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QLVDRVRGAVTGMSRRLVVGAVGAALVSGLVGAVGGTATAGAFSRPGLPVEYLQVPSPSMGRDIKVQFQS GGANSPALYLLDGLRAQDDFSGWDINTPAFEWYDQSGLSVVMPVGGQSSFYSDWYQPACGKAGCQTYKWE TFLTSELPGWLQANRHVKPTGSAVVGLSMAASSALTLAIYHPQQFVYAGAMSGLLDPSQAMGPTLIGLAM GDAGGYKASDMWGPKEDPAWQRNDPLLNVGKLIANNTRVWVYCGNGKPSDLGGNNLPAKFLEGFVRTSNI KFQDAYNAGGGHNGVFDFPDSGTHSWEYWGAQLNAMKPDLQRALGATPNTGPAPQGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3804c | fbpA | - | 100% (338) | SECRETED ANTIGEN 85-A FBPA (MYCOLYL TRANSFERASE 85A) (FIBRONECTIN-BINDING PROTEIN A) (ANTIGEN 85 COMPLEX A) |
| M. tuberculosis H37Rv | Rv1886c | fbpB | e-157 | 78.86% (317) | secreted antigen 85-B fbpB (85B) (antigen 85 complex B) |
| M. tuberculosis H37Rv | Rv0129c | fbpC | e-134 | 67.26% (336) | secreted antigen 85-C FBPC (85C) (antigen 85 complex C) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3834c | fbpA | 0.0 | 100.00% (338) | secreted antigen 85-A FBPA (Mycolyl transferase 85A) |
| M. gilvum PYR-GCK | Mflv_4459 | - | 1e-136 | 69.02% (326) | putative esterase |
| M. leprae Br4923 | MLBr_00097 | fbpA | 1e-166 | 82.98% (329) | antigen 85A, mycolytransferase |
| M. abscessus ATCC 19977 | MAB_0176 | - | 1e-117 | 63.64% (330) | antigen 85-A precursor |
| M. marinum M | MMAR_5368 | fbpA | 1e-172 | 84.02% (338) | secreted antigen 85-A FbpA |
| M. avium 104 | MAV_0214 | - | 1e-171 | 82.54% (338) | antigen 85-A |
| M. smegmatis MC2 155 | MSMEG_6398 | - | 1e-138 | 68.77% (333) | antigen 85-A |
| M. thermoresistible (build 8) | TH_2078 | fbpA | 1e-132 | 66.27% (335) | SECRETED ANTIGEN 85-A FBPA (MYCOLYL TRANSFERASE 85A) |
| M. ulcerans Agy99 | MUL_4987 | fbpA | 1e-171 | 83.43% (338) | secreted antigen 85-A FbpA |
| M. vanbaalenii PYR-1 | Mvan_1902 | - | 1e-140 | 70.25% (326) | putative esterase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3804c|M.tuberculosis_H37Rv MQLVDRVRGAVTGM-SRRLVVGAVGAALVSGLVGAVGG---TATAGAFSR
Mb3834c|M.bovis_AF2122/97 MQLVDRVRGAVTGM-SRRLVVGAVGAALVSGLVGAVGG---TATAGAFSR
MLBr_00097|M.leprae_Br4923 MKFVDRFRGAVAGM-LRRLVVEAMGVALLSALIGVVG----SAPAEAFSR
MMAR_5368|M.marinum_M MKLVDRFRGAVTGT-PRRLMVGAVGAALLSGLVGFVGG---SATASAFSR
MUL_4987|M.ulcerans_Agy99 MKLVDRFRGAATGT-SRRLMVGAVGAALLSGLVGFVGG---SATASAFSR
MAV_0214|M.avium_104 MTLVDRLRGAVAGM-PRRLVVGAAGAALLSGLIGAVGG---SATAGAFSR
Mflv_4459|M.gilvum_PYR-GCK MRLLDRIRGPWA----RRLGIATLAALLLPGVVGLTGG---SVTAGAFSR
Mvan_1902|M.vanbaalenii_PYR-1 MRLLDRIRGPWA----RRLGIAALAAVLLPGVVGLTGG---SATAGAFSR
MSMEG_6398|M.smegmatis_MC2_155 MKFVGRMRGAAAGL-SRRLTVAVAAAAVLPGLVGVVGG---SATAGAWSR
TH_2078|M.thermoresistible__bu MKLVAKLRGAARAL-PRRLTVAALAAALLPGLVGAFGG---SATAGAFSR
MAB_0176|M.abscessus_ATCC_1997 MKLFSKMRGALARQSARRIAVAATAVAVLPGVAGIVGGTALTPVAGAFSR
* :. :.**. **: : . .. ::..: * * : * *:**
Rv3804c|M.tuberculosis_H37Rv PGLPVEYLQVPSPSMGRDIKVQFQSGGANSPALYLLDGLRAQDDFSGWDI
Mb3834c|M.bovis_AF2122/97 PGLPVEYLQVPSPSMGRDIKVQFQSGGANSPALYLLDGLRAQDDFSGWDI
MLBr_00097|M.leprae_Br4923 PGLPVEYLQVPSPSMGRDIKVQFQNGGANSPALYLLDGLRAQDDFSGWDI
MMAR_5368|M.marinum_M PGLPVEYLQVPSAAMGRNIKVQFQSGGANSPALYLLDGMRAQDDFSGWDI
MUL_4987|M.ulcerans_Agy99 PGLPVEYLQVPSVAMGRNIKVQFQSGGANSPALYLLDGMRAQDDFSGWDI
MAV_0214|M.avium_104 PGLPVEYLQVPSAAMGRDIKVQFQSGGANSPALYLLDGMRAQDDFNGWDI
Mflv_4459|M.gilvum_PYR-GCK PGLPVEYLMVPSPSMGRDIKVQFQSGGPNSPALYLLDGLRAQDDFNGWDI
Mvan_1902|M.vanbaalenii_PYR-1 PGLPVEYLMVPSPSMGRDIKIQFQSGGPNSPALYLLDGLRAQDDFNGWDI
MSMEG_6398|M.smegmatis_MC2_155 PGLPVEYLEVPSAAMGRDIRVEFQSGGPGAPALYLLDGMRAREDQNGWDI
TH_2078|M.thermoresistible__bu PGLPVEYLMVPSAAMGRDIKVQFQSGGEGSPGVYLLDGLRARDDFNGWDI
MAB_0176|M.abscessus_ATCC_1997 PGLPVEYLQVPSASMGREIKVQFQPGG--AKAVYLLDGLRARDDFSGWDI
******** *** :***:*:::** ** : .:*****:**::* .****
Rv3804c|M.tuberculosis_H37Rv NTPAFEWYDQSGLSVVMPVGGQSSFYSDWYQPACGKA--GCQTYKWETFL
Mb3834c|M.bovis_AF2122/97 NTPAFEWYDQSGLSVVMPVGGQSSFYSDWYQPACGKA--GCQTYKWETFL
MLBr_00097|M.leprae_Br4923 NTTAFEWYYQSGISVVMPVGGQSSFYSDWYSPACGKA--GCQTYKWETFL
MMAR_5368|M.marinum_M NTPAFEWYYQSGISVAMPVGGQSSFYSDWYNPACGKA--GCTTYKWETFL
MUL_4987|M.ulcerans_Agy99 NTPAFEWYYQSGISVAMPVGGQSSFYSDWYNPACGKA--GCTTYKWETFL
MAV_0214|M.avium_104 NTPAFEWYNQSGISVAMPVGGQSSFYSDWYKPACGKA--GCTTYKWETFL
Mflv_4459|M.gilvum_PYR-GCK NTQAFEWYLDSGISVVMPVGGQSSFYSNWYKPACGKN--GCLTYNWETFL
Mvan_1902|M.vanbaalenii_PYR-1 NTQAFEWYLDSGISVIMPVGGQSSFYSNWYKPACGKS--GCLTYNWETFL
MSMEG_6398|M.smegmatis_MC2_155 ELPTFEWFLNSGISVVMPVGGQSSFYSDWYKPACGSKDGGCKTYKWETFL
TH_2078|M.thermoresistible__bu ETAAFEWYYESGLSVIMPVGGQSSFYSDWYSPACGNN--GCQTYKWETFL
MAB_0176|M.abscessus_ATCC_1997 ETTAFEDYYQSGISMVMPVGGQSSFYTDWYNPAKGKD--GVWTYKWETFT
: :** : :**:*: **********::**.** *. * **:****
Rv3804c|M.tuberculosis_H37Rv TSELPGWLQANRHVKPTGSAVVGLSMAASSALTLAIYHPQQFVYAGAMSG
Mb3834c|M.bovis_AF2122/97 TSELPGWLQANRHVKPTGSAVVGLSMAASSALTLAIYHPQQFVYAGAMSG
MLBr_00097|M.leprae_Br4923 TSELPQYLQSNKQIKPTGSAAVGLSMAGLSALTLAIYHPDQFIYVGSMSG
MMAR_5368|M.marinum_M TSELPQYLSANKGVKPTGSGVVGLSMAGSSALILAAYHPDQFVYSGSLSA
MUL_4987|M.ulcerans_Agy99 TSELPQYLSANKGVKPTGSGVVGLSMAGSSALILAAYHPDQFVYSGSLSA
MAV_0214|M.avium_104 TSELPQYLSAQKQVKPTGSGVVGLSMAGSSALILAAYHPDQFVYAGSLSA
Mflv_4459|M.gilvum_PYR-GCK TQELPAWLQANRDVRPTNNAAVGLSMAGGSSLVLAAHHPGQFSYAGSMSG
Mvan_1902|M.vanbaalenii_PYR-1 TQELPGWLQANRDVKPTGSAAVGLSMAGGSSLVLAAHHPGQFVWAGSMSG
MSMEG_6398|M.smegmatis_MC2_155 TQELPAWLAANRDVKPTGSAVVGLSMAGSSALMLAARHPQQFIYAASLSG
TH_2078|M.thermoresistible__bu TQELPAYLASNYGVDRNRNAAVGLSMAGSAALVLAIYYPQQFQYAASLSG
MAB_0176|M.abscessus_ATCC_1997 TQELPAYLAANKGISQTGNAVVGLSMGASAALTLSIYHPQLFVYAGALSG
*.*** :* :: : . ...*****.. ::* *: :* * : .::*.
Rv3804c|M.tuberculosis_H37Rv LLDPSQAMGPTLIGLAMGDAGGYKASDMWGPKEDP--AWQRNDPLLNVGK
Mb3834c|M.bovis_AF2122/97 LLDPSQAMGPTLIGLAMGDAGGYKASDMWGPKEDP--AWQRNDPLLNVGK
MLBr_00097|M.leprae_Br4923 LLDPSNAMGPSLIGLAMGDAGGYKAADMWGPSTDP--AWKRNDPTVNVGT
MMAR_5368|M.marinum_M LLDPSQGMGPSLIGLAMGDAGGYKASDMWGPKDDP--AWARNDPMLQVGK
MUL_4987|M.ulcerans_Agy99 LLDPSQGIGPSLIGLAMGDAGGYKASDMWGPKDDP--AWARNDPMLQVGK
MAV_0214|M.avium_104 LLDPSQGMGPSLIGLAMGDAGGYKAADMWGPKEDP--AWARNDPSLQVGK
Mflv_4459|M.gilvum_PYR-GCK FLNPSEGWWPGLINISMGDAGGYKANDMWG-PAETDPAWQYNDPMVQIPN
Mvan_1902|M.vanbaalenii_PYR-1 FLNPSEGWWPGLINISMGDAGGYKANDMWG-PAETDPAWQYNDPMVQIPR
MSMEG_6398|M.smegmatis_MC2_155 TLNPSEGWWPMLIGISMGDAGGYKADDMWGSTNDPNNAWKANDPTENVAT
TH_2078|M.thermoresistible__bu FLNLSEGWWPMLVGLAMGDAGGYDPNDMWGRTEDPNSAWKRNDPMVNIDK
MAB_0176|M.abscessus_ATCC_1997 FLNPSD--MKFQIGLAMGDAGGFSASDMWGPDSDP--AWQRNDPFLNIQK
*: *: :.::******:.. **** :. ** *** ::
Rv3804c|M.tuberculosis_H37Rv LIANNTRVWVYCGNGKPSDLG-----GNNLPAKFLEGFVRTSNIKFQDAY
Mb3834c|M.bovis_AF2122/97 LIANNTRVWVYCGNGKPSDLG-----GNNLPAKFLEGFVRTSNIKFQDAY
MLBr_00097|M.leprae_Br4923 LIANNTRIWMYCGNGKPTELG-----GNNLPAKLLEGLVRTSNIKFQDGY
MMAR_5368|M.marinum_M LVANNTRIWVYCGNGKPSDLG-----GDNLPAKFLEGFVRTSNMKFQAAY
MUL_4987|M.ulcerans_Agy99 LVANNTRIWVYCGNGKPSDLG-----GDNLPAKFLEGFVRTSNMKFQAAY
MAV_0214|M.avium_104 LVANNTRIWVYCGNGKPSDLG-----GDNLPAKFLEGFVRTSNLKFQDAY
Mflv_4459|M.gilvum_PYR-GCK LVANNSRIWVYCGNGTPNELG-----GGDLPATFLEGLTIRTNRTFQDNY
Mvan_1902|M.vanbaalenii_PYR-1 LVANNSRIWVYCGNGQPNELG-----GGDLPATFLEGLTIRTNRTFQDNY
MSMEG_6398|M.smegmatis_MC2_155 IANNGTRIWVYCGNGKPGELG-----GTDLPAKFLEGFVCRTNSTFQEKY
TH_2078|M.thermoresistible__bu LVANNTRIWVFCGDGTPADIGAGVPEGDNFNAKFLESFTLRTNKTFQQEY
MAB_0176|M.abscessus_ATCC_1997 IIDNGTRLWIYCGTGDSTDLDATRNGFENFTGGFLEGMAIGSNKKFVEAY
: *.:*:*::** * . ::. :: . :**.:. :* .* *
Rv3804c|M.tuberculosis_H37Rv NAGGGHNGVFDFPDSGTHSWEYWGAQLNAMKPDLQRALGATPN-------
Mb3834c|M.bovis_AF2122/97 NAGGGHNGVFDFPDSGTHSWEYWGAQLNAMKPDLQRALGATPN-------
MLBr_00097|M.leprae_Br4923 NAGGGHNAVFNFPDSGTHSWEYWGEQLNDMKPDLQQYLGATP--------
MMAR_5368|M.marinum_M NAAGGHNAVWNFDDNGTHSWEYWGAQLNAMKPDLQHTLGATP--------
MUL_4987|M.ulcerans_Agy99 NAAGGHNAVWNFDDNGTHSWEYWGAQLNAMRPDLQHTLGATP--------
MAV_0214|M.avium_104 NGAGGHNAVWNFDANGTHDWPYWGAQLQAMKPDLQSVLGATPGAGPATAA
Mflv_4459|M.gilvum_PYR-GCK LAAGGKNGVFNFPNNGTHNWAYWGRELQAMKPDLQAHLLG----------
Mvan_1902|M.vanbaalenii_PYR-1 IAAGGTNGVFNFPNNGTHNWAYWGRELQAMKPDLQAHLL-----------
MSMEG_6398|M.smegmatis_MC2_155 IEAGGKNGVFNFPQSGTHNWAYWGQQLQAMKPDLQRVLGATPTA------
TH_2078|M.thermoresistible__bu IAAGGKNGVFNFPDAGTHSWGYWGQQLQQMKPDIQRVLGVSAA-------
MAB_0176|M.abscessus_ATCC_1997 TAAGGKNAHIEFPPGGIHNWTYWGQQLRAMKPDMVAYLQSH---------
.** *. :* * *.* *** :*. *:**: *
Rv3804c|M.tuberculosis_H37Rv --TGPAPQGA
Mb3834c|M.bovis_AF2122/97 --TGPAPQGA
MLBr_00097|M.leprae_Br4923 --------GA
MMAR_5368|M.marinum_M --NTGDTQGA
MUL_4987|M.ulcerans_Agy99 --NTGDTQGA
MAV_0214|M.avium_104 ATNAGNGQGT
Mflv_4459|M.gilvum_PYR-GCK ----------
Mvan_1902|M.vanbaalenii_PYR-1 ----------
MSMEG_6398|M.smegmatis_MC2_155 ----------
TH_2078|M.thermoresistible__bu ----------
MAB_0176|M.abscessus_ATCC_1997 ----------