
MLBr_01539|M.leprae_Br4923 LLSCVMLACVLLYHCAPALSRRLAGIRLPVFPSATSRWVFEARPDLPNTV
MAB_3757|M.abscessus_ATCC_1997 LGAVLGSVGICAVALSPRVAMVLARLPLPPVPTQGAPSR-PEHSTAPIEA
: : : :. :: : . * . *
MSMEG_0623|M.smegmatis_MC2_155 ARPLSVLADLPRRVRVSQAHQTG-----------VIAAGVLLGVAGSVAL
TH_3948|M.thermoresistible__bu AQPLRVLEDLPRRVRVGDSHQTG-----------LIAAGVLLSVAGSVAL
Mflv_0321|M.gilvum_PYR-GCK ALPRRVLEDLPRRIRAGDAYQTG-----------FIAAGVLLAVTGSVLV
Mvan_0420|M.vanbaalenii_PYR-1 APPLRVLEDLPRRIRASDAHQTG-----------FIAAGVLLGVAGSVFA
Mb3917c|M.bovis_AF2122/97 VAPVSEADADDEDNELTGITARGTAIAASARLVNAVQVGMCVGVSLVLPA
Rv3887c|M.tuberculosis_H37Rv VAPVSEADADDEDNELTDITARGTAIAASARLVNAVQVGMCVGVSLVLPA
MAV_0157|M.avium_104 VAPVSEDESEEQDNELTDITARGAAIAASARLVNAVQVGLCVGVSIVLPA
MMAR_2677|M.marinum_M AVAAGGPPVLEGPASVRDVVLQ-------AERARSFLSGLLVGLGVLMVV
MUL_3080|M.ulcerans_Agy99 AVAAGGPPVLEGPASVRDVVLQ-------AERARSFLSGLLVGLGVLMVV
MLBr_01539|M.leprae_Br4923 VRSDGGPPVLEGPASVRDVLLQ-------SERARSYLSGLLLGLGVLLVV
MAB_3757|M.abscessus_ATCC_1997 IEGLDGLDTEGDDVEDATALPPLPDLREKALRAHAVLTGLVCGTSAVTAV
*: .
MSMEG_0623|M.smegmatis_MC2_155 ---------VSS-----ANASPWAWYIVVAAAAGAALR-ARVWDSAACKA
TH_3948|M.thermoresistible__bu ---------VAP-----PGASGWAWYVVVAAAAGSTLR-ARVWDAASCKL
Mflv_0321|M.gilvum_PYR-GCK ---------VWPAVSGDGGVPVWSWYLVAATALAAALR-ARVWDSSACKA
Mvan_0420|M.vanbaalenii_PYR-1 ---------VWPGVGGDGSASPWAWLLVGATALGAVLR-ARVWDSASCKA
Mb3917c|M.bovis_AF2122/97 ---------AVWGVLTPRQPWAWLALLVAGLTVGLFITQGRGFAAKYQAV
Rv3887c|M.tuberculosis_H37Rv ---------AVWGVLTPRQPWAWLALLVAGLTVGLFITQGRGFAAKYQAV
MAV_0157|M.avium_104 ---------AVWGVLTPGRPWAWLALVVAGLVVGIFITQGRGFAAKYQAV
MMAR_2677|M.marinum_M ---------SLTSLCNPHTSERWLPLMLAGFTSGFLMLRGRSYVDRWQSI
MUL_3080|M.ulcerans_Agy99 ---------SLTSLCNPHTSERWLPLMLAGFTSGFLMLRGRSYVDRWQSI
MLBr_01539|M.leprae_Br4923 ---------SLTALSNPHVGQRWLPLLLAGFTSGFLLLRGRSYVDRWQAI
MAB_3757|M.abscessus_ATCC_1997 GAMLAALTFSGAGGHHPTGAHRLSGVVLAGLIALAMMLRARSHADLAQTV
:: . : .*
MSMEG_0623|M.smegmatis_MC2_155 WLLGHSYLLAVALLVAFVIGDRYQAALWALAALAVLVLVWIVAALNPKIA
TH_3948|M.thermoresistible__bu WLLSHSYLITVALLIGFTVTERYPAAWLALAVLALLVTVWAVVVAYPRIA
Mflv_0321|M.gilvum_PYR-GCK WLLGHGYLVTTVLLVLSAAHEKYSAAWWALGVLAVLVAAWAVAALNPRIA
Mvan_0420|M.vanbaalenii_PYR-1 WLLAQPFLMSAVLLGIFAVTGRYDAAWWTLGAFAVLAAAWVVAALNPRIA
Mb3917c|M.bovis_AF2122/97 ALVCGASAAVCAGVLKYALDTPKGVQTGLLWPAIFVAAFAALGLAVALVV
Rv3887c|M.tuberculosis_H37Rv ALVCGASAAVCAGVLKYALDTPKGVQTGLLWPAIFVAAFAALGLAVALVV
MAV_0157|M.avium_104 ALVCGASAAVCAGVVKYALAAPHDAMTGLLWPVVAVTTFAAFGLAAALLV
MMAR_2677|M.marinum_M TLAVTAVIVVAAVSVRYALVLSS--PLSVSIVASLLVLLPAAGMTAAAVV
MUL_3080|M.ulcerans_Agy99 TLAVTAVIVVAAVSVRYALVLSS--PLSVSIVASLLVLLPAAGMTAAAVV
MLBr_01539|M.leprae_Br4923 TLAATAVLIVAAVVVRYALVLSS--PLAVSIGAAILVLLPAAGLIAAAVV
MAB_3757|M.abscessus_ATCC_1997 AINLGGIAIPAAAFAFVAVAYPT----AAVFTTVLAAIAAGSAIALGFLV
: . . . :.
MSMEG_0623|M.smegmatis_MC2_155 SPDTYSLPMRRMVGFLATGLDASLIPVMALLVGLFSLVLDR---
TH_3948|M.thermoresistible__bu SPDSYSLPMRRLTGFLATALDASLIPVMAYLVGLFSWVLNR---
Mflv_0321|M.gilvum_PYR-GCK QPDTYSLPMRRVVGFVATALDASVIPVMAYLVGLFTLVLNGF--
Mvan_0420|M.vanbaalenii_PYR-1 EPQTYSLPMRRLLGFVAAAVDASVIPVMAYLVGLFAWALNGV--
Mb3917c|M.bovis_AF2122/97 PATRFRPIIRLTVEWLEVLAMIALLPAAAALGGLFAWLRH----
Rv3887c|M.tuberculosis_H37Rv PATRFRPIIRLTVEWLEVLAMIALLPAAAALGGLFAWLRH----
MAV_0157|M.avium_104 PAMRFRPFIRLTVEWVEVLAFIVLLPAAAALGGLFTWIRH----
MMAR_2677|M.marinum_M PNTIYSPLFRKFVEWTEYLCLMPIFPLAFWLMNVYAAIRYR---
MUL_3080|M.ulcerans_Agy99 PNTIYSPLFRKFVEWTEYLCLMPIFPLAFWLMNVYAAIRYR---
MLBr_01539|M.leprae_Br4923 PNTIYSPLFRKLVEWIEYLCLVPIFPLALWLMDVYTAIRYR---
MAB_3757|M.abscessus_ATCC_1997 SARKYSPVARRTVEIIEYIALSLIVPIAVWVCGVYSAVRGLNLP
: * :.* : .:::